Aliases for KLRG2 Gene

Aliases for KLRG2 Gene

  • Killer Cell Lectin Like Receptor G2 2 3 5
  • Killer Cell Lectin-Like Receptor Subfamily G, Member 2 2 3
  • Killer Cell Lectin-Like Receptor Subfamily G Member 2 3 4
  • C-Type Lectin Domain Family 15 Member B 3 4
  • CLEC15B 3 4
  • C-Type Lectin Domain Family 15, Member B 2

External Ids for KLRG2 Gene

Previous GeneCards Identifiers for KLRG2 Gene

  • GC07M138787
  • GC07M139137
  • GC07M133447
  • GC07M139453

Summaries for KLRG2 Gene

GeneCards Summary for KLRG2 Gene

KLRG2 (Killer Cell Lectin Like Receptor G2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is CD69.

Additional gene information for KLRG2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLRG2 Gene

Genomics for KLRG2 Gene

GeneHancer (GH) Regulatory Elements for KLRG2 Gene

Promoters and enhancers for KLRG2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J139482 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 507.4 +0.2 210 2.2 MYC USF1 ZFX CTCF ZNF10 ZIC2 ZBTB26 HDAC2 MXI1 ZNF341 KLRG2 TTC26 piR-33614-258
GH07J139339 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 14.2 +142.5 142503 4 RXRA FOXK2 ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 POLR2G LUC7L2 AJ535831-005 FMC1 FMC1-LUC7L2 TRR-CCT4-1 piR-30229 UBN2 ENSG00000273391 TTC26 KLRG2
GH07J139452 Enhancer 0.7 Ensembl ENCODE 12.3 +30.1 30115 2 CTCF ZBTB11 GABPA RAD21 ATF2 CTCFL ZNF770 KDM1A SMARCA5 KLRG2 ENSG00000273391 RNU6-911P RF00026-1043 piR-38716-149
GH07J139441 Enhancer 0.3 ENCODE 16.9 +41.4 41368 1 ADNP EGR2 piR-34047-013 ENSG00000273391 KLRG2 lnc-LUC7L2-2
GH07J139321 Enhancer 0.7 Ensembl 7.7 +162.1 162111 0.8 CTCF TEAD4 ZNF263 REST RAD21 MYC SMC3 MXD4 BATF SMAD4 RF00017-6680 KLRG2 ENSG00000273391 piR-44878-045 UBN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLRG2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLRG2

Top Transcription factor binding sites by QIAGEN in the KLRG2 gene promoter:
  • AhR
  • Arnt
  • CUTL1
  • FOXO1
  • FOXO1a
  • Nkx5-1
  • Pax-4a
  • Pbx1a
  • XBP-1

Genomic Locations for KLRG2 Gene

Genomic Locations for KLRG2 Gene
56,779 bases
Minus strand
31,023 bases
Minus strand

Genomic View for KLRG2 Gene

Genes around KLRG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLRG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLRG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRG2 Gene

Proteins for KLRG2 Gene

  • Protein details for KLRG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Killer cell lectin-like receptor subfamily G member 2
    Protein Accession:
    Secondary Accessions:
    • Q2NL79
    • Q6ZTV6

    Protein attributes for KLRG2 Gene

    409 amino acids
    Molecular mass:
    42851 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLRG2 Gene


neXtProt entry for KLRG2 Gene

Post-translational modifications for KLRG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLRG2 Gene

No data available for DME Specific Peptides for KLRG2 Gene

Domains & Families for KLRG2 Gene

Gene Families for KLRG2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for KLRG2 Gene

Suggested Antigen Peptide Sequences for KLRG2 Gene

GenScript: Design optimal peptide antigens:
  • C-type lectin domain family 15 member B (KLRG2_HUMAN)
genes like me logo Genes that share domains with KLRG2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KLRG2 Gene

Function for KLRG2 Gene

Phenotypes From GWAS Catalog for KLRG2 Gene

Gene Ontology (GO) - Molecular Function for KLRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with KLRG2: view
genes like me logo Genes that share phenotypes with KLRG2: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KLRG2 Gene

Localization for KLRG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRG2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLRG2 gene
Compartment Confidence
extracellular 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
plasma membrane 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KLRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KLRG2: view

Pathways & Interactions for KLRG2 Gene

PathCards logo

SuperPathways for KLRG2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLRG2 Gene


No data available for Pathways by source and SIGNOR curated interactions for KLRG2 Gene

Drugs & Compounds for KLRG2 Gene

No Compound Related Data Available

Transcripts for KLRG2 Gene

mRNA/cDNA for KLRG2 Gene

6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLRG2 Gene

No ASD Table

Relevant External Links for KLRG2 Gene

GeneLoc Exon Structure for

Expression for KLRG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLRG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLRG2 Gene

This gene is overexpressed in Nerve - Tibial (x8.6), Esophagus - Mucosa (x8.6), Thyroid (x7.1), Minor Salivary Gland (x5.4), Skin - Sun Exposed (Lower leg) (x5.2), and Skin - Not Sun Exposed (Suprapubic) (x4.5).

Protein differential expression in normal tissues from HIPED for KLRG2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (42.5), Fetal ovary (16.4), and Fetal testis (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLRG2 Gene

Protein tissue co-expression partners for KLRG2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLRG2

SOURCE GeneReport for Unigene cluster for KLRG2 Gene:


Evidence on tissue expression from TISSUES for KLRG2 Gene

  • Eye(4.1)
genes like me logo Genes that share expression patterns with KLRG2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLRG2 Gene

Orthologs for KLRG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLRG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLRG2 31 30
  • 99.35 (n)
(Canis familiaris)
Mammalia KLRG2 30
  • 82.46 (n)
-- 31
  • 50 (a)
-- 31
  • 34 (a)
(Bos Taurus)
Mammalia KLRG2 31 30
  • 78.21 (n)
(Rattus norvegicus)
Mammalia Klrg2 30
  • 72.65 (n)
(Mus musculus)
Mammalia Klrg2 17 31 30
  • 72.39 (n)
(Monodelphis domestica)
Mammalia KLRG2 31
  • 43 (a)
(Gallus gallus)
Aves KLRG2 31
  • 23 (a)
Species where no ortholog for KLRG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRG2 Gene

Gene Tree for KLRG2 (if available)
Gene Tree for KLRG2 (if available)
Evolutionary constrained regions (ECRs) for KLRG2: view image

Paralogs for KLRG2 Gene

Variants for KLRG2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLRG2 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs17160911 - p.Gly339Ala
rs1860150 - p.Lys152Thr

Additional dbSNP identifiers (rs#s) for KLRG2 Gene

Structural Variations from Database of Genomic Variants (DGV) for KLRG2 Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV deletion 23290073
nsv526644 CNV loss 19592680
nsv526825 CNV loss 19592680

Variation tolerance for KLRG2 Gene

Gene Damage Index Score: 10.32; 90.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLRG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLRG2 Gene

Disorders for KLRG2 Gene

Additional Disease Information for KLRG2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KLRG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLRG2 Gene

Publications for KLRG2 Gene

  1. Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability. (PMID: 30194290) Adhikari H … Counter CM (Nature communications 2018) 3 54
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54
  4. Fine-mapping of prostate cancer aggressiveness loci on chromosome 7q22-35. (PMID: 20945404) Liu X … Witte JS (The Prostate 2011) 3 54
  5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S … Mohammed S (Analytical chemistry 2009) 4 54

Products for KLRG2 Gene

Sources for KLRG2 Gene