Aliases for KLRG1 Gene
External Ids for KLRG1 Gene
Previous GeneCards Identifiers for KLRG1 Gene
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. [provided by RefSeq, Jun 2016]
GeneCards Summary for KLRG1 Gene
KLRG1 (Killer Cell Lectin Like Receptor G1) is a Protein Coding gene. Diseases associated with KLRG1 include Mastocytosis and Mast-Cell Leukemia. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC12B.
UniProtKB/Swiss-Prot Summary for KLRG1 Gene
Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.