Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KLRF2 Gene

Aliases for KLRF2 Gene

  • Killer Cell Lectin Like Receptor F2 2 3 5
  • Killer Cell Lectin-Like Receptor Subfamily F, Member 2 2 3
  • Activating Coreceptor NKp65 3 4
  • Lectin-Like Receptor F2 3 4
  • Killer Cell Lectin-Like Receptor Subfamily F Member 2 3
  • NKp65 3

External Ids for KLRF2 Gene

Previous GeneCards Identifiers for KLRF2 Gene

  • GC12U901452
  • GC12P009776
  • GC12P010034

Summaries for KLRF2 Gene

GeneCards Summary for KLRF2 Gene

KLRF2 (Killer Cell Lectin Like Receptor F2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and carbohydrate binding. An important paralog of this gene is KLRF1.

UniProtKB/Swiss-Prot for KLRF2 Gene

  • C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A.

Additional gene information for KLRF2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRF2 Gene

Genomics for KLRF2 Gene

GeneHancer (GH) Regulatory Elements for KLRF2 Gene

Promoters and enhancers for KLRF2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I009881 Promoter 0.5 EPDnew 550.8 0.0 -19 0.1 KLRF2 CLEC2B CLEC2A
GH12I009605 Promoter/Enhancer 1 EPDnew FANTOM5 ENCODE 12.5 -274.6 -274589 3.2 ZNF512 KLRB1 CLEC2D ENSG00000214776 LOC642846 KLRF2 DDX12P LOC374443 LINC02367 KLRF1 PIR60914
GH12I009756 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.5 -120.2 -120210 10 HDGF PKNOX1 ATF1 SMAD1 ARNT IRF4 TCF12 POLR2B GATA2 ATF7 CD69 CLECL1 KLRF1 CLEC7A OLR1 KLRB1 CLEC12A ENSG00000213443 DDX12P PZP
GH12I009813 Enhancer 1.2 FANTOM5 Ensembl ENCODE 2.2 -67.2 -67231 1.3 CTCF PKNOX1 BACH1 ZNF76 SIN3A EBF1 ZIC2 ZNF2 IRF4 RAD21 KLRF1 KLRD1 CD69 KLRB1 A2MP1 CLEC2B KLRF2 LOC100419929 LOC105369653
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KLRF2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for KLRF2 Gene

Genomic Locations for KLRF2 Gene
14,345 bases
Plus strand

Genomic View for KLRF2 Gene

Genes around KLRF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLRF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRF2 Gene

Proteins for KLRF2 Gene

  • Protein details for KLRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Killer cell lectin-like receptor subfamily F member 2
    Protein Accession:

    Protein attributes for KLRF2 Gene

    207 amino acids
    Molecular mass:
    24008 Da
    Quaternary structure:
    • Homodimer; non disulfide-linked. Interacts with CLEC2A.

    Three dimensional structures from OCA and Proteopedia for KLRF2 Gene

neXtProt entry for KLRF2 Gene

Post-translational modifications for KLRF2 Gene

Other Protein References for KLRF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLRF2 Gene

Domains & Families for KLRF2 Gene

Gene Families for KLRF2 Gene

Protein Domains for KLRF2 Gene

Suggested Antigen Peptide Sequences for KLRF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLRF2: view

No data available for UniProtKB/Swiss-Prot for KLRF2 Gene

Function for KLRF2 Gene

Molecular function for KLRF2 Gene

UniProtKB/Swiss-Prot Function:
C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A.

Phenotypes From GWAS Catalog for KLRF2 Gene

Gene Ontology (GO) - Molecular Function for KLRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20194751
GO:0030246 carbohydrate binding IEA --
GO:0042803 protein homodimerization activity IDA 20194751
genes like me logo Genes that share ontologies with KLRF2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KLRF2 Gene

Localization for KLRF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRF2 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLRF2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for KLRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IDA 20194751
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KLRF2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLRF2 Gene

Pathways & Interactions for KLRF2 Gene

SuperPathways for KLRF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043320 natural killer cell degranulation TAS 20194751
GO:0050663 cytokine secretion TAS 20194751
genes like me logo Genes that share ontologies with KLRF2: view

No data available for Pathways by source and SIGNOR curated interactions for KLRF2 Gene

Drugs & Compounds for KLRF2 Gene

No Compound Related Data Available

Transcripts for KLRF2 Gene

mRNA/cDNA for KLRF2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLRF2 Gene

No ASD Table

Relevant External Links for KLRF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLRF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLRF2 Gene

mRNA differential expression in normal tissues according to GTEx for KLRF2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x24.2) and Skin - Not Sun Exposed (Suprapubic) (x18.6).

NURSA nuclear receptor signaling pathways regulating expression of KLRF2 Gene:


SOURCE GeneReport for Unigene cluster for KLRF2 Gene:

genes like me logo Genes that share expression patterns with KLRF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLRF2 Gene

Orthologs for KLRF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLRF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLRF2 33 34
  • 97.75 (n)
(Bos Taurus)
Mammalia KLRF2 33 34
  • 79.46 (n)
(Canis familiaris)
Mammalia KLRF2 33
  • 78.72 (n)
(Gallus gallus)
Aves BLEC2 34
  • 19 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 29 (a)
-- 34
  • 25 (a)
-- 34
  • 9 (a)
Species where no ortholog for KLRF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRF2 Gene

Gene Tree for KLRF2 (if available)
Gene Tree for KLRF2 (if available)

Paralogs for KLRF2 Gene

Paralogs for KLRF2 Gene

(2) SIMAP similar genes for KLRF2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLRF2: view

Variants for KLRF2 Gene

Sequence variations from dbSNP and Humsavar for KLRF2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000115796 -- 9,894,491(+) C/T intron_variant
rs1000453609 -- 9,886,165(+) T/G intron_variant
rs1000486619 -- 9,896,164(+) C/A downstream_transcript_variant
rs1000660993 -- 9,891,531(+) T/C intron_variant
rs1000700205 -- 9,890,686(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLRF2 Gene

Variant ID Type Subtype PubMed ID
nsv523050 CNV loss 19592680
nsv1051530 CNV gain 25217958
nsv1044587 CNV loss 25217958

Variation tolerance for KLRF2 Gene

Gene Damage Index Score: 1.91; 35.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLRF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLRF2 Gene

Disorders for KLRF2 Gene

Additional Disease Information for KLRF2

No disorders were found for KLRF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLRF2 Gene

Publications for KLRF2 Gene

  1. Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes. (PMID: 20194751) Spreu J … Steinle A (Proceedings of the National Academy of Sciences of the United States of America 2010) 2 3 4 58
  2. Structure of NKp65 bound to its keratinocyte ligand reveals basis for genetically linked recognition in natural killer gene complex. (PMID: 23803857) Li Y … Mariuzza RA (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 4 58
  3. The Activating C-type Lectin-like Receptor NKp65 Signals through a Hemi-immunoreceptor Tyrosine-based Activation Motif (hemITAM) and Spleen Tyrosine Kinase (Syk). (PMID: 28082678) Bauer B … Steinle A (The Journal of biological chemistry 2017) 3 58
  4. Key residues at the membrane-distal surface of KACL, but not glycosylation, determine the functional interaction of the keratinocyte-specific C-type lectin-like receptor KACL with its high-affinity receptor NKp65. (PMID: 25510854) Bauer B … Steinle A (Immunology 2015) 3 58
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 58

Products for KLRF2 Gene

Sources for KLRF2 Gene

Loading form....