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Aliases for KLRF1 Gene

Aliases for KLRF1 Gene

  • Killer Cell Lectin Like Receptor F1 2 3 5
  • Killer Cell Lectin-Like Receptor Subfamily F, Member 1 2 3
  • C-Type Lectin Domain Family 5 Member C 3 4
  • Activating Coreceptor NKp80 3 4
  • Lectin-Like Receptor F1 3 4
  • CLEC5C 3 4
  • Killer Cell Lectin-Like Receptor Subfamily F Member 1 3
  • NKp80 3
  • ML 4

External Ids for KLRF1 Gene

Previous GeneCards Identifiers for KLRF1 Gene

  • GC12P009662
  • GC12P010102
  • GC12P009880
  • GC12P009871
  • GC12P009980

Summaries for KLRF1 Gene

Entrez Gene Summary for KLRF1 Gene

  • KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009]

GeneCards Summary for KLRF1 Gene

KLRF1 (Killer Cell Lectin Like Receptor F1) is a Protein Coding gene. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and MHC class I receptor activity. An important paralog of this gene is KLRF2.

UniProtKB/Swiss-Prot for KLRF1 Gene

  • Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts.

Additional gene information for KLRF1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRF1 Gene

Genomics for KLRF1 Gene

GeneHancer (GH) Regulatory Elements for KLRF1 Gene

Promoters and enhancers for KLRF1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I009826 Promoter/Enhancer 0.9 EPDnew ENCODE 550.8 0.0 -27 1.3 ZNF146 JUNB KLRF1 LOC100419929
GH12I009756 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.2 -66.1 -66113 10 HDGF PKNOX1 ATF1 SMAD1 ARNT IRF4 TCF12 POLR2B GATA2 ATF7 CD69 CLECL1 KLRF1 CLEC7A OLR1 KLRB1 CLEC12A ENSG00000213443 DDX12P PZP
GH12I010303 Promoter/Enhancer 1.5 EPDnew FANTOM5 ENCODE dbSUPER 19.9 +477.7 477670 3.5 JUNB STAT3 FOS BATF EP300 RUNX3 KLRD1 KLRC4-KLRK1 KLRF1 KLRC3 KLRK1 KLRC4 ENSG00000255958 GABARAPL1 KLRC1 KLRC2
GH12I009829 Enhancer 0.7 FANTOM5 34.8 +2.7 2661 0.3 ZNF639 RNF2 ZNF621 GFI1B FEZF1 OSR2 ZNF148 PRDM6 BCL11A BCL6B KLRF1 KLRD1 MAGOHB TAS2R10 CLEC12A CLEC12A-AS1 KLRB1 CD69 ENSG00000255882
GH12I009614 Enhancer 0.9 FANTOM5 Ensembl ENCODE 15.1 -210.9 -210884 3.3 PKNOX1 RUNX3 MAFK SPI1 LOC374443 CLEC2D KLRB1 KLRF1 ENSG00000214776 ENSG00000257027 CD69 CLECL1 CLEC2B ENSG00000284634
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KLRF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLRF1 gene promoter:

Genomic Locations for KLRF1 Gene

Genomic Locations for KLRF1 Gene
17,616 bases
Plus strand

Genomic View for KLRF1 Gene

Genes around KLRF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLRF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRF1 Gene

Proteins for KLRF1 Gene

  • Protein details for KLRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Killer cell lectin-like receptor subfamily F member 1
    Protein Accession:
    Secondary Accessions:
    • Q4KMT5
    • Q96PR2
    • Q96PR3
    • Q9NZS1

    Protein attributes for KLRF1 Gene

    232 amino acids
    Molecular mass:
    26666 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for KLRF1 Gene


neXtProt entry for KLRF1 Gene

Post-translational modifications for KLRF1 Gene

  • Glycosylation at isoforms=77, isoforms=91, posLast=9696, and isoforms=2177

No data available for DME Specific Peptides for KLRF1 Gene

Domains & Families for KLRF1 Gene

Gene Families for KLRF1 Gene

Protein Domains for KLRF1 Gene

Suggested Antigen Peptide Sequences for KLRF1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLRF1: view

No data available for UniProtKB/Swiss-Prot for KLRF1 Gene

Function for KLRF1 Gene

Molecular function for KLRF1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts.

Phenotypes From GWAS Catalog for KLRF1 Gene

Gene Ontology (GO) - Molecular Function for KLRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 10671213
GO:0030246 carbohydrate binding IEA --
GO:0032393 MHC class I receptor activity TAS 10671213
genes like me logo Genes that share ontologies with KLRF1: view
genes like me logo Genes that share phenotypes with KLRF1: view

Animal Model Products

CRISPR Products

miRNA for KLRF1 Gene

miRTarBase miRNAs that target KLRF1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLRF1 Gene

Localization for KLRF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRF1 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLRF1 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KLRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10671213
GO:0016020 membrane IEA,TAS 10671213
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KLRF1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLRF1 Gene

Pathways & Interactions for KLRF1 Gene

genes like me logo Genes that share pathways with KLRF1: view

Interacting Proteins for KLRF1 Gene

Selected Interacting proteins: Q9NZS2-KLRF1_HUMAN for KLRF1 Gene via IID

Gene Ontology (GO) - Biological Process for KLRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway TAS 10671213
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with KLRF1: view

No data available for SIGNOR curated interactions for KLRF1 Gene

Drugs & Compounds for KLRF1 Gene

No Compound Related Data Available

Transcripts for KLRF1 Gene

mRNA/cDNA for KLRF1 Gene

Unigene Clusters for KLRF1 Gene

Killer cell lectin-like receptor subfamily F, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLRF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: -
SP4: - -
SP5: - - -
SP6: - - -
SP8: - - - -

Relevant External Links for KLRF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLRF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLRF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLRF1 Gene

This gene is overexpressed in Whole Blood (x23.0) and Spleen (x9.4).

NURSA nuclear receptor signaling pathways regulating expression of KLRF1 Gene:


SOURCE GeneReport for Unigene cluster for KLRF1 Gene:


mRNA Expression by UniProt/SwissProt for KLRF1 Gene:

Tissue specificity: Strongly expressed in peripheral blood leukocytes and spleen, with weaker expression in lymph node and adult liver, and no expression detected in bone marrow, thymus, and fetal liver. Not expressed in brain, heart, placenta, lung, kidney, skeletal muscle, and pancreas. Within peripheral blood leukocyte and immunocyte cell lines, expression was predominant in NK cells but was also detected in monocytes.
genes like me logo Genes that share expression patterns with KLRF1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLRF1 Gene

Orthologs for KLRF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLRF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLRF1 33 34
  • 99.13 (n)
(Canis familiaris)
Mammalia KLRF1 33 34
  • 85.22 (n)
(Bos Taurus)
Mammalia LOC613393 33
  • 80.38 (n)
KLRF1 34
  • 72 (a)
(Gallus gallus)
Aves BLEC2 34
  • 24 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 28 (a)
-- 34
  • 27 (a)
-- 34
  • 13 (a)
Species where no ortholog for KLRF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRF1 Gene

Gene Tree for KLRF1 (if available)
Gene Tree for KLRF1 (if available)

Paralogs for KLRF1 Gene

Paralogs for KLRF1 Gene

(8) SIMAP similar genes for KLRF1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KLRF1: view

Variants for KLRF1 Gene

Sequence variations from dbSNP and Humsavar for KLRF1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000095648 -- 9,834,103(+) GGGGG/GGGGGG genic_downstream_transcript_variant, intron_variant
rs1000311033 -- 9,839,563(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000447826 -- 9,833,751(+) TTATTTATT/TTATT downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000779881 -- 9,838,330(+) A/C genic_downstream_transcript_variant, intron_variant
rs1000917012 -- 9,838,547(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLRF1 Gene

Variant ID Type Subtype PubMed ID
nsv1051530 CNV gain 25217958

Variation tolerance for KLRF1 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.70; 66.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLRF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLRF1 Gene

Disorders for KLRF1 Gene

Additional Disease Information for KLRF1

No disorders were found for KLRF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLRF1 Gene

Publications for KLRF1 Gene

  1. Human KLRF1, a novel member of the killer cell lectin-like receptor gene family: molecular characterization, genomic structure, physical mapping to the NK gene complex and expression analysis. (PMID: 10671213) Roda-Navarro P … Fernández-Ruiz E (European journal of immunology 2000) 2 3 4 22 58
  2. Molecular characterization of two novel alternative spliced variants of the KLRF1 gene and subcellular distribution of KLRF1 isoforms. (PMID: 11513955) Roda-Navarro P … Fernández-Ruiz E (Biochimica et biophysica acta 2001) 3 4 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Identification of NKp80, a novel triggering molecule expressed by human NK cells. (PMID: 11265639) Vitale M … Moretta A (European journal of immunology 2001) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for KLRF1 Gene

Sources for KLRF1 Gene

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