This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the... See more...

Aliases for KLRC4-KLRK1 Gene

Aliases for KLRC4-KLRK1 Gene

  • KLRC4-KLRK1 Readthrough 2 3 5 13
  • Killer Cell Lectin-Like Receptor Subfamily K Member 1 3
  • NKG2-D Type II Integral Membrane Protein 3
  • NKG2-D-Activating NK Receptor 3
  • NK Cell Receptor D 3
  • KLRC4-KLRK1 5

External Ids for KLRC4-KLRK1 Gene

Previous GeneCards Identifiers for KLRC4-KLRK1 Gene

  • GC12U901579
  • GC12M010526
  • GC12M010618

Summaries for KLRC4-KLRK1 Gene

Entrez Gene Summary for KLRC4-KLRK1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. [provided by RefSeq, Dec 2010]

GeneCards Summary for KLRC4-KLRK1 Gene

KLRC4-KLRK1 (KLRC4-KLRK1 Readthrough) is a Protein Coding gene. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and RET signaling. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is KLRC4.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLRC4-KLRK1 Gene

Genomics for KLRC4-KLRK1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KLRC4-KLRK1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J010408 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 600.7 +0.8 755 1.1 ZBTB44 FOXK2 ZBTB48 ZBTB17 IRF3 JUNB STAT1 FEZF1 JUND CHAMP1 KLRC4 KLRC4-KLRK1 KLRC3 KLRK1-AS1 KLRC2 piR-34099-004 KLRK1
GH12J010410 Enhancer 0.8 ENCODE dbSUPER 600.7 -1.2 -1241 1.1 CTCF TRIM22 SCRT2 CEBPB ZSCAN29 ZNF580 USF1 ZBTB17 RAD21 ZNF335 KLRC4 KLRC4-KLRK1 KLRC3 KLRC2
GH12J010303 Promoter/Enhancer 1.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.3 +105.5 105532 4.4 RUNX3 FOS EP300 JUNB BHLHE40 STAT3 BATF KLRD1 NONHSAG010477.2 KLRC4-KLRK1 KLRF1 KLRC3 KLRK1 KLRC4 ENSG00000255958 GABARAPL1 KLRC1
GH12J010384 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.4 +22.7 22694 5.1 ZNF629 ZSCAN4 ZNF747 ZNF639 ZNF248 NFE2 ZEB1 TSHZ1 NR3C1 CEBPB KLRK1 TAS2R19 TAS2R31 TAS2R14 TAS2R10 KLRA1P TAS2R15P MAGOHB TAS2R20 KLRC3
GH12J010391 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.5 +15.4 15363 7.4 GATAD2A ATF7 ZNF629 ZNF692 RCOR2 ZNF174 BACH1 FOXA1 PRDM1 ZIC2 piR-34099-004 piR-34593-011 KLRK1 KLRA1P KLRC3 KLRC4 KLRC2 KLRK1-AS1 TAS2R31 TAS2R20
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLRC4-KLRK1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLRC4-KLRK1

Genomic Locations for KLRC4-KLRK1 Gene

Genomic Locations for KLRC4-KLRK1 Gene
chr12:10,372,353-10,410,146
(GRCh38/hg38)
Size:
37,794 bases
Orientation:
Minus strand
chr12:10,524,952-10,562,745
(GRCh37/hg19)
Size:
37,794 bases
Orientation:
Minus strand

Genomic View for KLRC4-KLRK1 Gene

Genes around KLRC4-KLRK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLRC4-KLRK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLRC4-KLRK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRC4-KLRK1 Gene

Proteins for KLRC4-KLRK1 Gene

  • Protein details for KLRC4-KLRK1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BQV0-H3BQV0_HUMAN
    Recommended name:
    KLRC4-KLRK1 readthrough
    Protein Accession:
    H3BQV0

    Protein attributes for KLRC4-KLRK1 Gene

    Size:
    150 amino acids
    Molecular mass:
    17279 Da
    Quaternary structure:
    No Data Available
  • Protein details for KLRC4-KLRK1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BU71-H3BU71_HUMAN
    Recommended name:
    KLRC4-KLRK1 readthrough
    Protein Accession:
    H3BU71

    Protein attributes for KLRC4-KLRK1 Gene

    Size:
    75 amino acids
    Molecular mass:
    8976 Da
    Quaternary structure:
    No Data Available
  • Protein details for KLRC4-KLRK1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BRK7-H3BRK7_HUMAN
    Recommended name:
    KLRC4-KLRK1 readthrough
    Protein Accession:
    H3BRK7

    Protein attributes for KLRC4-KLRK1 Gene

    Size:
    37 amino acids
    Molecular mass:
    4700 Da
    Quaternary structure:
    No Data Available
  • Protein details for KLRC4-KLRK1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    K7EPB6-K7EPB6_HUMAN
    Recommended name:
    KLRC4-KLRK1 readthrough
    Protein Accession:
    K7EPB6

    Protein attributes for KLRC4-KLRK1 Gene

    Size:
    35 amino acids
    Molecular mass:
    4367 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLRC4-KLRK1 Gene

Post-translational modifications for KLRC4-KLRK1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for KLRC4-KLRK1 Gene

Domains & Families for KLRC4-KLRK1 Gene

Protein Domains for KLRC4-KLRK1 Gene

genes like me logo Genes that share domains with KLRC4-KLRK1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KLRC4-KLRK1 Gene

Function for KLRC4-KLRK1 Gene

Phenotypes From GWAS Catalog for KLRC4-KLRK1 Gene

Gene Ontology (GO) - Molecular Function for KLRC4-KLRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10426993
GO:0030246 carbohydrate binding IEA --
GO:0032394 MHC class Ib receptor activity IEA --
GO:0038023 signaling receptor activity IDA, IBA 17562706
GO:0042288 MHC class I protein binding IEA --
genes like me logo Genes that share ontologies with KLRC4-KLRK1: view

Phenotypes for KLRC4-KLRK1 Gene

genes like me logo Genes that share phenotypes with KLRC4-KLRK1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KLRC4-KLRK1 Gene

Localization for KLRC4-KLRK1 Gene

Gene Ontology (GO) - Cellular Components for KLRC4-KLRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA, TAS --
GO:0005887 integral component of plasma membrane TAS 2007850
GO:0009897 external side of plasma membrane IBA 21873635
GO:0009986 cell surface IDA, IBA 10426994
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with KLRC4-KLRK1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for KLRC4-KLRK1 Gene

Pathways & Interactions for KLRC4-KLRK1 Gene

genes like me logo Genes that share pathways with KLRC4-KLRK1: view

Pathways by source for KLRC4-KLRK1 Gene

Interacting Proteins for KLRC4-KLRK1 Gene

Gene Ontology (GO) - Biological Process for KLRC4-KLRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway IEA --
GO:0002250 adaptive immune response IEA --
GO:0007165 signal transduction TAS 2007850
GO:0030101 natural killer cell activation TAS 18676862
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with KLRC4-KLRK1: view

No data available for SIGNOR curated interactions for KLRC4-KLRK1 Gene

Drugs & Compounds for KLRC4-KLRK1 Gene

No Compound Related Data Available

Transcripts for KLRC4-KLRK1 Gene

mRNA/cDNA for KLRC4-KLRK1 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLRC4-KLRK1

Alternative Splicing Database (ASD) splice patterns (SP) for KLRC4-KLRK1 Gene

No ASD Table

Relevant External Links for KLRC4-KLRK1 Gene

GeneLoc Exon Structure for
KLRC4-KLRK1

Expression for KLRC4-KLRK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLRC4-KLRK1 Gene

mRNA differential expression in normal tissues according to GTEx for KLRC4-KLRK1 Gene

This gene is overexpressed in Whole Blood (x5.4) and Spleen (x5.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLRC4-KLRK1

genes like me logo Genes that share expression patterns with KLRC4-KLRK1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLRC4-KLRK1 Gene

Orthologs for KLRC4-KLRK1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLRC4-KLRK1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KLRC4 31
  • 91 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 38 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia KLRC1 31
  • 29 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Klri2 31
  • 12 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 5 (a)
OneToMany
Species where no ortholog for KLRC4-KLRK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for KLRC4-KLRK1 Gene

ENSEMBL:
Gene Tree for KLRC4-KLRK1 (if available)
TreeFam:
Gene Tree for KLRC4-KLRK1 (if available)

Paralogs for KLRC4-KLRK1 Gene

(5) SIMAP similar genes for KLRC4-KLRK1 Gene using alignment to 4 proteins:

  • H3BQV0_HUMAN
  • H3BRK7_HUMAN
  • H3BU71_HUMAN
  • K7EPB6_HUMAN
genes like me logo Genes that share paralogs with KLRC4-KLRK1: view

Variants for KLRC4-KLRK1 Gene

Additional dbSNP identifiers (rs#s) for KLRC4-KLRK1 Gene

Structural Variations from Database of Genomic Variants (DGV) for KLRC4-KLRK1 Gene

Variant ID Type Subtype PubMed ID
dgv2358n54 CNV loss 21841781
esv3892136 CNV loss 25118596
esv4003 CNV loss 18987735
nsv1036390 CNV loss 25217958
nsv1051292 CNV loss 25217958
nsv521062 CNV gain 19592680
nsv557455 CNV loss 21841781
nsv606 CNV deletion 18451855
nsv832328 CNV gain 17160897
nsv8914 CNV loss 18304495

Variation tolerance for KLRC4-KLRK1 Gene

Gene Damage Index Score: 0.04; 0.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLRC4-KLRK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLRC4-KLRK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLRC4-KLRK1 Gene

Disorders for KLRC4-KLRK1 Gene

No disorders were found for KLRC4-KLRK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLRC4-KLRK1 Gene

Publications for KLRC4-KLRK1 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 13
  2. A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding. (PMID: 28559451) Zuo J … Moss P (Science signaling 2017) 3
  3. CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling. (PMID: 23696226) Hosomi S … Blumberg RS (European journal of immunology 2013) 3
  4. Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. (PMID: 23291587) Kirino Y … Kastner DL (Nature genetics 2013) 3
  5. Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation. (PMID: 22585739) Serrano-Pertierra E … López-Larrea C (European journal of immunology 2012) 3

Products for KLRC4-KLRK1 Gene

  • Signalway Proteins for KLRC4-KLRK1

Sources for KLRC4-KLRK1 Gene