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Aliases for KLRC4 Gene

Aliases for KLRC4 Gene

  • Killer Cell Lectin Like Receptor C4 2 3 5
  • Killer Cell Lectin-Like Receptor Subfamily C, Member 4 2 3
  • NKG2-F-Activating NK Receptor 3 4
  • NK Cell Receptor F 3 4
  • NKG2F 3 4
  • NKG2-F Type II Integral Membrane Protein 3
  • Natual Killer Cell Group 2-F 3
  • NKG2-F 3

External Ids for KLRC4 Gene

Previous GeneCards Identifiers for KLRC4 Gene

  • GC12M010207
  • GC12M010648
  • GC12M010426
  • GC12M010451
  • GC12M010417
  • GC12M010418
  • GC12M010559
  • GC12M010303
  • GC12M010713
  • GC12M010779
  • GC12M011015
  • GC12M011302
  • GC12M011536
  • GC12M011729
  • GC12M011916

Summaries for KLRC4 Gene

Entrez Gene Summary for KLRC4 Gene

  • Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member. [provided by RefSeq, Dec 2010]

GeneCards Summary for KLRC4 Gene

KLRC4 (Killer Cell Lectin Like Receptor C4) is a Protein Coding gene. Diseases associated with KLRC4 include Behcet Syndrome. Among its related pathways are Allograft rejection. An important paralog of this gene is KLRC4-KLRK1.

UniProtKB/Swiss-Prot for KLRC4 Gene

  • May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells.

Gene Wiki entry for KLRC4 Gene

Additional gene information for KLRC4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRC4 Gene

Genomics for KLRC4 Gene

GeneHancer (GH) Regulatory Elements for KLRC4 Gene

Promoters and enhancers for KLRC4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J010408 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 650.7 +0.4 366 1.1 STAT1 IRF3 JUNB FEZF1 NCOA2 CHAMP1 JUND ZBTB48 FOXK2 ZBTB17 KLRC4 KLRC4-KLRK1 KLRC3 LOC101928100 KLRC2 KLRK1
GH12J010410 Enhancer 1.1 Ensembl ENCODE dbSUPER 650.7 -1.6 -1630 1.1 CTCF KLF1 USF1 RAD21 ZNF335 SCRT2 SMC3 ZSCAN29 ZNF362 CEBPB KLRC4 KLRC4-KLRK1 KLRC3 KLRC2
GH12J010391 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.3 +15.0 14974 7.4 FOXA2 SMAD1 ARID4B SIN3A FEZF1 ATF7 RUNX3 DEK JUNB REST KLRK1 KLRA1P KLRC3 KLRC4 KLRC2 LOC101928100 TAS2R31 TAS2R20 MAGOHB TAS2R10
GH12J010384 Promoter/Enhancer 1.7 EPDnew FANTOM5 ENCODE dbSUPER 14.3 +22.3 22319 5.1 FOXA2 ZSCAN4 FEZF1 ZEB1 GTF3C2 FOS ZNF362 YY2 CEBPB ZNF662 KLRK1 GC12P010386 TAS2R19 TAS2R31 KLRA1P TAS2R14 TAS2R10 TAS2R15P MAGOHB TAS2R20
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLRC4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLRC4 gene promoter:
  • c-Jun
  • AP-1
  • c-Fos

Genomic Locations for KLRC4 Gene

Genomic Locations for KLRC4 Gene
2,376 bases
Minus strand
2,374 bases
Minus strand

Genomic View for KLRC4 Gene

Genes around KLRC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLRC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLRC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRC4 Gene

Proteins for KLRC4 Gene

  • Protein details for KLRC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NKG2-F type II integral membrane protein
    Protein Accession:
    Secondary Accessions:
    • O60851

    Protein attributes for KLRC4 Gene

    158 amino acids
    Molecular mass:
    18234 Da
    Quaternary structure:
    • Can form disulfide-bonded heterodimer with CD94.

neXtProt entry for KLRC4 Gene

Post-translational modifications for KLRC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLRC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLRC4 Gene

Domains & Families for KLRC4 Gene

Gene Families for KLRC4 Gene

Protein Domains for KLRC4 Gene

Suggested Antigen Peptide Sequences for KLRC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLRC4: view

No data available for UniProtKB/Swiss-Prot for KLRC4 Gene

Function for KLRC4 Gene

Molecular function for KLRC4 Gene

UniProtKB/Swiss-Prot Function:
May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells.
GENATLAS Biochemistry:
natural killer cell lectin-like receptor subfamily C,member 4,expressed on NK cells,complexing with KAP10 to form an activating complex receptor for MICA

Phenotypes From GWAS Catalog for KLRC4 Gene

genes like me logo Genes that share phenotypes with KLRC4: view

Human Phenotype Ontology for KLRC4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLRC4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for KLRC4 Gene

Localization for KLRC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRC4 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLRC4 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KLRC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KLRC4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLRC4 Gene

Pathways & Interactions for KLRC4 Gene

SuperPathways for KLRC4 Gene

SuperPathway Contained pathways
1 Allograft rejection
genes like me logo Genes that share pathways with KLRC4: view

Pathways by source for KLRC4 Gene

1 KEGG pathway for KLRC4 Gene

Gene Ontology (GO) - Biological Process for KLRC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 9683661
genes like me logo Genes that share ontologies with KLRC4: view

No data available for SIGNOR curated interactions for KLRC4 Gene

Drugs & Compounds for KLRC4 Gene

No Compound Related Data Available

Transcripts for KLRC4 Gene

mRNA/cDNA for KLRC4 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(84) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLRC4 Gene

Killer cell lectin-like receptor subfamily C, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLRC4

Alternative Splicing Database (ASD) splice patterns (SP) for KLRC4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c
SP1: - - - - - - - - - -
SP2: - - - - - - -
SP3: - -
SP4: -
SP5: -

Relevant External Links for KLRC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLRC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLRC4 Gene

Protein differential expression in normal tissues from HIPED for KLRC4 Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLRC4 Gene

Protein tissue co-expression partners for KLRC4 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLRC4 Gene:


SOURCE GeneReport for Unigene cluster for KLRC4 Gene:


mRNA Expression by UniProt/SwissProt for KLRC4 Gene:

Tissue specificity: Natural killer cells.

Evidence on tissue expression from TISSUES for KLRC4 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with KLRC4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLRC4 Gene

Orthologs for KLRC4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLRC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLRC4 34
  • 96 (a)
(Bos Taurus)
Mammalia NKG2A 34
  • 31 (a)
(Canis familiaris)
Mammalia -- 34
  • 29 (a)
(Mus musculus)
Mammalia Klrc3 34
  • 19 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 5 (a)
Species where no ortholog for KLRC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRC4 Gene

Gene Tree for KLRC4 (if available)
Gene Tree for KLRC4 (if available)

Paralogs for KLRC4 Gene

Paralogs for KLRC4 Gene

(4) SIMAP similar genes for KLRC4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLRC4: view

Variants for KLRC4 Gene

Sequence variations from dbSNP and Humsavar for KLRC4 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000493383 -- 10,407,897(-) A/T intron_variant
rs1000814830 -- 10,408,166(-) T/C intron_variant
rs1000944291 -- 10,407,228(-) A/G downstream_transcript_variant
rs1001799321 -- 10,410,989(-) G/C upstream_transcript_variant
rs1002676637 -- 10,410,626(-) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KLRC4 Gene

Variant ID Type Subtype PubMed ID
dgv2358n54 CNV loss 21841781
esv3892136 CNV loss 25118596
nsv1036390 CNV loss 25217958
nsv1051292 CNV loss 25217958
nsv521062 CNV gain 19592680
nsv557455 CNV loss 21841781
nsv606 CNV deletion 18451855
nsv832328 CNV gain 17160897
nsv8914 CNV loss 18304495

Variation tolerance for KLRC4 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLRC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLRC4 Gene

Disorders for KLRC4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLRC4 Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
behcet syndrome
  • behcet disease; bd
- elite association - COSMIC cancer census association via MalaCards
Search KLRC4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KLRC4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KLRC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLRC4 Gene

Publications for KLRC4 Gene

  1. Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. (PMID: 9598306) Plougastel B … Trowsdale J (Genomics 1998) 2 3 4 22 58
  2. Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. (PMID: 11751968) Shum BP … Parham P (Journal of immunology (Baltimore, Md. : 1950) 2002) 3 4 22 58
  3. Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes. (PMID: 9394807) Plougastel B … Trowsdale J (European journal of immunology 1997) 3 4 22 58
  4. Association of NKG2D genetic polymorphism with susceptibility to chronic hepatitis B in a Han Chinese population. (PMID: 20648603) Ma J … Liu Y (Journal of medical virology 2010) 3 44 58
  5. Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis. (PMID: 18006695) Sellick GS … Houlston RS (Blood 2008) 3 44 58

Products for KLRC4 Gene

Sources for KLRC4 Gene

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