Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG... See more...

Aliases for KLRC3 Gene

Aliases for KLRC3 Gene

  • Killer Cell Lectin Like Receptor C3 2 3 5
  • Killer Cell Lectin-Like Receptor Subfamily C, Member 3 2 3
  • NKG2-E Type II Integral Membrane Protein 3 4
  • NKG2-E-Activating NK Receptor 3 4
  • NK Cell Receptor E 3 4
  • NKG2-E 2 3
  • NKG2E 3 4
  • KLRC3 5

External Ids for KLRC3 Gene

Previous GeneCards Identifiers for KLRC3 Gene

  • GC12U990043
  • GC12M010687
  • GC12M010465
  • GC12M010456
  • GC12M010564
  • GC12M010307
  • GC12M010718
  • GC12M012415
  • GC12M012635
  • GC12M012790
  • GC12M013375
  • GC12M010781
  • GC12M011018
  • GC12M011305
  • GC12M011539
  • GC12M011731
  • GC12M011918
  • GC12M012104
  • GC12M012281
  • GC12M013868
  • GC12M014388

Summaries for KLRC3 Gene

Entrez Gene Summary for KLRC3 Gene

  • Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLRC3 Gene

KLRC3 (Killer Cell Lectin Like Receptor C3) is a Protein Coding gene. Diseases associated with KLRC3 include Nasal Type Extranodal Nk/T-Cell Lymphoma and Monkeypox. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Allograft rejection. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is ENSG00000255641.

UniProtKB/Swiss-Prot Summary for KLRC3 Gene

  • Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLRC3 Gene

Genomics for KLRC3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KLRC3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J010422 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 264.2 -1.8 -1805 1.2 CTBP1 SMARCE1 DPF2 NCOA3 SP7 KLRC3 HSALNG0089228 KLRC1 HSALNG0089231 HSALNG0089232 ENSG00000255641
GH12J010421 Promoter 0.5 Ensembl 250.7 +0.3 294 0.2 PRDM10 ZNF335 HSALNG0089228 HSALNG0089231 KLRC3 HSALNG0089229 KLRC4-KLRK1 ENSG00000255641
GH12J010420 Promoter 0.4 EPDnew 250.7 +0.0 26 0.1 ZNF335 HSALNG0089228 HSALNG0089231 KLRC3 KLRC4-KLRK1 ENSG00000255641
GH12J010391 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.9 +25.8 25812 7.4 BCLAF1 ZNF600 ZNF580 ATF2 CEBPA NFIC ZIC2 BCL11A CEBPB FOXA1 piR-34593-011 piR-34099-004 KLRK1 KLRC3 KLRA1P KLRC4 KLRC2 KLRK1-AS1 TAS2R43 TAS2R20
GH12J010384 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.1 +33.1 33143 5.1 CEBPB FEZF1 ZNF639 ZEB1 ZNF513 EP300 FOXA2 TBP TCF7L2 NFE2 KLRK1 TAS2R19 TAS2R14 TAS2R31 TAS2R15P TAS2R10 MAGOHB KLRA1P KLRC3 KLRK1-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLRC3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLRC3

Top Transcription factor binding sites by QIAGEN in the KLRC3 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun

Genomic Locations for KLRC3 Gene

Latest Assembly
chr12:10,412,315-10,420,595
(GRCh38/hg38)
Size:
8,281 bases
Orientation:
Minus strand

Previous Assembly
chr12:10,564,914-10,573,194
(GRCh37/hg19 by Entrez Gene)
Size:
8,281 bases
Orientation:
Minus strand

chr12:10,564,911-10,573,194
(GRCh37/hg19 by Ensembl)
Size:
8,284 bases
Orientation:
Minus strand

Genomic View for KLRC3 Gene

Genes around KLRC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLRC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLRC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRC3 Gene

Proteins for KLRC3 Gene

  • Protein details for KLRC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07444-NKG2E_HUMAN
    Recommended name:
    NKG2-E type II integral membrane protein
    Protein Accession:
    Q07444
    Secondary Accessions:
    • Q8WXA4
    • Q96RL0
    • Q9UP04

    Protein attributes for KLRC3 Gene

    Size:
    240 amino acids
    Molecular mass:
    27100 Da
    Quaternary structure:
    • Can form disulfide-bonded heterodimer with CD94.

    Alternative splice isoforms for KLRC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLRC3 Gene

Post-translational modifications for KLRC3 Gene

  • Glycosylation at Asn100, Asn149, and Asn179
  • Modification sites at PhosphoSitePlus

Other Protein References for KLRC3 Gene

No data available for DME Specific Peptides for KLRC3 Gene

Domains & Families for KLRC3 Gene

Gene Families for KLRC3 Gene

Protein Domains for KLRC3 Gene

Suggested Antigen Peptide Sequences for KLRC3 Gene

GenScript: Design optimal peptide antigens:
  • NKG2-E-activating NK receptor (NKG2E_HUMAN)
  • Type II integral membrane protein (Q71V82_HUMAN)
genes like me logo Genes that share domains with KLRC3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KLRC3 Gene

Function for KLRC3 Gene

Molecular function for KLRC3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
GENATLAS Biochemistry:
natural killer cell lectin-like receptor subfamily C,member 3

Phenotypes From GWAS Catalog for KLRC3 Gene

Gene Ontology (GO) - Molecular Function for KLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 9683661
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with KLRC3: view
genes like me logo Genes that share phenotypes with KLRC3: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLRC3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLRC3 Gene

Localization for KLRC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRC3 Gene

Membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLRC3 gene
Compartment Confidence
plasma membrane 2
nucleus 2
cytosol 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KLRC3: view

Pathways & Interactions for KLRC3 Gene

PathCards logo

SuperPathways for KLRC3 Gene

SuperPathway Contained pathways
1 Immune response Role of DAP12 receptors in NK cells
.32
2 Allograft rejection
genes like me logo Genes that share pathways with KLRC3: view

Pathways by source for KLRC3 Gene

1 GeneGo (Thomson Reuters) pathway for KLRC3 Gene
  • Immune response Role of DAP12 receptors in NK cells

Interacting Proteins for KLRC3 Gene

Gene Ontology (GO) - Biological Process for KLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 9683661
genes like me logo Genes that share ontologies with KLRC3: view

No data available for SIGNOR curated interactions for KLRC3 Gene

Drugs & Compounds for KLRC3 Gene

No Compound Related Data Available

Transcripts for KLRC3 Gene

mRNA/cDNA for KLRC3 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLRC3

Alternative Splicing Database (ASD) splice patterns (SP) for KLRC3 Gene

No ASD Table

Relevant External Links for KLRC3 Gene

GeneLoc Exon Structure for
KLRC3

Expression for KLRC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLRC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLRC3 Gene

This gene is overexpressed in Whole Blood (x7.5) and Brain - Amygdala (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLRC3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLRC3

SOURCE GeneReport for Unigene cluster for KLRC3 Gene:

Hs.654362

mRNA Expression by UniProt/SwissProt for KLRC3 Gene:

Q07444-NKG2E_HUMAN
Tissue specificity: Natural killer cells.
genes like me logo Genes that share expression patterns with KLRC3: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLRC3 Gene

Orthologs for KLRC3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLRC3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KLRC3 29 30
  • 96.61 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 56 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia NKG2A 30
  • 46 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 26 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Klri1 30
  • 23 (a)
ManyToMany
Species where no ortholog for KLRC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for KLRC3 Gene

ENSEMBL:
Gene Tree for KLRC3 (if available)
TreeFam:
Gene Tree for KLRC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLRC3: view image
Alliance of Genome Resources:
Additional Orthologs for KLRC3

Paralogs for KLRC3 Gene

(9) SIMAP similar genes for KLRC3 Gene using alignment to 2 proteins:

  • NKG2E_HUMAN
  • J3KPJ5_HUMAN
genes like me logo Genes that share paralogs with KLRC3: view

Variants for KLRC3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLRC3 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs150804808 Benign: not provided 10,418,495(-) C/A
NM_002261.3(KLRC3):c.335G>T (p.Arg112Leu)
MISSENSE
rs2682489 Benign: not provided 10,420,546(-) C/Tp.Ser2Asn
NM_002261.3(KLRC3):c.5G>A (p.Ser2Asn)
MISSENSE
rs2682490 Benign: not provided 10,420,496(-) A/Gp.Trp19Arg
NM_002261.3(KLRC3):c.55T>C (p.Trp19Arg)
MISSENSE
rs2682491 Benign: not provided 10,420,495(-) C/G
NM_002261.3(KLRC3):c.56G>C (p.Trp19Ser)
MISSENSE
rs749992751 Benign: not provided 10,415,652(-) TTA/T
NM_002261.3(KLRC3):c.678+50_678+51del
FRAMESHIFT_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KLRC3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KLRC3 Gene

Variant ID Type Subtype PubMed ID
dgv2358n54 CNV loss 21841781
dgv2359n54 CNV loss 21841781
dgv250e214 CNV loss 21293372
dgv263e199 CNV deletion 23128226
dgv270n67 CNV loss 20364138
esv25005 CNV loss 19812545
esv2745535 CNV deletion 23290073
esv32543 CNV loss 17666407
esv3580111 CNV loss 25503493
esv3628535 CNV loss 21293372
esv3892136 CNV loss 25118596
esv4003 CNV loss 18987735
nsv1036390 CNV loss 25217958
nsv1051292 CNV loss 25217958
nsv1131038 CNV deletion 24896259
nsv1138097 CNV deletion 24896259
nsv435631 CNV deletion 17901297
nsv521062 CNV gain 19592680
nsv557465 CNV gain 21841781
nsv606 CNV deletion 18451855
nsv832328 CNV gain 17160897
nsv8914 CNV loss 18304495
nsv976573 CNV duplication 23825009

Variation tolerance for KLRC3 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.85; 67.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLRC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLRC3
Leiden Open Variation Database (LOVD)
KLRC3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLRC3 Gene

Disorders for KLRC3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KLRC3 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
nasal type extranodal nk/t-cell lymphoma
  • extranodal nasal nk/t cell lymphoma
monkeypox
  • monkeypox virus infection
- elite association - COSMIC cancer census association via MalaCards
Search KLRC3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KLRC3

genes like me logo Genes that share disorders with KLRC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLRC3 Gene

Publications for KLRC3 Gene

  1. Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. (PMID: 11751968) Shum BP … Parham P (Journal of immunology (Baltimore, Md. : 1950) 2002) 3 4 22
  2. Triggering of effector functions on a CD8+ T cell clone upon the aggregation of an activatory CD94/kp39 heterodimer. (PMID: 10201920) Bellón T … Aparicio P (Journal of immunology (Baltimore, Md. : 1950) 1999) 3 4 22
  3. The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. (PMID: 9683661) Glienke J … Francis F (Immunogenetics 1998) 3 4
  4. Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. (PMID: 9598306) Plougastel B … Trowsdale J (Genomics 1998) 2 3
  5. Natural killer lectin-like receptors have divergent carboxy-termini, distinct from C-type lectins. (PMID: 8276468) Adamkiewicz TV … Houchins JP (Immunogenetics 1994) 3 4

Products for KLRC3 Gene

Sources for KLRC3 Gene