Aliases for KLRC2 Gene
Aliases for KLRC2 Gene
External Ids for KLRC2 Gene
- HGNC: 6375
- Entrez Gene: 3822
- Ensembl: ENSG00000205809
- OMIM: 602891
- UniProtKB: P26717
Previous GeneCards Identifiers for KLRC2 Gene
- GC12P010266
- GC12U900034
- GC12M010484
- GC12M010474
- GC12M010583
- GC12M010690
- GC12M010719
- GC12M010782
- GC12M011019
- GC12M011306
- GC12M011540
- GC12M011732
Summaries for KLRC2 Gene
-
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for KLRC2 Gene
KLRC2 (Killer Cell Lectin Like Receptor C2) is a Protein Coding gene. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and MHC class I protein complex binding. An important paralog of this gene is ENSG00000255641.
UniProtKB/Swiss-Prot for KLRC2 Gene
-
Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Additional gene information for KLRC2 Gene
- Monarch Initiative
- Search for KLRC2 at DataMed
- Search for KLRC2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRC2 Gene
Genomics for KLRC2 Gene
GeneHancer (GH) Regulatory Elements for KLRC2 Gene
Promoters and enhancers for KLRC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around KLRC2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for KLRC2 Gene
Genomic Locations for KLRC2 Gene
- chr12:10,426,854-10,442,300
- (GRCh38/hg38)
- Size:
- 15,447 bases
- Orientation:
- Minus strand
- chr12:10,579,453-10,594,899
- (GRCh37/hg19)
Genomic View for KLRC2 Gene
Genes around KLRC2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.2 by Ensembl
- 12p13.2 by Entrez Gene
- 12p13 by HGNC
KLRC2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KLRC2 Gene
Proteins for KLRC2 Gene
-
Protein details for KLRC2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P26717-NKG2C_HUMAN
- Recommended name:
- NKG2-C type II integral membrane protein
- Protein Accession:
- P26717
- O43802
- Q52M74
- Q9NR42
Protein attributes for KLRC2 Gene
- Size:
- 231 amino acids
- Molecular mass:
- 26072 Da
- Quaternary structure:
-
- Can form disulfide-bonded heterodimer with CD94. Interacts with TYROBP.
Post-translational modifications for KLRC2 Gene
- Glycosylation at posLast=100100, posLast=149149, and posLast=178178
Other Protein References for KLRC2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for KLRC2 (NKG2C/CD159c)
-
Custom Antibody ServicesOriGene Antibodies for KLRC2
- Novus Biologicals Antibodies for KLRC2
-
Abcam antibodies for KLRC2
-
Cloud-Clone Corp. Antibodies for KLRC2
- Invitrogen Antibodies for KLRC2
- GeneTex KLRC2 antibody for KLRC2
Protein Products
-
OriGene Purified Proteins for KLRC2
- Search Origene for MassSpec and Protein Over-expression Lysates for KLRC2
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- ProSpec Recombinant Proteins for KLRC2
-
Cloud-Clone Corp. Proteins for KLRC2
- Search GeneTex for Proteins for KLRC2
-
Abcam proteins for KLRC2
Assay Products
- antibodies-online: Search results for 1 available KLRC2 Elisa Kits ranked by validation data
- Compare Top KLRC2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for KLRC2 Gene
Domains & Families for KLRC2 Gene
Gene Families for KLRC2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for KLRC2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for KLRC2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for KLRC2 Gene
Function for KLRC2 Gene
Molecular function for KLRC2 Gene
- GENATLAS Biochemistry:
- natural killer cell lectin-like receptor subfamily C,member 2
- UniProtKB/Swiss-Prot Function:
- Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Phenotypes From GWAS Catalog for KLRC2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | TAS | 9683661 |
| GO:0005515 | protein binding | IPI | 18448674 |
| GO:0023024 | MHC class I protein complex binding | IPI | 18448674 |
| GO:0030246 | carbohydrate binding | IEA | -- |
| GO:1990405 | protein antigen binding | IDA | 18448674 |
Phenotypes for KLRC2 Gene
- GenomeRNAi human phenotypes for KLRC2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for KLRC2 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for KLRC2
- genomics-online: gRNA clones - Search results for available KLRC2 gene related products
- Applied Biological Materials CRISPR for KLRC2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLRC2
- GenScript: Design CRISPR guide RNA sequences for KLRC2
miRNA for KLRC2 Gene
- miRTarBase miRNAs that target KLRC2
miRNA Products
- Search ViGene Biosciences for KLRC2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLRC2
- Browse OriGene Inhibitory RNA Products For KLRC2
- genomics-online: shRNA clones - Search results for available KLRC2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for KLRC2 gene
Clone Products
- Sino Biological Human cDNA Clone for KLRC2
- VectorBuilder custom plasmid, inducible vectors for KLRC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KLRC2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for KLRC2
- genomics-online: cdna clones - Search results for available KLRC2 gene related products
- orf clones - Search results for available KLRC2 gene related products
- Applied Biological Materials Clones for KLRC2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KLRC2
-
ViGene Biosciences adenoviral particle packaged cDNA for KLRC2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for KLRC2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KLRC2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLRC2 Gene
Localization for KLRC2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KLRC2 Gene
- Membrane; Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 8436421 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0043235 | receptor complex | IDA | 18448674 |
Pathways & Interactions for KLRC2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Immune response Role of DAP12 receptors in NK cells | ||
| 2 | RET signaling |
.92
|
|
| 3 | Innate Immune System |
.61
|
|
| 4 | Allograft rejection | ||
| 5 | Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers | ||
Pathways by source for KLRC2 Gene
4 Reactome pathways for KLRC2 Gene
2 KEGG pathways for KLRC2 Gene
1 GeneGo (Thomson Reuters) pathway for KLRC2 Gene
1 R&D Systems pathway for KLRC2 Gene
Interacting Proteins for KLRC2 Gene
Selected Interacting proteins:
P26717-NKG2C_HUMAN
ENSP00000371327
for KLRC2 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002228 | natural killer cell mediated immunity | IDA | 18448674 |
| GO:0006968 | cellular defense response | TAS | 9683661 |
| GO:0007165 | signal transduction | TAS | 2007850 |
| GO:0045087 | innate immune response | TAS | -- |
No data available for SIGNOR curated interactions for KLRC2 Gene
Transcripts for KLRC2 Gene
mRNA/cDNA for KLRC2 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (53) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for KLRC2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for KLRC2
- genomics-online: gRNA clones - Search results for available KLRC2 gene related products
- Applied Biological Materials CRISPR for KLRC2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLRC2
- GenScript: Design CRISPR guide RNA sequences for KLRC2
miRNA Products
- Search ViGene Biosciences for KLRC2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLRC2
- Browse OriGene Inhibitory RNA Products For KLRC2
- genomics-online: shRNA clones - Search results for available KLRC2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for KLRC2 gene
Clone Products
- Sino Biological Human cDNA Clone for KLRC2
- VectorBuilder custom plasmid, inducible vectors for KLRC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KLRC2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for KLRC2
- genomics-online: cdna clones - Search results for available KLRC2 gene related products
- orf clones - Search results for available KLRC2 gene related products
- Applied Biological Materials Clones for KLRC2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for KLRC2 Gene
mRNA differential expression in normal tissues according to GTEx for KLRC2 Gene
This gene is overexpressed in Brain - Amygdala (x5.2) and Brain - Substantia nigra (x4.4).
NURSA nuclear receptor signaling pathways regulating expression of KLRC2 Gene:
KLRC2SOURCE GeneReport for Unigene cluster for KLRC2 Gene:
Hs.591157mRNA Expression by UniProt/SwissProt for KLRC2 Gene:
P26717-NKG2C_HUMAN
Tissue specificity:
Natural killer cells.
Evidence on tissue expression from TISSUES for KLRC2 Gene
- Liver(4.1)
- Blood(2.2)
Primer Products
-
OriGene qPCR primer pairs for KLRC2
- genomics-online: primer clones - Search results for available KLRC2 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLRC2 Gene
Orthologs for KLRC2 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC101058094 33 |
|
||
| KLRC2 34 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | LOC609192 33 |
|
||
| -- 34 |
|
ManyToMany | |||
| cow (Bos Taurus) |
Mammalia | -- 34 |
|
ManyToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Klre1 34 |
|
ManyToMany |
- Species where no ortholog for KLRC2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for KLRC2 Gene
(19) SIMAP similar genes for KLRC2 Gene using alignment to 6 proteins:
Pseudogenes.org Pseudogenes for KLRC2 Gene
Variants for KLRC2 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for KLRC2 Gene
- NKG2C_HUMAN-P26717
- Two alleles are known. The sequence shown is that of allele NKG2-C*01.
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000733034 | -- | 10,434,142(-) | T/C | intron_variant | |
| rs1002336991 | -- | 10,430,734(-) | TTTT/TTT | 3_prime_UTR_variant | |
| rs1005212643 | -- | 10,437,162(-) | G/A | upstream_transcript_variant | |
| rs1005738016 | -- | 10,436,189(-) | T/C | upstream_transcript_variant | |
| rs1006808993 | -- | 10,433,907(-) | T/C | coding_sequence_variant, missense_variant |
Residual Variation Intolerance Score:
88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.30;
6.67% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KLRC2 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for KLRC2 Gene
Additional Disease Information for KLRC2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for KLRC2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLRC2 Gene
Publications for KLRC2 Gene
- Molecular genetic analyses of human NKG2C (KLRC2) gene deletion. (PMID: 14688071) Miyashita R … Tokunaga K (International immunology 2004) 3 22 44 58
- Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population. (PMID: 12618865) Hikami K … Tokunaga K (Genes and immunity 2003) 3 22 44 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- The structural basis for intramembrane assembly of an activating immunoreceptor complex. (PMID: 20890284) Call ME … Chou JJ (Nature immunology 2010) 3 4 58
- Inhibitory NKG2A and activating NKG2D and NKG2C natural killer cell receptor genes: susceptibility for rheumatoid arthritis. (PMID: 18700876) Park KS … Song YW (Tissue antigens 2008) 3 44 58
Products for KLRC2 Gene
- R&D Systems Antibodies for KLRC2 (NKG2C/CD159c)
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- Custom Antibody ServicesOriGene Antibodies for KLRC2
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for KLRC2
- VectorBuilder custom plasmid, inducible vectors for KLRC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KLRC2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for KLRC2
- antibodies-online: Search results for 51 available KLRC2 Antibodies ranked by validation data
- Compare Top KLRC2 Antibodies
- antibodies-online: Search results for 1 available KLRC2 Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Search results for 14 available KLRC2 Proteins ranked by validation data
- Compare Top KLRC2 Proteins
- GeneTex KLRC2 antibody for KLRC2
- Search GeneTex for Proteins for KLRC2
- ViGene Biosciences adenoviral particle packaged cDNA for KLRC2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for KLRC2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for KLRC2 gene
- Search ViGene Biosciences for KLRC2
- Horizon Cell Lines for KLRC2
- genomics-online: cdna clones - Search results for available KLRC2 gene related products
- orf clones - Search results for available KLRC2 gene related products
- genomics-online: gRNA clones - Search results for available KLRC2 gene related products
- genomics-online: primer clones - Search results for available KLRC2 gene related products
- genomics-online: shRNA clones - Search results for available KLRC2 gene related products
Sources for KLRC2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
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