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Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]
KLRB1 (Killer Cell Lectin Like Receptor B1) is a Protein Coding gene. Diseases associated with KLRB1 include Inflammatory Bowel Disease 18 and T-Cell Prolymphocytic Leukemia. Among its related pathways are Hematopoietic Stem Cells and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is KLRF1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | TAS | 8077657 |
GO:0005515 | protein binding | IPI | 21572041 |
GO:0030246 | carbohydrate binding | TAS,IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Malaria |
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2 | Hematopoietic Stem Cells and Lineage-specific Markers | ||
3 | Innate Lymphoid Cells Differentiation | ||
4 | Class I MHC mediated antigen processing and presentation | ||
5 | Innate Immune System |
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007166 | cell surface receptor signaling pathway | TAS | 8077657 |
GO:0050776 | regulation of immune response | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
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Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
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3-O-Sulfogalactosylceramide (d18:1/12:0) |
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852100-88-0 |
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3-O-Sulfogalactosylceramide (d18:1/14:0) |
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3-O-Sulfogalactosylceramide (d18:1/16:0) |
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862509-48-6 |
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3-O-Sulfogalactosylceramide (d18:1/18:0) |
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244215-65-4 |
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3-O-Sulfogalactosylceramide (d18:1/18:1(9Z)) |
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This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | KLRB1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | KLRB1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | KLRB1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Klrb1a 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Klrb1a 30 17 31 |
|
OneToMany | |
Klrb1 31 |
|
OneToMany | |||
Klrb1f 31 |
|
OneToMany | |||
Klrb1b 17 31 |
|
OneToMany | |||
Klrb1c 17 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759878 | CNV | gain+loss | 17122850 |
esv3303085 | CNV | tandem duplication | 20981092 |
esv3628509 | CNV | loss | 21293372 |
esv3628510 | CNV | loss | 21293372 |
esv3628511 | CNV | gain | 21293372 |
nsv1051530 | CNV | gain | 25217958 |
nsv428271 | CNV | gain | 18775914 |
nsv602 | CNV | deletion | 18451855 |
nsv603 | CNV | insertion | 18451855 |
nsv8909 | CNV | gain | 18304495 |
Disorder | Aliases | PubMed IDs |
---|---|---|
inflammatory bowel disease 18 |
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t-cell prolymphocytic leukemia |
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