The protein encoded by this gene is a kallikrein-related serine protease. This gene is activated by steroid hormones in a human breast cancer cell line, making it a good marker for cancer detection. The encoded protein is found primarily in the cytoplasm.[provided by RefSeq, Oct 2010] See more...

Aliases for KLK9 Gene

Aliases for KLK9 Gene

  • Kallikrein Related Peptidase 9 2 3 5
  • KLK-L3 2 3 4
  • Kallikrein-Like Protein 3 3 4
  • Kallikrein-9 3 4
  • Kallikrein 9 2
  • EC 3.4.21.4 51
  • EC 3.4.21.- 4
  • EC 3.4.21 51
  • KLKL3 3
  • KLK9 5

External Ids for KLK9 Gene

Previous GeneCards Identifiers for KLK9 Gene

  • GC19M052136
  • GC19M051867
  • GC19M056181
  • GC19M056192
  • GC19M056197
  • GC19M056194
  • GC19M051505
  • GC19M047838

Summaries for KLK9 Gene

Entrez Gene Summary for KLK9 Gene

  • The protein encoded by this gene is a kallikrein-related serine protease. This gene is activated by steroid hormones in a human breast cancer cell line, making it a good marker for cancer detection. The encoded protein is found primarily in the cytoplasm.[provided by RefSeq, Oct 2010]

GeneCards Summary for KLK9 Gene

KLK9 (Kallikrein Related Peptidase 9) is a Protein Coding gene. Diseases associated with KLK9 include High-Grade Astrocytoma and Toxic Pneumonitis. Among its related pathways are Collagen chain trimerization and MSP-RON Signaling. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is ENSG00000269741.

Gene Wiki entry for KLK9 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLK9 Gene

Genomics for KLK9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KLK9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051009 Promoter/Enhancer 0.8 EPDnew ENCODE 250.7 -0.6 -584 1.8 ZNF189 ZFP3 FOS EZH2 ENSG00000269741 KLK9 ENSG00000268739 HSALNG0127160 KLK10 ENSG00000267879
GH19J051010 Promoter 0.4 EPDnew 250.7 +0.4 361 0.1 EZH2 ENSG00000269741 KLK9 HSALNG0127160 KLK8 ENSG00000267879
GH19J051016 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 0.4 -9.0 -8989 4 ZBTB10 CEBPA IKZF1 ETS1 ZNF217 CTCF ZEB1 ELF1 ZIC2 REST KLK10 HSALNG0127163 HSALNG0127164 ZNF175 ZNF615 ZNF577 ZNF473 POLD1 SPACA6 ZNF613
GH19J050999 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 0.4 +8.2 8163 3.5 TBP MNT IKZF1 NBN TRIM25 ZNF341 ZBTB5 SKIL NKRF PRDM10 KLK8 HSALNG0127160 HSALNG0127161 lnc-KLK9-1 KLK7 KLK10 ENSG00000269741 KLK9 ENSG00000267879
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLK9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLK9

Top Transcription factor binding sites by QIAGEN in the KLK9 gene promoter:
  • AML1a
  • c-Myb
  • ER-alpha
  • Gfi-1
  • HEN1
  • NF-E2
  • NF-E2 p45
  • Zic3
  • ZID

Genomic Locations for KLK9 Gene

Latest Assembly
chr19:51,002,508-51,009,634
(GRCh38/hg38)
Size:
7,127 bases
Orientation:
Minus strand

Previous Assembly
chr19:51,505,764-51,512,848
(GRCh37/hg19 by Entrez Gene)
Size:
7,085 bases
Orientation:
Minus strand

chr19:51,503,806-51,512,890
(GRCh37/hg19 by Ensembl)
Size:
9,085 bases
Orientation:
Minus strand

Genomic View for KLK9 Gene

Genes around KLK9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK9 Gene

Proteins for KLK9 Gene

  • Protein details for KLK9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKQ9-KLK9_HUMAN
    Recommended name:
    Kallikrein-9
    Protein Accession:
    Q9UKQ9
    Secondary Accessions:
    • Q6QA55

    Protein attributes for KLK9 Gene

    Size:
    250 amino acids
    Molecular mass:
    27513 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLK9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLK9 Gene

Selected DME Specific Peptides for KLK9 Gene

Q9UKQ9:
  • GDSGGPL
  • CLISGWG
  • SGGPLVC
  • CQGDSGGP
  • DIMLIRL

Post-translational modifications for KLK9 Gene

  • Glycosylation at Asn131, Asn166, and Asn211
  • Modification sites at PhosphoSitePlus

Other Protein References for KLK9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for KLK9 Gene

Gene Families for KLK9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted secreted proteins

Protein Domains for KLK9 Gene

InterPro:
Blocks:
  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature
ProtoNet:

Suggested Antigen Peptide Sequences for KLK9 Gene

GenScript: Design optimal peptide antigens:
  • Kallikrein-like protein 3 (KLK9_HUMAN)
  • Kallikrein 9 (Q2XQG4_HUMAN)
  • Kallikrein 9, isoform CRA_b (Q2XQG6_HUMAN)
  • Kallikrein-like protein 3 splice variant 1 (Q9HC80_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UKQ9

UniProtKB/Swiss-Prot:

KLK9_HUMAN :
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK9: view

Function for KLK9 Gene

Enzyme Numbers (IUBMB) for KLK9 Gene

Phenotypes From GWAS Catalog for KLK9 Gene

Gene Ontology (GO) - Molecular Function for KLK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity NAS 11054574
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with KLK9: view
genes like me logo Genes that share phenotypes with KLK9: view

Animal Models for KLK9 Gene

MGI Knock Outs for KLK9:
  • Klk9 Klk9<tm1a(KOMP)Wtsi>

Animal Models for research

  • Taconic Biosciences Mouse Models for KLK9

miRNA for KLK9 Gene

miRTarBase miRNAs that target KLK9

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK9

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLK9 Gene

Localization for KLK9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK9 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLK9 gene
Compartment Confidence
extracellular 4
plasma membrane 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KLK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0030141 secretory granule IBA 21873635
genes like me logo Genes that share ontologies with KLK9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLK9 Gene

Pathways & Interactions for KLK9 Gene

PathCards logo

SuperPathways for KLK9 Gene

SuperPathway Contained pathways
1 Collagen chain trimerization
.48
.46
2 MSP-RON Signaling
-
genes like me logo Genes that share pathways with KLK9: view

Pathways by source for KLK9 Gene

3 Qiagen pathways for KLK9 Gene
  • Blood Coagulation Cascade
  • Intrinsic Prothrombin Activation Pathway
  • MSP-RON Signaling

Gene Ontology (GO) - Biological Process for KLK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with KLK9: view

No data available for SIGNOR curated interactions for KLK9 Gene

Drugs & Compounds for KLK9 Gene

No Compound Related Data Available

Transcripts for KLK9 Gene

mRNA/cDNA for KLK9 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK9

Alternative Splicing Database (ASD) splice patterns (SP) for KLK9 Gene

No ASD Table

Relevant External Links for KLK9 Gene

GeneLoc Exon Structure for
KLK9

Expression for KLK9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLK9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLK9

SOURCE GeneReport for Unigene cluster for KLK9 Gene:

Hs.448942

mRNA Expression by UniProt/SwissProt for KLK9 Gene:

Q9UKQ9-KLK9_HUMAN
Tissue specificity: Skin, thymus, trachea, cerebellum and spinal cord.
genes like me logo Genes that share expression patterns with KLK9: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLK9 Gene

Orthologs for KLK9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLK9 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia KLK9 30
  • 88.4 (n)
-- 31
  • 23 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia KLK9 30 31
  • 87.07 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Klk9 30
  • 79.15 (n)
Mouse
(Mus musculus)
Mammalia Klk9 30 17 31
  • 78.3 (n)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 76 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 45 (a)
OneToMany
Species where no ortholog for KLK9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for KLK9 Gene

ENSEMBL:
Gene Tree for KLK9 (if available)
TreeFam:
Gene Tree for KLK9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLK9: view image

Paralogs for KLK9 Gene

genes like me logo Genes that share paralogs with KLK9: view

Variants for KLK9 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KLK9 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KLK9 Gene

Variant ID Type Subtype PubMed ID
dgv6515n54 CNV loss 21841781
dgv6516n54 CNV loss 21841781
esv2671814 CNV deletion 23128226
esv29146 CNV loss 19812545
esv3644663 CNV loss 21293372
nsv1058277 CNV gain 25217958
nsv1112751 CNV deletion 24896259
nsv1140251 OTHER inversion 24896259
nsv579961 CNV loss 21841781

Variation tolerance for KLK9 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLK9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLK9

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLK9 Gene

Disorders for KLK9 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KLK9 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
high-grade astrocytoma
toxic pneumonitis
  • acute chemical fume pulmonary edema
postpoliomyelitis syndrome
  • postpolio syndrome
- elite association - COSMIC cancer census association via MalaCards
Search KLK9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KLK9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with KLK9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLK9 Gene

Publications for KLK9 Gene

  1. The expanded human kallikrein gene family: locus characterization and molecular cloning of a new member, KLK-L3 (KLK9). (PMID: 10783266) Yousef GM … Diamandis EP (Genomics 2000) 3 4 23
  2. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PMID: 20424135) Klein RJ … Lilja H (Cancer prevention research (Philadelphia, Pa.) 2010) 3 41
  3. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PMID: 16800724) Lundwall A … Yousef GM (Biological chemistry 2006) 2 3
  4. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PMID: 16800723) (Biological chemistry 2006) 2 3
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4

Products for KLK9 Gene

Sources for KLK9 Gene