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KLK5 Gene(Protein Coding)

Kallikrein Related Peptidase 5

GCID:
GC19M050943
GIFtS:
48
Genes Participants
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Aliases for KLK5 Gene

Aliases for KLK5 Gene

  • Kallikrein Related Peptidase 5 2 3 5
  • Stratum Corneum Tryptic Enzyme 3 4
  • Kallikrein-Like Protein 2 3 4
  • Kallikrein-5 3 4
  • KLK-L2 3 4
  • SCTE 3 4
  • Kallikrein 5 2
  • EC 3.4.21.4 56
  • EC 3.4.21.- 4
  • EC 3.4.21 56
  • KLKL2 3

External Ids for KLK5 Gene

Previous GeneCards Identifiers for KLK5 Gene

  • GC19M052075
  • GC19M051807
  • GC19M056122
  • GC19M056138
  • GC19M051446
  • GC19M047780

Summaries for KLK5 Gene

Entrez Gene Summary for KLK5 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLK5 Gene

KLK5 (Kallikrein Related Peptidase 5) is a Protein Coding gene. Diseases associated with KLK5 include Ovarian Cancer. Among its related pathways are Collagen chain trimerization and Keratinization. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK4.

UniProtKB/Swiss-Prot for KLK5 Gene

Gene Wiki entry for KLK5 Gene

Additional gene information for KLK5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK5 Gene

Genomics for KLK5 Gene

GeneHancer (GH) Regulatory Elements for KLK5 Gene

Promoters and enhancers for KLK5 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19J050951 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 606.8 +0.6 566 1.8 CREB1 SCRT1 ZNF366 MCM7 KLK5 ENSG00000269495 KLK10
GH19J050968 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 8.9 -15.9 -15901 2.2 EGR1 FOSL2 CREB1 ZNF512 CTBP1 ZFX KLF4 ESRRA ZNF217 DPF2 KLK6 ENSG00000267879 KLK7 KLK5 ENSG00000269495 ZNF473 LOC105372442
GH19J050975 Enhancer 0.9 Ensembl ENCODE 8.2 -22.1 -22109 2.4 NCOA3 FOSL2 CREB1 CTBP1 KLF4 ZNF217 DPF2 TCF7L2 GATAD2B ELF1 KLK5 ENSG00000267879 KLK6 KLK7 LOC105372442
GH19J050861 Enhancer 0.2 dbSUPER 5.9 +91.4 91437 0.5 KLK2 GC19P050860 KLK15 KLK1 LINC01869 C19orf48 SNORD88C SNORD88A SNORD88B KLK5
GH19J050962 Enhancer 0.5 FANTOM5 0.4 -9.3 -9296 0.3 SP1 SP2 EHMT2 FOS ENSG00000279676 LOC105372442 KLK4 SIGLECL1 KLK14 ACP4 IGLON5 ETFB SYT3 KLK5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLK5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLK5 gene promoter:
  • AML1a
  • AREB6
  • Meis-1
  • Meis-1a
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Nkx2-5

Genomic Locations for KLK5 Gene

Genomic Locations for KLK5 Gene
chr19:50,943,299-50,953,093
(GRCh38/hg38)
Size:
9,795 bases
Orientation:
Minus strand
chr19:51,446,559-51,456,349
(GRCh37/hg19)
Size:
9,791 bases
Orientation:
Minus strand

Genomic View for KLK5 Gene

Genes around KLK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for KLK5 Gene

Proteins for KLK5 Gene

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  • Protein details for KLK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y337-KLK5_HUMAN
    Recommended name:
    Kallikrein-5
    Protein Accession:
    Q9Y337
    Secondary Accessions:
    • A0A024R4G4
    • Q53ZR3
    • Q9HBG8

    Protein attributes for KLK5 Gene

    Size:
    293 amino acids
    Molecular mass:
    32020 Da
    Quaternary structure:
    • Interacts with SPINK9.
    SequenceCaution:
    • Sequence=AAG33358.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAG33358.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KLK5 Gene

neXtProt entry for KLK5 Gene

Protein Expression for KLK5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for KLK5 Gene

Q9Y337:
  • DSGGPVVCNG
  • DSCQGDSGG
  • CQGDSGGP

Post-translational modifications for KLK5 Gene

  • Glycosylation at posLast=173173, posLast=208208, isoforms=69, and isoforms=252
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for KLK5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for KLK5 Gene

Gene Families for KLK5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted secreted proteins

Protein Domains for KLK5 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KLK5 Gene

GenScript: Design optimal peptide antigens:
  • Stratum corneum tryptic enzyme (KLK5_HUMAN)
  • Kallikrein 5, isoform CRA_a (Q53ZR3_HUMAN)
  • Kallikrein 5, isoform CRA_b (Q6S9W8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y337

UniProtKB/Swiss-Prot:

KLK5_HUMAN :
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK5: view

Function for KLK5 Gene

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  2. CRISPR
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Molecular function for KLK5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in desquamation.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by Zn2+.

Enzyme Numbers (IUBMB) for KLK5 Gene

Gene Ontology (GO) - Molecular Function for KLK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity NAS,IEA 11054574
GO:0005515 protein binding IPI 19194479
GO:0008233 peptidase activity TAS,IMP 17012259
GO:0008236 serine-type peptidase activity TAS 10514489
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with KLK5: view
genes like me logo Genes that share phenotypes with KLK5: view

Animal Models for KLK5 Gene

MGI Knock Outs for KLK5:
  • Klk5 Klk5<tm2a(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for KLK5

CRISPR Products

miRNA for KLK5 Gene

miRTarBase miRNAs that target KLK5

Clone Products

  • Applied Biological Materials (abm): Clones for KLK5 - Now 50% OFF >
  • * KLK5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * KLK5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLK5 Gene

Localization for KLK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLK5 gene
Compartment Confidence
extracellular 5
cytosol 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KLK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS,IMP 17012259
GO:0005829 cytosol TAS --
GO:0030141 secretory granule IBA 21873635
GO:0097209 epidermal lamellar body IDA 15675955
genes like me logo Genes that share ontologies with KLK5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLK5 Gene

Pathways & Interactions for KLK5 Gene

GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards
genes like me logo Genes that share pathways with KLK5: view

Pathways by source for KLK5 Gene

Gene Ontology (GO) - Biological Process for KLK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002803 positive regulation of antibacterial peptide production IMP 17012259
GO:0006508 proteolysis IEA --
GO:0008544 epidermis development TAS 10514489
GO:0022617 extracellular matrix disassembly IBA 21873635
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway IDA 16885167
genes like me logo Genes that share ontologies with KLK5: view

No data available for SIGNOR curated interactions for KLK5 Gene

Drugs & Compounds for KLK5 Gene

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(2) Drugs for KLK5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KLK5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLK5: view

Transcripts for KLK5 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for KLK5 Gene

(3) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(58) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for KLK5 Gene

Kallikrein-related peptidase 5:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for KLK5 - Now 50% OFF >
  • * KLK5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * KLK5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for KLK5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2:
SP3: - -
SP4: -
SP5:

Relevant External Links for KLK5 Gene

GeneLoc Exon Structure for
KLK5
ECgene alternative splicing isoforms for
KLK5

Expression for KLK5 Gene

Products:

  1. Primer
  2. Gene Expression Assay
GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLK5 Gene

mRNA expression in normal human tissues for KLK5 Gene
mRNA expression by BioGPS for KLK5 GenemRNA expression by GTEx for KLK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLK5 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x21.5) and Skin - Not Sun Exposed (Suprapubic) (x17.7).

Protein differential expression in normal tissues from HIPED for KLK5 Gene

This gene is overexpressed in Testis (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLK5 Gene



Protein tissue co-expression partners for KLK5 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLK5 Gene:

KLK5

SOURCE GeneReport for Unigene cluster for KLK5 Gene:

Hs.50915

mRNA Expression by UniProt/SwissProt for KLK5 Gene:

Q9Y337-KLK5_HUMAN
Tissue specificity: Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar skin.

Evidence on tissue expression from TISSUES for KLK5 Gene

  • Skin(4.7)
genes like me logo Genes that share expression patterns with KLK5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KLK5 Gene

Orthologs for KLK5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia KLK5 35 34
  • 99.09 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia KLK5 35 34
  • 81.46 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia KLK5 35 34
  • 80.09 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Klk5 17 35 34
  • 75.49 (n)
rat
(Rattus norvegicus)
 Mammalia LOC102546758 34
  • 73.44 (n)
oppossum
(Monodelphis domestica)
 Mammalia KLK5 35
  • 56 (a)
 OneToOne
Species where no ortholog for KLK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK5 Gene

ENSEMBL:
Gene Tree for KLK5 (if available)
TreeFam:
Gene Tree for KLK5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLK5: view image

Paralogs for KLK5 Gene

Paralogs for KLK5 Gene

(54) SIMAP similar genes for KLK5 Gene using alignment to 3 proteins:

  • KLK5_HUMAN
  • M0QXX2_HUMAN
  • Q6S9W8_HUMAN

Pseudogenes.org Pseudogenes for KLK5 Gene

genes like me logo Genes that share paralogs with KLK5: view

Variants for KLK5 Gene

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Sequence variations from dbSNP and Humsavar for KLK5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000100544 -- 50,954,133(-) C/T upstream_transcript_variant
rs1000240368 -- 50,948,567(-) G/A intron_variant
rs1000310379 -- 50,954,543(-) A/G upstream_transcript_variant
rs1000359265 -- 50,944,775(-) C/T intron_variant
rs1000420913 -- 50,949,300(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLK5 Gene

Variant ID Type Subtype PubMed ID
esv3583474 CNV loss 25503493
nsv1140251 OTHER inversion 24896259

Variation tolerance for KLK5 Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLK5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLK5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK5 Gene

Disorders for KLK5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLK5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • ovarian cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search KLK5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KLK5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KLK5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLK5 Gene

Publications for KLK5 Gene

  1. Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation. (PMID: 10514489) Brattsand M … Egelrud T (The Journal of biological chemistry 1999) 2 3 4 23 58
  2. SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor. (PMID: 19194479) Brattsand M … Egelrud T (The Journal of investigative dermatology 2009) 3 4 23 58
  3. Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin. (PMID: 17012259) Yamasaki K … Gallo RL (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006) 2 3 23 58
  4. The new kallikrein-like gene, KLK-L2. Molecular characterization, mapping, tissue expression, and hormonal regulation. (PMID: 10608802) Yousef GM … Diamandis EP (The Journal of biological chemistry 1999) 2 3 23 58
  5. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PMID: 20424135) Klein RJ … Lilja H (Cancer prevention research (Philadelphia, Pa.) 2010) 3 45 58

ExternalLinks

View latest publications for KLK5 gene in Mastermind

Products for KLK5 Gene

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Sources for KLK5 Gene

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