Free for academic non-profit institutions. Other users need a Commercial license
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
KLK5 (Kallikrein Related Peptidase 5) is a Protein Coding gene. Diseases associated with KLK5 include Netherton Syndrome and Facial Dermatosis. Among its related pathways are Collagen chain trimerization and Developmental Biology. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004252 | serine-type endopeptidase activity | IEA,NAS | 11054574 |
GO:0005515 | protein binding | IPI | 19194479 |
GO:0008233 | peptidase activity | IEA,IMP | 17012259 |
GO:0008236 | serine-type peptidase activity | IEA,TAS | 10514489 |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | TAS,IMP | 17012259 |
GO:0005829 | cytosol | TAS | -- |
GO:0030141 | secretory granule | IBA | 21873635 |
GO:0097209 | epidermal lamellar body | IDA | 15675955 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Collagen chain trimerization |
Intrinsic Prothrombin Activation Pathway
.48
|
Blood Coagulation Cascade
.46
|
2 | Keratinization |
.33
|
|
3 | MSP-RON Signaling |
MSP-RON Signaling
-
|
|
4 | Developmental Biology |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002803 | positive regulation of antibacterial peptide production | IBA,IMP | 17012259 |
GO:0006508 | proteolysis | IEA | -- |
GO:0008544 | epidermis development | TAS | 10514489 |
GO:0022617 | extracellular matrix disassembly | IBA | 21873635 |
GO:0045745 | positive regulation of G protein-coupled receptor signaling pathway | IDA | 16885167 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||
SP2: | |||||||||||||||||
SP3: | - | - | |||||||||||||||
SP4: | - | ||||||||||||||||
SP5: |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | KLK5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | KLK5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | KLK5 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Klk5 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | LOC102546758 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | KLK5 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3583474 | CNV | loss | 25503493 |
nsv1140251 | OTHER | inversion | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
netherton syndrome |
|
|
facial dermatosis |
|
|
ovarian cancer |
|
|
rosacea |
|
|
tinea barbae |
|
|