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Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease which is synthesized in the epithelial cells of the prostate gland, and is present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. The serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019]
KLK3 (Kallikrein Related Peptidase 3) is a Protein Coding gene. Diseases associated with KLK3 include Prostatitis and Urethral Stricture. Among its related pathways are Androgen receptor signaling pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004175 | endopeptidase activity | IDA | 18714013 |
GO:0004252 | serine-type endopeptidase activity | IEA,IMP | 15563730 |
GO:0005515 | protein binding | IPI | 1725227 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008236 | serine-type peptidase activity | IEA,TAS | 2470553 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IDA | 8665956 |
GO:0005634 | nucleus | HDA | 21630459 |
GO:0030141 | secretory granule | IBA | 21873635 |
GO:0032991 | protein-containing complex | IDA | 8665956 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Collagen chain trimerization |
Intrinsic Prothrombin Activation Pathway
.48
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Blood Coagulation Cascade
.46
|
2 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
3 | Signaling by Rho GTPases | ||
4 | Adhesion |
-
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5 | Pathways in cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002778 | antibacterial peptide production | IDA | 18714013 |
GO:0003073 | regulation of systemic arterial blood pressure | IBA | 21873635 |
GO:0006508 | proteolysis | IEA,IMP | 15563730 |
GO:0016525 | negative regulation of angiogenesis | NAS | 10675891 |
GO:0031638 | zymogen activation | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Cyproterone Acetate | Approved, Investigational | Pharma | Target | Androgen receptor antagonist | 48 | |
Gallium Ga-68 gozetotide | Approved | Pharma | Target, binder | 0 | ||
Mifepristone | Approved, Investigational | Pharma | Target | Progesterone receptor antagonist, Progesterone and glucocorticoid receptor antagonist | 186 | |
MVA-BN | Pharma | 0 | ||||
PRX302 | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP13: | - | - | - | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | KLK3 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Klk1b22 30 17 |
|
||
Klk1b16 17 31 |
|
ManyToMany | |||
Klk1 17 |
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Klk1b1 17 |
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Klk1b11 17 |
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||||
Klk1b21 17 |
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Klk1b24 17 |
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Klk1b26 17 |
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Klk1b27 17 |
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Klk1b3 17 |
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Klk1b4 17 |
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Klk1b5 17 |
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Klk1b8 17 |
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Klk1b9 17 |
|
||||
Dog (Canis familiaris) |
Mammalia | KLK2 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1599990489 | Not Provided: Hereditary angioedema with normal C1Inh | 50,856,308(+) |
C/CA NM_001648.2(KLK3):c.116dup (p.Val40fs) |
FRAMESHIFT | |
rs1599996938 | Not Provided: Hereditary angioedema with normal C1Inh | 50,860,131(+) |
C/T NM_001648.2(KLK3):c.*4C>T |
THREE_PRIME_UTR | |
rs200712655 | Benign: not provided | 50,856,309(+) |
A/T NM_001648.2(KLK3):c.116A>T (p.Gln39Leu) |
MISSENSE | |
rs2271092 | Benign: not provided. - | 50,856,287(+) |
G/Ap.Glu32Lys NM_001648.2(KLK3):c.94G>A (p.Glu32Lys) |
MISSENSE | |
rs372190695 | Likely Benign: not provided | 50,858,496(+) |
T/C NM_001648.2(KLK3):c.531T>C (p.His177=) |
SYNONYMOUS |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2763208 | CNV | gain | 21179565 |
nsv1140251 | OTHER | inversion | 24896259 |
nsv2531 | CNV | deletion | 18451855 |
nsv524465 | CNV | loss | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
prostatitis |
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urethral stricture |
|
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prostatic hypertrophy |
|
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nodular prostate |
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urethral syndrome |
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