Aliases for KLK3 Gene
External Ids for KLK3 Gene
Previous HGNC Symbols for KLK3 Gene
Previous GeneCards Identifiers for KLK3 Gene
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease which is synthesized in the epithelial cells of the prostate gland, and is present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. The serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019]
GeneCards Summary for KLK3 Gene
KLK3 (Kallikrein Related Peptidase 3) is a Protein Coding gene. Diseases associated with KLK3 include Prostatitis and Urethral Stricture. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Adhesion. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK2.
UniProtKB/Swiss-Prot Summary for KLK3 Gene
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.