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Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present ... See more...
Aliases for KLK3 Gene
Aliases for KLK3 Gene
External Ids for KLK3 Gene
- HGNC: 6364
- Entrez Gene: 354
- Ensembl: ENSG00000142515
- OMIM: 176820
- UniProtKB: P07288
Previous HGNC Symbols for KLK3 Gene
- APS
Previous GeneCards Identifiers for KLK3 Gene
- GC19P051987
- GC19P051719
- GC19P056034
- GC19P056049
- GC19P051358
- GC19P047693
Summaries for KLK3 Gene
-
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for KLK3 Gene
KLK3 (Kallikrein Related Peptidase 3) is a Protein Coding gene. Diseases associated with KLK3 include Prostatitis and Urethral Stricture. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Adhesion. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK2.
UniProtKB/Swiss-Prot Summary for KLK3 Gene
-
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
Additional gene information for KLK3 Gene
- Monarch Initiative
- Search for KLK3 at DataMed
- Search for KLK3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLK3 Gene
Genomics for KLK3 Gene
GeneHancer (GH) Regulatory Elements for KLK3 Gene
Promoters and enhancers for KLK3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around KLK3 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLK3
- Top Transcription factor binding sites by QIAGEN in the KLK3 gene promoter:
-
- STAT3
Genomic Locations for KLK3 Gene
Genomic Locations for KLK3 Gene
- chr19:50,854,915-50,877,702
- (GRCh38/hg38)
- Size:
- 22,788 bases
- Orientation:
- Plus strand
- chr19:51,358,171-51,364,020
- (GRCh37/hg19)
- Size:
- 5,850 bases
- Orientation:
- Plus strand
Genomic View for KLK3 Gene
Genes around KLK3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
KLK3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KLK3 Gene
Proteins for KLK3 Gene
-
Protein details for KLK3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07288-KLK3_HUMAN
- Recommended name:
- Prostate-specific antigen
- Protein Accession:
- P07288
- C9JXH3
- G3V0H4
- G3XAE3
- Q15096
- Q16272
- Q86TG8
- Q8IXI4
Protein attributes for KLK3 Gene
- Size:
- 261 amino acids
- Molecular mass:
- 28741 Da
- Quaternary structure:
-
- Forms a heterodimer with SERPINA5.
- SequenceCaution:
-
- Sequence=AAD14185.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAA32124.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for KLK3 Gene
Protein Expression for KLK3 Gene
Selected DME Specific Peptides for KLK3 Gene
- P07288:
-
- GVLQGIT
- VLTAAHC
- GDSGGPL
- CGGVLVH
- GGWECEKHS
- SGGPLVC
- QKVTKFMLCAG
- DLMLLRLSEPA
- WVLTAAH
Post-translational modifications for KLK3 Gene
Other Protein References for KLK3 Gene
Antibody Products
- NSJ Bioreagents PSA Antibody Cocktail (Mouse Monoclonal)
- Creative Diagnostics Anti-PSA monoclonal antibody, clone C729M
-
Creative Biolabs
- Recombinant Anti-human KLK3 Antibody
- Recombinant Anti-human KLK3 Antibody Fab Fragment
- Mouse Anti-KLK3 Recombinant Antibody (GF1)
- Mouse Anti-KLK3 Recombinant Antibody (1H12)
- Mouse Anti-KLK3 Recombinant Antibody (KLK3/801+KLK3/1248)
- Mouse Anti-KLK3 Recombinant Antibody (Pa3)
- Mouse Anti-KLK3 Recombinant Antibody (B499)
- Mouse Anti-KLK3 Recombinant Antibody (2G8)
- Mouse Anti-KLK3 Recombinant Antibody (14i41)
- Mouse Anti-KLK3 Recombinant Antibody (5A11E9)
- Hi-Affi™ Recombinant Rabbit Anti-KLK3 Monoclonal Antibody (DS1962AB)
-
Custom Antibody ServicesOriGene Antibodies for KLK3
- 4P33-1H12
- 4P33-2H9
- 4P33-5A6
- 4P33-5G6
- 4P33-8A6
- 4P33-PS1
- 4P33-PS2
- AM01213PU-N
- AM05050PU-N
- AM05051PU-N
- AM05052HR-N
- AM05052PU-N
- AM06205SU-N
- AM06775SU-N
- AM09250HR-N
- AM09250PU-N
- AM09251PU-N
- AM20265SU-N
- AM20830PU-N
- AM20831PU-N
- AM20832PU-N
- AM32793PU-N
- AM32794PU-N
- AM32795PU-N
- AM32796PU-N
- AM33042PU-N
- AM50013PU-N
- AM50013PU-S
- AM50122PU-S
- AM50122PU-T
- AP05510PU-N
- AP06294PU-N
- AP08122PU-N
- AP08122PU-S
- AP13360PU-N
- BM695
- BM798
- CF808292
- CF808293
- CF808335
- CF808342
- CF808353
- CF808354
- CF808356
- CF808357
- DM1035
- DM1036
- DM1036HRP
- DM1225
- DP033
- DP033-05
- RA19044-100
- SM3072B
- SM3072P
- TA323386
- TA323387
- TA326253
- TA327729
- TA336588
- TA336798
- TA347464
- TA354527
- TA354544
- TA354555
- TA354799
- TA808292
- TA808292S
- TA808293
- TA808293S
- TA808335
- TA808335S
- TA808342
- TA808342S
- TA808353
- TA808353S
- TA808354
- TA808354S
- TA808356
- TA808356S
- TA808357
- TA808357S
- Novus Biologicals Antibodies for KLK3
-
Abcam antibodies for KLK3
- Invitrogen Antibodies for KLK3 (AFLGC-KLK3)
-
Custom Antibody ServicesProSci Antibodies for KLK3
-
Santa Cruz Biotechnology (SCBT) Antibodies for KLK3
- Sino Biological Antibodies for KLK3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for KLK3
- Origene Custom Protein Services for KLK3
- Sino Biological Recombinant Proteins for KLK3
- Sino Biological Cell Lysates for KLK3
- ProSpec Recombinant Proteins for KLK3
-
Abcam proteins for KLK3
Assay Products
- G Biosciences Immunotag™ Prostate-specific antigen ELISA Kit
- RayBiotech Human PSA free ELISA and Human PSA-total ELISA
- Creative Diagnostics Human KLK3 ELISA Kit, Prostate Specific Antigen Human ELISA Kit, and Total PSA ELISA Kit
-
Aviva Systems Biology
- Novus Biologicals ELISA Kits for KLK3
- antibodies-online: Show 83 available PSA-Total Elisa Kits ranked by validation data
- Compare Top PSA-Total Elisa Kits
-
Quality Products:
- ABIN1116720
- ABIN2685319
- ABIN419849
- ABIN365819
- ABIN491839
- ABIN1380036
- ABIN2708300
- ABIN5067601
- ABIN649037
- ABIN504784
- ABIN1116719
- ABIN1570918
- ABIN366314
- ABIN5525864
- ABIN5670311
- ABIN628123
- ABIN5656155
- ABIN1503353
- ABIN2535757
- ABIN2950743
- ABIN1116718
- ABIN366471
- ABIN1570919
- ABIN5525865
- ABIN5671011
- ABIN627308
- ABIN1503352
- ABIN5656156
- ABIN4970608
- ABIN2535758
- ABIN995041
- ABIN1503358
-
Abcam assays for KLK3
- Sino Biological Assays for KLK3
Domains & Families for KLK3 Gene
Gene Families for KLK3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for KLK3 Gene
- Blocks:
-
- Serine protease, trypsin family
- Chymotrypsin serine protease family (S1) signature
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for KLK3 Gene
- GenScript: Design optimal peptide antigens:
-
- Semenogelase (KLK3_HUMAN)
- APS protein (Q15096_HUMAN)
- APS protein (Q15098_HUMAN)
- cDNA, FLJ93384, Homo sapiens kallikrein 3, (prostate specific antigen) (KLK3),transcript variant 1, mRNA (Q546G3_HUMAN)
- APS protein (Q6LDS3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P07288- Family:
-
- Belongs to the peptidase S1 family. Kallikrein subfamily.
Function for KLK3 Gene
Molecular function for KLK3 Gene
- UniProtKB/Swiss-Prot Function:
- Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Preferential cleavage: -Tyr- -Xaa-.; EC=3.4.21.77;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders.
- GENATLAS Biochemistry:
- kallikrein 3,prostate specific antigen,serine protease,overexpressed in prostate and breast carcinomas
Enzyme Numbers (IUBMB) for KLK3 Gene
Phenotypes From GWAS Catalog for KLK3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004175 | endopeptidase activity | IDA | 18714013 |
| GO:0004252 | serine-type endopeptidase activity | IMP,IEA | 15563730 |
| GO:0005515 | protein binding | IPI | 1725227 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008236 | serine-type peptidase activity | IEA,TAS | 2470553 |
Phenotypes for KLK3 Gene
- GenomeRNAi human phenotypes for KLK3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for KLK3 - Select products 50% OFF >
- * KLK3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * KLK3 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for KLK3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLK3
- genomics-online: gRNA clones - Search for available PSA-Total gRNA products
- Overview of 150 available PSA-Total gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLK3
miRNA for KLK3 Gene
- miRTarBase miRNAs that target KLK3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLK3
- Browse OriGene Inhibitory RNA Products For KLK3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK3
- genomics-online: shRNA clones - Search for available PSA-Total shRNA products
- Overview of 150 available PSA-Total gene related products
Clone Products
- Applied Biological Materials (abm): Clones for KLK3 - Select products 50% OFF >
- * KLK3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * KLK3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
OriGene ORF clones in human for KLK3
- RC202740
- RC211624
- RC211729
- RC217029
- RG202740
- RG211624
- RG211729
- RG217029
- RC202740L1
- RC202740L1V
- RC202740L2
- RC202740L2V
- RC202740L3
- RC202740L3V
- RC202740L4
- RC202740L4V
- RC211624L3
- RC211624L3V
- RC211624L4
- RC211624L4V
- RC211729L3
- RC211729L3V
- RC211729L4
- RC211729L4V
- RC217029L3
- RC217029L3V
- RC217029L4
- RC217029L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KLK3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLK3
Cell Line Products
-
Horizon Cell Lines for KLK3
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLK3 Gene
Localization for KLK3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KLK3 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| nucleus | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IDA | 8665956 |
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0030141 | secretory granule | IBA | 21873635 |
| GO:0032991 | protein-containing complex | IDA | 8665956 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLK3 Gene
Pathways & Interactions for KLK3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Collagen chain trimerization |
Intrinsic Prothrombin Activation Pathway
.48
|
Blood Coagulation Cascade
.46
|
| 2 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 3 | Signaling by Rho GTPases | ||
| 4 | Adhesion |
-
|
|
| 5 | Pathways in cancer | ||
Pathways by source for KLK3 Gene
4 BioSystems pathways for KLK3 Gene
7 Reactome pathways for KLK3 Gene
2 KEGG pathways for KLK3 Gene
2 GeneGo (Thomson Reuters) pathways for KLK3 Gene
- Cell adhesion_ECM remodeling
- Transcription Androgen Receptor nuclear signaling
4 Qiagen pathways for KLK3 Gene
- Blood Coagulation Cascade
- Insulin Receptor Pathway
- Intrinsic Prothrombin Activation Pathway
- MSP-RON Signaling
1 Cell Signaling Technology pathway for KLK3 Gene
Interacting Proteins for KLK3 Gene
Selected Interacting proteins:
P07288-KLK3_HUMAN
ENSP00000314151
for KLK3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for KLK3
SIGNOR curated interactions for KLK3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002778 | antibacterial peptide production | IDA | 18714013 |
| GO:0003073 | regulation of systemic arterial blood pressure | IBA | 21873635 |
| GO:0006508 | proteolysis | IEA,IMP | 15563730 |
| GO:0016525 | negative regulation of angiogenesis | NAS | 10675891 |
| GO:0031638 | zymogen activation | IBA | 21873635 |
Drugs & Compounds for KLK3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cyproterone Acetate | Approved, Investigational | Pharma | Target | Androgen receptor antagonist | 46 | |
| Mifepristone | Approved, Investigational | Pharma | Agonist, Antagonist, Mixed, Target | Progesterone receptor antagonist, Progesterone and glucocorticoid receptor antagonist | 179 | |
| MVA-BN | Pharma | 0 | ||||
| PRX302 | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
Transcripts for KLK3 Gene
mRNA/cDNA for KLK3 Gene
- 5 REFSEQ mRNAs :
- 29 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000326003 1464 bps (ENST00000326003.7)
- ENST00000360617 1664 bps (ENST00000360617.7)
- ENST00000422986 1393 bps (ENST00000422986.6)
- ENST00000593997 1035 bps (ENST00000593997.5)
- ENST00000595151 571 bps (ENST00000595151.5)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for KLK3 - Select products 50% OFF >
- * KLK3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * KLK3 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for KLK3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLK3
- genomics-online: gRNA clones - Search for available PSA-Total gRNA products
- Overview of 150 available PSA-Total gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLK3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLK3
- Browse OriGene Inhibitory RNA Products For KLK3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK3
- genomics-online: shRNA clones - Search for available PSA-Total shRNA products
- Overview of 150 available PSA-Total gene related products
Clone Products
- Applied Biological Materials (abm): Clones for KLK3 - Select products 50% OFF >
- * KLK3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * KLK3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
OriGene ORF clones in human for KLK3
- RC202740
- RC211624
- RC211729
- RC217029
- RG202740
- RG211624
- RG211729
- RG217029
- RC202740L1
- RC202740L1V
- RC202740L2
- RC202740L2V
- RC202740L3
- RC202740L3V
- RC202740L4
- RC202740L4V
- RC211624L3
- RC211624L3V
- RC211624L4
- RC211624L4V
- RC211729L3
- RC211729L3V
- RC211729L4
- RC211729L4V
- RC217029L3
- RC217029L3V
- RC217029L4
- RC217029L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KLK3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLK3
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - |
Relevant External Links for KLK3 Gene
- GeneLoc Exon Structure for
- KLK3
Expression for KLK3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
-
Prostate (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for KLK3 Gene
This gene is overexpressed in Prostate (x52.7).
This gene is overexpressed in Cervix (32.5) and Prostate (27.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KLK3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLK3
SOURCE GeneReport for Unigene cluster for KLK3 Gene:
Hs.171995Evidence on tissue expression from TISSUES for KLK3 Gene
- Blood(4.6)
- Nervous system(4.6)
- Intestine(3.5)
- Lymph node(3)
- Urine(2.8)
- Bone(2.4)
Primer Products
-
OriGene qPCR primer pairs for KLK3
-
OriGene qPCR primer pairs and template standards for KLK3
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLK3 Gene
Orthologs for KLK3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KLK3 31 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Klk1b22 30 |
|
||
| Klk1b16 31 |
|
ManyToMany | |||
| Klk1b9 17 |
|
||||
| dog (Canis familiaris) |
Mammalia | KLK2 31 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | -- 31 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany |
- Species where no ortholog for KLK3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for KLK3 Gene
- ENSEMBL:
- Gene Tree for KLK3 (if available)
- TreeFam:
- Gene Tree for KLK3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KLK3: view image
Paralogs for KLK3 Gene
Paralogs for KLK3 Gene
(59) SIMAP similar genes for KLK3 Gene using alignment to 10 proteins:
- KLK3_HUMAN
- M0QX57_HUMAN
- M0QZF9_HUMAN
- M0R1F0_HUMAN
- M0R1Z7_HUMAN
- M0R294_HUMAN
- Q546G3_HUMAN
- Q8NCW4_HUMAN
- Q8WTQ8_HUMAN
- Q96A30_HUMAN
- APS
- KLK2
- KLK1
- KLK4
- KLK7
- KLK8
- KLK9
- KLK6
- KLK11
- KLK13
- TMPRSS12
- KLK5
- DKFZp586F0824
- TMPRSS6
- PRSS1
- AZU1
- CMA1
- GZMK
- CTRB1
- CELA2B
- DF
- KLK14
- CFD
- PRSS3
- TRY8
- CELA1
- factor IX F9
- GZMM
- CTRB2
- KLK12
- PRSS2
- TMPRSS9
- PRSS55
- PRSS42
- F9 p22
- CELA2A
- PROC
- ELA2B
- PRTN3
- PRSS45
- OVCH1
- GZMA
- TMPRSS11F
- HABP2
- ELANE
- CTSG
- GZMB
- KLKB1
- ELA2A
- PRSS58
- PRSS8
- TMPRSS11E
- DESC1
- F12
- ST14
- TMPRSS15
- TMPRSS11D
- PRSS38
- HPN
Pseudogenes.org Pseudogenes for KLK3 Gene
Variants for KLK3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLK3 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs17632542 | - | p.Ile179Thr | |||
| rs2003783 | - | p.Leu132Ile | |||
| rs2271092 | - | p.Glu32Lys |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2763208 | CNV | gain | 21179565 |
| nsv1140251 | OTHER | inversion | 24896259 |
| nsv2531 | CNV | deletion | 18451855 |
| nsv524465 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.84;
47.96% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KLK3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK3 Gene
Disorders for KLK3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| prostatitis |
|
|
| urethral stricture |
|
|
| prostatic adenoma |
|
|
| prostatic hypertrophy |
|
|
| nodular prostate |
|
Search KLK3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KLK3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for KLK3 Gene
Publications for KLK3 Gene
- Shorter CAG repeats in androgen receptor and non-GG genotypes in prostate-specific antigen loci are associated with decreased risk of benign prostatic hyperplasia and prostate cancer. (PMID: 18495332) Das K … Lau W (Cancer letters 2008) 3 23 41 54
- Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody. (PMID: 18187150) Ménez R … Stura EA (Journal of molecular biology 2008) 3 4 23 54
- Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer. (PMID: 17507624) Cunningham JM … Thibodeau SN (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007) 3 23 41 54
- A G/A polymorphism in the androgen response element 1 of prostate-specific antigen gene correlates with the response to androgen deprivation therapy in Japanese population. (PMID: 17094454) Shibahara T … Sugimura Y (Anticancer research 2006) 3 23 41 54
- Polymorphism in ARE-I region of prostate-specific antigen gene associated with low serum testosterone level and high-grade prostate cancer. (PMID: 15893813) Schatzl G … Gsur A (Urology 2005) 3 23 41 54
ExternalLinks
Products for KLK3 Gene
- View all 15 R&D Systems KLK3 (Kallikrein 3/PSA) Products
- View all R&D Systems KLK3 (Kallikrein 3/PSA) Proteins and Enzymes
- View all 6 R&D Systems KLK3 (Kallikrein 3/PSA) Primary Antibodies
- View all 2 R&D Systems KLK3 (Kallikrein 3/PSA) ELISAs
- View all R&D Systems KLK3 (Kallikrein 3/PSA) Luminex Assays
- View all 5 R&D Systems KLK3 (Kallikrein 3/PSA) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom KLK3 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for KLK3
- 4P33-1H12
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- 4P33-5A6
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- 4P33-PS2
- AM01213PU-N
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- AM09250PU-N
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- AM20265SU-N
- AM20830PU-N
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- AM20832PU-N
- AM32793PU-N
- AM32794PU-N
- AM32795PU-N
- AM32796PU-N
- AM33042PU-N
- AM50013PU-N
- AM50013PU-S
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- AP05510PU-N
- AP06294PU-N
- AP08122PU-N
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- AP13360PU-N
- BM695
- BM798
- CF808292
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- DM1035
- DM1036
- DM1036HRP
- DM1225
- DP033
- DP033-05
- RA19044-100
- SM3072B
- SM3072P
- TA323386
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- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for KLK3
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLK3
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- OriGene qPCR primer pairs for KLK3
- OriGene qPCR primer pairs and template standards for KLK3
- OriGene CRISPR knockouts for KLK3
- OriGene ORF clones in human for KLK3
- RC202740
- RC211624
- RC211729
- RC217029
- RG202740
- RG211624
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- RC202740L1
- RC202740L1V
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- RC202740L2V
- RC202740L3
- RC202740L3V
- RC202740L4
- RC202740L4V
- RC211624L3
- RC211624L3V
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- RC211729L3
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- RC217029L3
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- RC217029L4
- RC217029L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For KLK3
- Sino Biological Human cDNA Clone for KLK3
- Sino Biological Recombinant Proteins for KLK3
- Sino Biological Cell Lysates for KLK3
- Sino Biological Antibodies for KLK3
- Sino Biological Assays for KLK3
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for KLK3
- Novus Biologicals proteins and lysates for KLK3
- Novus Biologicals ELISA Kits for KLK3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for KLK3
- Abcam proteins for KLK3
- Abcam assays for KLK3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- antibodies-online: Show 4 available PSA-Total Antibodies ranked by validation data
- Compare Top PSA-Total Antibodies
- antibodies-online: Show 83 available PSA-Total Elisa Kits ranked by validation data
- Compare Top PSA-Total Elisa Kits
- Quality Products:
- ABIN1116720
- ABIN2685319
- ABIN419849
- ABIN365819
- ABIN491839
- ABIN1380036
- ABIN2708300
- ABIN5067601
- ABIN649037
- ABIN504784
- ABIN1116719
- ABIN1570918
- ABIN366314
- ABIN5525864
- ABIN5670311
- ABIN628123
- ABIN5656155
- ABIN1503353
- ABIN2535757
- ABIN2950743
- ABIN1116718
- ABIN366471
- ABIN1570919
- ABIN5525865
- ABIN5671011
- ABIN627308
- ABIN1503352
- ABIN5656156
- ABIN4970608
- ABIN2535758
- ABIN995041
- ABIN1503358
- antibodies-online: Show 14 available PSA-Total Proteins ranked by validation data
- Compare Top PSA-Total Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for KLK3
- Search Santa Cruz Biotechnology (SCBT) for KLK3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for KLK3
- Custom Antibody ServicesProSci Antibodies for KLK3
- Horizon Cell Lines for KLK3
- genomics-online: cdna clones - Search for available PSA-Total CDNA products
- Overview of 150 available PSA-Total gene related products
- orf clones - Search for available PSA-Total ORF products
- Overview of 150 available PSA-Total gene related products
- genomics-online: gRNA clones - Search for available PSA-Total gRNA products
- Overview of 150 available PSA-Total gene related products
- genomics-online: primer clones - Search for available PSA-Total Primer products
- Overview of 150 available PSA-Total gene related products
- genomics-online: shRNA clones - Search for available PSA-Total shRNA products
- Overview of 150 available PSA-Total gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLK3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLK3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for KLK3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK3
Sources for KLK3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176)