Aliases for KLK3 Gene
Aliases for KLK3 Gene
External Ids for KLK3 Gene
- HGNC: 6364
- Entrez Gene: 354
- Ensembl: ENSG00000142515
- OMIM: 176820
- UniProtKB: P07288
Previous HGNC Symbols for KLK3 Gene
- APS
Previous GeneCards Identifiers for KLK3 Gene
- GC19P051987
- GC19P051719
- GC19P056034
- GC19P056049
- GC19P051358
- GC19P047693
Summaries for KLK3 Gene
-
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for KLK3 Gene
KLK3 (Kallikrein Related Peptidase 3) is a Protein Coding gene. Diseases associated with KLK3 include Prostatitis and Clear Cell Adenocarcinoma. Among its related pathways are Cell adhesion_ECM remodeling and Transcription Androgen Receptor nuclear signaling. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK2.
UniProtKB/Swiss-Prot for KLK3 Gene
-
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
Additional gene information for KLK3 Gene
- Monarch Initiative
- Search for KLK3 at DataMed
- Search for KLK3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK3 Gene
Genomics for KLK3 Gene
GeneHancer (GH) Regulatory Elements for KLK3 Gene
Promoters and enhancers for KLK3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around KLK3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the KLK3 gene promoter:
-
- STAT3
Regulatory Element Products
Genomic Locations for KLK3 Gene
Genomic Locations for KLK3 Gene
- chr19:50,854,915-50,877,702
- (GRCh38/hg38)
- Size:
- 22,788 bases
- Orientation:
- Plus strand
- chr19:51,358,171-51,364,020
- (GRCh37/hg19)
- Size:
- 5,850 bases
- Orientation:
- Plus strand
Genomic View for KLK3 Gene
Genes around KLK3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by Entrez Gene
- 19q13.33 by HGNC
- 19q13.33 by Ensembl
KLK3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KLK3 Gene
Proteins for KLK3 Gene
-
Protein details for KLK3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07288-KLK3_HUMAN
- Recommended name:
- Prostate-specific antigen
- Protein Accession:
- P07288
- C9JXH3
- G3V0H4
- G3XAE3
- Q15096
- Q16272
- Q86TG8
- Q8IXI4
Protein attributes for KLK3 Gene
- Size:
- 261 amino acids
- Molecular mass:
- 28741 Da
- Quaternary structure:
-
- Forms a heterodimer with SERPINA5.
- SequenceCaution:
-
- Sequence=AAD14185.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA32124.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for KLK3 Gene
Protein Expression for KLK3 Gene
Post-translational modifications for KLK3 Gene
Other Protein References for KLK3 Gene
Antibody Products
- R&D Systems Antibodies for KLK3 (Kallikrein 3/PSA)
-
Custom Antibody ServicesOriGene Antibodies for KLK3
- AM01212PU-N
- AM01213PU-N
- AM01215PU-N
- AM05050PU-N
- AM05051PU-N
- AM05052HR-N
- AM05052PU-N
- AM06205SU-N
- AM06775SU-N
- AM09250HR-N
- AM09250PU-N
- AM09251PU-N
- AM20265SU-N
- AM20543PU-N
- AM20830PU-N
- AM20831PU-N
- AM20832PU-N
- AM31369PU-N
- AM32793PU-N
- AM32794PU-N
- AM32795PU-N
- AM32796PU-N
- AM33042PU-N
- AM50013PU-N
- AM50013PU-S
- AM50122PU-N
- AM50122PU-S
- AM50122PU-T
- AP05510PU-N
- AP06294PU-N
- AP08122PU-N
- AP08122PU-S
- AP13360PU-N
- AP22659PU-N
- BM695
- BM696
- BM798
- DM1035
- DM1036
- DM1036HRP
- DM1225
- DP033
- DP033-05
- SM3072B
- SM3072P
- TA323386
- TA323387
- TA326253
- TA327729
- TA336588
- TA336798
- TA347464
- TA354045
- TA808292
- CF808292
- TA808293
- CF808293
- TA808335
- CF808335
- TA808342
- CF808342
- TA808353
- CF808353
- TA808354
- CF808354
- TA808356
- CF808356
- TA808357
- CF808357
- Novus Biologicals Antibodies for KLK3
-
Abcam antibodies for KLK3
- Invitrogen Antibodies for KLK3
- antibodies-online: Search results for 22 available Prostate Specific Antigen Antibodies ranked by validation data
- Compare Top Prostate Specific Antigen Antibodies
-
Quality Products:
- ABIN1869811
- ABIN236108
- ABIN2010651
- ABIN458043
- ABIN2340695
- ABIN5567881
- ABIN5567882
- ABIN5567884
- ABIN5567883
- ABIN2340696
- ABIN1869811
- ABIN236108
- ABIN2010651
- ABIN458043
- ABIN2340695
- ABIN5567881
- ABIN5567882
- ABIN5567884
- ABIN5567883
- ABIN2340696
- ABIN1869811
- ABIN236108
- ABIN2010651
- ABIN458043
- ABIN2340695
- ABIN5567881
- ABIN5567882
- ABIN5567884
- ABIN5567883
- ABIN2340696
- GeneTex KLK3 Antibody for KLK3
-
Custom Antibody ServicesProSci Antibodies for KLK3
-
Santa Cruz Biotechnology (SCBT) Antibodies for KLK3
- Sino Biological Antibodies for KLK3
Protein Products
- R&D Systems Proteins and Enzymes for KLK3 (Kallikrein 3/PSA)
-
OriGene Purified Proteins for KLK3
- Search Origene for MassSpec and Protein Over-expression Lysates for KLK3
- Origene Custom Protein Services for KLK3
- Sino Biological Recombinant Proteins for KLK3
- Sino Biological Cell Lysates for KLK3
- ProSpec Recombinant Proteins for KLK3
- Search GeneTex for Proteins for KLK3
-
Abcam proteins for KLK3
Assay Products
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for KLK3 (Kallikrein 3/PSA)
- Novus Biologicals ELISA Kits for KLK3
-
Abcam assays for KLK3
- Sino Biological Assays for KLK3
No data available for DME Specific Peptides for KLK3 Gene
Domains & Families for KLK3 Gene
Gene Families for KLK3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for KLK3 Gene
Suggested Antigen Peptide Sequences for KLK3 Gene
Graphical View of Domain Structure for InterPro Entry
P07288- Family:
-
- Belongs to the peptidase S1 family. Kallikrein subfamily.
Function for KLK3 Gene
Molecular function for KLK3 Gene
- UniProtKB/Swiss-Prot Function:
- Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Preferential cleavage: -Tyr- -Xaa-.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders.
- GENATLAS Biochemistry:
- kallikrein 3,prostate specific antigen,serine protease,overexpressed in prostate and breast carcinomas
Enzyme Numbers (IUBMB) for KLK3 Gene
Phenotypes From GWAS Catalog for KLK3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004175 | endopeptidase activity | IDA | 18714013 |
| GO:0004252 | serine-type endopeptidase activity | TAS,IEA | -- |
| GO:0005515 | protein binding | IPI | 1725227 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008236 | serine-type peptidase activity | TAS,IEA | 2470553 |
Phenotypes for KLK3 Gene
- GenomeRNAi human phenotypes for KLK3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for KLK3
-
CRISPR Products
-
OriGene CRISPR knockouts for KLK3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLK3
- Applied Biological Materials CRISPR for KLK3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLK3
- GenScript: Design CRISPR guide RNA sequences for KLK3
miRNA for KLK3 Gene
- miRTarBase miRNAs that target KLK3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLK3
- Browse OriGene Inhibitory RNA Products For KLK3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK3
Clone Products
- Sino Biological Human cDNA Clone for KLK3
- VectorBuilder custom plasmid, inducible vectors for KLK3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KLK3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLK3
- genomics-online: cdna clones - Search results for 29 available Prostate Specific Antigen gene related products
- Overview of 29 available Prostate Specific Antigen gene related products
- orf clones - Search results for 29 available Prostate Specific Antigen gene related products
- Overview of 29 available Prostate Specific Antigen gene related products
- Applied Biological Materials Clones for KLK3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KLK3
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLK3 Gene
Localization for KLK3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KLK3 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IDA | 8665956 |
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0030141 | secretory granule | IBA | -- |
| GO:0032991 | protein-containing complex | IDA | 8665956 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLK3 Gene
Pathways & Interactions for KLK3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Collagen chain trimerization | ||
| 2 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 3 | Signaling by Rho GTPases | ||
| 4 | Pathways in cancer | ||
| 5 | Endometrial cancer |
.32
|
|
Pathways by source for KLK3 Gene
4 BioSystems pathways for KLK3 Gene
7 Reactome pathways for KLK3 Gene
2 KEGG pathways for KLK3 Gene
2 GeneGo (Thomson Reuters) pathways for KLK3 Gene
4 Qiagen pathways for KLK3 Gene
1 Cell Signaling Technology pathway for KLK3 Gene
Interacting Proteins for KLK3 Gene
Selected Interacting proteins:
P07288-KLK3_HUMAN
ENSP00000314151
for KLK3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for KLK3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002526 | acute inflammatory response | IBA | -- |
| GO:0002778 | antibacterial peptide production | IDA | 18714013 |
| GO:0003073 | regulation of systemic arterial blood pressure | IBA | -- |
| GO:0006508 | proteolysis | IMP,IEA | 15563730 |
| GO:0016525 | negative regulation of angiogenesis | NAS | 10675891 |
No data available for SIGNOR curated interactions for KLK3 Gene
Drugs & Compounds for KLK3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cyproterone Acetate | Approved, Investigational | Pharma | Target | Androgen receptor antagonist | 45 | |
| Mifepristone | Approved, Investigational | Pharma | Agonist, Antagonist, Mixed, Target | Progesterone receptor antagonist, Progesterone and glucocorticoid receptor antagonist | 167 | |
| MVA-BN | Pharma | 0 | ||||
| PRX302 | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for KLK3 Gene
mRNA/cDNA for KLK3 Gene
- (5) REFSEQ mRNAs :
- (24) Additional mRNA sequences :
- (1035) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000601503 559 bps (uc061btf.1)
- ENST00000596185 1130 bps (uc061btg.1)
- ENST00000326003 1463 bps (uc021uyi.2)
- ENST00000422986 1393 bps (uc010eof.4)
- ENST00000601349 2702 bps (uc061bth.1)
Unigene Clusters for KLK3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for KLK3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLK3
- Applied Biological Materials CRISPR for KLK3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLK3
- GenScript: Design CRISPR guide RNA sequences for KLK3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLK3
- Browse OriGene Inhibitory RNA Products For KLK3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK3
Clone Products
- Sino Biological Human cDNA Clone for KLK3
- VectorBuilder custom plasmid, inducible vectors for KLK3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KLK3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLK3
- genomics-online: cdna clones - Search results for 29 available Prostate Specific Antigen gene related products
- Overview of 29 available Prostate Specific Antigen gene related products
- orf clones - Search results for 29 available Prostate Specific Antigen gene related products
- Overview of 29 available Prostate Specific Antigen gene related products
- Applied Biological Materials Clones for KLK3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - |
Expression for KLK3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
-
Prostate (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for KLK3 Gene
This gene is overexpressed in Prostate (x52.7).
This gene is overexpressed in Cervix (32.5) and Prostate (27.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KLK3 Gene
NURSA nuclear receptor signaling pathways regulating expression of KLK3 Gene:
KLK3SOURCE GeneReport for Unigene cluster for KLK3 Gene:
Hs.171995Evidence on tissue expression from TISSUES for KLK3 Gene
- Blood(4.6)
- Nervous system(4.6)
- Intestine(3.5)
- Lymph node(3)
- Urine(2.8)
- Bone(2.4)
Primer Products
-
OriGene qPCR primer pairs and template standards for KLK3
-
OriGene qPCR primer pairs for KLK3
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLK3 Gene
Orthologs for KLK3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KLK3 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Klk1b22 33 |
|
||
| Klk1b16 34 |
|
ManyToMany | |||
| Klk1b9 16 |
|
||||
| dog (Canis familiaris) |
Mammalia | KLK2 34 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | -- 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany |
- Species where no ortholog for KLK3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for KLK3 Gene
- ENSEMBL:
- Gene Tree for KLK3 (if available)
- TreeFam:
- Gene Tree for KLK3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KLK3: view image
Paralogs for KLK3 Gene
(59) SIMAP similar genes for KLK3 Gene using alignment to 10 proteins:
- KLK3_HUMAN
- M0QX57_HUMAN
- M0QZF9_HUMAN
- M0R1F0_HUMAN
- M0R1Z7_HUMAN
- M0R294_HUMAN
- Q546G3_HUMAN
- Q8NCW4_HUMAN
- Q8WTQ8_HUMAN
- Q96A30_HUMAN
- APS
- KLK2
- KLK1
- KLK4
- KLK7
- KLK8
- KLK9
- KLK6
- KLK11
- KLK13
- TMPRSS12
- KLK5
- DKFZp586F0824
- TMPRSS6
- PRSS1
- AZU1
- CMA1
- GZMK
- CTRB1
- CELA2B
- DF
- KLK14
- CFD
- PRSS3
- TRY8
- CELA1
- factor IX F9
- GZMM
- CTRB2
- KLK12
- PRSS2
- TMPRSS9
- PRSS55
- PRSS42
- F9 p22
- CELA2A
- PROC
- ELA2B
- PRTN3
- PRSS45
- OVCH1
- GZMA
- TMPRSS11F
- HABP2
- ELANE
- CTSG
- GZMB
- KLKB1
- ELA2A
- PRSS58
- PRSS8
- TMPRSS11E
- DESC1
- F12
- ST14
- TMPRSS15
- TMPRSS11D
- PRSS38
- HPN
Pseudogenes.org Pseudogenes for KLK3 Gene
Variants for KLK3 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000017069 | -- | 50,854,071(+) | G/T | upstream_transcript_variant | |
| rs1000202085 | -- | 50,858,994(+) | C/T | intron_variant | |
| rs1000494085 | -- | 50,859,151(+) | G/A/T | intron_variant | |
| rs1000880200 | -- | 50,857,574(+) | G/A | intron_variant | |
| rs1001023093 | -- | 50,855,159(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2763208 | CNV | gain | 21179565 |
| nsv1140251 | OTHER | inversion | 24896259 |
| nsv2531 | CNV | deletion | 18451855 |
| nsv524465 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.84;
47.96% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KLK3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK3 Gene
Disorders for KLK3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| prostatitis |
|
|
| clear cell adenocarcinoma |
|
|
| urethral stricture |
|
|
| prostatic hypertrophy |
|
|
| nodular prostate |
|
Search KLK3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KLK3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for KLK3 Gene
Publications for KLK3 Gene
- Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody. (PMID: 18187150) Ménez R … Stura EA (Journal of molecular biology 2008) 3 4 22 58
- Shorter CAG repeats in androgen receptor and non-GG genotypes in prostate-specific antigen loci are associated with decreased risk of benign prostatic hyperplasia and prostate cancer. (PMID: 18495332) Das K … Lau W (Cancer letters 2008) 3 22 44 58
- Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer. (PMID: 17507624) Cunningham JM … Thibodeau SN (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007) 3 22 44 58
- A G/A polymorphism in the androgen response element 1 of prostate-specific antigen gene correlates with the response to androgen deprivation therapy in Japanese population. (PMID: 17094454) Shibahara T … Sugimura Y (Anticancer research 2006) 3 22 44 58
- Polymorphism in ARE-I region of prostate-specific antigen gene associated with low serum testosterone level and high-grade prostate cancer. (PMID: 15893813) Schatzl G … Gsur A (Urology 2005) 3 22 44 58
Products for KLK3 Gene
- R&D Systems Antibodies for KLK3 (Kallikrein 3/PSA)
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- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for KLK3 (Kallikrein 3/PSA)
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- Custom Antibody ServicesOriGene Antibodies for KLK3
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- ProSpec Recombinant Proteins for KLK3
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- VectorBuilder custom plasmid, inducible vectors for KLK3
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- antibodies-online: Search results for 22 available Prostate Specific Antigen Antibodies ranked by validation data
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- antibodies-online: Search results for 6 available Prostate Specific Antigen Elisa Kits ranked by validation data
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- antibodies-online: Search results for 19 available Prostate Specific Antigen Proteins ranked by validation data
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- GeneTex KLK3 Antibody for KLK3
- Search GeneTex for Proteins for KLK3
- Santa Cruz Biotechnology (SCBT) Antibodies for KLK3
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- genomics-online: cdna clones - Search results for 29 available Prostate Specific Antigen gene related products
- Overview of 29 available Prostate Specific Antigen gene related products
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLK3
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Sources for KLK3 Gene
- (1) GeneCards
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- (68) Cloud-Clone Corp.
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