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This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is p... See more...
Aliases for KLK2 Gene
Aliases for KLK2 Gene
External Ids for KLK2 Gene
- HGNC: 6363
- NCBI Entrez Gene: 3817
- Ensembl: ENSG00000167751
- OMIM®: 147960
- UniProtKB/Swiss-Prot: P20151
Previous GeneCards Identifiers for KLK2 Gene
- GC19P052005
- GC19P051737
- GC19P056052
- GC19P056068
- GC19P051376
- GC19P047711
- GC19P051369
Summaries for KLK2 Gene
-
This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]
GeneCards Summary for KLK2 Gene
KLK2 (Kallikrein Related Peptidase 2) is a Protein Coding gene. Diseases associated with KLK2 include Prostate Cancer and Prostate Disease. Among its related pathways are Signaling by GPCR and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLK3.
UniProtKB/Swiss-Prot Summary for KLK2 Gene
-
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Additional gene information for KLK2 Gene
- HGNC (6363)
- NCBI Entrez Gene (3817)
- Ensembl (ENSG00000167751)
- OMIM® (147960)
- UniProtKB/Swiss-Prot (P20151)
- Open Targets Platform(ENSG00000167751)
- Monarch Initiative
- Search for KLK2 at DataMed
- Search for KLK2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLK2 Gene
Genomics for KLK2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for KLK2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH19J050873 | Promoter/Enhancer | 0.7 | EPDnew dbSUPER | 250.4 | +11.9 | 11852 | 0.1 | EGR2 ZFHX2 | HSALNG0127146 lnc-KLK15-2 KLK2 KLK4 | |
| GH19J050875 | Promoter/Enhancer | 0.5 | EPDnew dbSUPER | 261.7 | +11.7 | 11712 | 0.1 | KLK2 HSALNG0127146 lnc-KLK15-2 KLK4 | ||
| GH19J050861 | Enhancer | 0.3 | dbSUPER | 258.6 | +0.7 | 665 | 2 | ZNF316 | KLK2 lnc-KLK3-2 KLK15 KLK1 LINC01869 KLK4 SNORD88C C19orf48 SNORD88A SNORD88B | |
| GH19J050835 | Promoter/Enhancer | 2 | FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 11.3 | -25.5 | -25467 | 1.4 | TBP ZBTB10 FEZF1 MNT IKZF1 SMAD5 MBD2 POLR2A BHLHE40 THAP11 | KLK15 ZNF175 NUP62 PTOV1-AS2 LINC01869 C19orf48 SNORD88C KLK2 SNORD88A SNORD88B | |
| GH19J050896 | Enhancer | 1.2 | Ensembl ENCODE | 11.6 | +35.5 | 35533 | 2.2 | TBP ZBTB10 SP1 BCL11A MNT POLR2A BHLHE40 ZEB1 REST ZNF639 | KLKP1 lnc-KLK2-3 lnc-KLK4-1 ZNF175 ZNF577 NUP62 KLK2 LINC01869 KLK15 KLK1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around KLK2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLK2
- Top Transcription factor binding sites by QIAGEN in the KLK2 gene promoter:
-
- NF-kappaB
- NF-kappaB1
Genomic Locations for KLK2 Gene
Latest Assembly
- chr19:50,861,568-50,880,567
- (GRCh38/hg38)
- Size:
- 19,000 bases
- Orientation:
- Plus strand
Previous Assembly
- chr19:51,376,695-51,383,823
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 7,129 bases
- Orientation:
- Plus strand
- chr19:51,364,824-51,383,823
- (GRCh37/hg19 by Ensembl)
- Size:
- 19,000 bases
- Orientation:
- Plus strand
Genomic View for KLK2 Gene
Genes around KLK2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
KLK2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KLK2 Gene
Proteins for KLK2 Gene
-
Protein details for KLK2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P20151-KLK2_HUMAN
- Recommended name:
- Kallikrein-2
- Protein Accession:
- P20151
- B4DU93
- B4DUB0
- F5H8L3
- Q15946
- Q9UJZ9
Protein attributes for KLK2 Gene
- Size:
- 261 amino acids
- Molecular mass:
- 28671 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAD13817.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Protein Expression for KLK2 Gene
Selected DME Specific Peptides for KLK2 Gene
- P20151:
-
- GVLQGIT
- VLTAAHC
- GDSGGPL
- PWQVAVY
- CGGVLVH
- GGWECEKHS
- SQPWQVA
- SGGPLVC
- DLMLLRLSEPA
- WVLTAAH
Post-translational modifications for KLK2 Gene
Other Protein References for KLK2 Gene
Antibodies for research
- G Biosciences Immunotag™ KLK2 Antibody
- NSJ Bioreagents Kallikrein-2 Antibody
- Novus Biologicals Antibodies for KLK2
-
Abcam antibodies for KLK2
- Invitrogen Antibodies for KLK2 (AFLGC-KLK2)
-
Custom Antibody ServicesProSci Antibodies for KLK2
Protein products for research
- G Biosciences Human Kallikrein 2/KLK2, Liquid
-
OriGene Purified Proteins for KLK2
- Search Origene for MassSpec and Protein Over-expression Lysates for KLK2
- Origene Custom Protein Services for KLK2
- ProSpec Recombinant Proteins for KLK2
-
Abcam proteins for KLK2
Assay products for research
- G Biosciences Immunotag™ Human KLK2 (Kallikrein-2) ELISA and Immunotag™ Kallikrein-2 ELISA Kit
Domains & Families for KLK2 Gene
Gene Families for KLK2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for KLK2 Gene
- InterPro:
- Blocks:
-
- Serine protease, trypsin family
- Chymotrypsin serine protease family (S1) signature
- ProtoNet:
Suggested Antigen Peptide Sequences for KLK2 Gene
- GenScript: Design optimal peptide antigens:
-
- Tissue kallikrein-2 (KLK2_HUMAN)
- Kallikrein 2 isoform 6 preproprotein (Q6T774_HUMAN)
- Kallikrein 2 isoform 5 preproprotein (Q6T775_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P20151- Family:
-
- Belongs to the peptidase S1 family. Kallikrein subfamily.
Function for KLK2 Gene
Molecular function for KLK2 Gene
- UniProtKB/Swiss-Prot Function:
- Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.; EC=3.4.21.35;.
- GENATLAS Biochemistry:
- kallikrein 2,glandular,expressed in the prostate,complexing with protease inhibitor 6 in prostate cancer tissue
Enzyme Numbers (IUBMB) for KLK2 Gene
Phenotypes From GWAS Catalog for KLK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004252 | serine-type endopeptidase activity | IDA | 9042371 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008236 | serine-type peptidase activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for KLK2 Gene
- GenomeRNAi human phenotypes for KLK2:
-
- no effect
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased vaccinia virus (VACV) infection
- Reduced mammosphere formation
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Strongly decreased CFP-tsO45G cell surface transport
- Increased NF-kappaB reporter expression
- Increased IL-8 secretion
- Increased S DNA content
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Increased centriole number
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for KLK2 - Starting at $85 >
- * KLK2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for KLK2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLK2
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLK2
miRNA for KLK2 Gene
- miRTarBase miRNAs that target KLK2
-
- hsa-miR-6805-3p (MIRT610785)
- hsa-miR-5691 (MIRT610786)
- hsa-miR-143-5p (MIRT610787)
- hsa-miR-3944-5p (MIRT610788)
- hsa-miR-3650 (MIRT610789)
- hsa-miR-3194-3p (MIRT610790)
- hsa-miR-378g (MIRT610791)
- hsa-miR-6860 (MIRT610792)
- hsa-miR-4486 (MIRT610793)
- hsa-miR-5189-5p (MIRT610794)
- hsa-miR-612 (MIRT610795)
- hsa-miR-3187-5p (MIRT610796)
- hsa-miR-1285-3p (MIRT610797)
- hsa-miR-330-5p (MIRT610798)
- hsa-miR-326 (MIRT610799)
- hsa-miR-1976 (MIRT610800)
- hsa-miR-6893-3p (MIRT610801)
- hsa-miR-370-3p (MIRT610802)
- hsa-miR-660-3p (MIRT610803)
- hsa-miR-5193 (MIRT610804)
- hsa-miR-6738-3p (MIRT646532)
- hsa-miR-544a (MIRT646533)
- hsa-miR-1178-3p (MIRT646534)
- hsa-miR-6828-3p (MIRT646535)
- hsa-miR-6071 (MIRT646536)
- hsa-miR-6749-3p (MIRT646537)
- hsa-miR-4266 (MIRT646538)
- hsa-miR-6894-5p (MIRT646539)
- hsa-miR-767-3p (MIRT646540)
- hsa-miR-1248 (MIRT646541)
- hsa-miR-5088-3p (MIRT646542)
- hsa-miR-6756-3p (MIRT646543)
- hsa-miR-3127-3p (MIRT646544)
- hsa-miR-4661-3p (MIRT646545)
- hsa-miR-4779 (MIRT646547)
- hsa-miR-4474-3p (MIRT722819)
- hsa-miR-7108-5p (MIRT722820)
- hsa-miR-4276 (MIRT722821)
- hsa-miR-766-3p (MIRT722822)
- hsa-miR-4267 (MIRT722823)
- hsa-miR-5190 (MIRT722824)
- hsa-miR-8079 (MIRT722825)
- hsa-miR-1245a (MIRT722826)
- hsa-miR-590-5p (MIRT722827)
- hsa-miR-21-5p (MIRT722828)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLK2
- Browse OriGene Inhibitory RNA Products For KLK2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK2
Clone products for research
- Applied Biological Materials (abm): Clones for KLK2 - Starting at $45 >
- * KLK2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
OriGene ORF clones in human for KLK2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KLK2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLK2
Cell Lines for research
-
Horizon Cell Lines for KLK2
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLK2 Gene
Localization for KLK2 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0030141 | secretory granule | IBA | 21873635 |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KLK2 Gene
Pathways & Interactions for KLK2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Collagen chain trimerization |
Intrinsic Prothrombin Activation Pathway
.48
|
Blood Coagulation Cascade
.46
|
| 2 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 3 | Degradation of the extracellular matrix | ||
| 4 | Signaling by Rho GTPases | ||
| 5 | Endocrine and other factor-regulated calcium reabsorption | ||
Pathways by source for KLK2 Gene
2 BioSystems pathways for KLK2 Gene
10 Reactome pathways for KLK2 Gene
2 KEGG pathways for KLK2 Gene
1 GeneGo (Thomson Reuters) pathway for KLK2 Gene
- Cell adhesion_ECM remodeling
3 Qiagen pathways for KLK2 Gene
- Blood Coagulation Cascade
- Intrinsic Prothrombin Activation Pathway
- MSP-RON Signaling
Interacting Proteins for KLK2 Gene
GPS-Prot Interaction Network for KLK2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003073 | regulation of systemic arterial blood pressure | IBA | 21873635 |
| GO:0006508 | proteolysis | IEA | -- |
| GO:0022617 | extracellular matrix disassembly | TAS | -- |
| GO:0031638 | zymogen activation | IBA | 21873635 |
Drugs & Compounds for KLK2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug products for research
- G Biosciences Human Kallikrein 2/KLK2, Liquid
Transcripts for KLK2 Gene
mRNA/cDNA for KLK2 Gene
- 4 REFSEQ mRNAs :
- 30 NCBI additional mRNA sequence :
- 23 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000325321 2829 nts (view in UCSC)
- ENST00000358049 2847 nts (view in UCSC)
- ENST00000391810 2674 nts (view in UCSC)
- ENST00000593493 512 nts (view in UCSC)
- ENST00000594174 1002 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for KLK2 - Starting at $85 >
- * KLK2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for KLK2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLK2
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLK2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLK2
- Browse OriGene Inhibitory RNA Products For KLK2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK2
Clone products for research
- Applied Biological Materials (abm): Clones for KLK2 - Starting at $45 >
- * KLK2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
OriGene ORF clones in human for KLK2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KLK2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLK2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: |
| ExUns: | 11b | · | 11c | · | 11d |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | |||||
| SP6: | |||||
| SP7: | |||||
| SP8: | |||||
| SP9: | |||||
| SP10: | |||||
| SP11: | |||||
| SP12: | |||||
| SP13: | |||||
| SP14: | |||||
| SP15: | |||||
| SP16: | |||||
| SP17: |
Relevant External Links for KLK2 Gene
- GeneLoc Exon Structure for
- KLK2
Expression for KLK2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Prostate (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for KLK2 Gene
This gene is overexpressed in Prostate (x52.3).
This gene is overexpressed in Prostate (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KLK2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLK2
SOURCE GeneReport for Unigene cluster for KLK2 Gene:
Hs.515560Evidence on tissue expression from TISSUES for KLK2 Gene
- Nervous system(2.4)
Primer products for research
-
OriGene qPCR primer pairs for KLK2
-
OriGene qPCR primer pairs and template standards for KLK2
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLK2 Gene
Orthologs for KLK2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | KLK2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | KLK1 31 |
|
OneToMany | |
| Dog (Canis familiaris) |
Mammalia | KLK2 31 |
|
OneToMany | |
| Mouse (Mus musculus) |
Mammalia | Klk1b3 31 |
|
ManyToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG17239 32 |
|
|
- Species where no ortholog for KLK2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for KLK2 Gene
- ENSEMBL:
- Gene Tree for KLK2 (if available)
- TreeFam:
- Gene Tree for KLK2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KLK2: view image
Paralogs for KLK2 Gene
Paralogs for KLK2 Gene
(76) SIMAP similar genes for KLK2 Gene using alignment to 8 proteins:
- KLK2_HUMAN
- M0QXQ7_HUMAN
- M0R0M2_HUMAN
- M0R0M4_HUMAN
- M0R1T3_HUMAN
- M0R2W5_HUMAN
- Q6T774_HUMAN
- Q6T775_HUMAN
- APS
- KLK1
- KLK3
- KLK6
- KLK8
- C1S
- KLK7
- KLK11
- KLK9
- PRSS1
- PRSS45
- CFD
- KLK5
- KLK4
- factor IX F9
- F9 p22
- KLK13
- TRY8
- KLK14
- PRSS33
- CTRB1
- GZMK
- CTRB2
- PRSS3
- PRSS2
- PRSS8
- PRSS55
- C1R
- CMA1
- KLK15
- GZMB
- TMPRSS11F
- PRSS44
- PROC
- KLKB1
- DF
- CELA1
- AZU1
- ACR
- TMPRSS13
- TMPRSS11D
- KLK10
- F2
- CELA2B
- CTRL
- tryptaseC
- TMPRSS6
- PRSS58
- F9
- CELA2A
- CTSG
- TPSB2
- TPSAB1
- PRSS21
- ELA2A
- KLK12
- PRSS27
- TMPRSS9
- PRSS42
- PRSS12
- OVCH1
- F11
- ELA2B
- CELA3B
- GZMH
- GZMA
- TMPRSS5
- TMPRSS3
- GZMM
- PRSS22
- TMPRSS11B
- PRSS38
- PLAU
- HGFAC
- CTRC
- CELA3A
Variants for KLK2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLK2 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs198977 | - |
p.Arg250Trp |
|||
| rs60268688 | - |
p.Asp255Ala |
|||
| rs6072 | - |
p.Val18Leu |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1059e212 | CNV | loss | 25503493 |
| esv1010987 | CNV | loss | 20482838 |
| esv2763208 | CNV | gain | 21179565 |
| esv3644659 | CNV | gain | 21293372 |
| nsv1140251 | OTHER | inversion | 24896259 |
| nsv2531 | CNV | deletion | 18451855 |
Residual Variation Intolerance Score:
72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.41;
54.43% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KLK2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KLK2
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK2 Gene
Disorders for KLK2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| prostate cancer |
|
|
| prostate disease |
|
|
Search KLK2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KLK2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for KLK2 Gene
Publications for KLK2 Gene
- Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PMID: 20424135) Klein RJ … Lilja H (Cancer prevention research (Philadelphia, Pa.) 2010) 3 23 41
- Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women. (PMID: 19372141) Lee JY … Kang D (Carcinogenesis 2009) 3 23 41
- Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin. (PMID: 17593395) Pal P … Deka R (Human genetics 2007) 3 23 41
- Variants of the hK2 protein gene (KLK2) are associated with serum hK2 levels and predict the presence of prostate cancer at biopsy. (PMID: 17085659) Nam RK … Narod SA (Clinical cancer research : an official journal of the American Association for Cancer Research 2006) 3 23 41
- Single nucleotide polymorphism of the human kallikrein-2 gene highly correlates with serum human kallikrein-2 levels and in combination enhances prostate cancer detection. (PMID: 12805332) Nam RK … Narod SA (Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003) 3 23 41
ExternalLinks
Products for KLK2 Gene
- Custom Antibody Services
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- OriGene qPCR primer pairs and template standards for KLK2
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- VectorBuilder Custom and pre-made DNA vectors for KLK2 (ie. gene expression, shRNA knockdown, CRISPR)
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- VectorBuilder Virus packaging for KLK2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for KLK2
- antibodies-online: Show 26 available Kallikrein 2 Antibodies ranked by validation data
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- antibodies-online: Show 12 available Kallikrein 2 Proteins ranked by validation data
- Compare Top Kallikrein 2 Proteins
- Horizon Cell Lines for KLK2
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLK2
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for KLK2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK2
Sources for KLK2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
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- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB