Aliases for KLK2 Gene
External Ids for KLK2 Gene
Previous GeneCards Identifiers for KLK2 Gene
This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]
GeneCards Summary for KLK2 Gene
KLK2 (Kallikrein Related Peptidase 2) is a Protein Coding gene. Diseases associated with KLK2 include Prostate Cancer and Male Reproductive Organ Cancer. Among its related pathways are Matrix Metalloproteinases and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLK3.
UniProtKB/Swiss-Prot for KLK2 Gene
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.