Aliases for KLK15 Gene
External Ids for KLK15 Gene
Previous GeneCards Identifiers for KLK15 Gene
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for KLK15 Gene
KLK15 (Kallikrein Related Peptidase 15) is a Protein Coding gene. Diseases associated with KLK15 include Prostate Cancer and Deafness, Autosomal Recessive 100. Among its related pathways are Collagen chain trimerization and PPAR Alpha Pathway. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is ENSG00000269741.
UniProtKB/Swiss-Prot Summary for KLK15 Gene
Protease whose physiological substrate is not yet known.