Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increase... See more...

Aliases for KLK15 Gene

Aliases for KLK15 Gene

  • Kallikrein Related Peptidase 15 2 3 5
  • Kallikrein-15 3 4
  • ACO Protease 3 4
  • Prostinogen 2 3
  • HSRNASPH 2 3
  • ACO 2 3
  • Kallikrein-Like Serine Protease 3
  • Kallikrein 15 2
  • EC 3.4.21.4 51
  • EC 3.4.21.- 4
  • EC 3.4.21 51
  • KLK15 5

External Ids for KLK15 Gene

Previous GeneCards Identifiers for KLK15 Gene

  • GC19M051957
  • GC19M051689
  • GC19M056004
  • GC19M056020
  • GC19M051328
  • GC19M047663

Summaries for KLK15 Gene

Entrez Gene Summary for KLK15 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLK15 Gene

KLK15 (Kallikrein Related Peptidase 15) is a Protein Coding gene. Diseases associated with KLK15 include Prostate Cancer and Deafness, Autosomal Recessive 100. Among its related pathways are Collagen chain trimerization and PPAR Alpha Pathway. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is ENSG00000269741.

UniProtKB/Swiss-Prot Summary for KLK15 Gene

Gene Wiki entry for KLK15 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLK15 Gene

Genomics for KLK15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KLK15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLK15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLK15

Top Transcription factor binding sites by QIAGEN in the KLK15 gene promoter:
  • STAT3

Genomic Locations for KLK15 Gene

Latest Assembly
chr19:50,825,289-50,837,213
(GRCh38/hg38)
Size:
11,925 bases
Orientation:
Minus strand

Previous Assembly
chr19:51,328,545-51,334,779
(GRCh37/hg19 by Entrez Gene)
Size:
6,235 bases
Orientation:
Minus strand

chr19:51,328,545-51,340,469
(GRCh37/hg19 by Ensembl)
Size:
11,925 bases
Orientation:
Minus strand

Genomic View for KLK15 Gene

Genes around KLK15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK15 Gene

Proteins for KLK15 Gene

  • Protein details for KLK15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2R5-KLK15_HUMAN
    Recommended name:
    Kallikrein-15
    Protein Accession:
    Q9H2R5
    Secondary Accessions:
    • A0AUY8
    • Q15358
    • Q6ISI0
    • Q9H2R3
    • Q9H2R4
    • Q9H2R6
    • Q9HBG9

    Protein attributes for KLK15 Gene

    Size:
    256 amino acids
    Molecular mass:
    28087 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for KLK15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLK15 Gene

Selected DME Specific Peptides for KLK15 Gene

Q9H2R5:
  • LQGIVSWG
  • GDSGGPL
  • WVLSAAHC
  • SQPWQVA
  • SGGPLVC
  • PGVYTKV
  • VRLGEHN
  • QGIVSWG

Post-translational modifications for KLK15 Gene

  • Glycosylation at Asn232 and Asn171
  • Modification sites at PhosphoSitePlus

Domains & Families for KLK15 Gene

Gene Families for KLK15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for KLK15 Gene

InterPro:
Blocks:
  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature
ProtoNet:

Suggested Antigen Peptide Sequences for KLK15 Gene

GenScript: Design optimal peptide antigens:
  • ACO protease (KLK15_HUMAN)
  • Kallikrein-related peptidase 15 (Q6ISI0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H2R5

UniProtKB/Swiss-Prot:

KLK15_HUMAN :
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK15: view

Function for KLK15 Gene

Molecular function for KLK15 Gene

UniProtKB/Swiss-Prot Function:
Protease whose physiological substrate is not yet known.

Enzyme Numbers (IUBMB) for KLK15 Gene

Phenotypes From GWAS Catalog for KLK15 Gene

Gene Ontology (GO) - Molecular Function for KLK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA,NAS 11010966
GO:0005515 protein binding IPI 25416956
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA,TAS 8018728
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with KLK15: view
genes like me logo Genes that share phenotypes with KLK15: view

Animal Models for research

  • Taconic Biosciences Mouse Models for KLK15

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK15

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KLK15 Gene

Localization for KLK15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK15 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLK15 gene
Compartment Confidence
extracellular 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
cytosol 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KLK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0030141 secretory granule IBA 21873635
genes like me logo Genes that share ontologies with KLK15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLK15 Gene

Pathways & Interactions for KLK15 Gene

PathCards logo

SuperPathways for KLK15 Gene

SuperPathway Contained pathways
1 Collagen chain trimerization
.48
.46
2 MSP-RON Signaling
-
3 PPAR Alpha Pathway
genes like me logo Genes that share pathways with KLK15: view

Pathways by source for KLK15 Gene

1 BioSystems pathway for KLK15 Gene
3 Qiagen pathways for KLK15 Gene
  • Blood Coagulation Cascade
  • Intrinsic Prothrombin Activation Pathway
  • MSP-RON Signaling

Gene Ontology (GO) - Biological Process for KLK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with KLK15: view

No data available for SIGNOR curated interactions for KLK15 Gene

Drugs & Compounds for KLK15 Gene

(3) Drugs for KLK15 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KLK15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLK15: view

Transcripts for KLK15 Gene

mRNA/cDNA for KLK15 Gene

6 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK15

Alternative Splicing Database (ASD) splice patterns (SP) for KLK15 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1:
SP2:
SP3:
SP4: - -

Relevant External Links for KLK15 Gene

GeneLoc Exon Structure for
KLK15

Expression for KLK15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLK15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLK15 Gene

This gene is overexpressed in Testis (x17.7), Colon - Transverse (x13.9), Prostate (x5.6), and Adrenal Gland (x4.6).

Protein differential expression in normal tissues from HIPED for KLK15 Gene

This gene is overexpressed in Monocytes (49.8) and Rectum (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLK15 Gene



Protein tissue co-expression partners for KLK15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLK15

SOURCE GeneReport for Unigene cluster for KLK15 Gene:

Hs.567535

mRNA Expression by UniProt/SwissProt for KLK15 Gene:

Q9H2R5-KLK15_HUMAN
Tissue specificity: Highest expression in the thyroid gland. Also expressed in the prostate, salivary, and adrenal glands and in the colon testis and kidney.

Evidence on tissue expression from TISSUES for KLK15 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with KLK15: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KLK15 Gene

Orthologs for KLK15 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLK15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KLK15 30 31
  • 99.48 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KLK15 30
  • 83.46 (n)
Cow
(Bos Taurus)
Mammalia KLK15 30 31
  • 81.77 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC102553035 30
  • 80.38 (n)
Mouse
(Mus musculus)
Mammalia Klk15 30 17 31
  • 79.61 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia KLK15 31
  • 66 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia KLK15 31
  • 65 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG17239 32
  • 33 (a)
Species where no ortholog for KLK15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for KLK15 Gene

ENSEMBL:
Gene Tree for KLK15 (if available)
TreeFam:
Gene Tree for KLK15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLK15: view image

Paralogs for KLK15 Gene

(63) SIMAP similar genes for KLK15 Gene using alignment to 7 proteins:

  • KLK15_HUMAN
  • M0QX22_HUMAN
  • M0R0D7_HUMAN
  • M0R2F7_HUMAN
  • Q6ISI0_HUMAN
  • Q6UBM2_HUMAN
  • S5TEP0_HUMAN
genes like me logo Genes that share paralogs with KLK15: view

Variants for KLK15 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLK15 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
VAR_036298 A breast cancer sample p.Ala137Thr
rs3212805 - p.Pro134Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KLK15 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KLK15 Gene

Variant ID Type Subtype PubMed ID
dgv1058e212 CNV loss 25503493
dgv1802n106 CNV deletion 24896259
dgv203n21 CNV loss 19592680
dgv204n21 CNV loss 19592680
esv2422090 CNV deletion 20811451
esv2662649 CNV deletion 23128226
esv2763099 CNV loss 21179565
esv3556538 CNV deletion 23714750
esv3583463 CNV loss 25503493
esv3583464 CNV loss 25503493
esv3644656 CNV loss 21293372
esv3644657 CNV gain 21293372
nsv1140251 OTHER inversion 24896259
nsv2531 CNV deletion 18451855
nsv515608 CNV loss 19592680

Variation tolerance for KLK15 Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLK15 Gene

Human Gene Mutation Database (HGMD)
KLK15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLK15

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK15 Gene

Disorders for KLK15 Gene

MalaCards: The human disease database

(4) MalaCards diseases for KLK15 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, somatic
deafness, autosomal recessive 100
  • dfnb100
peripheral vascular disease
  • arterial occlusive disease
deafness, autosomal recessive 71
  • dfnb71
- elite association - COSMIC cancer census association via MalaCards
Search KLK15 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KLK15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with KLK15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLK15 Gene

Publications for KLK15 Gene

  1. Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer. (PMID: 11010966) Yousef GM … Diamandis EP (The Journal of biological chemistry 2001) 2 3 4 23
  2. The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer. (PMID: 12439720) Yousef GM … Diamandis EP (British journal of cancer 2002) 2 3 23
  3. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PMID: 20424135) Klein RJ … Lilja H (Cancer prevention research (Philadelphia, Pa.) 2010) 3 41
  4. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 41
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41

Products for KLK15 Gene

Sources for KLK15 Gene