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Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
KLK15 (Kallikrein Related Peptidase 15) is a Protein Coding gene. Diseases associated with KLK15 include Prostate Cancer and Deafness, Autosomal Recessive 100. Among its related pathways are Collagen chain trimerization and PPAR Alpha Pathway. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is ENSG00000269741.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004252 | serine-type endopeptidase activity | IEA,NAS | 11010966 |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008236 | serine-type peptidase activity | IEA,TAS | 8018728 |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0030141 | secretory granule | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Collagen chain trimerization |
Intrinsic Prothrombin Activation Pathway
.48
|
Blood Coagulation Cascade
.46
|
2 | MSP-RON Signaling |
MSP-RON Signaling
-
|
|
3 | PPAR Alpha Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IEA | -- |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||
SP2: | |||||||||||||||||
SP3: | |||||||||||||||||
SP4: | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | KLK15 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | KLK15 30 |
|
||
Cow (Bos Taurus) |
Mammalia | KLK15 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | LOC102553035 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Klk15 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | KLK15 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | KLK15 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG17239 32 |
|
|
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
VAR_036298 | A breast cancer sample |
p.Ala137Thr |
|||
rs3212805 | - |
p.Pro134Leu |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1058e212 | CNV | loss | 25503493 |
dgv1802n106 | CNV | deletion | 24896259 |
dgv203n21 | CNV | loss | 19592680 |
dgv204n21 | CNV | loss | 19592680 |
esv2422090 | CNV | deletion | 20811451 |
esv2662649 | CNV | deletion | 23128226 |
esv2763099 | CNV | loss | 21179565 |
esv3556538 | CNV | deletion | 23714750 |
esv3583463 | CNV | loss | 25503493 |
esv3583464 | CNV | loss | 25503493 |
esv3644656 | CNV | loss | 21293372 |
esv3644657 | CNV | gain | 21293372 |
nsv1140251 | OTHER | inversion | 24896259 |
nsv2531 | CNV | deletion | 18451855 |
nsv515608 | CNV | loss | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
prostate cancer |
|
|
deafness, autosomal recessive 100 |
|
|
peripheral vascular disease |
|
|
deafness, autosomal recessive 71 |
|
|