Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by st... See more...

Aliases for KLK13 Gene

Aliases for KLK13 Gene

  • Kallikrein Related Peptidase 13 2 3 5
  • KLK-L4 2 3 4
  • Kallikrein-Like Protein 4 3 4
  • Kallikrein-13 3 4
  • KLKL4 3 4
  • Kallikrein-Like Gene 4 3
  • Kallikrein 13 2
  • EC 3.4.21.- 4
  • EC 3.4.21 51
  • KLK13 5

External Ids for KLK13 Gene

Previous GeneCards Identifiers for KLK13 Gene

  • GC19M052189
  • GC19M051920
  • GC19M056235
  • GC19M056251
  • GC19M051559
  • GC19M047892

Summaries for KLK13 Gene

Entrez Gene Summary for KLK13 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. [provided by RefSeq, Jan 2017]

GeneCards Summary for KLK13 Gene

KLK13 (Kallikrein Related Peptidase 13) is a Protein Coding gene. Diseases associated with KLK13 include Breast Cancer. Among its related pathways are Metabolism of proteins and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include hydrolase activity and endopeptidase activity. An important paralog of this gene is KLK6.

Gene Wiki entry for KLK13 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLK13 Gene

Genomics for KLK13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KLK13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051064 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 266 +0.1 113 1.2 MNT VEZF1 SAFB ADNP CBX1 NRF1 SP1 EP400 EGR1 TEAD4 KLK13 LOC107985341 LRRC4B SHANK1 KLK14 ENSG00000268390 KLK12
GH19J051065 Promoter 0.6 EPDnew 250.7 -0.6 -585 0.1 ZNF316 EGR1 NR2F6 NR2C1 EMSY KLK13 LOC107985341 lnc-SIGLEC9-5 KLK14
GH19J050329 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.8 +734.1 734113 7.2 TBP ZBTB10 SP1 MXD4 FEZF1 CEBPA SIX5 NR2C1 MNT IKZF1 KCNC3 NR1H2 HSALNG0127087 LOC105372437 lnc-POLD1-3 NUP62 PRR12 POLD1 CPT1C ENSG00000268047
GH19J050383 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 9.8 +680.5 680490 3.2 TBP ZBTB10 MXD4 FEZF1 NR2C1 MNT IKZF1 SMAD5 MBD2 POLR2A POLD1 HSALNG0127094 NUP62 CTU1 ENSG00000268047 PRR12 PTOV1-AS2 NR1H2 RRAS PNKP
GH19J050802 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 9.8 +260.8 260831 4.2 CHD2 ZBTB10 SP1 MXD4 FEZF1 CEBPA MNT SMAD5 ETS1 IRF2 LINC01869 C19orf48 HSALNG0127138 LINC01869-001 SNORD88C lnc-KLK1-2 NUP62 PTOV1-AS2 ZNF175 POLD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLK13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLK13

Top Transcription factor binding sites by QIAGEN in the KLK13 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • AREB6
  • C/EBPbeta
  • MyoD
  • Pax-4a
  • RREB-1

Genomic Locations for KLK13 Gene

Latest Assembly
chr19:51,055,626-51,065,114
(GRCh38/hg38)
Size:
9,489 bases
Orientation:
Minus strand

Previous Assembly
chr19:51,558,883-51,568,349
(GRCh37/hg19 by Entrez Gene)
Size:
9,467 bases
Orientation:
Minus strand

chr19:51,559,463-51,568,371
(GRCh37/hg19 by Ensembl)
Size:
8,909 bases
Orientation:
Minus strand

Genomic View for KLK13 Gene

Genes around KLK13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK13 Gene

Proteins for KLK13 Gene

  • Protein details for KLK13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKR3-KLK13_HUMAN
    Recommended name:
    Kallikrein-13
    Protein Accession:
    Q9UKR3
    Secondary Accessions:
    • A7UNK6
    • Q86VI8
    • Q9Y433

    Protein attributes for KLK13 Gene

    Size:
    277 amino acids
    Molecular mass:
    30570 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLK13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLK13 Gene

Selected DME Specific Peptides for KLK13 Gene

Q9UKR3:
  • VLTAAHC
  • GDSGGPL
  • CGGVLVH
  • EGGKDSC
  • SGGPLVC
  • WVLTAAH

Post-translational modifications for KLK13 Gene

  • Glycosylation at Asn30 and Asn225
  • Modification sites at PhosphoSitePlus

Domains & Families for KLK13 Gene

Gene Families for KLK13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted secreted proteins

Protein Domains for KLK13 Gene

InterPro:
Blocks:
  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature
ProtoNet:

Suggested Antigen Peptide Sequences for KLK13 Gene

GenScript: Design optimal peptide antigens:
  • Kallikrein 13 (B5BUM9_HUMAN)
  • Kallikrein-like protein 4 (KLK13_HUMAN)
  • Kallikrein 13 splice variant 4 (Q5BQ99_HUMAN)
  • Kallikrein 13, isoform CRA_c (Q86VI7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UKR3

UniProtKB/Swiss-Prot:

KLK13_HUMAN :
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK13: view

Function for KLK13 Gene

Enzyme Numbers (IUBMB) for KLK13 Gene

Phenotypes From GWAS Catalog for KLK13 Gene

Gene Ontology (GO) - Molecular Function for KLK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA --
GO:0004252 serine-type endopeptidase activity IEA,NAS 10766816
GO:0005515 protein binding IPI 14687906
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with KLK13: view
genes like me logo Genes that share phenotypes with KLK13: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK13

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KLK13 Gene

Localization for KLK13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK13 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLK13 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KLK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 10766816
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IDA 12642628
GO:0030141 secretory granule IBA 21873635
genes like me logo Genes that share ontologies with KLK13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLK13 Gene

Pathways & Interactions for KLK13 Gene

PathCards logo

SuperPathways for KLK13 Gene

SuperPathway Contained pathways
1 Collagen chain trimerization
.48
.46
2 Keratinization
3 MSP-RON Signaling
-
4 Developmental Biology
5 Metabolism of proteins
genes like me logo Genes that share pathways with KLK13: view

Pathways by source for KLK13 Gene

3 Qiagen pathways for KLK13 Gene
  • Blood Coagulation Cascade
  • Intrinsic Prothrombin Activation Pathway
  • MSP-RON Signaling

Gene Ontology (GO) - Biological Process for KLK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,NAS 10766816
GO:0016485 protein processing IEA --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KLK13: view

No data available for SIGNOR curated interactions for KLK13 Gene

Drugs & Compounds for KLK13 Gene

(1) Drugs for KLK13 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KLK13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLK13: view

Transcripts for KLK13 Gene

mRNA/cDNA for KLK13 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK13

Alternative Splicing Database (ASD) splice patterns (SP) for KLK13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c
SP1: - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5: - - - - -
SP6: - - -
SP7: -
SP8: - - - - - - -

Relevant External Links for KLK13 Gene

GeneLoc Exon Structure for
KLK13

Expression for KLK13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLK13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLK13 Gene

This gene is overexpressed in Esophagus - Mucosa (x33.1), Vagina (x6.2), Cervix - Ectocervix (x6.2), and Minor Salivary Gland (x5.1).

Protein differential expression in normal tissues from HIPED for KLK13 Gene

This gene is overexpressed in Cervix (59.3) and Oral epithelium (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLK13 Gene



Protein tissue co-expression partners for KLK13 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLK13

SOURCE GeneReport for Unigene cluster for KLK13 Gene:

Hs.165296

mRNA Expression by UniProt/SwissProt for KLK13 Gene:

Q9UKR3-KLK13_HUMAN
Tissue specificity: Expressed in prostate, breast, testis and salivary gland.

Evidence on tissue expression from TISSUES for KLK13 Gene

  • Skin(4.5)
genes like me logo Genes that share expression patterns with KLK13: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KLK13 Gene

Orthologs for KLK13 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLK13 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KLK13 30 31
  • 99.52 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KLK13 30 31
  • 86.4 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC540297 30
  • 83.87 (n)
KLK13 31
  • 80 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Klk13 30 17 31
  • 78.91 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Klk13 30
  • 78.79 (n)
Oppossum
(Monodelphis domestica)
Mammalia KLK13 31
  • 69 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG17239 32
  • 35 (a)
CG11911 32
  • 34 (a)
Species where no ortholog for KLK13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for KLK13 Gene

ENSEMBL:
Gene Tree for KLK13 (if available)
TreeFam:
Gene Tree for KLK13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLK13: view image

Paralogs for KLK13 Gene

Paralogs for KLK13 Gene

genes like me logo Genes that share paralogs with KLK13: view

Variants for KLK13 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLK13 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs34089525 - p.His109Tyr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KLK13 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KLK13 Gene

Variant ID Type Subtype PubMed ID
esv2763209 CNV loss 21179565
esv34104 CNV loss 18971310
nsv1140251 OTHER inversion 24896259
nsv524556 CNV gain 19592680
nsv819004 CNV gain 19587683
nsv828585 CNV loss 20364138

Variation tolerance for KLK13 Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLK13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLK13

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK13 Gene

Disorders for KLK13 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLK13 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search KLK13 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KLK13

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with KLK13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLK13 Gene

Publications for KLK13 Gene

  1. Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues. (PMID: 10766816) Yousef GM … Diamandis EP (The Journal of biological chemistry 2000) 3 4 23
  2. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PMID: 20424135) Klein RJ … Lilja H (Cancer prevention research (Philadelphia, Pa.) 2010) 3 41
  3. Understanding the accuracy of statistical haplotype inference with sequence data of known phase. (PMID: 17922479) Andrés AM … Hixson JE (Genetic epidemiology 2007) 3 4
  4. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PMID: 16800723) (Biological chemistry 2006) 2 3
  5. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PMID: 16800724) Lundwall A … Yousef GM (Biological chemistry 2006) 2 3

Products for KLK13 Gene

  • Boster Bio Antibodies for KLK13
  • Boster Bio ELISA Kits for KLK13

Sources for KLK13 Gene