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Aliases for KLK13 Gene

Aliases for KLK13 Gene

  • Kallikrein Related Peptidase 13 2 3 5
  • Kallikrein-Like Protein 4 3 4
  • KLK-L4 3 4
  • KLKL4 3 4
  • Kallikrein-Like Gene 4 3
  • Kallikrein-13 3
  • Kallikrein 13 2
  • EC 3.4.21.- 4

External Ids for KLK13 Gene

Previous GeneCards Identifiers for KLK13 Gene

  • GC19M052189
  • GC19M051920
  • GC19M056235
  • GC19M056251
  • GC19M051559
  • GC19M047892

Summaries for KLK13 Gene

Entrez Gene Summary for KLK13 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. [provided by RefSeq, Jan 2017]

GeneCards Summary for KLK13 Gene

KLK13 (Kallikrein Related Peptidase 13) is a Protein Coding gene. Among its related pathways are Keratinization and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include hydrolase activity and endopeptidase activity. An important paralog of this gene is KLK11.

Gene Wiki entry for KLK13 Gene

Additional gene information for KLK13 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK13 Gene

Genomics for KLK13 Gene

GeneHancer (GH) Regulatory Elements for KLK13 Gene

Promoters and enhancers for KLK13 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051064 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 666.1 -0.2 -178 1.4 HDAC1 SMAD1 ZBTB40 ZNF766 EGR1 EGR2 SMARCA5 SP3 GATAD2B ELF1 KLK13 KLK14
GH19J051018 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 11.2 +45.7 45682 2.4 ZNF335 TCF12 GLIS2 EGR1 ZNF366 ZNF416 ETV6 EGR2 SMARCA5 SP3 KLK10 ZNF577 ZNF649 ZNF175 KLK13 KLK6 ZNF350 KLK14 ZNF473 SNORD88C
GH19J051016 Enhancer 1.1 Ensembl ENCODE 11.2 +47.7 47737 1.5 PKNOX1 ATF1 SIN3A GLI4 ETS1 ZNF121 GLIS2 ZNF143 KLF7 KLF13 ZNF175 ZNF615 KLK10 ZNF577 LRRC4B POLD1 SPACA6 ZNF613 ZNF350 KLK13
GH19J051045 Enhancer 0.7 ENCODE 0.4 +18.2 18239 2.1 PKNOX1 ZNF687 USF1 RFX1 MAX ELF1 ETS1 SP1 NFIC ZNF512B ENSG00000267808 ENSG00000268390 KLK13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLK13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLK13 gene promoter:
  • AREB6
  • RREB-1
  • MyoD
  • AP-2beta
  • C/EBPbeta
  • AP-2alpha
  • AP-2alphaA
  • AP-2gamma
  • Pax-4a

Genomic Locations for KLK13 Gene

Genomic Locations for KLK13 Gene
8,909 bases
Minus strand
8,909 bases
Minus strand

Genomic View for KLK13 Gene

Genes around KLK13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK13 Gene

Proteins for KLK13 Gene

  • Protein details for KLK13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A7UNK6
    • Q86VI8
    • Q9Y433

    Protein attributes for KLK13 Gene

    277 amino acids
    Molecular mass:
    30570 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLK13 Gene


neXtProt entry for KLK13 Gene

Post-translational modifications for KLK13 Gene

  • Glycosylation at Asn225 and isoforms=30
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KLK13 Gene

Domains & Families for KLK13 Gene

Gene Families for KLK13 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family. Kallikrein subfamily.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK13: view

Function for KLK13 Gene

Enzyme Numbers (IUBMB) for KLK13 Gene

Phenotypes From GWAS Catalog for KLK13 Gene

Gene Ontology (GO) - Molecular Function for KLK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity NAS,IEA 10766816
GO:0005515 protein binding IPI 14687906
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA,IDA 14687906
genes like me logo Genes that share ontologies with KLK13: view
genes like me logo Genes that share phenotypes with KLK13: view

Animal Model Products

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KLK13 Gene

Localization for KLK13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK13 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLK13 gene
Compartment Confidence
extracellular 5
cytosol 1

Gene Ontology (GO) - Cellular Components for KLK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 10766816
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IDA 12642628
GO:0030141 secretory granule IBA --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with KLK13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLK13 Gene

Pathways & Interactions for KLK13 Gene

genes like me logo Genes that share pathways with KLK13: view

Gene Ontology (GO) - Biological Process for KLK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,NAS 10766816
GO:0016485 protein processing IEA --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KLK13: view

No data available for SIGNOR curated interactions for KLK13 Gene

Drugs & Compounds for KLK13 Gene

(1) Drugs for KLK13 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KLK13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLK13: view

Transcripts for KLK13 Gene

mRNA/cDNA for KLK13 Gene

Unigene Clusters for KLK13 Gene

Kallikrein-related peptidase 13:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLK13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c
SP1: - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5: - - - - -
SP6: - - -
SP7: -
SP8: - - - - - - -

Relevant External Links for KLK13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLK13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLK13 Gene

mRNA differential expression in normal tissues according to GTEx for KLK13 Gene

This gene is overexpressed in Esophagus - Mucosa (x33.1), Vagina (x6.2), Cervix - Ectocervix (x6.2), and Minor Salivary Gland (x5.1).

Protein differential expression in normal tissues from HIPED for KLK13 Gene

This gene is overexpressed in Cervix (59.3) and Oral epithelium (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLK13 Gene

Protein tissue co-expression partners for KLK13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KLK13 Gene:


SOURCE GeneReport for Unigene cluster for KLK13 Gene:


mRNA Expression by UniProt/SwissProt for KLK13 Gene:

Tissue specificity: Expressed in prostate, breast, testis and salivary gland.

Evidence on tissue expression from TISSUES for KLK13 Gene

  • Skin(4.3)
genes like me logo Genes that share expression patterns with KLK13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLK13 Gene

Orthologs for KLK13 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLK13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLK13 34 33
  • 99.52 (n)
(Canis familiaris)
Mammalia KLK13 34 33
  • 86.4 (n)
(Bos Taurus)
Mammalia LOC540297 33
  • 83.87 (n)
KLK13 34
  • 80 (a)
(Mus musculus)
Mammalia Klk13 16 34 33
  • 78.91 (n)
(Rattus norvegicus)
Mammalia Klk13 33
  • 78.79 (n)
(Monodelphis domestica)
Mammalia KLK13 34
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17239 35
  • 35 (a)
CG11911 35
  • 34 (a)
Species where no ortholog for KLK13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK13 Gene

Gene Tree for KLK13 (if available)
Gene Tree for KLK13 (if available)
Evolutionary constrained regions (ECRs) for KLK13: view image

Paralogs for KLK13 Gene

Paralogs for KLK13 Gene

genes like me logo Genes that share paralogs with KLK13: view

Variants for KLK13 Gene

Sequence variations from dbSNP and Humsavar for KLK13 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000550319 -- 51,058,029(-) T/C intron_variant
rs1000577423 -- 51,061,924(-) C/T intron_variant
rs1000784158 -- 51,067,023(-) T/A upstream_transcript_variant
rs1001474517 -- 51,056,721(-) A/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1001560544 -- 51,059,512(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLK13 Gene

Variant ID Type Subtype PubMed ID
esv2763209 CNV loss 21179565
esv34104 CNV loss 18971310
nsv1140251 OTHER inversion 24896259
nsv524556 CNV gain 19592680
nsv819004 CNV gain 19587683
nsv828585 CNV loss 20364138

Variation tolerance for KLK13 Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLK13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK13 Gene

Disorders for KLK13 Gene

Additional Disease Information for KLK13

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KLK13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLK13 Gene

Publications for KLK13 Gene

  1. Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues. (PMID: 10766816) Yousef GM … Diamandis EP (The Journal of biological chemistry 2000) 3 4 22 58
  2. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PMID: 20424135) Klein RJ … Lilja H (Cancer prevention research (Philadelphia, Pa.) 2010) 3 44 58
  3. Understanding the accuracy of statistical haplotype inference with sequence data of known phase. (PMID: 17922479) Andrés AM … Hixson JE (Genetic epidemiology 2007) 3 4 58
  4. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PMID: 16800723) (Biological chemistry 2006) 2 3 58
  5. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PMID: 16800724) Lundwall A … Yousef GM (Biological chemistry 2006) 2 3 58

Products for KLK13 Gene

  • Boster Bio Antibodies for KLK13
  • Boster Bio ELISA Kits for KLK13

Sources for KLK13 Gene

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