Free for academic non-profit institutions. Other users need a Commercial license
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. [provided by RefSeq, Jan 2017]
KLK13 (Kallikrein Related Peptidase 13) is a Protein Coding gene. Diseases associated with KLK13 include Breast Cancer. Among its related pathways are Metabolism of proteins and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include hydrolase activity and endopeptidase activity. An important paralog of this gene is KLK6.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004175 | endopeptidase activity | IEA | -- |
GO:0004252 | serine-type endopeptidase activity | IEA,NAS | 10766816 |
GO:0005515 | protein binding | IPI | 14687906 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008236 | serine-type peptidase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | 10766816 |
GO:0005615 | extracellular space | IEA | -- |
GO:0005737 | cytoplasm | IDA | 12642628 |
GO:0030141 | secretory granule | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Collagen chain trimerization |
Intrinsic Prothrombin Activation Pathway
.48
|
Blood Coagulation Cascade
.46
|
2 | Keratinization |
.33
|
|
3 | MSP-RON Signaling |
MSP-RON Signaling
-
|
|
4 | Developmental Biology | ||
5 | Metabolism of proteins |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IEA,NAS | 10766816 |
GO:0016485 | protein processing | IEA | -- |
GO:0070268 | cornification | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||
SP5: | - | - | - | - | - | ||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | KLK13 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | KLK13 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LOC540297 30 |
|
||
KLK13 31 |
|
OneToOne | |||
Mouse (Mus musculus) |
Mammalia | Klk13 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Klk13 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | KLK13 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG17239 32 |
|
|
|
CG11911 32 |
|
|
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs34089525 | - |
p.His109Tyr |
Disorder | Aliases | PubMed IDs |
---|---|---|
breast cancer |
|
|