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Aliases for KLK12 Gene

Aliases for KLK12 Gene

  • Kallikrein Related Peptidase 12 2 3 5
  • Kallikrein-Like Protein 5 3 4
  • KLK-L5 3 4
  • KLKL5 3 4
  • Kallikrein-12 3
  • Kallikrein 12 2
  • EC 3.4.21.- 4

External Ids for KLK12 Gene

Previous GeneCards Identifiers for KLK12 Gene

  • GC19M052162
  • GC19M051893
  • GC19M056202
  • GC19M056224
  • GC19M051532
  • GC19M047864

Summaries for KLK12 Gene

Entrez Gene Summary for KLK12 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLK12 Gene

KLK12 (Kallikrein Related Peptidase 12) is a Protein Coding gene. Among its related pathways are Keratinization and MSP-RON Signaling. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK10.

Gene Wiki entry for KLK12 Gene

Additional gene information for KLK12 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK12 Gene

Genomics for KLK12 Gene

GeneHancer (GH) Regulatory Elements for KLK12 Gene

Promoters and enhancers for KLK12 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051034 Promoter 0.8 EPDnew 650.7 +0.7 726 0.1 PKNOX1 ZNF687 CREB1 ZNF592 KLK12 ENSG00000268906
GH19J051035 Promoter 0.8 EPDnew 650.7 +0.9 865 0.1 PKNOX1 ZNF687 CREB1 ZNF592 KLK12 ENSG00000268906
GH19J050375 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 7.2 +658.8 658831 2.1 ZFP64 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC ZC3H11A ZNF610 NR1H2 NAPSB POLD1 NUP62 SNORD35B SNORD35A IRF3 PIH1D1 ALDH16A1 PNKP
GH19J051025 Promoter/Enhancer 1 EPDnew ENCODE 6.1 +9.0 8953 2.5 MTA3 PKNOX1 MCM3 ZNF223 ZBTB33 KLK11 POLD1 ENSG00000268316 SIGLEC17P ZNF577 ZNF350 ZNF613 KLK12 KLK10
GH19J050264 Enhancer 0.8 FANTOM5 5.2 +771.1 771059 0.1 ATF1 RB1 RAD21 TCF12 ATF7 CREM PHF21A NFYC USF2 REST KLK12 IZUMO2 PIR48748 GC19P050308 MYH14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLK12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLK12 gene promoter:
  • ER-alpha
  • ZID
  • GATA-1
  • PPAR-gamma2
  • PPAR-gamma1
  • LCR-F1
  • GR
  • GR-alpha

Genomic Locations for KLK12 Gene

Genomic Locations for KLK12 Gene
6,693 bases
Minus strand
6,139 bases
Minus strand

Genomic View for KLK12 Gene

Genes around KLK12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK12 Gene

Proteins for KLK12 Gene

  • Protein details for KLK12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q9UKR1
    • Q9UKR2

    Protein attributes for KLK12 Gene

    248 amino acids
    Molecular mass:
    26734 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLK12 Gene


neXtProt entry for KLK12 Gene

Post-translational modifications for KLK12 Gene

  • Glycosylation at isoforms=2163 and isoforms=2, 324
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KLK12 Gene

Domains & Families for KLK12 Gene

Gene Families for KLK12 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for KLK12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family. Kallikrein subfamily.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK12: view

Function for KLK12 Gene

Enzyme Numbers (IUBMB) for KLK12 Gene

Phenotypes From GWAS Catalog for KLK12 Gene

Gene Ontology (GO) - Molecular Function for KLK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity NAS 11054574
GO:0008233 peptidase activity IEA,IDA 21628462
GO:0008236 serine-type peptidase activity IDA,IEA 15300858
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with KLK12: view
genes like me logo Genes that share phenotypes with KLK12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KLK12

miRNA for KLK12 Gene

miRTarBase miRNAs that target KLK12

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLK12 Gene

Localization for KLK12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK12 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLK12 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for KLK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space NAS 21628462
GO:0030141 secretory granule IBA --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with KLK12: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLK12 Gene

Pathways & Interactions for KLK12 Gene

genes like me logo Genes that share pathways with KLK12: view

Pathways by source for KLK12 Gene

Gene Ontology (GO) - Biological Process for KLK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 21628462
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KLK12: view

No data available for SIGNOR curated interactions for KLK12 Gene

Drugs & Compounds for KLK12 Gene

No Compound Related Data Available

Transcripts for KLK12 Gene

mRNA/cDNA for KLK12 Gene

(5) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLK12 Gene

Kallikrein-related peptidase 12:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLK12 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - - - -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for KLK12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLK12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLK12 Gene

mRNA differential expression in normal tissues according to GTEx for KLK12 Gene

This gene is overexpressed in Esophagus - Mucosa (x26.8), Cervix - Ectocervix (x12.8), Vagina (x6.8), and Minor Salivary Gland (x4.3).

Protein differential expression in normal tissues from HIPED for KLK12 Gene

This gene is overexpressed in Saliva (52.9) and Salivary gland (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLK12 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLK12 Gene:


SOURCE GeneReport for Unigene cluster for KLK12 Gene:

genes like me logo Genes that share expression patterns with KLK12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLK12 Gene

Orthologs for KLK12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLK12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLK12 34 33
  • 98.45 (n)
(Bos Taurus)
Mammalia KLK12 34 33
  • 82.39 (n)
(Canis familiaris)
Mammalia KLK12 33
  • 81.72 (n)
-- 34
  • 25 (a)
(Mus musculus)
Mammalia Klk12 16 34 33
  • 75.3 (n)
(Rattus norvegicus)
Mammalia Klk12 33
  • 73.37 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 45 (a)
Species where no ortholog for KLK12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK12 Gene

Gene Tree for KLK12 (if available)
Gene Tree for KLK12 (if available)
Evolutionary constrained regions (ECRs) for KLK12: view image

Paralogs for KLK12 Gene

Variants for KLK12 Gene

Sequence variations from dbSNP and Humsavar for KLK12 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000053353 -- 51,036,554(-) C/T upstream_transcript_variant
rs1000646429 -- 51,032,808(-) G/A intron_variant
rs1000953191 -- 51,032,629(-) C/T intron_variant
rs1001308962 -- 51,032,089(-) A/G coding_sequence_variant, intron_variant, missense_variant
rs1002149454 -- 51,033,177(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLK12 Gene

Variant ID Type Subtype PubMed ID
nsv1140251 OTHER inversion 24896259

Variation tolerance for KLK12 Gene

Residual Variation Intolerance Score: 70.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLK12 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK12 Gene

Disorders for KLK12 Gene

Additional Disease Information for KLK12

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KLK12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLK12 Gene

Publications for KLK12 Gene

  1. Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity. (PMID: 15300858) Shinmura K … Sugimura H (Human mutation 2004) 3 22 44 58
  2. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PMID: 20424135) Klein RJ … Lilja H (Cancer prevention research (Philadelphia, Pa.) 2010) 3 44 58
  3. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PMID: 16800723) (Biological chemistry 2006) 2 3 58
  4. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PMID: 16800724) Lundwall A … Yousef GM (Biological chemistry 2006) 2 3 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58

Products for KLK12 Gene

Sources for KLK12 Gene

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