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Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternat... See more...
Aliases for KLK11 Gene
Aliases for KLK11 Gene
External Ids for KLK11 Gene
- HGNC: 6359
- Entrez Gene: 11012
- Ensembl: ENSG00000167757
- OMIM: 604434
- UniProtKB: Q9UBX7
Previous HGNC Symbols for KLK11 Gene
- PRSS20
Previous GeneCards Identifiers for KLK11 Gene
- GC19M052155
- GC19M051886
- GC19M056201
- GC19M056217
- GC19M051525
- GC19M047858
Summaries for KLK11 Gene
-
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]
GeneCards Summary for KLK11 Gene
KLK11 (Kallikrein Related Peptidase 11) is a Protein Coding gene. Among its related pathways are Collagen chain trimerization and MSP-RON Signaling. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK5.
UniProtKB/Swiss-Prot Summary for KLK11 Gene
-
Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLK11 Gene
Genomics for KLK11 Gene
GeneHancer (GH) Regulatory Elements for KLK11 Gene
Promoters and enhancers for KLK11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around KLK11 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the KLK11 gene promoter:
-
- ER-alpha
- NF-E2
- NF-E2 p45
- ZID
Genomic Locations for KLK11 Gene
Genomic Locations for KLK11 Gene
- chr19:51,022,216-51,028,039
- (GRCh38/hg38)
- Size:
- 5,824 bases
- Orientation:
- Minus strand
- chr19:51,525,472-51,531,295
- (GRCh37/hg19)
- Size:
- 5,824 bases
- Orientation:
- Minus strand
Genomic View for KLK11 Gene
Genes around KLK11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.41 by HGNC
- 19q13.41 by Entrez Gene
- 19q13.41 by Ensembl
KLK11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KLK11 Gene
Proteins for KLK11 Gene
-
Protein details for KLK11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UBX7-KLK11_HUMAN
- Recommended name:
- Kallikrein-11
- Protein Accession:
- Q9UBX7
- O75837
- Q0WXX5
- Q8IXD7
- Q9NS65
Protein attributes for KLK11 Gene
- Size:
- 282 amino acids
- Molecular mass:
- 31059 Da
- Quaternary structure:
- No Data Available
Protein Expression for KLK11 Gene
Selected DME Specific Peptides for KLK11 Gene
- Q9UBX7:
-
- GDSGGPL
- CLISGWG
- EGGKDSC
- SGGPLVC
- PGVYTKV
- DSCQGDSGG
- CQGDSGGP
Post-translational modifications for KLK11 Gene
- About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.
-
Glycosylation at Asn131, Asn197, Asn213, and Asn242
- NX_Q9UBX7 (NX_Q9UBX7-2)
- Modification sites at PhosphoSitePlus
Other Protein References for KLK11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents Kallikrein-11 Antibody
- Creative Diagnostics Anti-KLK11 monoclonal antibody, Anti-KLK11 (C-terminal) polyclonal antibody, and Anti-KLK11 (aa 1-275) polyclonal antibody
-
Creative Biolabs
- Recombinant Anti-Human KLK11 Antibody Fab Fragment
- Recombinant Anti-Human KLK11 Antibody
- Rabbit Anti-KLK11 Recombinant Antibody (121)
- Rat Anti-KLK11 Recombinant Antibody (371604)
- Recombinant Rat Anti-KLK11 Antibody (CBL624)
- Mouse Anti-KLK11 Recombinant Antibody (14L658)
- Mouse Anti-KLK11 Recombinant Antibody (6A7B2C7)
- Mouse Anti-KLK11 Recombinant Antibody (4N39)
- Rabbit Anti-KLK11 Recombinant Antibody (CBFYH-2608)
- Mouse Anti-KLK11 Recombinant Antibody (MM0427-4N39)
- Hi-Affi™ Recombinant Rabbit Anti-KLK11 Monoclonal Antibody (SI378DS)
- Recombinant Mouse Anti-Human KLK11 Antibody (clone NN0538-5O40)
-
Custom Antibody ServicesOriGene Antibodies for KLK11
- Novus Biologicals Antibodies for KLK11
-
Abcam antibodies for KLK11
- Invitrogen Antibodies for KLK11 (AFLGC-KLK11)
- antibodies-online: Show 50 available Kallikrein 11 Antibodies ranked by validation data
- Compare Top Kallikrein 11 Antibodies
-
Recommended
- 18 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 18 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 85 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 10 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
-
Boster Bio Antibodies for KLK11
-
Santa Cruz Biotechnology (SCBT) Antibodies for KLK11
- Sino Biological Antibodies for KLK11
Protein Products
- G Biosciences Human Kallikrein 11/KLK11, Liquid
- Search Origene for MassSpec and Protein Over-expression Lysates for KLK11
- Origene Custom Protein Services for KLK11
- Novus Biologicals lysates for KLK11
- Sino Biological Recombinant Proteins for KLK11
- Sino Biological Cell Lysates for KLK11
- ProSpec Recombinant Proteins for KLK11
-
ProSci Proteins for KLK11
-
Abcam proteins for KLK11
Assay Products
- G Biosciences Immunotag™ Kallikrein-11 ELISA Kit
- RayBiotech Custom Human Kallikrein 11 ELISA
- Creative Diagnostics Human Kallikrein-Related Peptidase 11, KLK11 ELISA Kit
- Aviva Systems Biology KLK11 ELISA Kit (Human) (OKEH03178) and KLK11 ELISA Kit (Human) (OKCD06643)
-
Boster Bio ELISA Kits for KLK11
-
Abcam assays for KLK11
- Sino Biological Assays for KLK11
Domains & Families for KLK11 Gene
Gene Families for KLK11 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for KLK11 Gene
Suggested Antigen Peptide Sequences for KLK11 Gene
- GenScript: Design optimal peptide antigens:
-
- Trypsin-like protease (KLK11_HUMAN)
- Kallikrein 11, isoform CRA_b (Q0WXX5_HUMAN)
- Variant form hippostasin/KLK11 (Q8IXD7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UBX7- Family:
-
- Belongs to the peptidase S1 family. Kallikrein subfamily.
Function for KLK11 Gene
Molecular function for KLK11 Gene
- UniProtKB/Swiss-Prot Function:
- Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
Enzyme Numbers (IUBMB) for KLK11 Gene
Phenotypes From GWAS Catalog for KLK11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004252 | serine-type endopeptidase activity | IEA | -- |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008236 | serine-type peptidase activity | TAS | 9765601 |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for KLK11 Gene
- GenomeRNAi human phenotypes for KLK11:
Animal Model Products
-
Taconic Biosciences Mouse Models for KLK11
CRISPR Products
-
OriGene CRISPR knockouts for KLK11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLK11
- genomics-online: gRNA clones - Search for available Kallikrein 11 gRNA products
- Overview of 138 available Kallikrein 11 gene related products
- Applied Biological Materials (abm): CRISPR Clones for KLK11 - Select products 50% OFF >
- * KLK11 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * KLK11 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLK11
miRNA for KLK11 Gene
- miRTarBase miRNAs that target KLK11
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for KLK11
- Browse OriGene Inhibitory RNA Products For KLK11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK11
- genomics-online: shRNA clones - Search for available Kallikrein 11 shRNA products
- Overview of 138 available Kallikrein 11 gene related products
Clone Products
-
- MG220496
- MG220500
- MR220496
- MR220496L3
- MR220496L3V
- MR220496L4
- MR220496L4V
- MR220500
- MR220500L3
- MR220500L3V
- MR220500L4
- MR220500L4V
- RC206022
- RC206022L1
- RC206022L1V
- RC206022L2
- RC206022L2V
- RC206022L3
- RC206022L3V
- RC206022L4
- RC206022L4V
- RC212547
- RC212547L1
- RC212547L1V
- RC212547L2
- RC212547L2V
- RC212547L3
- RC212547L3V
- RC212547L4
- RC212547L4V
- RC227537
- RC227537L3
- RC227537L3V
- RC227537L4
- RC227537L4V
- RC229810
- RC229810L3
- RC229810L3V
- RC229810L4
- RC229810L4V
- RG206022
- RG212547
- RG227537
- RG229810
- RR210478
- RR210478L1
- RR210478L1V
- RR210478L2
- RR210478L2V
- RR210478L3
- RR210478L3V
- RR210478L4
- RR210478L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KLK11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLK11
- Applied Biological Materials (abm): Clones for KLK11 - Select products 50% OFF >
- * KLK11 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * KLK11 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for KLK11
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLK11 Gene
Localization for KLK11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KLK11 Gene
- Isoform 1: Secreted.
- Isoform 2: Golgi apparatus.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| golgi apparatus | 5 |
| plasma membrane | 3 |
| cytosol | 1 |
| lysosome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | HDA | 16502470 |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0030141 | secretory granule | IBA | 21873635 |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLK11 Gene
Pathways & Interactions for KLK11 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Collagen chain trimerization |
Intrinsic Prothrombin Activation Pathway
.48
|
Blood Coagulation Cascade
.46
|
| 2 | MSP-RON Signaling |
MSP-RON Signaling
-
|
|
Pathways by source for KLK11 Gene
3 Qiagen pathways for KLK11 Gene
- Blood Coagulation Cascade
- Intrinsic Prothrombin Activation Pathway
- MSP-RON Signaling
Interacting Proteins for KLK11 Gene
GPS-Prot Interaction Network for KLK11
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA | -- |
No data available for SIGNOR curated interactions for KLK11 Gene
Drugs & Compounds for KLK11 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for KLK11 Gene
mRNA/cDNA for KLK11 Gene
- (4) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (66) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000600362 759 bps (ENST00000600362.5)
- ENST00000319720 1198 bps (ENST00000319720.11)
- ENST00000594768 1347 bps (ENST00000594768.5)
- ENST00000593681 733 bps (ENST00000593681.5)
- ENST00000453757 1176 bps (ENST00000453757.7)
CRISPR Products
-
OriGene CRISPR knockouts for KLK11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLK11
- genomics-online: gRNA clones - Search for available Kallikrein 11 gRNA products
- Overview of 138 available Kallikrein 11 gene related products
- Applied Biological Materials (abm): CRISPR Clones for KLK11 - Select products 50% OFF >
- * KLK11 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * KLK11 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLK11
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for KLK11
- Browse OriGene Inhibitory RNA Products For KLK11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK11
- genomics-online: shRNA clones - Search for available Kallikrein 11 shRNA products
- Overview of 138 available Kallikrein 11 gene related products
Clone Products
-
- MG220496
- MG220500
- MR220496
- MR220496L3
- MR220496L3V
- MR220496L4
- MR220496L4V
- MR220500
- MR220500L3
- MR220500L3V
- MR220500L4
- MR220500L4V
- RC206022
- RC206022L1
- RC206022L1V
- RC206022L2
- RC206022L2V
- RC206022L3
- RC206022L3V
- RC206022L4
- RC206022L4V
- RC212547
- RC212547L1
- RC212547L1V
- RC212547L2
- RC212547L2V
- RC212547L3
- RC212547L3V
- RC212547L4
- RC212547L4V
- RC227537
- RC227537L3
- RC227537L3V
- RC227537L4
- RC227537L4V
- RC229810
- RC229810L3
- RC229810L3V
- RC229810L4
- RC229810L4V
- RG206022
- RG212547
- RG227537
- RG229810
- RR210478
- RR210478L1
- RR210478L1V
- RR210478L2
- RR210478L2V
- RR210478L3
- RR210478L3V
- RR210478L4
- RR210478L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KLK11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLK11
- Applied Biological Materials (abm): Clones for KLK11 - Select products 50% OFF >
- * KLK11 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * KLK11 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP8: | - |
Expression for KLK11 Gene
mRNA differential expression in normal tissues according to GTEx for KLK11 Gene
This gene is overexpressed in Esophagus - Mucosa (x11.7), Skin - Sun Exposed (Lower leg) (x9.0), Skin - Not Sun Exposed (Suprapubic) (x7.3), Vagina (x5.9), Minor Salivary Gland (x5.0), and Cervix - Ectocervix (x4.2).
This gene is overexpressed in Cervix (40.6), Oral epithelium (8.2), and Pancreas (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLK11 Gene
NURSA nuclear receptor signaling pathways regulating expression of KLK11 Gene:
KLK11SOURCE GeneReport for Unigene cluster for KLK11 Gene:
Hs.57771mRNA Expression by UniProt/SwissProt for KLK11 Gene:
Q9UBX7-KLK11_HUMAN
Tissue specificity:
Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).
Evidence on tissue expression from TISSUES for KLK11 Gene
- Nervous system(4.3)
- Skin(2.9)
- Stomach(2.2)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for KLK11
-
OriGene qPCR primer pairs and template standards for KLK11
- genomics-online: primer clones - Search for available Kallikrein 11 Primer products
- Overview of 138 available Kallikrein 11 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLK11 Gene
Orthologs for KLK11 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KLK11 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | KLK11 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | KLK11 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Klk11 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Klk11 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | KLK11 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100485189 32 |
|
- Species where no ortholog for KLK11 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for KLK11 Gene
- ENSEMBL:
- Gene Tree for KLK11 (if available)
- TreeFam:
- Gene Tree for KLK11 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KLK11: view image
Paralogs for KLK11 Gene
Paralogs for KLK11 Gene
(80) SIMAP similar genes for KLK11 Gene using alignment to 5 proteins:
- KLK11_HUMAN
- M0QYW4_HUMAN
- M0QZI8_HUMAN
- M0QZV0_HUMAN
- M0R151_HUMAN
- KLK8
- KLK9
- KLK5
- KLK13
- KLK15
- KLK6
- KLK14
- KLK4
- PRSS45
- F2
- KLK2
- KLK1
- PRSS1
- KLK12
- KLK7
- PRSS3
- KLK3
- APS
- KLK10
- CTRL
- TRY8
- PRSS2
- CFD
- GZMK
- CTRB1
- F9 p22
- CELA3A
- PRSS55
- DF
- factor IX F9
- PROC
- GZMM
- CELA1
- PRSS33
- DKFZp779M0222
- PRSS21
- serase-1B
- TMPRSS15
- GZMA
- F9
- TMPRSS13
- GZMB
- TMPRSS9
- PRSS58
- PRSS44
- OVCH1
- KLKB1
- F11
- ELA2A
- CTSG
- CTRB2
- CELA2A
- TMPRSS11D
- TMPRSS4
- F7
- TMPRSS2
- TMPRSS11F
- PRSS41
- PRSS36
- PLAU
- F12
- CELA3B
- GZMH
- ELA3A
- AZU1
- TMPRSS5
- PLAT
- PRTN3
- TMPRSS11B
- PRSSL1
- PRSS57
- PRSS42
- HGFAC
- CORIN
- DKFZp586F0824
- TMPRSS7
- TMPRSS3
- PRSS56
- ELA2B
- CELA2B
Pseudogenes.org Pseudogenes for KLK11 Gene
Variants for KLK11 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000229842 | -- | 51,022,644(-) | G/A | coding_sequence_variant, synonymous_variant | |
| rs1000324018 | -- | 51,027,142(-) | G/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000806507 | -- | 51,022,105(-) | G/T | downstream_transcript_variant | |
| rs1000852292 | -- | 51,022,438(-) | G/A/T | 3_prime_UTR_variant | |
| rs1001555186 | -- | 51,023,411(-) | G/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1140251 | OTHER | inversion | 24896259 |
Residual Variation Intolerance Score:
91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.27;
70.31% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KLK11 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KLK11
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK11 Gene
Disorders for KLK11 Gene
Additional Disease Information for KLK11
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for KLK11 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLK11 Gene
Publications for KLK11 Gene
- Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family. (PMID: 10662548) Yousef GM … Diamandis EP (Genomics 2000) 2 3 4 23 56
- Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin. (PMID: 16911518) Mitsui S … Yamaguchi N (The FEBS journal 2006) 3 4 23 56
- Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma. (PMID: 12845660) Borgoño CA … Katsaros D (International journal of cancer 2003) 3 23 43 56
- Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate. (PMID: 12539228) Nakamura T … Yamaguchi N (The Prostate 2003) 3 4 23 56
- A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate. (PMID: 10872828) Mitsui S … Yamaguchi N (Biochemical and biophysical research communications 2000) 3 4 23 56
ExternalLinks
Products for KLK11 Gene
- View all 6 R&D Systems KLK11 (Kallikrein 11) Products
- View all R&D Systems KLK11 (Kallikrein 11) Proteins and Enzymes
- View all 3 R&D Systems KLK11 (Kallikrein 11) Primary Antibodies
- View all 2 R&D Systems KLK11 (Kallikrein 11) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom KLK11 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for KLK11
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- Origene sirna, shrna, and RNAi products in human, mouse, rat for KLK11
- Browse OriGene Inhibitory RNA Products For KLK11
- OriGene qPCR primer pairs for KLK11
- OriGene qPCR primer pairs and template standards for KLK11
- OriGene CRISPR knockouts for KLK11
- MG220496
- MG220500
- MR220496
- MR220496L3
- MR220496L3V
- MR220496L4
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- RC206022
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- RG206022
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- RR210478
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For KLK11
- Sino Biological Human cDNA Clone for KLK11
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- Find your next knockout model in the Taconic Knockout Repository
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- Invitrogen Antibodies for KLK11 (AFLGC-KLK11)
- antibodies-online: Show 50 available Kallikrein 11 Antibodies ranked by validation data
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- 18 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 18 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 85 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 10 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- antibodies-online: Show 28 available Kallikrein 11 Elisa Kits ranked by validation data
- Compare Top Kallikrein 11 Elisa Kits
- antibodies-online: Show 24 available Kallikrein 11 Proteins ranked by validation data
- Compare Top Kallikrein 11 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for KLK11
- Search Santa Cruz Biotechnology (SCBT) for KLK11 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for KLK11
- Horizon Cell Lines for KLK11
- genomics-online: cdna clones - Search for available Kallikrein 11 CDNA products
- Overview of 138 available Kallikrein 11 gene related products
- orf clones - Search for available Kallikrein 11 ORF products
- Overview of 138 available Kallikrein 11 gene related products
- genomics-online: gRNA clones - Search for available Kallikrein 11 gRNA products
- Overview of 138 available Kallikrein 11 gene related products
- genomics-online: primer clones - Search for available Kallikrein 11 Primer products
- Overview of 138 available Kallikrein 11 gene related products
- genomics-online: shRNA clones - Search for available Kallikrein 11 shRNA products
- Overview of 138 available Kallikrein 11 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLK11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLK11
- Search GeneCopoeia for miRNA 3'UTR Target clone products for KLK11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK11
Sources for KLK11 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource