Aliases for KLK11 Gene
External Ids for KLK11 Gene
Previous HGNC Symbols for KLK11 Gene
Previous GeneCards Identifiers for KLK11 Gene
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]
GeneCards Summary for KLK11 Gene
KLK11 (Kallikrein Related Peptidase 11) is a Protein Coding gene. Diseases associated with KLK11 include Thyroid Hormone Resistance, Selective Pituitary and Prostate Cancer. Among its related pathways are Collagen chain trimerization and MSP-RON Signaling. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK8.
UniProtKB/Swiss-Prot Summary for KLK11 Gene
Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.