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Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternat... See more...
Aliases for KLK11 Gene
Aliases for KLK11 Gene
External Ids for KLK11 Gene
- HGNC: 6359
- NCBI Entrez Gene: 11012
- Ensembl: ENSG00000167757
- OMIM®: 604434
- UniProtKB/Swiss-Prot: Q9UBX7
Previous HGNC Symbols for KLK11 Gene
- PRSS20
Previous GeneCards Identifiers for KLK11 Gene
- GC19M052155
- GC19M051886
- GC19M056201
- GC19M056217
- GC19M051525
- GC19M047858
Summaries for KLK11 Gene
-
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]
GeneCards Summary for KLK11 Gene
KLK11 (Kallikrein Related Peptidase 11) is a Protein Coding gene. Diseases associated with KLK11 include Thyroid Hormone Resistance, Selective Pituitary and Prostate Cancer. Among its related pathways are Collagen chain trimerization and MSP-RON Signaling. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK8.
UniProtKB/Swiss-Prot Summary for KLK11 Gene
-
Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
Additional gene information for KLK11 Gene
- HGNC (6359)
- NCBI Entrez Gene (11012)
- Ensembl (ENSG00000167757)
- OMIM® (604434)
- UniProtKB/Swiss-Prot (Q9UBX7)
- Open Targets Platform(ENSG00000167757)
- Search for KLK11 at DataMed
- Search for KLK11 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLK11 Gene
Genomics for KLK11 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for KLK11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around KLK11 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLK11
- Top Transcription factor binding sites by QIAGEN in the KLK11 gene promoter:
-
- ER-alpha
- NF-E2
- NF-E2 p45
- ZID
Genomic Locations for KLK11 Gene
Latest Assembly
- chr19:51,022,216-51,028,039
- (GRCh38/hg38)
- Size:
- 5,824 bases
- Orientation:
- Minus strand
Previous Assembly
- chr19:51,525,492-51,531,247
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 5,756 bases
- Orientation:
- Minus strand
- chr19:51,525,472-51,531,295
- (GRCh37/hg19 by Ensembl)
- Size:
- 5,824 bases
- Orientation:
- Minus strand
Genomic View for KLK11 Gene
Genes around KLK11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.41 by HGNC
- 19q13.41 by Entrez Gene
- 19q13.41 by Ensembl
KLK11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KLK11 Gene
Proteins for KLK11 Gene
-
Protein details for KLK11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UBX7-KLK11_HUMAN
- Recommended name:
- Kallikrein-11
- Protein Accession:
- Q9UBX7
- O75837
- Q0WXX5
- Q8IXD7
- Q9NS65
Protein attributes for KLK11 Gene
- Size:
- 282 amino acids
- Molecular mass:
- 31059 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- [Isoform 3]: Localized in the prostate secretory epithelium.
Protein Expression for KLK11 Gene
Selected DME Specific Peptides for KLK11 Gene
- Q9UBX7:
-
- GDSGGPL
- CLISGWG
- EGGKDSC
- SGGPLVC
- PGVYTKV
- DSCQGDSGG
- CQGDSGGP
Post-translational modifications for KLK11 Gene
- About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.
-
Glycosylation at Asn131, Asn197, Asn213, and Asn242
- NX_Q9UBX7 (NX_Q9UBX7-2)
- Modification sites at PhosphoSitePlus
Other Protein References for KLK11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences KLK11 / Kallikrein 11 Antibody
- NSJ Bioreagents Kallikrein-11 Antibody
-
Custom Antibody ServicesOriGene Antibodies for KLK11
- Novus Biologicals Antibodies for KLK11
-
Abcam antibodies for KLK11
- Invitrogen Antibodies for KLK11 (AFLGC-Klk11)
- antibodies-online: Show 50 available Kallikrein 11 Antibodies ranked by validation data
- Compare Top Kallikrein 11 Antibodies
-
Recommended
- 18 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 18 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 85 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 10 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
-
Santa Cruz Biotechnology (SCBT) Antibodies for KLK11
- Sino Biological Antibodies for KLK11
Protein products for research
- G Biosciences Human Kallikrein 11/KLK11, Liquid
- Search Origene for MassSpec and Protein Over-expression Lysates for KLK11
- Origene Custom Protein Services for KLK11
- Novus Biologicals lysates for KLK11
- Sino Biological Recombinant Proteins for KLK11
- Sino Biological Cell Lysates for KLK11
- ProSpec Recombinant Proteins for KLK11
-
ProSci Proteins for KLK11
-
Abcam proteins for KLK11
Assay products for research
- G Biosciences Immunotag™ Kallikrein-11 ELISA Kit
- RayBiotech Custom Human Kallikrein 11 ELISA
-
Custom Assay ServicesOriGene ELISA Kits for KLK11
-
Boster Bio ELISA Kits for KLK11
-
Abcam assays for KLK11
- Sino Biological Assays for KLK11
Domains & Families for KLK11 Gene
Gene Families for KLK11 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for KLK11 Gene
- InterPro:
- Blocks:
-
- Serine protease, trypsin family
- Chymotrypsin serine protease family (S1) signature
- ProtoNet:
Suggested Antigen Peptide Sequences for KLK11 Gene
- GenScript: Design optimal peptide antigens:
-
- Trypsin-like protease (KLK11_HUMAN)
- Kallikrein 11, isoform CRA_b (Q0WXX5_HUMAN)
- Variant form hippostasin/KLK11 (Q8IXD7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UBX7- Family:
-
- Belongs to the peptidase S1 family. Kallikrein subfamily.
Function for KLK11 Gene
Molecular function for KLK11 Gene
- UniProtKB/Swiss-Prot Function:
- Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
Enzyme Numbers (IUBMB) for KLK11 Gene
Phenotypes From GWAS Catalog for KLK11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004252 | serine-type endopeptidase activity | IEA | -- |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008236 | serine-type peptidase activity | IEA,TAS | 9765601 |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for KLK11 Gene
- MGI mutant phenotypes for KLK11:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for KLK11:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased vaccinia virus (VACV) infection
- Increased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance
- Decreased HPV16-GFP infection
- Increased mitotic delay (prometaphase or metaphase alignment problems, MAP)
Animal Models for research
-
Taconic Biosciences Mouse Models for KLK11
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for KLK11 - Starting at $85 >
- * KLK11 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for KLK11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLK11
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLK11
miRNA for KLK11 Gene
- miRTarBase miRNAs that target KLK11
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLK11
- Browse OriGene Inhibitory RNA Products For KLK11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK11
Clone products for research
- Applied Biological Materials (abm): Clones for KLK11 - Starting at $45 >
- * KLK11 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG220496
- MG220500
- MR220496
- MR220496L3
- MR220496L4
- MR220500
- MR220500L3
- MR220500L4
- RC206022
- RC206022L1
- RC206022L2
- RC206022L3
- RC206022L4
- RC212547
- RC212547L1
- RC212547L2
- RC212547L3
- RC212547L4
- RC227537
- RC227537L3
- RC227537L4
- RC229810
- RC229810L3
- RC229810L4
- RG206022
- RG212547
- RG227537
- RG229810
- RR210478
- RR210478L3
- RR210478L4
- MR220496L3V
- MR220496L4V
- MR220500L3V
- MR220500L4V
- RC206022L1V
- RC206022L2V
- RC206022L3V
- RC206022L4V
- RC212547L1V
- RC212547L2V
- RC212547L3V
- RC212547L4V
- RC227537L3V
- RC227537L4V
- RC229810L3V
- RC229810L4V
- RR210478L3V
- RR210478L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KLK11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLK11
Cell Lines for research
-
Horizon Cell Lines for KLK11
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLK11 Gene
Localization for KLK11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KLK11 Gene
- [Isoform 1]: Secreted.
- [Isoform 2]: Golgi apparatus.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| golgi apparatus | 5 |
| plasma membrane | 3 |
| cytoskeleton | 2 |
| nucleus | 2 |
| cytosol | 2 |
| lysosome | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | HDA | 16502470 |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0030141 | secretory granule | IBA | 21873635 |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLK11 Gene
Pathways & Interactions for KLK11 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Collagen chain trimerization |
Intrinsic Prothrombin Activation Pathway
.48
|
Blood Coagulation Cascade
.46
|
| 2 | MSP-RON Signaling |
MSP-RON Signaling
-
|
|
Pathways by source for KLK11 Gene
3 Qiagen pathways for KLK11 Gene
- Blood Coagulation Cascade
- Intrinsic Prothrombin Activation Pathway
- MSP-RON Signaling
Interacting Proteins for KLK11 Gene
GPS-Prot Interaction Network for KLK11
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA | -- |
No data available for SIGNOR curated interactions for KLK11 Gene
Drugs & Compounds for KLK11 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug products for research
- G Biosciences Human Kallikrein 11/KLK11, Liquid
Transcripts for KLK11 Gene
mRNA/cDNA for KLK11 Gene
- 4 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000319720 1198 nts (view in UCSC)
- ENST00000319756 1268 nts (view in UCSC)
- ENST00000391804 930 nts (view in UCSC)
- ENST00000453757 1176 nts (view in UCSC)
- ENST00000593681 733 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for KLK11 - Starting at $85 >
- * KLK11 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for KLK11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLK11
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLK11
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLK11
- Browse OriGene Inhibitory RNA Products For KLK11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK11
Clone products for research
- Applied Biological Materials (abm): Clones for KLK11 - Starting at $45 >
- * KLK11 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG220496
- MG220500
- MR220496
- MR220496L3
- MR220496L4
- MR220500
- MR220500L3
- MR220500L4
- RC206022
- RC206022L1
- RC206022L2
- RC206022L3
- RC206022L4
- RC212547
- RC212547L1
- RC212547L2
- RC212547L3
- RC212547L4
- RC227537
- RC227537L3
- RC227537L4
- RC229810
- RC229810L3
- RC229810L4
- RG206022
- RG212547
- RG227537
- RG229810
- RR210478
- RR210478L3
- RR210478L4
- MR220496L3V
- MR220496L4V
- MR220500L3V
- MR220500L4V
- RC206022L1V
- RC206022L2V
- RC206022L3V
- RC206022L4V
- RC212547L1V
- RC212547L2V
- RC212547L3V
- RC212547L4V
- RC227537L3V
- RC227537L4V
- RC229810L3V
- RC229810L4V
- RR210478L3V
- RR210478L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KLK11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLK11
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP8: | - |
Relevant External Links for KLK11 Gene
- GeneLoc Exon Structure for
- KLK11
Expression for KLK11 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Esophagus (Gastrointestinal Tract)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for KLK11 Gene
This gene is overexpressed in Esophagus - Mucosa (x11.7), Skin - Sun Exposed (Lower leg) (x9.0), Skin - Not Sun Exposed (Suprapubic) (x7.3), Vagina (x5.9), Minor Salivary Gland (x5.0), and Cervix - Ectocervix (x4.2).
This gene is overexpressed in Cervix (40.6), Oral epithelium (8.2), and Pancreas (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLK11 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLK11
SOURCE GeneReport for Unigene cluster for KLK11 Gene:
Hs.57771mRNA Expression by UniProt/SwissProt for KLK11 Gene:
Q9UBX7-KLK11_HUMAN
Tissue specificity:
Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).
Evidence on tissue expression from TISSUES for KLK11 Gene
- Nervous system(4.4)
- Skin(3.1)
- Stomach(2.6)
- Lung(2.5)
- Pancreas(2.3)
- Blood(2.3)
- Intestine(2.1)
Primer products for research
-
OriGene qPCR primer pairs for KLK11
-
OriGene qPCR primer pairs and template standards for KLK11
Gene Expression Assays for research
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLK11 Gene
Orthologs for KLK11 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | KLK11 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | KLK11 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | KLK11 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Klk11 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Klk11 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | KLK11 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100485189 30 |
|
- Species where no ortholog for KLK11 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for KLK11 Gene
- ENSEMBL:
- Gene Tree for KLK11 (if available)
- TreeFam:
- Gene Tree for KLK11 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KLK11: view image
Paralogs for KLK11 Gene
Paralogs for KLK11 Gene
(80) SIMAP similar genes for KLK11 Gene using alignment to 5 proteins:
- KLK11_HUMAN
- M0QYW4_HUMAN
- M0QZI8_HUMAN
- M0QZV0_HUMAN
- M0R151_HUMAN
- KLK8
- KLK9
- KLK5
- KLK13
- KLK15
- KLK6
- KLK14
- KLK4
- PRSS45
- F2
- KLK2
- KLK1
- PRSS1
- KLK12
- KLK7
- PRSS3
- KLK3
- APS
- KLK10
- CTRL
- TRY8
- PRSS2
- CFD
- GZMK
- CTRB1
- F9 p22
- CELA3A
- PRSS55
- DF
- factor IX F9
- PROC
- GZMM
- CELA1
- PRSS33
- DKFZp779M0222
- PRSS21
- serase-1B
- TMPRSS15
- GZMA
- F9
- TMPRSS13
- GZMB
- TMPRSS9
- PRSS58
- PRSS44
- OVCH1
- KLKB1
- F11
- ELA2A
- CTSG
- CTRB2
- CELA2A
- TMPRSS11D
- TMPRSS4
- F7
- TMPRSS2
- TMPRSS11F
- PRSS41
- PRSS36
- PLAU
- F12
- CELA3B
- GZMH
- ELA3A
- AZU1
- TMPRSS5
- PLAT
- PRTN3
- TMPRSS11B
- PRSSL1
- PRSS57
- PRSS42
- HGFAC
- CORIN
- DKFZp586F0824
- TMPRSS7
- TMPRSS3
- PRSS56
- ELA2B
- CELA2B
Pseudogenes.org Pseudogenes for KLK11 Gene
Variants for KLK11 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1140251 | OTHER | inversion | 24896259 |
Residual Variation Intolerance Score:
91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.27;
70.31% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KLK11 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KLK11
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK11 Gene
Disorders for KLK11 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| thyroid hormone resistance, selective pituitary |
|
|
| prostate cancer |
|
|
Search KLK11 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KLK11
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for KLK11 Gene
Publications for KLK11 Gene
- Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family. (PMID: 10662548) Yousef GM … Diamandis EP (Genomics 2000) 2 3 4 23
- Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin. (PMID: 16911518) Mitsui S … Yamaguchi N (The FEBS journal 2006) 3 4 23
- Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate. (PMID: 12539228) Nakamura T … Yamaguchi N (The Prostate 2003) 3 4 23
- Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma. (PMID: 12845660) Borgoño CA … Katsaros D (International journal of cancer 2003) 3 23 41
- A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate. (PMID: 10872828) Mitsui S … Yamaguchi N (Biochemical and biophysical research communications 2000) 3 4 23
ExternalLinks
Products for KLK11 Gene
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Sources for KLK11 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
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- (27) ASD
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- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
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- (43) HuGE
- (44) Atlas
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- (63) OCA
- (64) Proteopedia
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- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
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- (104) diseasecard
- (105) NIH Rare Diseases
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