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KLK11 Gene(Protein Coding)

Kallikrein Related Peptidase 11

GCID:
GC19M051023
GIFtS:
49
Genes Participants
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Aliases for KLK11 Gene

Aliases for KLK11 Gene

  • Kallikrein Related Peptidase 11 2 3 5
  • Trypsin-Like Protease 3 4
  • Serine Protease 20 3 4
  • Hippostasin 3 4
  • PRSS20 3 4
  • TLSP 3 4
  • HK11 3 4
  • Kallikrein 11 2
  • Kallikrein-11 3
  • EC 3.4.21.4 56
  • EC 3.4.21.- 4
  • EC 3.4.21 56

External Ids for KLK11 Gene

Previous HGNC Symbols for KLK11 Gene

  • PRSS20

Previous GeneCards Identifiers for KLK11 Gene

  • GC19M052155
  • GC19M051886
  • GC19M056201
  • GC19M056217
  • GC19M051525
  • GC19M047858

Summaries for KLK11 Gene

Entrez Gene Summary for KLK11 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]

GeneCards Summary for KLK11 Gene

KLK11 (Kallikrein Related Peptidase 11) is a Protein Coding gene. Among its related pathways are MSP-RON Signaling and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is ENSG00000269741.

UniProtKB/Swiss-Prot for KLK11 Gene

  • Possible multifunctional protease. Efficiently cleaves bz-Phe-Arg-4-methylcoumaryl-7-amide, a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.

Gene Wiki entry for KLK11 Gene

Additional gene information for KLK11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK11 Gene

Genomics for KLK11 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for KLK11 Gene

Promoters and enhancers for KLK11 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19I051025 Promoter/Enhancer 1 EPDnew ENCODE 550.8 +1.3 1340 2.5 MTA3 PKNOX1 MCM3 ZNF223 ZBTB33 KLK11 POLD1 ENSG00000268316 SIGLEC17P ZNF577 ZNF350 ZNF613 KLK12 KLK10
GH19I051027 Promoter 0.5 EPDnew 550.8 +0.0 28 0.1 KLK11 KLK10
GH19I050896 Enhancer 1.2 Ensembl ENCODE 10 +130.9 130938 1.8 HDGF PKNOX1 IRF4 ZNF766 ZNF143 FOS SP3 JUNB REST ZNF592 KLKP1 ZNF175 ZNF577 NUP62 KLK2 LINC01869 KLK15 KLK1 KLK11 POLD1
GH19I051121 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.3 -98.1 -98096 10.3 PKNOX1 ATF1 FOXA2 TCF12 FOS ATF7 RXRA MBD2 MEF2D ATF4 SIGLEC9 ZNF613 ZNF841 ZNF577 POLD1 SIGLEC18P KLK11 CTU1 C19orf81 SIGLEC10
GH19I050759 Enhancer 0.8 ENCODE 9.6 +268.0 267990 0.2 PKNOX1 ATF1 ARNT NFRKB ZNF76 ETS1 CHAMP1 ZNF143 FOS CREM GPR32P1 SNORD88C LINC01869 C19orf48 KLK11 GPR32
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KLK11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLK11 gene promoter:

Genomic Locations for KLK11 Gene

Genomic Locations for KLK11 Gene
chr19:51,022,216-51,028,039
(GRCh38/hg38)
Size:
5,824 bases
Orientation:
Minus strand
chr19:51,525,472-51,531,295
(GRCh37/hg19)

Genomic View for KLK11 Gene

Genes around KLK11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK11 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for KLK11 Gene

Proteins for KLK11 Gene

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  1. Antibody
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  • Protein details for KLK11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBX7-KLK11_HUMAN
    Recommended name:
    Kallikrein-11
    Protein Accession:
    Q9UBX7
    Secondary Accessions:
    • O75837
    • Q0WXX5
    • Q8IXD7
    • Q9NS65

    Protein attributes for KLK11 Gene

    Size:
    282 amino acids
    Molecular mass:
    31059 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLK11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLK11 Gene

Protein Expression for KLK11 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for KLK11 Gene

Q9UBX7:
  • GDSGGPL
  • CLISGWG
  • EGGKDSC
  • SGGPLVC
  • PGVYTKV
  • DSCQGDSGG
  • CQGDSGGP

Post-translational modifications for KLK11 Gene

  • About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.
  • Glycosylation at isoforms=2, 3, 499, posLast=165165, posLast=181181, and posLast=210210
  • Modification sites at PhosphoSitePlus

Other Protein References for KLK11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for KLK11 Gene

Gene Families for KLK11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for KLK11 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KLK11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBX7

UniProtKB/Swiss-Prot:

KLK11_HUMAN :
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK11: view

Function for KLK11 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for KLK11 Gene

UniProtKB/Swiss-Prot Function:
Possible multifunctional protease. Efficiently cleaves bz-Phe-Arg-4-methylcoumaryl-7-amide, a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.

Enzyme Numbers (IUBMB) for KLK11 Gene

Phenotypes From GWAS Catalog for KLK11 Gene

Gene Ontology (GO) - Molecular Function for KLK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS 9765601
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with KLK11: view
genes like me logo Genes that share phenotypes with KLK11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KLK11

miRNA for KLK11 Gene

miRTarBase miRNAs that target KLK11

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLK11 Gene

Localization for KLK11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK11 Gene

Isoform 1: Secreted.
Isoform 2: Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLK11 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 3
cytosol 2
lysosome 1

Gene Ontology (GO) - Cellular Components for KLK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA,HDA 16502470
GO:0005794 Golgi apparatus IEA --
GO:0070062 extracellular exosome HDA,IDA 23533145
genes like me logo Genes that share ontologies with KLK11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLK11 Gene

Pathways & Interactions for KLK11 Gene

genes like me logo Genes that share pathways with KLK11: view

Pathways by source for KLK11 Gene

Gene Ontology (GO) - Biological Process for KLK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with KLK11: view

No data available for SIGNOR curated interactions for KLK11 Gene

Drugs & Compounds for KLK11 Gene

Products:

  1. Drug

(13) Drugs for KLK11 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(14) Additional Compounds for KLK11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLK11: view

Transcripts for KLK11 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for KLK11 Gene

(10) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(66) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLK11 Gene

Kallikrein-related peptidase 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLK11 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5:
SP6: - -
SP7: - - - - - -
SP8: -

Relevant External Links for KLK11 Gene

GeneLoc Exon Structure for
KLK11
ECgene alternative splicing isoforms for
KLK11

Expression for KLK11 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLK11 Gene

mRNA expression in normal human tissues for KLK11 Gene
mRNA expression by GTEx for KLK11 GenemRNA expression by BioGPS for KLK11 Gene

mRNA differential expression in normal tissues according to GTEx for KLK11 Gene

This gene is overexpressed in Esophagus - Mucosa (x11.7), Skin - Sun Exposed (Lower leg) (x9.0), Skin - Not Sun Exposed (Suprapubic) (x7.3), Vagina (x5.9), Minor Salivary Gland (x5.0), and Cervix - Ectocervix (x4.2).

Protein differential expression in normal tissues from HIPED for KLK11 Gene

This gene is overexpressed in Cervix (40.6), Oral epithelium (8.2), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLK11 Gene



NURSA nuclear receptor signaling pathways regulating expression of KLK11 Gene:

KLK11

SOURCE GeneReport for Unigene cluster for KLK11 Gene:

Hs.57771

mRNA Expression by UniProt/SwissProt for KLK11 Gene:

Q9UBX7-KLK11_HUMAN
Tissue specificity: Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).

Evidence on tissue expression from TISSUES for KLK11 Gene

  • Nervous system(4.3)
  • Skin(2.9)
  • Stomach(2.2)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with KLK11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLK11 Gene

Orthologs for KLK11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLK11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia KLK11 33 34
  • 98.82 (n)
cow
(Bos Taurus)
 Mammalia KLK11 33 34
  • 85.87 (n)
dog
(Canis familiaris)
 Mammalia KLK11 33 34
  • 85.73 (n)
mouse
(Mus musculus)
 Mammalia Klk11 33 16 34
  • 82.97 (n)
rat
(Rattus norvegicus)
 Mammalia Klk11 33
  • 82.97 (n)
oppossum
(Monodelphis domestica)
 Mammalia KLK11 34
  • 73 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 46 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100485189 33
  • 55.01 (n)
Species where no ortholog for KLK11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK11 Gene

ENSEMBL:
Gene Tree for KLK11 (if available)
TreeFam:
Gene Tree for KLK11 (if available)

Paralogs for KLK11 Gene

Paralogs for KLK11 Gene

(80) SIMAP similar genes for KLK11 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for KLK11 Gene

genes like me logo Genes that share paralogs with KLK11: view

Variants for KLK11 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for KLK11 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000229842 -- 51,022,644(-) G/A coding_sequence_variant, synonymous_variant
rs1000324018 -- 51,027,142(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000806507 -- 51,022,105(-) G/T downstream_transcript_variant
rs1000852292 -- 51,022,438(-) G/T 3_prime_UTR_variant
rs1001555186 -- 51,023,411(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLK11 Gene

Variant ID Type Subtype PubMed ID
nsv1140251 OTHER inversion 24896259

Variation tolerance for KLK11 Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.27; 70.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLK11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLK11

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK11 Gene

Disorders for KLK11 Gene

Additional Disease Information for KLK11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KLK11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLK11 Gene

Publications for KLK11 Gene

  1. Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family. (PMID: 10662548) Yousef GM … Diamandis EP (Genomics 2000) 2 3 4 22 58
  2. Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin. (PMID: 16911518) Mitsui S … Yamaguchi N (The FEBS journal 2006) 3 4 22 58
  3. Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate. (PMID: 12539228) Nakamura T … Yamaguchi N (The Prostate 2003) 3 4 22 58
  4. Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma. (PMID: 12845660) Borgoño CA … Katsaros D (International journal of cancer 2003) 3 22 44 58
  5. A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate. (PMID: 10872828) Mitsui S … Yamaguchi N (Biochemical and biophysical research communications 2000) 3 4 22 58

Products for KLK11 Gene

Sources for KLK11 Gene

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