Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may pl... See more...

Aliases for KLK10 Gene

Aliases for KLK10 Gene

  • Kallikrein Related Peptidase 10 2 3 5
  • NES1 2 3 4
  • Normal Epithelial Cell-Specific 1 3 4
  • Protease Serine-Like 1 3 4
  • Kallikrein-10 3 4
  • PRSSL1 3 4
  • Breast Normal Epithelial Cell Associated Serine Protease 3
  • Kallikrein 10 Protein 12 3
  • Kallikrein 10 Protein 13 3
  • Kallikrein 10 Protein 1 3
  • Kallikrein 10 Protein 2 3
  • Kallikrein 10 Protein 3 3
  • Kallikrein 10 Protein 4 3
  • Kallikrein 10 Protein 5 3
  • Kallikrein 10 Protein 7 3
  • Kallikrein 10 Protein 8 3
  • Kallikrein 10 Protein 9 3
  • Kallikrein 10 2
  • EC 3.4.21.74 51
  • EC 3.4.21.- 4
  • EC 3.4.21 51
  • KLK10 5

External Ids for KLK10 Gene

Previous HGNC Symbols for KLK10 Gene

  • PRSSL1

Previous GeneCards Identifiers for KLK10 Gene

  • GC19M052148
  • GC19M051877
  • GC19M056193
  • GC19M056209
  • GC19M051516
  • GC19M047848

Summaries for KLK10 Gene

Entrez Gene Summary for KLK10 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLK10 Gene

KLK10 (Kallikrein Related Peptidase 10) is a Protein Coding gene. Diseases associated with KLK10 include Gastroesophageal Adenocarcinoma and Breast Cancer. Among its related pathways are Collagen chain trimerization and MSP-RON Signaling. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is F12.

UniProtKB/Swiss-Prot Summary for KLK10 Gene

Gene Wiki entry for KLK10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLK10 Gene

Genomics for KLK10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KLK10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051016 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 274.3 +1.6 1552 4 ZBTB10 CEBPA IKZF1 ETS1 ZNF217 CTCF ZEB1 ELF1 ZIC2 REST KLK10 HSALNG0127163 HSALNG0127164 ZNF175 ZNF615 ZNF577 ZNF473 POLD1 SPACA6 ZNF613
GH19J051021 Enhancer 0.7 ENCODE 250.7 -1.0 -1045 0.2 CTCF REST RUNX1 RAD21 SMC3 RAD51 ZNF362 ZNF384 ZNF143 ESRRA HSALNG0127164 KLK10 lnc-KLK12-1 KLK11
GH19J051136 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -117.9 -117896 3.9 TBP IKZF1 SMAD5 MBD2 ZNF395 REST MAFF ELF1 ZFP91 ZNF316 ENSG00000267990 lnc-SIGLEC9-1 SIGLEC17P CTU1 SIGLEC9 KLK14 KLK10 SIGLEC7 SIGLEC10 CD33
GH19J050999 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 6.7 +18.7 18704 3.5 TBP MNT IKZF1 NBN TRIM25 ZNF341 ZBTB5 SKIL NKRF PRDM10 KLK8 HSALNG0127160 HSALNG0127161 lnc-KLK9-1 KLK7 KLK10 ENSG00000269741 KLK9 ENSG00000267879
GH19J051070 Enhancer 0.7 ENCODE 11.3 -51.0 -50953 1 ARID3A ZNF217 MBD2 CUX1 HES1 CTBP1 GATA3 TCF7L2 SMARCE1 FOXA1 CTU1 KLK10 KLK11 KLK2 lnc-SIGLEC9-5 LOC107985341 KLK13 KLK14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLK10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLK10

Top Transcription factor binding sites by QIAGEN in the KLK10 gene promoter:
  • ER-alpha
  • NF-E2
  • NF-E2 p45
  • ZID

Genomic Locations for KLK10 Gene

Latest Assembly
chr19:51,012,739-51,020,175
(GRCh38/hg38)
Size:
7,437 bases
Orientation:
Minus strand

Previous Assembly
chr19:51,515,995-51,523,353
(GRCh37/hg19 by Entrez Gene)
Size:
7,359 bases
Orientation:
Minus strand

chr19:51,515,995-51,523,431
(GRCh37/hg19 by Ensembl)
Size:
7,437 bases
Orientation:
Minus strand

Genomic View for KLK10 Gene

Genes around KLK10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK10 Gene

Proteins for KLK10 Gene

  • Protein details for KLK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43240-KLK10_HUMAN
    Recommended name:
    Kallikrein-10
    Protein Accession:
    O43240
    Secondary Accessions:
    • A6NC12
    • Q53YL3
    • Q99920
    • Q9GZW9

    Protein attributes for KLK10 Gene

    Size:
    276 amino acids
    Molecular mass:
    30170 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KLK10 Gene

neXtProt entry for KLK10 Gene

Selected DME Specific Peptides for KLK10 Gene

O43240:
  • VLTAAHC
  • WVLTAAH
  • QGILSWG
  • SGGPLVC

Post-translational modifications for KLK10 Gene

  • Glycosylation at Asn39
  • Modification sites at PhosphoSitePlus

Domains & Families for KLK10 Gene

Gene Families for KLK10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted secreted proteins

Protein Domains for KLK10 Gene

InterPro:
Blocks:
  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature
ProtoNet:

Suggested Antigen Peptide Sequences for KLK10 Gene

GenScript: Design optimal peptide antigens:
  • Protease serine-like 1 (KLK10_HUMAN)
  • cDNA FLJ76060, highly similar to Homo sapiens kallikrein 10 (KLK10), transcript variant 1, mRNA (Q6ICR6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43240

UniProtKB/Swiss-Prot:

KLK10_HUMAN :
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK10: view

Function for KLK10 Gene

Molecular function for KLK10 Gene

UniProtKB/Swiss-Prot Function:
Has a tumor-suppressor role for NES1 in breast and prostate cancer.

Enzyme Numbers (IUBMB) for KLK10 Gene

Phenotypes From GWAS Catalog for KLK10 Gene

Gene Ontology (GO) - Molecular Function for KLK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS 8764136
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with KLK10: view
genes like me logo Genes that share phenotypes with KLK10: view

Animal Models for research

  • Taconic Biosciences Mouse Models for KLK10

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK10

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLK10 Gene

Localization for KLK10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLK10 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 3
nucleus 3
cytosol 3
mitochondrion 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KLK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0030141 secretory granule IBA 21873635
genes like me logo Genes that share ontologies with KLK10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLK10 Gene

Pathways & Interactions for KLK10 Gene

PathCards logo

SuperPathways for KLK10 Gene

SuperPathway Contained pathways
1 Collagen chain trimerization
.48
.46
2 MSP-RON Signaling
-
genes like me logo Genes that share pathways with KLK10: view

Pathways by source for KLK10 Gene

3 Qiagen pathways for KLK10 Gene
  • Blood Coagulation Cascade
  • Intrinsic Prothrombin Activation Pathway
  • MSP-RON Signaling

Gene Ontology (GO) - Biological Process for KLK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with KLK10: view

No data available for SIGNOR curated interactions for KLK10 Gene

Drugs & Compounds for KLK10 Gene

(9) Drugs for KLK10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KLK10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLK10: view

Transcripts for KLK10 Gene

mRNA/cDNA for KLK10 Gene

3 REFSEQ mRNAs :
30 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLK10

Alternative Splicing Database (ASD) splice patterns (SP) for KLK10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2:
SP3:

Relevant External Links for KLK10 Gene

GeneLoc Exon Structure for
KLK10

Expression for KLK10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLK10 Gene

mRNA differential expression in normal tissues according to GTEx for KLK10 Gene

This gene is overexpressed in Esophagus - Mucosa (x23.1), Vagina (x6.8), Cervix - Ectocervix (x6.5), and Minor Salivary Gland (x4.4).

Protein differential expression in normal tissues from HIPED for KLK10 Gene

This gene is overexpressed in Cervix (48.1), Saliva (8.2), and Hair follicle (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLK10 Gene



Protein tissue co-expression partners for KLK10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLK10

SOURCE GeneReport for Unigene cluster for KLK10 Gene:

Hs.275464

mRNA Expression by UniProt/SwissProt for KLK10 Gene:

O43240-KLK10_HUMAN
Tissue specificity: Expressed in breast, ovary and prostate.

Evidence on tissue expression from TISSUES for KLK10 Gene

  • Pancreas(2.8)
  • Skin(2.7)
  • Intestine(2.3)
  • Kidney(2.2)
  • Nervous system(2.1)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with KLK10: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLK10 Gene

Orthologs for KLK10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLK10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KLK10 30 31
  • 98.79 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KLK10 30 31
  • 86.71 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KLK10 30 31
  • 82.49 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Klk10 30 17 31
  • 76.89 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Klk10 30
  • 75.6 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia KLK10 31
  • 48 (a)
OneToOne
Species where no ortholog for KLK10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for KLK10 Gene

ENSEMBL:
Gene Tree for KLK10 (if available)
TreeFam:
Gene Tree for KLK10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLK10: view image

Paralogs for KLK10 Gene

Paralogs for KLK10 Gene

(38) SIMAP similar genes for KLK10 Gene using alignment to 4 proteins:

  • KLK10_HUMAN
  • M0R132_HUMAN
  • M0R2S4_HUMAN
  • Q6ICR6_HUMAN
genes like me logo Genes that share paralogs with KLK10: view

Variants for KLK10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLK10 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs2075690 - p.Leu149Pro
rs3745535 - p.Ser50Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KLK10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KLK10 Gene

Variant ID Type Subtype PubMed ID
esv2677627 CNV deletion 23128226
nsv1140251 OTHER inversion 24896259
nsv579961 CNV loss 21841781

Variation tolerance for KLK10 Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.66; 72.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLK10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLK10

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK10 Gene

Disorders for KLK10 Gene

MalaCards: The human disease database

(5) MalaCards diseases for KLK10 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
gastroesophageal adenocarcinoma
  • gastric and esophageal adenocarcinoma
breast cancer
  • breast cancer, familial
ovarian cancer
  • ovarian cancer, somatic
prostate cancer
  • prostate cancer, somatic
leukemia, acute lymphoblastic
  • all
- elite association - COSMIC cancer census association via MalaCards
Search KLK10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KLK10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with KLK10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLK10 Gene

Publications for KLK10 Gene

  1. Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression. (PMID: 8764136) Liu XL … Band V (Cancer research 1996) 2 3 4 23
  2. Identification of new splice variants and differential expression of the human kallikrein 10 gene, a candidate cancer biomarker. (PMID: 16103744) Yousef GM … Diamandis EP (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2005) 3 4 23
  3. Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers. (PMID: 11920956) Bharaj BB … Diamandis EP (The Prostate 2002) 3 23 41
  4. The new human kallikrein gene family: implications in carcinogenesis. (PMID: 10675891) Diamandis EP … Obiezu CV (Trends in endocrinology and metabolism: TEM 2000) 2 3 23
  5. Structural characterization and mapping of the normal epithelial cell-specific 1 gene. (PMID: 9647736) Luo L … Diamandis EP (Biochemical and biophysical research communications 1998) 3 4 23

Products for KLK10 Gene

Sources for KLK10 Gene