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KLHL42 (Kelch Like Family Member 42) is a Protein Coding gene. Diseases associated with KLHL42 include Bardet-Biedl Syndrome 10. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is KLHL32.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004842 | contributes_to ubiquitin-protein transferase activity | IDA | 19261606 |
GO:0005515 | protein binding | IEA,IPI | 16189514 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005819 | spindle | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005856 | cytoskeleton | IEA | -- |
GO:0031463 | Cul3-RING ubiquitin ligase complex | IDA | 19261606 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Class I MHC mediated antigen processing and presentation | ||
2 | Innate Immune System |
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000209 | protein polyubiquitination | IDA | 19261606 |
GO:0007049 | cell cycle | IEA | -- |
GO:0016567 | protein ubiquitination | IEA | -- |
GO:0032886 | regulation of microtubule-based process | IBA,IMP | 19261606 |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | IDA | 19261606 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | KLHDC5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | KLHL42 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | KLHL42 31 |
|
OneToOne | |
KLHDC5 30 |
|
||||
Mouse (Mus musculus) |
Mammalia | Klhl42 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Klhl42 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | KLHL42 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | KLHDC5 30 |
|
||
KLHL42 31 |
|
OneToOne | |||
Lizard (Anolis carolinensis) |
Reptilia | KLHL42 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | klhl42 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG1812 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2421n54 | CNV | gain | 21841781 |
dgv2422n54 | CNV | gain+loss | 21841781 |
dgv2423n54 | CNV | gain+loss | 21841781 |
dgv2424n54 | CNV | gain | 21841781 |
dgv2425n54 | CNV | gain+loss | 21841781 |
dgv2426n54 | CNV | gain | 21841781 |
dgv2427n54 | CNV | loss | 21841781 |
dgv2428n54 | CNV | loss | 21841781 |
dgv2429n54 | CNV | loss | 21841781 |
esv2745664 | CNV | deletion | 23290073 |
esv28802 | CNV | loss | 19812545 |
nsv557824 | CNV | gain | 21841781 |
nsv557829 | CNV | gain+loss | 21841781 |
nsv557838 | CNV | loss | 21841781 |
nsv557845 | CNV | gain | 21841781 |
nsv557861 | CNV | gain | 21841781 |
nsv557863 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
bardet-biedl syndrome 10 |
|
|