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Aliases for KLHL42 Gene
Aliases for KLHL42 Gene
External Ids for KLHL42 Gene
- HGNC: 29252
- NCBI Entrez Gene: 57542
- Ensembl: ENSG00000087448
- OMIM®: 618919
- UniProtKB/Swiss-Prot: Q9P2K6
Previous HGNC Symbols for KLHL42 Gene
- KLHDC5
Previous GeneCards Identifiers for KLHL42 Gene
- GC12P027932
Summaries for KLHL42 Gene
GeneCards Summary for KLHL42 Gene
KLHL42 (Kelch Like Family Member 42) is a Protein Coding gene. Diseases associated with KLHL42 include Bardet-Biedl Syndrome 10. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is KLHL13.
UniProtKB/Swiss-Prot Summary for KLHL42 Gene
-
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis.
Additional gene information for KLHL42 Gene
- HGNC (29252)
- NCBI Entrez Gene (57542)
- Ensembl (ENSG00000087448)
- OMIM® (618919)
- UniProtKB/Swiss-Prot (Q9P2K6)
- Open Targets Platform(ENSG00000087448)
- Search for KLHL42 at DataMed
- Search for KLHL42 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLHL42 Gene
Genomics for KLHL42 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for KLHL42 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around KLHL42 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLHL42
Genomic Locations for KLHL42 Gene
Latest Assembly
- chr12:27,780,048-27,803,040
- (GRCh38/hg38)
- Size:
- 22,993 bases
- Orientation:
- Plus strand
Previous Assembly
- chr12:27,933,166-27,955,973
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 22,808 bases
- Orientation:
- Plus strand
- chr12:27,932,953-27,955,973
- (GRCh37/hg19 by Ensembl)
- Size:
- 23,021 bases
- Orientation:
- Plus strand
Genomic View for KLHL42 Gene
Genes around KLHL42 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p11.22 by HGNC
- 12p11.22 by Entrez Gene
- 12p11.22 by Ensembl
KLHL42 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KLHL42 Gene
Proteins for KLHL42 Gene
-
Protein details for KLHL42 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9P2K6-KLH42_HUMAN
- Recommended name:
- Kelch-like protein 42
- Protein Accession:
- Q9P2K6
- Q2VPK1
- Q8N334
Protein attributes for KLHL42 Gene
- Size:
- 505 amino acids
- Molecular mass:
- 56868 Da
- Quaternary structure:
-
- Component of the BCR(KLHL42) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL42. Interacts (via the BTB domain) with CUL3. Interacts (via the kelch domains) with KATNA1.
- SequenceCaution:
-
- Sequence=AAH28742.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for KLHL42 Gene
Post-translational modifications for KLHL42 Gene
Other Protein References for KLHL42 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for KLHL42
- Invitrogen Antibodies for KLHL42 (AFLGC-KLHL42)
- antibodies-online: Show 4 available KLHL42 Antibodies ranked by validation data
-
Boster Bio Antibodies for KLHL42
-
Custom Antibody ServicesProSci Antibodies for KLHL42
Protein products for research
-
OriGene Purified Proteins for KLHL42
- Search Origene for MassSpec and Protein Over-expression Lysates for KLHL42
- Origene Custom Protein Services for KLHL42
Assay products for research
No data available for DME Specific Peptides for KLHL42 Gene
Domains & Families for KLHL42 Gene
Gene Families for KLHL42 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for KLHL42 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for KLHL42 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ38086 fis, clone CTONG2018632, highly similar to Kelch domain-containing protein 5 (B2RNT7_HUMAN)
- Kelch domain-containing protein 5 (KLDC5_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KLHL42 Gene
Function for KLHL42 Gene
Molecular function for KLHL42 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated during mitosis.
Phenotypes From GWAS Catalog for KLHL42 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | contributes_to ubiquitin-protein transferase activity | IDA | 19261606 |
| GO:0005515 | protein binding | IEA,IPI | 16189514 |
Phenotypes for KLHL42 Gene
- MGI mutant phenotypes for KLHL42:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for KLHL42:
Animal Models for KLHL42 Gene
- MGI Knock Outs for KLHL42:
-
- Klhl42 Klhl42<tm1b(EUCOMM)Hmgu>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for KLHL42 - Starting at $85 >
- * KLHL42 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for KLHL42
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLHL42
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLHL42
miRNA for KLHL42 Gene
- miRTarBase miRNAs that target KLHL42
-
- hsa-miR-1-3p (MIRT003852)
- mmu-miR-425-5p (MIRT008651)
- mmu-miR-17-5p (MIRT010050)
- mmu-miR-26a-5p (MIRT011292)
- mmu-miR-34b-5p (MIRT012767)
- hsa-miR-615-3p (MIRT016145)
- hsa-miR-340-5p (MIRT019582)
- hsa-miR-181a-5p (MIRT025204)
- hsa-miR-192-5p (MIRT026594)
- hsa-miR-32-5p (MIRT028299)
- hsa-miR-21-5p (MIRT030926)
- hsa-miR-30c-5p (MIRT047964)
- hsa-miR-19a-3p (MIRT063998)
- hsa-miR-19b-3p (MIRT063999)
- hsa-miR-26a-5p (MIRT134087)
- hsa-miR-26b-5p (MIRT134088)
- hsa-miR-490-3p (MIRT134103)
- hsa-miR-92a-3p (MIRT134135)
- hsa-miR-92b-3p (MIRT134141)
- hsa-miR-155-5p (MIRT134158)
- hsa-miR-548a-3p (MIRT134163)
- hsa-miR-548e-3p (MIRT134168)
- hsa-miR-548f-3p (MIRT134169)
- hsa-miR-548ar-3p (MIRT134181)
- hsa-miR-548az-3p (MIRT134184)
- hsa-miR-6835-3p (MIRT134187)
- hsa-miR-200b-3p (MIRT271934)
- hsa-miR-200c-3p (MIRT271935)
- hsa-miR-429 (MIRT271936)
- hsa-miR-589-5p (MIRT271937)
- hsa-miR-593-5p (MIRT271938)
- hsa-miR-610 (MIRT271939)
- hsa-miR-3925-5p (MIRT271940)
- hsa-miR-29b-1-5p (MIRT336785)
- hsa-miR-299-5p (MIRT336786)
- hsa-miR-6715a-3p (MIRT336788)
- hsa-miR-124-3p (MIRT384397)
- hsa-miR-506-3p (MIRT384399)
- hsa-miR-3714 (MIRT384400)
- hsa-miR-3910 (MIRT384401)
- hsa-miR-3163 (MIRT405280)
- hsa-miR-6505-5p (MIRT405283)
- hsa-miR-7848-3p (MIRT522824)
- hsa-miR-892b (MIRT522825)
- hsa-miR-193b-3p (MIRT522826)
- hsa-miR-193a-3p (MIRT522827)
- hsa-miR-8084 (MIRT522828)
- hsa-miR-5582-3p (MIRT522829)
- hsa-miR-362-3p (MIRT542887)
- hsa-miR-329-3p (MIRT542888)
- hsa-miR-8485 (MIRT542889)
- hsa-miR-2054 (MIRT556672)
- hsa-miR-380-3p (MIRT556673)
- hsa-miR-4521 (MIRT562056)
- hsa-miR-144-5p (MIRT562057)
- hsa-miR-374c-3p (MIRT562058)
- hsa-miR-3941 (MIRT612814)
- hsa-miR-371a-5p (MIRT612815)
- hsa-miR-603 (MIRT612816)
- hsa-miR-6715b-3p (MIRT630778)
- hsa-miR-4422 (MIRT713380)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLHL42
- Browse OriGene Inhibitory RNA Products For KLHL42
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLHL42
Clone products for research
- Applied Biological Materials (abm): Clones for KLHL42 - Starting at $45 >
- * KLHL42 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for KLHL42
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLHL42
Cell Lines for research
-
Horizon Cell Lines for KLHL42
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLHL42 Gene
Localization for KLHL42 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KLHL42 Gene
- Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Predominantly in mitotic cells. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase cells is localized between the two sets of separated chromosomes as well as at the spindle poles. During telophase is localized arround the nuclei of the two daughter cells. Not detected at the midbody region during cytokinesis.
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| cytoskeleton | 3 |
| extracellular | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005819 | spindle | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0031463 | Cul3-RING ubiquitin ligase complex | IDA | 19261606 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLHL42 Gene
Pathways & Interactions for KLHL42 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for KLHL42 Gene
4 Reactome pathways for KLHL42 Gene
UniProtKB/Swiss-Prot Q9P2K6-KLH42_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for KLHL42 Gene
Selected Interacting proteins:
Q9P2K6-KLH42_HUMAN
ENSP00000370671
for KLHL42 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for KLHL42
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | IDA | 19261606 |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0032886 | regulation of microtubule-based process | IBA,IMP | 19261606 |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | IBA,IDA | 19261606 |
No data available for SIGNOR curated interactions for KLHL42 Gene
Transcripts for KLHL42 Gene
mRNA/cDNA for KLHL42 Gene
- 1 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000381271 6490 nts (view in UCSC)
- ENST00000539176 1894 nts (view in UCSC)
- ENST00000540301 793 nts (view in UCSC)
- ENST00000543254 772 nts (view in UCSC)
- ENST00000649445 3278 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for KLHL42 - Starting at $85 >
- * KLHL42 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for KLHL42
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLHL42
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLHL42
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLHL42
- Browse OriGene Inhibitory RNA Products For KLHL42
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLHL42
Clone products for research
- Applied Biological Materials (abm): Clones for KLHL42 - Starting at $45 >
- * KLHL42 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for KLHL42
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLHL42
Relevant External Links for KLHL42 Gene
- GeneLoc Exon Structure for
- KLHL42
Expression for KLHL42 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Trophoblast (Extraembryonic Tissues)
- Mural Trophectoderm Cells Mural Trophectoderm
This gene is overexpressed in Urinary Bladder (13.8), Colon (8.0), Seminal vesicle (7.2), Testis (6.7), and Fetal Brain (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KLHL42 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLHL42
SOURCE GeneReport for Unigene cluster for KLHL42 Gene:
Hs.505104Evidence on tissue expression from TISSUES for KLHL42 Gene
- Nervous system(4.8)
Primer products for research
-
OriGene qPCR primer pairs for KLHL42
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL42 Gene
Orthologs for KLHL42 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | KLHDC5 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | KLHL42 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | KLHL42 31 |
|
OneToOne | |
| KLHDC5 30 |
|
||||
| Mouse (Mus musculus) |
Mammalia | Klhl42 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Klhl42 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | KLHL42 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | KLHDC5 30 |
|
||
| KLHL42 31 |
|
OneToOne | |||
| Lizard (Anolis carolinensis) |
Reptilia | KLHL42 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | klhl42 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG1812 31 |
|
OneToMany |
- Species where no ortholog for KLHL42 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for KLHL42 Gene
- ENSEMBL:
- Gene Tree for KLHL42 (if available)
- TreeFam:
- Gene Tree for KLHL42 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KLHL42: view image
Paralogs for KLHL42 Gene
Paralogs for KLHL42 Gene
- KLHL13 5
- KLHL9 5
- KLHL32 5
- KBTBD11 5
- KLHL14 5
- KLHL26 5
- KLHL36 5
- KLHL15 5
- KLHL29 5
- KLHL21 5
- KLHL5 5
- KLHL28 5
- KBTBD13 5
- KLHL3 5
- IPP 5
- KLHL35 5
- KLHL34 5
- KLHL1 5
- KLHL17 5
- KEAP1 5
- KLHDC7B 5
- KLHL4 5
- KLHL18 5
- KLHL31 5
- KLHL38 5
- KLHL2 5
- KBTBD3 5
- KLHL6 5
- KLHL24 5
- KLHL20 5
- KLHL12 5
- KLHL7 5
- KLHDC7A 5
- KLHL8 5
- KLHL10 5
- GAN 5
- KLHL30 5
- KLHL22 5
- KLHL33 5
- KBTBD2 5
- KBTBD8 5
- KLHL41 5
- KLHL23 5
- KLHL40 5
- KBTBD12 5
- IVNS1ABP 5
- CCIN 5
- KBTBD6 5
- KBTBD7 5
- KLHDC8B 5
- BTBD18 5
- KLHDC8A 5
- BACH2 5
- GRIK1-AS2 5
- ENSG00000277971 5
(2) SIMAP similar genes for KLHL42 Gene using alignment to 3 proteins:
- KLH42_HUMAN
- F5H523_HUMAN
- H0YGN2_HUMAN
Variants for KLHL42 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2421n54 | CNV | gain | 21841781 |
| dgv2422n54 | CNV | gain+loss | 21841781 |
| dgv2423n54 | CNV | gain+loss | 21841781 |
| dgv2424n54 | CNV | gain | 21841781 |
| dgv2425n54 | CNV | gain+loss | 21841781 |
| dgv2426n54 | CNV | gain | 21841781 |
| dgv2427n54 | CNV | loss | 21841781 |
| dgv2428n54 | CNV | loss | 21841781 |
| dgv2429n54 | CNV | loss | 21841781 |
| esv2745664 | CNV | deletion | 23290073 |
| esv28802 | CNV | loss | 19812545 |
| nsv557824 | CNV | gain | 21841781 |
| nsv557829 | CNV | gain+loss | 21841781 |
| nsv557838 | CNV | loss | 21841781 |
| nsv557845 | CNV | gain | 21841781 |
| nsv557861 | CNV | gain | 21841781 |
| nsv557863 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
17.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.53;
11.53% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KLHL42 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KLHL42
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLHL42 Gene
Disorders for KLHL42 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bardet-biedl syndrome 10 |
|
|
Search KLHL42 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KLHL42
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for KLHL42 Gene
Publications for KLHL42 Gene
- The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells. (PMID: 19261606) Cummings CM … Singer JD (The Journal of biological chemistry 2009) 2 3 4
- Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis. (PMID: 32071084) Lear TB … Chen BB (The Journal of biological chemistry 2020) 2 3
- The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4
ExternalLinks
Products for KLHL42 Gene
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- Browse OriGene Inhibitory RNA Products For KLHL42
- OriGene qPCR primer pairs for KLHL42
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- Sino Biological Human cDNA Clone for KLHL42
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- High-throughput Antibody Production Service
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- Invitrogen Antibodies for KLHL42 (AFLGC-KLHL42)
- VectorBuilder Custom and pre-made DNA vectors for KLHL42 (ie. gene expression, shRNA knockdown, CRISPR)
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- antibodies-online: Show 4 available KLHL42 Antibodies ranked by validation data
- antibodies-online: Search results for available KLHL42 related products ranked by validation data
- antibodies-online: Search results for available KLHL42 related products ranked by validation data
- Horizon Cell Lines for KLHL42
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLHL42
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLHL42
- Boster Bio Antibodies for KLHL42
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Sources for KLHL42 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
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- (15) ProtoNet
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- (25) DrugBank
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- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
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- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB