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Aliases for KLHL38 Gene

Aliases for KLHL38 Gene

  • Kelch Like Family Member 38 2 3 5
  • C8ORFK36 3 4
  • Kelch-Like 38 (Drosophila) 2
  • Kelch-Like Protein 38 3
  • Kelch-Like 38 3

External Ids for KLHL38 Gene

Previous GeneCards Identifiers for KLHL38 Gene

  • GC08M124730
  • GC08M119983
  • GC08M124657

Summaries for KLHL38 Gene

GeneCards Summary for KLHL38 Gene

KLHL38 (Kelch Like Family Member 38) is a Protein Coding gene. An important paralog of this gene is KLHL29.

Additional gene information for KLHL38 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL38 Gene

Genomics for KLHL38 Gene

GeneHancer (GH) Regulatory Elements for KLHL38 Gene

Promoters and enhancers for KLHL38 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I123652 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.2 -200 3.7 PKNOX1 FOXA2 ZSCAN9 RAD21 RARA EGR2 RXRA NFIL3 CEBPA HNF4A KLHL38 LOC105375738 GC08P123594 LOC105375739
GH08I123516 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +136.7 136658 2.4 PKNOX1 IRF4 ETS1 ZNF121 FOS ATF7 RUNX3 SP3 JUNB MEF2D FBXO32 KLHL38 LOC105375738 GC08M123523 GC08M123499
GH08I123616 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.5 +35.5 35461 5 HDGF FOXA2 ARNT MLX ZFP64 ARID4B ZNF48 ZNF280A SLC30A9 CBX5 DERL1 FAM91A1 KLHL38 FBXO32 LOC105375738 GC08P123594
GH08I123688 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.2 -38.1 -38085 6 FOXA2 NFRKB RAD21 RARA RFX5 ZNF143 RUNX3 DEK SMARCA5 ZNF362 ANXA13 TATDN1 KLHL38 ATAD2 WDYHV1 LOC105375738 FBXO32 DUTP2 RNU6-875P MIR548AA1
GH08I123512 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 10.1 +141.3 141268 0.8 HDAC1 ATF1 ZBTB40 TCF12 ZNF766 ETV6 ATF7 CREM CEBPB MEF2D FBXO32 LOC105375738 KLHL38 GC08M123499 GC08M123523
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KLHL38 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLHL38 gene promoter:

Genomic Locations for KLHL38 Gene

Genomic Locations for KLHL38 Gene
chr8:123,645,505-123,653,866
(GRCh38/hg38)
Size:
8,362 bases
Orientation:
Minus strand
chr8:124,657,767-124,665,190
(GRCh37/hg19)

Genomic View for KLHL38 Gene

Genes around KLHL38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL38 Gene

Proteins for KLHL38 Gene

  • Protein details for KLHL38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2WGJ6-KLH38_HUMAN
    Recommended name:
    Kelch-like protein 38
    Protein Accession:
    Q2WGJ6
    Secondary Accessions:
    • A0PK12

    Protein attributes for KLHL38 Gene

    Size:
    581 amino acids
    Molecular mass:
    65541 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHL38 Gene

Post-translational modifications for KLHL38 Gene

No Post-translational modifications

Other Protein References for KLHL38 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL38 Gene

Domains & Families for KLHL38 Gene

Gene Families for KLHL38 Gene

Suggested Antigen Peptide Sequences for KLHL38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLHL38: view

No data available for UniProtKB/Swiss-Prot for KLHL38 Gene

Function for KLHL38 Gene

Phenotypes From GWAS Catalog for KLHL38 Gene

Gene Ontology (GO) - Molecular Function for KLHL38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding IPI 22939624
genes like me logo Genes that share ontologies with KLHL38: view
genes like me logo Genes that share phenotypes with KLHL38: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL38 Gene

Localization for KLHL38 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL38 gene
Compartment Confidence
nucleus 3
cytosol 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KLHL38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KLHL38: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHL38 Gene

Pathways & Interactions for KLHL38 Gene

SuperPathways for KLHL38 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHL38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with KLHL38: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL38 Gene

Drugs & Compounds for KLHL38 Gene

No Compound Related Data Available

Transcripts for KLHL38 Gene

mRNA/cDNA for KLHL38 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL38 Gene

Kelch-like family member 38:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL38 Gene

No ASD Table

Relevant External Links for KLHL38 Gene

GeneLoc Exon Structure for
KLHL38
ECgene alternative splicing isoforms for
KLHL38

Expression for KLHL38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHL38 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL38 Gene

This gene is overexpressed in Muscle - Skeletal (x31.9), Heart - Left Ventricle (x10.6), and Heart - Atrial Appendage (x4.1).

Protein differential expression in normal tissues from HIPED for KLHL38 Gene

This gene is overexpressed in Breast (46.9) and Peripheral blood mononuclear cells (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLHL38 Gene



Protein tissue co-expression partners for KLHL38 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLHL38 Gene:

KLHL38

SOURCE GeneReport for Unigene cluster for KLHL38 Gene:

Hs.450252

Evidence on tissue expression from TISSUES for KLHL38 Gene

  • Heart(4.3)
  • Muscle(4.3)
genes like me logo Genes that share expression patterns with KLHL38: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL38 Gene

Orthologs for KLHL38 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL38 33 34
  • 96.3 (n)
cow
(Bos Taurus)
Mammalia KLHL38 33 34
  • 87.05 (n)
dog
(Canis familiaris)
Mammalia KLHL38 33 34
  • 86.4 (n)
mouse
(Mus musculus)
Mammalia Klhl38 33 16 34
  • 84.25 (n)
rat
(Rattus norvegicus)
Mammalia Klhl38 33
  • 83.94 (n)
oppossum
(Monodelphis domestica)
Mammalia KLHL38 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL38 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLHL38 33 34
  • 72.52 (n)
lizard
(Anolis carolinensis)
Reptilia KLHL38 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl38 33
  • 66.26 (n)
zebrafish
(Danio rerio)
Actinopterygii klhl38a 33 34
  • 60.24 (n)
klhl38b 34
  • 51 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6535 33
Species where no ortholog for KLHL38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL38 Gene

ENSEMBL:
Gene Tree for KLHL38 (if available)
TreeFam:
Gene Tree for KLHL38 (if available)

Paralogs for KLHL38 Gene

(13) SIMAP similar genes for KLHL38 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLHL38: view

Variants for KLHL38 Gene

Sequence variations from dbSNP and Humsavar for KLHL38 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000221852 -- 123,653,212(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000223787 -- 123,651,717(-) A/C coding_sequence_variant, missense_variant
rs1000854489 -- 123,649,301(-) A/C intron_variant
rs1001136823 -- 123,654,059(-) G/A upstream_transcript_variant
rs1001364539 -- 123,648,630(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL38 Gene

Variant ID Type Subtype PubMed ID
nsv1032155 CNV loss 25217958
nsv612140 CNV loss 21841781
nsv831450 CNV gain 17160897

Variation tolerance for KLHL38 Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.43; 88.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLHL38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHL38

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL38 Gene

Disorders for KLHL38 Gene

Additional Disease Information for KLHL38

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KLHL38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL38 Gene

Publications for KLHL38 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations. (PMID: 25055868) Sano M … Japan Pharmacogenomics Data Science Consortium (JPDSC) (Human molecular genetics 2014) 3 58
  3. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M … Lindquist S (Cell 2014) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa BS … Friedman JS (Human genomics 2013) 3 58

Products for KLHL38 Gene

Sources for KLHL38 Gene

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