Aliases for KLHL36 Gene

Aliases for KLHL36 Gene

  • Kelch Like Family Member 36 2 3 5
  • Kelch-Like Protein 36 3 4
  • C16orf44 3 4
  • Chromosome 16 Open Reading Frame 44 2
  • Kelch-Like 36 (Drosophila) 2
  • Kelch-Like 36 3

External Ids for KLHL36 Gene

Previous HGNC Symbols for KLHL36 Gene

  • C16orf44

Previous GeneCards Identifiers for KLHL36 Gene

  • GC16P083240
  • GC16P084682
  • GC16P070437

Summaries for KLHL36 Gene

GeneCards Summary for KLHL36 Gene

KLHL36 (Kelch Like Family Member 36) is a Protein Coding gene. An important paralog of this gene is KLHL13.

UniProtKB/Swiss-Prot Summary for KLHL36 Gene

  • Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Additional gene information for KLHL36 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLHL36 Gene

Genomics for KLHL36 Gene

GeneHancer (GH) Regulatory Elements for KLHL36 Gene

Promoters and enhancers for KLHL36 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLHL36 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLHL36 gene promoter:
  • AhR
  • Arnt
  • ATF
  • c-Myc
  • CREB
  • deltaCREB
  • Elk-1
  • En-1
  • Nkx2-2
  • Pax-5

Genomic Locations for KLHL36 Gene

Genomic Locations for KLHL36 Gene
chr16:84,648,511-84,667,686
(GRCh38/hg38)
Size:
19,176 bases
Orientation:
Plus strand
chr16:84,682,131-84,701,292
(GRCh37/hg19)
Size:
19,162 bases
Orientation:
Plus strand

Genomic View for KLHL36 Gene

Genes around KLHL36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL36 Gene

Proteins for KLHL36 Gene

  • Protein details for KLHL36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4N3-KLH36_HUMAN
    Recommended name:
    Kelch-like protein 36
    Protein Accession:
    Q8N4N3
    Secondary Accessions:
    • Q8N5G6
    • Q9H9U6

    Protein attributes for KLHL36 Gene

    Size:
    616 amino acids
    Molecular mass:
    69896 Da
    Quaternary structure:
    • Interacts with CUL3.

    Alternative splice isoforms for KLHL36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHL36 Gene

Post-translational modifications for KLHL36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL36 Gene

No data available for DME Specific Peptides for KLHL36 Gene

Domains & Families for KLHL36 Gene

Gene Families for KLHL36 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KLHL36 Gene

GenScript: Design optimal peptide antigens:
  • Kelch-like protein 36 (KLH36_HUMAN)
genes like me logo Genes that share domains with KLHL36: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KLHL36 Gene

Function for KLHL36 Gene

Molecular function for KLHL36 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Phenotypes From GWAS Catalog for KLHL36 Gene

genes like me logo Genes that share phenotypes with KLHL36: view

Animal Model Products

CRISPR Products

miRNA for KLHL36 Gene

miRTarBase miRNAs that target KLHL36

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLHL36

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL36 Gene

Localization for KLHL36 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL36 gene
Compartment Confidence
nucleus 1
cytosol 1
plasma membrane 0
mitochondrion 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL36 Gene

Pathways & Interactions for KLHL36 Gene

PathCards logo

SuperPathways for KLHL36 Gene

No Data Available

UniProtKB/Swiss-Prot Q8N4N3-KLH36_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for KLHL36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with KLHL36: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL36 Gene

Drugs & Compounds for KLHL36 Gene

No Compound Related Data Available

Transcripts for KLHL36 Gene

mRNA/cDNA for KLHL36 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLHL36

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL36 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - - -
SP2: - - - - - -
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for KLHL36 Gene

GeneLoc Exon Structure for
KLHL36
ECgene alternative splicing isoforms for
KLHL36

Expression for KLHL36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHL36 Gene

Protein differential expression in normal tissues from HIPED for KLHL36 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.4), Pancreas (11.9), Testis (10.3), and Plasma (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KLHL36 Gene



Protein tissue co-expression partners for KLHL36 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KLHL36 Gene:

KLHL36

SOURCE GeneReport for Unigene cluster for KLHL36 Gene:

Hs.578546

Evidence on tissue expression from TISSUES for KLHL36 Gene

  • Blood(4.1)
genes like me logo Genes that share expression patterns with KLHL36: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL36 Gene

Orthologs for KLHL36 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL36 33 32
  • 99.62 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KLHL36 33 32
  • 92.97 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL36 33 32
  • 92.8 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL36 33
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLHL36 33
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhl36 17 33 32
  • 86.35 (n)
rat
(Rattus norvegicus)
Mammalia Klhl36 32
  • 85.97 (n)
chicken
(Gallus gallus)
Aves KLHL36 33 32
  • 74.96 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl36 32
  • 68.62 (n)
zebrafish
(Danio rerio)
Actinopterygii klhl36 33 32
  • 63.75 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4879 32
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 31 (a)
ManyToMany
-- 33
  • 31 (a)
ManyToMany
CSA.449 33
  • 31 (a)
ManyToMany
Species where no ortholog for KLHL36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL36 Gene

ENSEMBL:
Gene Tree for KLHL36 (if available)
TreeFam:
Gene Tree for KLHL36 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLHL36: view image

Paralogs for KLHL36 Gene

(35) SIMAP similar genes for KLHL36 Gene using alignment to 4 proteins:

  • KLH36_HUMAN
  • H3BPB9_HUMAN
  • H3BQE9_HUMAN
  • H3BQW5_HUMAN
genes like me logo Genes that share paralogs with KLHL36: view

Variants for KLHL36 Gene

Sequence variations from dbSNP and Humsavar for KLHL36 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000141679 -- 84,651,694(+) T/C intron_variant
rs1000148983 -- 84,663,440(+) C/A/G 3_prime_UTR_variant, non_coding_transcript_variant
rs1000180647 -- 84,663,239(+) C/G 3_prime_UTR_variant, non_coding_transcript_variant
rs1000218197 -- 84,649,506(+) G/A intron_variant
rs1000477222 -- 84,653,771(+) C/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL36 Gene

Variant ID Type Subtype PubMed ID
dgv1373n106 CNV deletion 24896259
nsv483044 CNV gain 15286789
nsv833311 CNV loss 17160897

Variation tolerance for KLHL36 Gene

Residual Variation Intolerance Score: 3.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLHL36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHL36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL36 Gene

Disorders for KLHL36 Gene

Additional Disease Information for KLHL36

No disorders were found for KLHL36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL36 Gene

Publications for KLHL36 Gene

  1. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PMID: 20966902) Croteau-Chonka DC … Mohlke KL (Obesity (Silver Spring, Md.) 2011) 3 43 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for KLHL36 Gene

  • Biorbyt antibodies for KLHL36

Sources for KLHL36 Gene