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Aliases for KLHL36 Gene

Aliases for KLHL36 Gene

  • Kelch Like Family Member 36 2 3 5
  • C16orf44 3 4
  • Chromosome 16 Open Reading Frame 44 2
  • Kelch-Like 36 (Drosophila) 2
  • Kelch-Like Protein 36 3
  • Kelch-Like 36 3

External Ids for KLHL36 Gene

Previous HGNC Symbols for KLHL36 Gene

  • C16orf44

Previous GeneCards Identifiers for KLHL36 Gene

  • GC16P083240
  • GC16P084682
  • GC16P070437

Summaries for KLHL36 Gene

GeneCards Summary for KLHL36 Gene

KLHL36 (Kelch Like Family Member 36) is a Protein Coding gene. An important paralog of this gene is KLHL9.

UniProtKB/Swiss-Prot for KLHL36 Gene

  • Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Additional gene information for KLHL36 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL36 Gene

Genomics for KLHL36 Gene

GeneHancer (GH) Regulatory Elements for KLHL36 Gene

Promoters and enhancers for KLHL36 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I084647 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 570.2 +1.0 966 4.1 ATF1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B ZNF48 YY1 GLIS2 KLHL36 LOC105371376 TAF1C ENSG00000261243 COTL1 USP10 HSDL1
GH16I085565 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 72.1 +920.6 920648 7.5 HDGF PKNOX1 CLOCK SMAD1 ARNT NEUROD1 SIN3A FEZF1 YBX1 ZNF2 ENSG00000270184 MTHFSD RNU1-103P KLHL36 RN7SL381P ZDHHC7 ENSG00000260859 CRISPLD2 EMC8 GSE1
GH16I085518 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 72 +874.2 874152 8.2 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 ZNF548 NFYC SSRP1 ENSG00000270184 KLHL36 RNU1-103P RN7SL381P ZDHHC7 CRISPLD2 GSE1 TLDC1 ENSG00000260859 EMC8
GH16I085609 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.3 +966.1 966066 9.6 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 GSE1 ENSG00000270184 MTHFSD RNU1-103P RN7SL381P KLHL36 ZDHHC7 GC16P085626 ENSG00000260417
GH16I085552 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 20.3 +907.8 907830 7.4 CLOCK MLX FEZF1 YY1 ZNF213 ZNF263 SP3 PPARGC1A MEF2D GLIS1 ENSG00000270184 MTHFSD RNU1-103P KLHL36 ZDHHC7 RN7SL381P GSE1 GINS2 GC16P085552 ENSG00000270124
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KLHL36 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLHL36 gene promoter:

Genomic Locations for KLHL36 Gene

Genomic Locations for KLHL36 Gene
chr16:84,648,511-84,667,686
(GRCh38/hg38)
Size:
19,176 bases
Orientation:
Plus strand
chr16:84,682,131-84,701,292
(GRCh37/hg19)

Genomic View for KLHL36 Gene

Genes around KLHL36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL36 Gene

Proteins for KLHL36 Gene

  • Protein details for KLHL36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4N3-KLH36_HUMAN
    Recommended name:
    Kelch-like protein 36
    Protein Accession:
    Q8N4N3
    Secondary Accessions:
    • Q8N5G6
    • Q9H9U6

    Protein attributes for KLHL36 Gene

    Size:
    616 amino acids
    Molecular mass:
    69896 Da
    Quaternary structure:
    • Interacts with CUL3.

    Alternative splice isoforms for KLHL36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHL36 Gene

Post-translational modifications for KLHL36 Gene

No Post-translational modifications

No data available for DME Specific Peptides for KLHL36 Gene

Domains & Families for KLHL36 Gene

Gene Families for KLHL36 Gene

Suggested Antigen Peptide Sequences for KLHL36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLHL36: view

No data available for UniProtKB/Swiss-Prot for KLHL36 Gene

Function for KLHL36 Gene

Molecular function for KLHL36 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Phenotypes From GWAS Catalog for KLHL36 Gene

Gene Ontology (GO) - Molecular Function for KLHL36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KLHL36: view
genes like me logo Genes that share phenotypes with KLHL36: view

Animal Model Products

miRNA for KLHL36 Gene

miRTarBase miRNAs that target KLHL36

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL36 Gene

Localization for KLHL36 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL36 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KLHL36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KLHL36: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHL36 Gene

Pathways & Interactions for KLHL36 Gene

SuperPathways for KLHL36 Gene

No Data Available

UniProtKB/Swiss-Prot Q8N4N3-KLH36_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for KLHL36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with KLHL36: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL36 Gene

Drugs & Compounds for KLHL36 Gene

No Compound Related Data Available

Transcripts for KLHL36 Gene

Unigene Clusters for KLHL36 Gene

Kelch-like family member 36:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL36 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - - -
SP2: - - - - - -
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for KLHL36 Gene

GeneLoc Exon Structure for
KLHL36
ECgene alternative splicing isoforms for
KLHL36

Expression for KLHL36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHL36 Gene

Protein differential expression in normal tissues from HIPED for KLHL36 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.4), Pancreas (11.9), Testis (10.3), and Plasma (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KLHL36 Gene



Protein tissue co-expression partners for KLHL36 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KLHL36 Gene:

KLHL36

SOURCE GeneReport for Unigene cluster for KLHL36 Gene:

Hs.578546

Evidence on tissue expression from TISSUES for KLHL36 Gene

  • Blood(4.1)
genes like me logo Genes that share expression patterns with KLHL36: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL36 Gene

Orthologs for KLHL36 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL36 33 34
  • 99.62 (n)
cow
(Bos Taurus)
Mammalia KLHL36 33 34
  • 92.97 (n)
dog
(Canis familiaris)
Mammalia KLHL36 33 34
  • 92.8 (n)
oppossum
(Monodelphis domestica)
Mammalia KLHL36 34
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL36 34
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhl36 33 16 34
  • 86.35 (n)
rat
(Rattus norvegicus)
Mammalia Klhl36 33
  • 85.97 (n)
chicken
(Gallus gallus)
Aves KLHL36 33 34
  • 74.96 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl36 33
  • 68.62 (n)
zebrafish
(Danio rerio)
Actinopterygii klhl36 33 34
  • 63.75 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4879 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
CSA.449 34
  • 31 (a)
ManyToMany
Species where no ortholog for KLHL36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL36 Gene

ENSEMBL:
Gene Tree for KLHL36 (if available)
TreeFam:
Gene Tree for KLHL36 (if available)

Paralogs for KLHL36 Gene

Variants for KLHL36 Gene

Sequence variations from dbSNP and Humsavar for KLHL36 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000141679 -- 84,651,694(+) T/C intron_variant
rs1000148983 -- 84,663,440(+) C/G 3_prime_UTR_variant, non_coding_transcript_variant
rs1000180647 -- 84,663,239(+) C/G 3_prime_UTR_variant, non_coding_transcript_variant
rs1000218197 -- 84,649,506(+) G/A intron_variant
rs1000477222 -- 84,653,771(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL36 Gene

Variant ID Type Subtype PubMed ID
dgv1373n106 CNV deletion 24896259
nsv483044 CNV gain 15286789
nsv833311 CNV loss 17160897

Variation tolerance for KLHL36 Gene

Residual Variation Intolerance Score: 3.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLHL36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHL36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL36 Gene

Disorders for KLHL36 Gene

Additional Disease Information for KLHL36

No disorders were found for KLHL36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL36 Gene

Publications for KLHL36 Gene

  1. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PMID: 20966902) Croteau-Chonka DC … Mohlke KL (Obesity (Silver Spring, Md.) 2011) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for KLHL36 Gene

Sources for KLHL36 Gene

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