Aliases for KLHL34 Gene

Aliases for KLHL34 Gene

  • Kelch Like Family Member 34 2 3 5
  • Kelch-Like Protein 34 3 4
  • RP11-450P7.3 2 3
  • Kelch-Like 34 (Drosophila) 2
  • Kelch-Like 34 3
  • FLJ34960 2
  • KLHL34 5

External Ids for KLHL34 Gene

Previous GeneCards Identifiers for KLHL34 Gene

  • GC0XM021583
  • GC0XM019415

Summaries for KLHL34 Gene

GeneCards Summary for KLHL34 Gene

KLHL34 (Kelch Like Family Member 34) is a Protein Coding gene. Diseases associated with KLHL34 include Ullrich Congenital Muscular Dystrophy 1. An important paralog of this gene is KLHL32.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLHL34 Gene

Genomics for KLHL34 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KLHL34 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ021658 Promoter/Enhancer 1 Ensembl ENCODE 250.7 -0.4 -371 1.8 ZNF623 ZNF433 HNF4A REST ZBTB21 AEBP2 ZNF140 ZC3H11A ZNF560 ZBTB8A HSALNG0136946 HSALNG0136947 KLHL34 YY2 SMPX
GH0XJ021656 Enhancer 0.2 Ensembl 250.7 +1.4 1429 0.6 HSALNG0136946 KLHL34 HSALNG0136944 CNKSR2
GH0XJ021659 Enhancer 0.2 Ensembl 250.7 -1.8 -1771 0.6 HSALNG0136946 HSALNG0136947 KLHL34 HSALNG0136948 SMPX
GH0XJ021634 Enhancer 0.2 Ensembl 13.4 +23.8 23829 0.2 KLHL34 HSALNG0136944 piR-48369-213 CNKSR2
GH0XJ021703 Enhancer 0.2 Ensembl 13.3 -45.8 -45771 0.6 KLHL34 piR-60112-010 SMPX
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLHL34 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLHL34

Top Transcription factor binding sites by QIAGEN in the KLHL34 gene promoter:
  • AhR
  • C/EBPalpha
  • C/EBPbeta
  • FOXI1
  • HFH-3
  • Msx-1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • YY1

Genomic Locations for KLHL34 Gene

Latest Assembly
3,641 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
3,641 bases
Minus strand

(GRCh37/hg19 by Ensembl)
2,840 bases
Minus strand

Genomic View for KLHL34 Gene

Genes around KLHL34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL34 Gene

Proteins for KLHL34 Gene

  • Protein details for KLHL34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 34
    Protein Accession:

    Protein attributes for KLHL34 Gene

    644 amino acids
    Molecular mass:
    70612 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHL34 Gene

Post-translational modifications for KLHL34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL34 Gene

Domains & Families for KLHL34 Gene

Gene Families for KLHL34 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KLHL34 Gene

  • BTB/POZ domain
  • BTB/Kelch-associated

Suggested Antigen Peptide Sequences for KLHL34 Gene

GenScript: Design optimal peptide antigens:
  • Kelch-like protein 34 (KLH34_HUMAN)
genes like me logo Genes that share domains with KLHL34: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KLHL34 Gene

Function for KLHL34 Gene

Gene Ontology (GO) - Molecular Function for KLHL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with KLHL34: view
genes like me logo Genes that share phenotypes with KLHL34: view

miRNA for KLHL34 Gene

miRTarBase miRNAs that target KLHL34

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLHL34

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL34 Gene

Localization for KLHL34 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL34 gene
Compartment Confidence
extracellular 4
mitochondrion 2
cytoskeleton 1
cytosol 1
nucleus 0

Gene Ontology (GO) - Cellular Components for KLHL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
genes like me logo Genes that share ontologies with KLHL34: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KLHL34 Gene

Pathways & Interactions for KLHL34 Gene

PathCards logo

SuperPathways for KLHL34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHL34 Gene


No data available for Pathways by source and SIGNOR curated interactions for KLHL34 Gene

Drugs & Compounds for KLHL34 Gene

No Compound Related Data Available

Transcripts for KLHL34 Gene

mRNA/cDNA for KLHL34 Gene

4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLHL34

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL34 Gene

No ASD Table

Relevant External Links for KLHL34 Gene

GeneLoc Exon Structure for

Expression for KLHL34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLHL34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLHL34 Gene

This gene is overexpressed in Muscle - Skeletal (x23.8) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for KLHL34 Gene

This gene is overexpressed in Placenta (10.2), Testis (7.5), and Heart (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLHL34 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLHL34

SOURCE GeneReport for Unigene cluster for KLHL34 Gene:

genes like me logo Genes that share expression patterns with KLHL34: view

Primer products for research

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL34 Gene

Orthologs for KLHL34 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHL34 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLHL34 30 31
  • 98.94 (n)
(Bos Taurus)
Mammalia KLHL34 30 31
  • 87.06 (n)
(Canis familiaris)
Mammalia KLHL34 30 31
  • 86.43 (n)
(Mus musculus)
Mammalia Klhl34 30 17 31
  • 79.68 (n)
(Rattus norvegicus)
Mammalia Klhl34 30
  • 78.9 (n)
(Monodelphis domestica)
Mammalia KLHL34 31
  • 71 (a)
(Gallus gallus)
Aves KLHL34 30 31
  • 59.06 (n)
(Anolis carolinensis)
Reptilia KLHL34 31
  • 53 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia klhl34 30
  • 53.5 (n)
(Danio rerio)
Actinopterygii LOC561692 30
  • 50 (n)
KLHL34 31
  • 41 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG1812 31
  • 24 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
-- 31
  • 23 (a)
CSA.8418 31
  • 22 (a)
Species where no ortholog for KLHL34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for KLHL34 Gene

Gene Tree for KLHL34 (if available)
Gene Tree for KLHL34 (if available)
Evolutionary constrained regions (ECRs) for KLHL34: view image

Paralogs for KLHL34 Gene

Variants for KLHL34 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KLHL34 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for KLHL34 Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 29.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLHL34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for KLHL34 Gene

Disorders for KLHL34 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLHL34 Gene - From: COP

Disorder Aliases PubMed IDs
ullrich congenital muscular dystrophy 1
  • ucmd1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for KLHL34

genes like me logo Genes that share disorders with KLHL34: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLHL34 Gene

Publications for KLHL34 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa BS … Friedman JS (Human genomics 2013) 3

Products for KLHL34 Gene

Sources for KLHL34 Gene