Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KLHL31 Gene

Aliases for KLHL31 Gene

  • Kelch Like Family Member 31 2 3 5
  • Kelch Repeat And BTB Domain-Containing Protein 1 3 4
  • Kelch Repeat And BTB (POZ) Domain Containing 1 2 3
  • BTB And Kelch Domain-Containing Protein 6 3 4
  • Kelch-Like Protein KLHL 3 4
  • KBTBD1 3 4
  • BKLHD6 3 4
  • KLHL 3 4
  • Kelch-Like 31 (Drosophila) 2
  • Kelch-Like Protein 31 3
  • BA345L23.2 3

External Ids for KLHL31 Gene

Previous HGNC Symbols for KLHL31 Gene

  • KBTBD1

Previous GeneCards Identifiers for KLHL31 Gene

  • GC06M053513
  • GC06M053344

Summaries for KLHL31 Gene

GeneCards Summary for KLHL31 Gene

KLHL31 (Kelch Like Family Member 31) is a Protein Coding gene. An important paralog of this gene is KLHL9.

UniProtKB/Swiss-Prot for KLHL31 Gene

  • Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).

Additional gene information for KLHL31 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL31 Gene

Genomics for KLHL31 Gene

GeneHancer (GH) Regulatory Elements for KLHL31 Gene

Promoters and enhancers for KLHL31 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I053664 Promoter/Enhancer 1.1 EPDnew ENCODE dbSUPER 556.8 +0.8 841 1.6 SP1 USF1 ZNF366 KLHL31 GCLC LINC01564
GH06I053791 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.4 -129.0 -129022 5.8 FOXA2 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 KLF13 SP3 LRRC1 ENSG00000228614 KLHL31 MLIP-IT1 ENSG00000227885 PIR32511
GH06I053718 Enhancer 0.7 ENCODE 18.5 -53.3 -53304 1.3 CTCF PKNOX1 BATF IRF4 RAD21 RFX5 SCRT2 SMC3 ZNF143 DEK KLHL31 ENSG00000227885
GH06I053733 Enhancer 1 Ensembl ENCODE 11 -69.0 -69016 3 RAD21 ZNF335 ZNF366 SCRT2 ZNF143 FOS RUNX3 ELK4 ZNF654 ZNF362 KLHL31 MLIP-IT1 LRRC1 ENSG00000227885
GH06I053492 Enhancer 1 Ensembl ENCODE 10.8 +172.6 172624 1.2 BMI1 DNMT3B RAD21 ARID2 ZNF143 MIXL1 ZNF654 REST PRDM6 CBX8 KLHL31 GC06M053483 GC06P053483 LOC105375095
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KLHL31 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLHL31 gene promoter:

Genomic Locations for KLHL31 Gene

Genomic Locations for KLHL31 Gene
17,946 bases
Minus strand

Genomic View for KLHL31 Gene

Genes around KLHL31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL31 Gene

Proteins for KLHL31 Gene

  • Protein details for KLHL31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 31
    Protein Accession:
    Secondary Accessions:
    • A6N9J2
    • B2RP49

    Protein attributes for KLHL31 Gene

    634 amino acids
    Molecular mass:
    70246 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHL31 Gene

Post-translational modifications for KLHL31 Gene

Other Protein References for KLHL31 Gene

No data available for DME Specific Peptides for KLHL31 Gene

Domains & Families for KLHL31 Gene

Gene Families for KLHL31 Gene

Suggested Antigen Peptide Sequences for KLHL31 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLHL31: view

No data available for UniProtKB/Swiss-Prot for KLHL31 Gene

Function for KLHL31 Gene

Molecular function for KLHL31 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).

Phenotypes From GWAS Catalog for KLHL31 Gene

Gene Ontology (GO) - Molecular Function for KLHL31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KLHL31: view
genes like me logo Genes that share phenotypes with KLHL31: view

Animal Model Products

CRISPR Products

miRNA for KLHL31 Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL31 Gene

Localization for KLHL31 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL31 gene
Compartment Confidence
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for KLHL31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KLHL31: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KLHL31 Gene

Pathways & Interactions for KLHL31 Gene

SuperPathways for KLHL31 Gene

No Data Available

Interacting Proteins for KLHL31 Gene

Gene Ontology (GO) - Biological Process for KLHL31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with KLHL31: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL31 Gene

Drugs & Compounds for KLHL31 Gene

No Compound Related Data Available

Transcripts for KLHL31 Gene

mRNA/cDNA for KLHL31 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL31 Gene

Kelch-like family member 31:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL31 Gene

No ASD Table

Relevant External Links for KLHL31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHL31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLHL31 Gene

This gene is overexpressed in Heart - Left Ventricle (x23.1), Heart - Atrial Appendage (x13.2), and Muscle - Skeletal (x9.4).

Protein differential expression in normal tissues from HIPED for KLHL31 Gene

This gene is overexpressed in Heart (55.8) and Fetal heart (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLHL31 Gene

Protein tissue co-expression partners for KLHL31 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLHL31 Gene:


SOURCE GeneReport for Unigene cluster for KLHL31 Gene:


mRNA Expression by UniProt/SwissProt for KLHL31 Gene:

Tissue specificity: Strongly expressed in skeletal muscle and weakly in heart. According to PubMed:15302408, not expressed in other tissues. According to PubMed:18719355, abundantly expressed in both embryonic skeletal and heart tissues.

Evidence on tissue expression from TISSUES for KLHL31 Gene

  • Heart(2.8)
  • Muscle(2.8)
genes like me logo Genes that share expression patterns with KLHL31: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL31 Gene

Orthologs for KLHL31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL31 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLHL31 33 34
  • 99.26 (n)
(Bos Taurus)
Mammalia KLHL31 34
  • 92 (a)
(Canis familiaris)
Mammalia KLHL31 33 34
  • 91.13 (n)
(Monodelphis domestica)
Mammalia KLHL31 34
  • 88 (a)
(Rattus norvegicus)
Mammalia Klhl31 33
  • 87.34 (n)
(Mus musculus)
Mammalia Klhl31 33 16 34
  • 87.13 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 87 (a)
-- 34
  • 86 (a)
(Gallus gallus)
Aves KLHL31 33 34
  • 77.07 (n)
(Anolis carolinensis)
Reptilia KLHL31 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl31 33
  • 73.93 (n)
(Danio rerio)
Actinopterygii klhl31 33 34
  • 69.82 (n)
Species where no ortholog for KLHL31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL31 Gene

Gene Tree for KLHL31 (if available)
Gene Tree for KLHL31 (if available)

Paralogs for KLHL31 Gene

(12) SIMAP similar genes for KLHL31 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLHL31: view

Variants for KLHL31 Gene

Sequence variations from dbSNP and Humsavar for KLHL31 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000250309 -- 53,648,152(-) A/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000301291 -- 53,648,378(-) A/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000826008 -- 53,666,307(-) G/T upstream_transcript_variant
rs1001174716 -- 53,666,495(-) G/A upstream_transcript_variant
rs1001198070 -- 53,659,580(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL31 Gene

Variant ID Type Subtype PubMed ID
esv2732097 CNV deletion 23290073
nsv1034955 CNV gain 25217958
nsv519037 CNV loss 19592680

Variation tolerance for KLHL31 Gene

Residual Variation Intolerance Score: 72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.16; 51.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLHL31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL31 Gene

Disorders for KLHL31 Gene

Additional Disease Information for KLHL31

No disorders were found for KLHL31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL31 Gene

Publications for KLHL31 Gene

  1. A novel zebrafish kelchlike gene klhl and its human ortholog KLHL display conserved expression patterns in skeletal and cardiac muscles. (PMID: 15302408) Wu YL … Gong Z (Gene 2004) 3 4 22 58
  2. A novel human BTB-kelch protein KLHL31, strongly expressed in muscle and heart, inhibits transcriptional activities of TRE and SRE. (PMID: 18719355) Yu W … Wu X (Molecules and cells 2008) 3 4 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  4. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa BS … Friedman JS (Human genomics 2013) 3 58
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58

Products for KLHL31 Gene

Sources for KLHL31 Gene

Loading form....