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Aliases for KLHL29 Gene

Aliases for KLHL29 Gene

  • Kelch Like Family Member 29 2 3 5
  • Kelch Repeat And BTB Domain-Containing Protein 9 3 4
  • Kelch Repeat And BTB (POZ) Domain Containing 9 2 3
  • KBTBD9 3 4
  • Kelch-Like 29 (Drosophila) 2
  • Kelch-Like Protein 29 3
  • Kelch-Like 29 3
  • KIAA1921 4

External Ids for KLHL29 Gene

Previous HGNC Symbols for KLHL29 Gene

  • KBTBD9

Previous GeneCards Identifiers for KLHL29 Gene

  • GC02P023460
  • GC02P023608

Summaries for KLHL29 Gene

GeneCards Summary for KLHL29 Gene

KLHL29 (Kelch Like Family Member 29) is a Protein Coding gene. An important paralog of this gene is KLHL24.

Additional gene information for KLHL29 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL29 Gene

Genomics for KLHL29 Gene

GeneHancer (GH) Regulatory Elements for KLHL29 Gene

Promoters and enhancers for KLHL29 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I023384 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.3 270 2.6 CTCF MXI1 ZNF777 SUZ12 BACH1 SIN3A EBF1 ZNF335 ZFHX2 GLIS2 KLHL29 PFN4 GC02P023420
GH02I023410 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 561.6 +26.8 26795 2.5 ZSCAN4 CEBPB RCOR1 FOSL2 FOS KLHL29 ENSG00000235497 GC02P023420
GH02I023350 Enhancer 1 Ensembl ENCODE 11 -33.5 -33494 1.7 ELF3 RB1 ZNF48 RAD21 ZNF335 ZNF143 RCOR1 RUNX3 CREM MIER2 ENSG00000235497 KLHL29 ENSG00000233714 ENSG00000223634
GH02I023497 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.1 +112.0 112036 0.5 POLR2A VEZF1 MAX ZIC2 MYC RUNX3 LOC105374325 KLHL29 ENSG00000235497 GC02M023498 GC02P023420
GH02I023425 Enhancer 0.8 Ensembl ENCODE 12 +41.5 41455 2.8 STAT1 USF1 HLF USF2 KLF17 CEBPB NR2F2 GATA3 FOS KLHL29 ENSG00000235497 GC02P023420 GC02M023498
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KLHL29 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLHL29 gene promoter:

Genomic Locations for KLHL29 Gene

Genomic Locations for KLHL29 Gene
chr2:23,385,217-23,708,613
(GRCh38/hg38)
Size:
323,397 bases
Orientation:
Plus strand
chr2:23,608,088-23,931,483
(GRCh37/hg19)

Genomic View for KLHL29 Gene

Genes around KLHL29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL29 Gene

Proteins for KLHL29 Gene

  • Protein details for KLHL29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CT2-KLH29_HUMAN
    Recommended name:
    Kelch-like protein 29
    Protein Accession:
    Q96CT2
    Secondary Accessions:
    • Q8N388
    • Q96BF0
    • Q96PW7

    Protein attributes for KLHL29 Gene

    Size:
    875 amino acids
    Molecular mass:
    94228 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH13982.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH15667.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB67814.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAD39171.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHL29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHL29 Gene

Post-translational modifications for KLHL29 Gene

No Post-translational modifications

Other Protein References for KLHL29 Gene

No data available for DME Specific Peptides for KLHL29 Gene

Domains & Families for KLHL29 Gene

Gene Families for KLHL29 Gene

Suggested Antigen Peptide Sequences for KLHL29 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLHL29: view

No data available for UniProtKB/Swiss-Prot for KLHL29 Gene

Function for KLHL29 Gene

Phenotypes From GWAS Catalog for KLHL29 Gene

Gene Ontology (GO) - Molecular Function for KLHL29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KLHL29: view
genes like me logo Genes that share phenotypes with KLHL29: view

Animal Models for KLHL29 Gene

MGI Knock Outs for KLHL29:

Animal Model Products

miRNA for KLHL29 Gene

miRTarBase miRNAs that target KLHL29

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLHL29 Gene

Localization for KLHL29 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL29 gene
Compartment Confidence
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KLHL29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KLHL29: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHL29 Gene

Pathways & Interactions for KLHL29 Gene

SuperPathways for KLHL29 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHL29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with KLHL29: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL29 Gene

Drugs & Compounds for KLHL29 Gene

No Compound Related Data Available

Transcripts for KLHL29 Gene

mRNA/cDNA for KLHL29 Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL29 Gene

Kelch-like family member 29:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL29 Gene

No ASD Table

Relevant External Links for KLHL29 Gene

GeneLoc Exon Structure for
KLHL29
ECgene alternative splicing isoforms for
KLHL29

Expression for KLHL29 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHL29 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLHL29 Gene

This gene is overexpressed in Plasma (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLHL29 Gene



Protein tissue co-expression partners for KLHL29 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KLHL29 Gene:

KLHL29

SOURCE GeneReport for Unigene cluster for KLHL29 Gene:

Hs.130593

Evidence on tissue expression from TISSUES for KLHL29 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with KLHL29: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL29 Gene

Orthologs for KLHL29 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL29 33 34
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia KLHL29 33 34
  • 93.64 (n)
cow
(Bos Taurus)
Mammalia KLHL29 33 34
  • 92.27 (n)
rat
(Rattus norvegicus)
Mammalia Klhl29 33
  • 91.09 (n)
mouse
(Mus musculus)
Mammalia Klhl29 33 16 34
  • 90.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL29 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLHL29 33 34
  • 79.06 (n)
lizard
(Anolis carolinensis)
Reptilia KLHL29 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl29 33
  • 74.27 (n)
zebrafish
(Danio rerio)
Actinopterygii KLHL29 34
  • 75 (a)
OneToMany
KLHL29 (1 of 2) 34
  • 73 (a)
OneToMany
LOC100334314 33
  • 71.83 (n)
Species where no ortholog for KLHL29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL29 Gene

ENSEMBL:
Gene Tree for KLHL29 (if available)
TreeFam:
Gene Tree for KLHL29 (if available)

Paralogs for KLHL29 Gene

genes like me logo Genes that share paralogs with KLHL29: view

Variants for KLHL29 Gene

Sequence variations from dbSNP and Humsavar for KLHL29 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000005592 -- 23,603,894(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000008316 -- 23,589,054(+) C/A/T genic_upstream_transcript_variant, intron_variant
rs1000011375 -- 23,471,710(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000028249 -- 23,461,268(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000028844 -- 23,668,973(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL29 Gene

Variant ID Type Subtype PubMed ID
nsv581176 CNV gain 21841781
nsv581173 CNV loss 21841781
nsv527636 CNV gain 19592680
nsv455886 CNV loss 19166990
nsv2639 CNV insertion 18451855
nsv214546 CNV deletion 16902084
nsv1134840 CNV deletion 24896259
nsv1126543 CNV deletion 24896259
nsv1004502 CNV gain 25217958
esv9475 CNV gain 19470904
esv3590059 CNV loss 21293372
esv3590058 CNV loss 21293372
esv3553744 CNV deletion 23714750
esv3445895 CNV duplication 20981092
esv3393749 CNV duplication 20981092
esv2719813 CNV deletion 23290073
esv2719812 CNV deletion 23290073
esv27159 CNV loss 19812545
esv2639907 CNV deletion 19546169
esv2552237 CNV deletion 19546169
esv1295316 CNV deletion 17803354
dgv6732n54 CNV gain 21841781
nsv997445 CNV gain 25217958
nsv978983 CNV duplication 23825009
nsv953756 CNV deletion 24416366
nsv833570 CNV gain 17160897
nsv581178 CNV loss 21841781
nsv581177 CNV loss 21841781

Variation tolerance for KLHL29 Gene

Gene Damage Index Score: 2.80; 47.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLHL29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHL29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL29 Gene

Disorders for KLHL29 Gene

Additional Disease Information for KLHL29

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KLHL29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL29 Gene

Publications for KLHL29 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
  2. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PMID: 21347282) Lettre G … Boerwinkle E (PLoS genetics 2011) 3 44 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58

Products for KLHL29 Gene

Sources for KLHL29 Gene

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