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Aliases for KLHL26 Gene

Aliases for KLHL26 Gene

  • Kelch Like Family Member 26 2 3 5
  • Kelch-Like 26 (Drosophila) 2

External Ids for KLHL26 Gene

Previous GeneCards Identifiers for KLHL26 Gene

  • GC19P018609
  • GC19P018747
  • GC19P018309

Summaries for KLHL26 Gene

GeneCards Summary for KLHL26 Gene

KLHL26 (Kelch Like Family Member 26) is a Protein Coding gene. An important paralog of this gene is KLHL13.

Additional gene information for KLHL26 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL26 Gene

Genomics for KLHL26 Gene

GeneHancer (GH) Regulatory Elements for KLHL26 Gene

Promoters and enhancers for KLHL26 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I018636 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 555.6 +0.4 386 2.7 HDGF PKNOX1 ATF1 GLI4 ZNF2 ZBTB7B YY1 TCF12 POLR2B GLIS2 KLHL26 NR2C2AP ENSG00000268030 TMEM161A MAU2 RPL18A CRTC1 SNORA68
GH19I018635 Enhancer 0.8 ENCODE dbSUPER 550.8 -1.8 -1819 0.2 KLF1 HLF BHLHE40 KLF17 CBFA2T3 ZIC2 RAD21 ZBTB48 HDAC2 POLR2A KLHL26 RN7SL155P
GH19I018168 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 5 -465.0 -465042 7.4 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZBTB7B IFI30 MPV17L2 LRRC25 ENSG00000268938 MEF2B MVB12A ENSG00000268030 PGLS UPF1 ENSG00000269191
GH19I018603 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 5.4 -28.3 -28251 11.1 ATF1 FOXA2 ARID4B DMAP1 ZNF2 ZNF48 ETS1 GLIS2 ATF7 KLF13 CRLF1 TMEM59L GC19P020238 UBA52 REX1BD KLHL26 SSBP4 KXD1 CRTC1 GDF1
GH19I018648 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 5.2 +13.2 13193 3.6 RXRA ZNF266 ZIC2 NR2F2 ZFHX2 POLR2A ZSCAN5C ZNF341 ZBTB33 ZNF600 ENSG00000268030 UPF1 ENSG00000268938 NR2C2AP ENSG00000269191 MAU2 IQCN MEF2B ELL CRTC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KLHL26 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLHL26 gene promoter:

Genomic Locations for KLHL26 Gene

Genomic Locations for KLHL26 Gene
chr19:18,636,965-18,671,714
(GRCh38/hg38)
Size:
34,750 bases
Orientation:
Plus strand
chr19:18,747,775-18,781,309
(GRCh37/hg19)

Genomic View for KLHL26 Gene

Genes around KLHL26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL26 Gene

Proteins for KLHL26 Gene

  • Protein details for KLHL26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53HC5-KLH26_HUMAN
    Recommended name:
    Kelch-like protein 26
    Protein Accession:
    Q53HC5
    Secondary Accessions:
    • Q8TAP0
    • Q9NUX3

    Protein attributes for KLHL26 Gene

    Size:
    615 amino acids
    Molecular mass:
    68139 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHL26 Gene

Post-translational modifications for KLHL26 Gene

  • Ubiquitination at posLast=329329, isoforms=447, and posLast=491491

No data available for DME Specific Peptides for KLHL26 Gene

Domains & Families for KLHL26 Gene

Gene Families for KLHL26 Gene

Suggested Antigen Peptide Sequences for KLHL26 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLHL26: view

No data available for UniProtKB/Swiss-Prot for KLHL26 Gene

Function for KLHL26 Gene

Phenotypes From GWAS Catalog for KLHL26 Gene

Gene Ontology (GO) - Molecular Function for KLHL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KLHL26: view
genes like me logo Genes that share phenotypes with KLHL26: view

Animal Model Products

miRNA for KLHL26 Gene

miRTarBase miRNAs that target KLHL26

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL26 Gene

Localization for KLHL26 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL26 gene
Compartment Confidence
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KLHL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KLHL26: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KLHL26 Gene

Pathways & Interactions for KLHL26 Gene

SuperPathways for KLHL26 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007286 spermatid development IBA --
GO:0008584 male gonad development IBA --
GO:0009566 fertilization IBA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with KLHL26: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL26 Gene

Drugs & Compounds for KLHL26 Gene

No Compound Related Data Available

Transcripts for KLHL26 Gene

Unigene Clusters for KLHL26 Gene

Kelch-like family member 26:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL26 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: - - -
SP3: -
SP4: - -

Relevant External Links for KLHL26 Gene

GeneLoc Exon Structure for
KLHL26
ECgene alternative splicing isoforms for
KLHL26

Expression for KLHL26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHL26 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL26 Gene

This gene is overexpressed in Artery - Tibial (x4.0).

Protein differential expression in normal tissues from HIPED for KLHL26 Gene

This gene is overexpressed in Testis (20.3), Gallbladder (14.2), CD8 Tcells (8.7), Retina (8.3), Colon (8.2), and Fetal ovary (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KLHL26 Gene



Protein tissue co-expression partners for KLHL26 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLHL26 Gene:

KLHL26

SOURCE GeneReport for Unigene cluster for KLHL26 Gene:

Hs.250632

Evidence on tissue expression from TISSUES for KLHL26 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with KLHL26: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL26 Gene

Orthologs for KLHL26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL26 33 34
  • 99.72 (n)
cow
(Bos Taurus)
Mammalia KLHL26 33 34
  • 90.82 (n)
dog
(Canis familiaris)
Mammalia KLHL26 33 34
  • 89.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL26 34
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhl26 33
  • 83.33 (n)
mouse
(Mus musculus)
Mammalia Klhl26 33 16 34
  • 83.05 (n)
oppossum
(Monodelphis domestica)
Mammalia KLHL26 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLHL26 33
  • 78.38 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 30 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl26 33
  • 68.13 (n)
zebrafish
(Danio rerio)
Actinopterygii klhl26 33 34
  • 70.57 (n)
wufi20e10 33
Species where no ortholog for KLHL26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL26 Gene

ENSEMBL:
Gene Tree for KLHL26 (if available)
TreeFam:
Gene Tree for KLHL26 (if available)

Paralogs for KLHL26 Gene

Variants for KLHL26 Gene

Sequence variations from dbSNP and Humsavar for KLHL26 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000018416 -- 18,639,933(+) G/A intron_variant
rs1000052547 -- 18,656,620(+) G/A intron_variant
rs1000100033 -- 18,662,260(+) C/G/T intron_variant
rs1000143534 -- 18,642,996(+) A/G intron_variant
rs1000220741 -- 18,658,300(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL26 Gene

Variant ID Type Subtype PubMed ID
dgv6297n54 CNV loss 21841781
nsv952422 CNV deletion 24416366
nsv833776 CNV loss 17160897
nsv578775 CNV loss 21841781
nsv578774 CNV loss 21841781
nsv578773 CNV loss 21841781
nsv578772 CNV loss 21841781
nsv578766 CNV gain 21841781
nsv578761 CNV loss 21841781
nsv578760 CNV gain+loss 21841781
nsv578759 CNV loss 21841781
nsv472611 CNV novel sequence insertion 20440878
nsv1151217 CNV deletion 26484159
nsv1142931 CNV tandem duplication 24896259
nsv1141785 CNV insertion 24896259
esv25959 CNV loss 19812545
esv24559 CNV gain 19812545
dgv6299n54 CNV loss 21841781
dgv6298n54 CNV gain+loss 21841781

Variation tolerance for KLHL26 Gene

Residual Variation Intolerance Score: 2.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 27.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLHL26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHL26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL26 Gene

Disorders for KLHL26 Gene

Additional Disease Information for KLHL26

No disorders were found for KLHL26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL26 Gene

Publications for KLHL26 Gene

  1. Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts. (PMID: 22419666) Shi M … Beaty TH (American journal of medical genetics. Part A 2012) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for KLHL26 Gene

Sources for KLHL26 Gene

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