Aliases for KLHL21 Gene

Aliases for KLHL21 Gene

  • Kelch Like Family Member 21 2 3 5
  • Kelch-Like Protein 21 3 4
  • KIAA0469 2 4
  • Kelch-Like 21 (Drosophila) 2
  • KLHL21 5

External Ids for KLHL21 Gene

Previous GeneCards Identifiers for KLHL21 Gene

  • GC01M006586
  • GC01M005798
  • GC01M006650

Summaries for KLHL21 Gene

GeneCards Summary for KLHL21 Gene

KLHL21 (Kelch Like Family Member 21) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is KLHL30.

UniProtKB/Swiss-Prot Summary for KLHL21 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.

Additional gene information for KLHL21 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLHL21 Gene

Genomics for KLHL21 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KLHL21 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLHL21 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLHL21

Top Transcription factor binding sites by QIAGEN in the KLHL21 gene promoter:
  • Bach1
  • CHOP-10
  • FOXL1
  • Lmo2
  • MIF-1
  • NF-E2
  • NF-E2 p45
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for KLHL21 Gene

Genomic Locations for KLHL21 Gene
chr1:6,590,724-6,614,607
(GRCh38/hg38)
Size:
23,884 bases
Orientation:
Minus strand
chr1:6,650,784-6,674,667
(GRCh37/hg19)
Size:
23,884 bases
Orientation:
Minus strand

Genomic View for KLHL21 Gene

Genes around KLHL21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL21 Gene

Proteins for KLHL21 Gene

  • Protein details for KLHL21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJP4-KLH21_HUMAN
    Recommended name:
    Kelch-like protein 21
    Protein Accession:
    Q9UJP4
    Secondary Accessions:
    • B3KQP2
    • O75057
    • Q5SY26
    • Q5SY28
    • Q8N4I6
    • Q8NF10

    Protein attributes for KLHL21 Gene

    Size:
    597 amino acids
    Molecular mass:
    66617 Da
    Quaternary structure:
    • Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL21 and RBX1.
    SequenceCaution:
    • Sequence=BAA32314.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHL21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHL21 Gene

Post-translational modifications for KLHL21 Gene

  • Ubiquitination at Lys33, Lys194, and Lys370
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL21 Gene

No data available for DME Specific Peptides for KLHL21 Gene

Domains & Families for KLHL21 Gene

Gene Families for KLHL21 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KLHL21 Gene

InterPro:
Blocks:
  • BTB/POZ domain
  • BTB/Kelch-associated
ProtoNet:

Suggested Antigen Peptide Sequences for KLHL21 Gene

GenScript: Design optimal peptide antigens:
  • Kelch-like protein 21 (KLH21_HUMAN)
genes like me logo Genes that share domains with KLHL21: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KLHL21 Gene

Function for KLHL21 Gene

Molecular function for KLHL21 Gene

UniProtKB/Swiss-Prot Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.

Phenotypes From GWAS Catalog for KLHL21 Gene

Gene Ontology (GO) - Molecular Function for KLHL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA 19995937
GO:0005515 protein binding IEA --
GO:0097602 cullin family protein binding IPI 14528312
genes like me logo Genes that share ontologies with KLHL21: view
genes like me logo Genes that share phenotypes with KLHL21: view

Animal Models for KLHL21 Gene

MGI Knock Outs for KLHL21:
  • Klhl21 Klhl21<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for KLHL21 Gene

miRTarBase miRNAs that target KLHL21

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLHL21

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLHL21 Gene

Localization for KLHL21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHL21 Gene

Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle midzone and targets CUL3 to this region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL21 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 2
golgi apparatus 2
plasma membrane 1
extracellular 1
mitochondrion 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KLHL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
GO:0005827 polar microtubule IDA 19995937
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KLHL21: view

Pathways & Interactions for KLHL21 Gene

genes like me logo Genes that share pathways with KLHL21: view

UniProtKB/Swiss-Prot Q9UJP4-KLH21_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for KLHL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006513 protein monoubiquitination IBA --
GO:0007049 cell cycle IEA --
GO:0016567 protein ubiquitination IEA,IDA 19995937
GO:0032465 regulation of cytokinesis IMP 19995937
GO:0035853 chromosome passenger complex localization to spindle midzone IMP 19995937
genes like me logo Genes that share ontologies with KLHL21: view

No data available for SIGNOR curated interactions for KLHL21 Gene

Drugs & Compounds for KLHL21 Gene

No Compound Related Data Available

Transcripts for KLHL21 Gene

mRNA/cDNA for KLHL21 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLHL21

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL21 Gene

No ASD Table

Relevant External Links for KLHL21 Gene

GeneLoc Exon Structure for
KLHL21

Expression for KLHL21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLHL21 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL21 Gene

This gene is overexpressed in Muscle - Skeletal (x5.5).

Protein differential expression in normal tissues from HIPED for KLHL21 Gene

This gene is overexpressed in Bone (30.7) and Platelet (25.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KLHL21 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLHL21

SOURCE GeneReport for Unigene cluster for KLHL21 Gene:

Hs.7764

Evidence on tissue expression from TISSUES for KLHL21 Gene

  • Nervous system(4.9)
  • Spleen(4.2)
  • Skin(4.1)
  • Lung(3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with KLHL21: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL21 Gene

Orthologs for KLHL21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL21 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KLHL21 30 31
  • 98.81 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia KLHL21 31
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia KLHL21 30 31
  • 92.52 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KLHL21 30 31
  • 91.96 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Klhl21 30
  • 90.03 (n)
Mouse
(Mus musculus)
Mammalia Klhl21 30 17 31
  • 89.61 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia KLHL21 31
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KLHL21 30 31
  • 79.52 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia klhl21 30
  • 68.98 (n)
Str.8269 30
Zebrafish
(Danio rerio)
Actinopterygii klhl21 30 31
  • 67.85 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 42 (a)
OneToOne
Species where no ortholog for KLHL21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for KLHL21 Gene

ENSEMBL:
Gene Tree for KLHL21 (if available)
TreeFam:
Gene Tree for KLHL21 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLHL21: view image

Paralogs for KLHL21 Gene

(20) SIMAP similar genes for KLHL21 Gene using alignment to 6 proteins:

  • KLH21_HUMAN
  • K7ELI0_HUMAN
  • K7EMF2_HUMAN
  • K7ESH2_HUMAN
  • L8E9P8_HUMAN
  • Q2NKK7_HUMAN
genes like me logo Genes that share paralogs with KLHL21: view

Variants for KLHL21 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLHL21 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1292721663 Uncertain Significance: Ependymoma 6,602,317(-) C/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for KLHL21 Gene

Structural Variations from Database of Genomic Variants (DGV) for KLHL21 Gene

Variant ID Type Subtype PubMed ID
nsv545269 CNV loss 21841781
nsv7880 CNV gain+loss 18304495
nsv826253 CNV gain 20364138
nsv831536 CNV loss 17160897
nsv955151 CNV deletion 24416366

Variation tolerance for KLHL21 Gene

Gene Damage Index Score: 2.84; 47.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLHL21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHL21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL21 Gene

Disorders for KLHL21 Gene

Additional Disease Information for KLHL21

No disorders were found for KLHL21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL21 Gene

Publications for KLHL21 Gene

  1. The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. (PMID: 19995937) Maerki S … Peter M (The Journal of cell biology 2009) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4
  4. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. (PMID: 14528312) Furukawa M … Xiong Y (Nature cell biology 2003) 3 4
  5. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4

Products for KLHL21 Gene

Sources for KLHL21 Gene