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Aliases for KLHL18 Gene

Aliases for KLHL18 Gene

  • Kelch Like Family Member 18 2 3 5
  • Kelch-Like 18 (Drosophila) 2
  • Kelch-Like Protein 18 3
  • KIAA0795 4

External Ids for KLHL18 Gene

Previous GeneCards Identifiers for KLHL18 Gene

  • GC03P047299
  • GC03P047325

Summaries for KLHL18 Gene

GeneCards Summary for KLHL18 Gene

KLHL18 (Kelch Like Family Member 18) is a Protein Coding gene. An important paralog of this gene is KLHL17.

Gene Wiki entry for KLHL18 Gene

Additional gene information for KLHL18 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL18 Gene

Genomics for KLHL18 Gene

GeneHancer (GH) Regulatory Elements for KLHL18 Gene

Promoters and enhancers for KLHL18 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J047280 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 650.7 +0.5 503 4.7 CLOCK MLX YBX1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 ZNF263 KIF9 KLHL18 PTPN23 DHX30 ZNF589 SETD2 BOLA2P2 CCDC12 SCAP NBEAL2
GH03J048085 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.1 +805.1 805061 5.3 CLOCK FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZNF263 MAP4 ATRIP DHX30 ZNF589 SETD2 ENSG00000235236 PTPN23 BOLA2P2 SCAP TMEM89
GH03J047379 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.2 +97.8 97849 3.3 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC PTPN23 ENSG00000260236 SETD2 ZNF589 NME6 CCDC12 MRPS18AP1 BOLA2P2 SCAP DHX30
GH03J047346 Enhancer 1.2 Ensembl ENCODE 11.4 +64.7 64676 1 PKNOX1 SMAD1 ARNT YBX1 IRF4 TCF12 ZNF766 GATA2 E2F8 ZNF207 ENSG00000280173 NBEAL2 SETD2 CCDC12 SCAP BOLA2P2 ZNF589 KIF9 KLHL18 KIF9-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLHL18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLHL18 gene promoter:
  • c-Ets-1
  • GCNF-2
  • GCNF-1
  • GCNF
  • Ik-3
  • PPAR-alpha
  • AML1a
  • AREB6
  • AP-4
  • FOXO4

Genomic Locations for KLHL18 Gene

Genomic Locations for KLHL18 Gene
63,977 bases
Plus strand
63,977 bases
Plus strand

Genomic View for KLHL18 Gene

Genes around KLHL18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL18 Gene

Proteins for KLHL18 Gene

  • Protein details for KLHL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 18
    Protein Accession:
    Secondary Accessions:
    • A8K612
    • Q7Z3E8
    • Q8N125

    Protein attributes for KLHL18 Gene

    574 amino acids
    Molecular mass:
    63638 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH32620.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD97920.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHL18 Gene


neXtProt entry for KLHL18 Gene

Post-translational modifications for KLHL18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KLHL18 Gene

Domains & Families for KLHL18 Gene

Gene Families for KLHL18 Gene

Protein Domains for KLHL18 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLHL18: view

No data available for UniProtKB/Swiss-Prot for KLHL18 Gene

Function for KLHL18 Gene

Phenotypes From GWAS Catalog for KLHL18 Gene

Gene Ontology (GO) - Molecular Function for KLHL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KLHL18: view
genes like me logo Genes that share phenotypes with KLHL18: view

Animal Models for KLHL18 Gene

MGI Knock Outs for KLHL18:
  • Klhl18 Klhl18<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLHL18

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLHL18 Gene

Localization for KLHL18 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL18 gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KLHL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KLHL18: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHL18 Gene

Pathways & Interactions for KLHL18 Gene

SuperPathways for KLHL18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with KLHL18: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL18 Gene

Drugs & Compounds for KLHL18 Gene

No Compound Related Data Available

Transcripts for KLHL18 Gene

Unigene Clusters for KLHL18 Gene

Kelch-like family member 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLHL18

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL18 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14
SP1: - - - - - -
SP2: - -
SP3: - - - - -
SP5: - - -
SP6: - - - - - -
SP7: -
SP8: -

Relevant External Links for KLHL18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHL18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLHL18 Gene

This gene is overexpressed in Retina (39.9) and Testis (29.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KLHL18 Gene

Protein tissue co-expression partners for KLHL18 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLHL18 Gene:


SOURCE GeneReport for Unigene cluster for KLHL18 Gene:


Evidence on tissue expression from TISSUES for KLHL18 Gene

  • Nervous system(4.6)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with KLHL18: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL18 Gene

Orthologs for KLHL18 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHL18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLHL18 34 33
  • 99.54 (n)
(Bos Taurus)
Mammalia KLHL18 34
  • 96 (a)
LOC100847139 33
  • 91.7 (n)
(Monodelphis domestica)
Mammalia KLHL18 34
  • 92 (a)
(Canis familiaris)
Mammalia KLHL18 34 33
  • 91.41 (n)
(Mus musculus)
Mammalia Klhl18 16 34 33
  • 91.11 (n)
(Rattus norvegicus)
Mammalia Klhl18 33
  • 90.77 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 39 (a)
(Gallus gallus)
Aves KLHL18 34 33
  • 83.54 (n)
(Anolis carolinensis)
Reptilia KLHL18 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl18 33
  • 79.63 (n)
(Danio rerio)
Actinopterygii klhl18 34 33
  • 74.63 (n)
wufi18c08 33
fruit fly
(Drosophila melanogaster)
Insecta KLHL18 34 33
  • 58.23 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011142 33
  • 57.95 (n)
(Caenorhabditis elegans)
Secernentea kel-3 34 33
  • 50 (n)
Species where no ortholog for KLHL18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLHL18 Gene

Gene Tree for KLHL18 (if available)
Gene Tree for KLHL18 (if available)
Evolutionary constrained regions (ECRs) for KLHL18: view image

Paralogs for KLHL18 Gene

(51) SIMAP similar genes for KLHL18 Gene using alignment to 8 proteins:

  • C9J4G4_HUMAN
  • F8WF78_HUMAN
  • Q647K1_HUMAN
  • Q96B51_HUMAN
genes like me logo Genes that share paralogs with KLHL18: view

Variants for KLHL18 Gene

Sequence variations from dbSNP and Humsavar for KLHL18 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000007578 -- 47,314,756(+) TTTT/TTT intron_variant
rs1000049746 -- 47,316,889(+) G/T intron_variant
rs1000058195 -- 47,321,346(+) G/T intron_variant
rs1000063514 -- 47,308,671(+) G/A intron_variant
rs1000241339 -- 47,322,727(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL18 Gene

Variant ID Type Subtype PubMed ID
esv2417653 CNV deletion 18987734
nsv1007714 CNV gain 25217958
nsv1076853 CNV insertion 25765185
nsv1116986 CNV deletion 24896259
nsv1117335 CNV tandem duplication 24896259
nsv1151504 CNV insertion 26484159
nsv428417 CNV loss 18775914
nsv955590 CNV deletion 24416366

Variation tolerance for KLHL18 Gene

Residual Variation Intolerance Score: 12.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLHL18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL18 Gene

Disorders for KLHL18 Gene

Additional Disease Information for KLHL18

No disorders were found for KLHL18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL18 Gene

Publications for KLHL18 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58

Products for KLHL18 Gene

Sources for KLHL18 Gene

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