Aliases for KLHL13 Gene
External Ids for KLHL13 Gene
Previous HGNC Symbols for KLHL13 Gene
Previous GeneCards Identifiers for KLHL13 Gene
This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
GeneCards Summary for KLHL13 Gene
KLHL13 (Kelch Like Family Member 13) is a Protein Coding gene. Among its related pathways are Aurora B signaling and Ubiquitin mediated proteolysis. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is KLHL9.
UniProtKB/Swiss-Prot Summary for KLHL13 Gene
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.