Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KLHL11 Gene

Aliases for KLHL11 Gene

  • Kelch Like Family Member 11 2 3 5
  • Kelch-Like 11 (Drosophila) 2
  • Kelch-Like Protein 11 3

External Ids for KLHL11 Gene

Previous GeneCards Identifiers for KLHL11 Gene

  • GC00U991260
  • GC17M040383
  • GC17M037263
  • GC17M040004
  • GC17M035772
  • GC17M040009

Summaries for KLHL11 Gene

GeneCards Summary for KLHL11 Gene

KLHL11 (Kelch Like Family Member 11) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. An important paralog of this gene is CCIN.

UniProtKB/Swiss-Prot for KLHL11 Gene

  • Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

Additional gene information for KLHL11 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL11 Gene

Genomics for KLHL11 Gene

GeneHancer (GH) Regulatory Elements for KLHL11 Gene

Promoters and enhancers for KLHL11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J041864 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.4 407 1.9 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF143 SP3 KLHL11 NT5C3B PLEKHH3 CCR10 KAT2A HSD17B1P1 HSD17B1 ENSG00000259623
GH17J041687 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 21.1 +175.0 175032 6.1 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 EIF1 GC17P041691 GC17P041692 ENSG00000267758 ENSG00000259623 KLHL10 CNTNAP1 HSD17B1 NT5C3B KAT2A
GH17J041781 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11 +80.8 80846 6.8 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 ZBTB7B YY1 POLR2B JUP KLHL10 ACLY HSD17B1 ENSG00000267765 DHX58 KLHL11 KAT2A ENSG00000267758 PLEKHH3
GH17J042386 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.9 -523.0 -523017 4.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 STAT3 GC17M042386 NBR1 ENSG00000267765 ENSG00000267002 KLHL10 HMGN1P29 ENSG00000267758 ENSG00000267340 TUBG2
GH17J042576 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.9 -712.8 -712753 4.2 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 GC17P042577 GC17P042580 PSMC3IP DHX8 HMGN1P29 ENSG00000267758 TUBG2 NBR2 MLX STAT5A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLHL11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLHL11 gene promoter:
  • STAT5B
  • Max1
  • N-Myc
  • Ik-1
  • NF-1
  • GATA-6
  • MyoD
  • SREBP-1c
  • SREBP-1b
  • SREBP-1a

Genomic Locations for KLHL11 Gene

Genomic Locations for KLHL11 Gene
16,914 bases
Minus strand
11,888 bases
Minus strand

Genomic View for KLHL11 Gene

Genes around KLHL11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL11 Gene

Proteins for KLHL11 Gene

  • Protein details for KLHL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 11
    Protein Accession:

    Protein attributes for KLHL11 Gene

    708 amino acids
    Molecular mass:
    80148 Da
    Quaternary structure:
    • Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity). Homodimer. Interacts with CUL3.

    Three dimensional structures from OCA and Proteopedia for KLHL11 Gene

neXtProt entry for KLHL11 Gene

Post-translational modifications for KLHL11 Gene

  • Ubiquitination at Lys682, Lys521, Lys489, isoforms=480, Lys469, Lys454, and Lys298
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL11 Gene

Domains & Families for KLHL11 Gene

Gene Families for KLHL11 Gene

Suggested Antigen Peptide Sequences for KLHL11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLHL11: view

No data available for UniProtKB/Swiss-Prot for KLHL11 Gene

Function for KLHL11 Gene

Molecular function for KLHL11 Gene

UniProtKB/Swiss-Prot Function:
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

Phenotypes From GWAS Catalog for KLHL11 Gene

Gene Ontology (GO) - Molecular Function for KLHL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IBA --
genes like me logo Genes that share ontologies with KLHL11: view
genes like me logo Genes that share phenotypes with KLHL11: view

Animal Model Products

miRNA for KLHL11 Gene

miRTarBase miRNAs that target KLHL11

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL11 Gene

Localization for KLHL11 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL11 gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 2
plasma membrane 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for KLHL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KLHL11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KLHL11 Gene

Pathways & Interactions for KLHL11 Gene

genes like me logo Genes that share pathways with KLHL11: view

Gene Ontology (GO) - Biological Process for KLHL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030162 regulation of proteolysis IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with KLHL11: view

No data available for SIGNOR curated interactions for KLHL11 Gene

Drugs & Compounds for KLHL11 Gene

No Compound Related Data Available

Transcripts for KLHL11 Gene

mRNA/cDNA for KLHL11 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(125) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL11 Gene

Kelch-like family member 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL11 Gene

No ASD Table

Relevant External Links for KLHL11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHL11 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL11 Gene

This gene is overexpressed in Testis (x6.4).

Protein differential expression in normal tissues from HIPED for KLHL11 Gene

This gene is overexpressed in Pancreatic juice (29.6), Platelet (11.3), and Peripheral blood mononuclear cells (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KLHL11 Gene

Protein tissue co-expression partners for KLHL11 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLHL11 Gene:


SOURCE GeneReport for Unigene cluster for KLHL11 Gene:

genes like me logo Genes that share expression patterns with KLHL11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL11 Gene

Orthologs for KLHL11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLHL11 34
  • 100 (a)
(Canis familiaris)
Mammalia KLHL11 34 33
  • 93.13 (n)
(Bos Taurus)
Mammalia KLHL11 34 33
  • 91.57 (n)
(Mus musculus)
Mammalia Klhl11 16 34 33
  • 89.6 (n)
(Rattus norvegicus)
Mammalia Klhl11 33
  • 89.21 (n)
(Monodelphis domestica)
Mammalia KLHL11 34
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia KLHL11 34
  • 83 (a)
(Gallus gallus)
Aves KLHL11 34 33
  • 75.77 (n)
(Anolis carolinensis)
Reptilia KLHL11 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl11 33
  • 68.86 (n)
(Danio rerio)
Actinopterygii klhl11 34 33
  • 68.83 (n)
wufd21e01 33
Species where no ortholog for KLHL11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL11 Gene

Gene Tree for KLHL11 (if available)
Gene Tree for KLHL11 (if available)
Evolutionary constrained regions (ECRs) for KLHL11: view image

Paralogs for KLHL11 Gene

Paralogs for KLHL11 Gene

genes like me logo Genes that share paralogs with KLHL11: view

Variants for KLHL11 Gene

Sequence variations from dbSNP and Humsavar for KLHL11 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000043828 -- 41,864,776(-) T/C intron_variant
rs1000049906 -- 41,861,591(-) C/G intron_variant
rs1000142918 -- 41,861,373(-) C/T intron_variant
rs1000251684 -- 41,854,632(-) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000512178 -- 41,866,479(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL11 Gene

Variant ID Type Subtype PubMed ID
dgv415e201 CNV deletion 23290073
esv2715943 CNV deletion 23290073
esv3640596 CNV loss 21293372
nsv1057008 CNV gain 25217958
nsv1146669 OTHER inversion 26484159
nsv833447 CNV loss 17160897

Variation tolerance for KLHL11 Gene

Residual Variation Intolerance Score: 9.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLHL11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL11 Gene

Disorders for KLHL11 Gene

Additional Disease Information for KLHL11

No disorders were found for KLHL11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL11 Gene

Publications for KLHL11 Gene

  1. Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases. (PMID: 23349464) Canning P … Bullock AN (The Journal of biological chemistry 2013) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for KLHL11 Gene

Sources for KLHL11 Gene

Loading form....