Aliases for KLHL11 Gene

Aliases for KLHL11 Gene

  • Kelch Like Family Member 11 2 3 5
  • Kelch-Like Protein 11 3 4
  • Kelch-Like 11 (Drosophila) 2
  • FLJ10572 2
  • KLHL11 5

External Ids for KLHL11 Gene

Previous GeneCards Identifiers for KLHL11 Gene

  • GC00U991260
  • GC17M040383
  • GC17M037263
  • GC17M040004
  • GC17M035772
  • GC17M040009

Summaries for KLHL11 Gene

GeneCards Summary for KLHL11 Gene

KLHL11 (Kelch Like Family Member 11) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is BTBD9.

UniProtKB/Swiss-Prot Summary for KLHL11 Gene

  • Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLHL11 Gene

Genomics for KLHL11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KLHL11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLHL11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLHL11

Top Transcription factor binding sites by QIAGEN in the KLHL11 gene promoter:
  • GATA-6
  • Ik-1
  • Max1
  • MyoD
  • N-Myc
  • NF-1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • STAT5B

Genomic Locations for KLHL11 Gene

Latest Assembly
chr17:41,848,514-41,865,423
(GRCh38/hg38)
Size:
16,910 bases
Orientation:
Minus strand

Previous Assembly
chr17:40,004,770-40,021,676
(GRCh37/hg19 by Entrez Gene)
Size:
16,907 bases
Orientation:
Minus strand

chr17:40,009,797-40,021,684
(GRCh37/hg19 by Ensembl)
Size:
11,888 bases
Orientation:
Minus strand

Genomic View for KLHL11 Gene

Genes around KLHL11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL11 Gene

Proteins for KLHL11 Gene

  • Protein details for KLHL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVR0-KLH11_HUMAN
    Recommended name:
    Kelch-like protein 11
    Protein Accession:
    Q9NVR0

    Protein attributes for KLHL11 Gene

    Size:
    708 amino acids
    Molecular mass:
    80148 Da
    Quaternary structure:
    • Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity). Homodimer. Interacts with CUL3.

    Three dimensional structures from OCA and Proteopedia for KLHL11 Gene

neXtProt entry for KLHL11 Gene

Post-translational modifications for KLHL11 Gene

  • Ubiquitination at Lys298, Lys454, Lys469, Lys480, Lys489, Lys521, and Lys682
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL11 Gene

Domains & Families for KLHL11 Gene

Gene Families for KLHL11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KLHL11 Gene

InterPro:
Blocks:
  • BTB/POZ domain
  • BTB/Kelch-associated
ProtoNet:

Suggested Antigen Peptide Sequences for KLHL11 Gene

GenScript: Design optimal peptide antigens:
  • Kelch-like protein 11 (KLH11_HUMAN)
genes like me logo Genes that share domains with KLHL11: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KLHL11 Gene

Function for KLHL11 Gene

Molecular function for KLHL11 Gene

UniProtKB/Swiss-Prot Function:
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

Phenotypes From GWAS Catalog for KLHL11 Gene

Gene Ontology (GO) - Molecular Function for KLHL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with KLHL11: view
genes like me logo Genes that share phenotypes with KLHL11: view

miRNA for KLHL11 Gene

miRTarBase miRNAs that target KLHL11

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLHL11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL11 Gene

Localization for KLHL11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL11 gene
Compartment Confidence
cytosol 4
extracellular 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
plasma membrane 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KLHL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KLHL11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHL11 Gene

Pathways & Interactions for KLHL11 Gene

genes like me logo Genes that share pathways with KLHL11: view

Gene Ontology (GO) - Biological Process for KLHL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with KLHL11: view

No data available for SIGNOR curated interactions for KLHL11 Gene

Drugs & Compounds for KLHL11 Gene

No Compound Related Data Available

Transcripts for KLHL11 Gene

mRNA/cDNA for KLHL11 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLHL11

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL11 Gene

No ASD Table

Relevant External Links for KLHL11 Gene

GeneLoc Exon Structure for
KLHL11

Expression for KLHL11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLHL11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for KLHL11 Gene

This gene is overexpressed in Testis (x6.4).

Protein differential expression in normal tissues from HIPED for KLHL11 Gene

This gene is overexpressed in Pancreatic juice (29.6), Platelet (11.3), and Peripheral blood mononuclear cells (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KLHL11 Gene



Protein tissue co-expression partners for KLHL11 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLHL11

SOURCE GeneReport for Unigene cluster for KLHL11 Gene:

Hs.592134

Evidence on tissue expression from TISSUES for KLHL11 Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with KLHL11: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL11 Gene

Orthologs for KLHL11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KLHL11 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia KLHL11 30 31
  • 93.13 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KLHL11 30 31
  • 91.57 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Klhl11 30 17 31
  • 89.6 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Klhl11 30
  • 89.21 (n)
Oppossum
(Monodelphis domestica)
Mammalia KLHL11 31
  • 88 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia KLHL11 31
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KLHL11 30 31
  • 75.77 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KLHL11 31
  • 78 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia klhl11 30
  • 68.86 (n)
Zebrafish
(Danio rerio)
Actinopterygii klhl11 30 31
  • 68.83 (n)
OneToOne
wufd21e01 30
Species where no ortholog for KLHL11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for KLHL11 Gene

ENSEMBL:
Gene Tree for KLHL11 (if available)
TreeFam:
Gene Tree for KLHL11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLHL11: view image

Paralogs for KLHL11 Gene

Paralogs for KLHL11 Gene

genes like me logo Genes that share paralogs with KLHL11: view

Variants for KLHL11 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KLHL11 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KLHL11 Gene

Variant ID Type Subtype PubMed ID
dgv415e201 CNV deletion 23290073
esv2715943 CNV deletion 23290073
esv3640596 CNV loss 21293372
nsv1057008 CNV gain 25217958
nsv1146669 OTHER inversion 26484159
nsv833447 CNV loss 17160897

Variation tolerance for KLHL11 Gene

Residual Variation Intolerance Score: 9.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLHL11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHL11

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLHL11 Gene

Disorders for KLHL11 Gene

Additional Disease Information for KLHL11

No disorders were found for KLHL11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL11 Gene

Publications for KLHL11 Gene

  1. Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases. (PMID: 23349464) Canning P … Bullock AN (The Journal of biological chemistry 2013) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3

Products for KLHL11 Gene

Sources for KLHL11 Gene