Aliases for KLHL10 Gene
External Ids for KLHL10 Gene
Previous GeneCards Identifiers for KLHL10 Gene
The protein encoded by this gene belongs to the kelch repeat-containing family, and contains an N-terminal BTB/POZ domain a BACK domain and six C-terminal kelch repeats. Kelch domains are thought to form a four stranded beta-sheet blade structure that can fold into a beta-propeller domain when multiple kelch repeats are found together. Mutations in this gene have been associated with oligozoospermia in some infertile males. [provided by RefSeq, Jul 2016]
GeneCards Summary for KLHL10 Gene
KLHL10 (Kelch Like Family Member 10) is a Protein Coding gene. Diseases associated with KLHL10 include Spermatogenic Failure 11 and Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation. An important paralog of this gene is KLHL20.
UniProtKB/Swiss-Prot Summary for KLHL10 Gene
May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.