Aliases for KLHDC9 Gene

Aliases for KLHDC9 Gene

  • Kelch Domain Containing 9 2 3 5
  • KARCA1 2 3 4
  • Kelch/Ankyrin Repeat-Containing Cyclin A1-Interacting Protein 3 4
  • Kelch Domain-Containing Protein 9 3 4
  • Kelch/Ankyrin Repeat Containing Cyclin A1 Interacting Protein 2
  • KLHDC9 5

External Ids for KLHDC9 Gene

Previous GeneCards Identifiers for KLHDC9 Gene

  • GC01P159335
  • GC01P161068
  • GC01P132425

Summaries for KLHDC9 Gene

GeneCards Summary for KLHDC9 Gene

KLHDC9 (Kelch Domain Containing 9) is a Protein Coding gene. An important paralog of this gene is LZTR1.

Additional gene information for KLHDC9 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLHDC9 Gene

Genomics for KLHDC9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KLHDC9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLHDC9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLHDC9

Top Transcription factor binding sites by QIAGEN in the KLHDC9 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • Elk-1
  • GATA-3
  • Olf-1
  • p53
  • POU3F1
  • Sp1

Genomic Locations for KLHDC9 Gene

Genomic Locations for KLHDC9 Gene
chr1:161,098,361-161,100,346
(GRCh38/hg38)
Size:
1,986 bases
Orientation:
Plus strand
chr1:161,068,151-161,070,138
(GRCh37/hg19)
Size:
1,988 bases
Orientation:
Plus strand

Genomic View for KLHDC9 Gene

Genes around KLHDC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHDC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHDC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHDC9 Gene

Proteins for KLHDC9 Gene

  • Protein details for KLHDC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEP7-KLDC9_HUMAN
    Recommended name:
    Kelch domain-containing protein 9
    Protein Accession:
    Q8NEP7
    Secondary Accessions:
    • Q5SY56
    • Q6NXT9
    • Q6PKN4
    • Q8N5E1
    • Q8NA16

    Protein attributes for KLHDC9 Gene

    Size:
    349 amino acids
    Molecular mass:
    37754 Da
    Quaternary structure:
    • Interacts with CCNA1.

    Alternative splice isoforms for KLHDC9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHDC9 Gene

Post-translational modifications for KLHDC9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHDC9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHDC9 Gene

Domains & Families for KLHDC9 Gene

Gene Families for KLHDC9 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KLHDC9 Gene

Suggested Antigen Peptide Sequences for KLHDC9 Gene

GenScript: Design optimal peptide antigens:
  • Kelch/ankyrin repeat containing cyclin A1 interacting protein, isoform CRA_b (D3DVF3_HUMAN)
  • Kelch/ankyrin repeat-containing cyclin A1-interacting protein (KLDC9_HUMAN)
genes like me logo Genes that share domains with KLHDC9: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KLHDC9 Gene

Function for KLHDC9 Gene

Phenotypes From GWAS Catalog for KLHDC9 Gene

Gene Ontology (GO) - Molecular Function for KLHDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0030332 cyclin binding IPI 15159402
genes like me logo Genes that share ontologies with KLHDC9: view
genes like me logo Genes that share phenotypes with KLHDC9: view

Animal Model Products

CRISPR Products

miRNA for KLHDC9 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLHDC9

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHDC9 Gene

Localization for KLHDC9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHDC9 gene
Compartment Confidence
mitochondrion 2
nucleus 2
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KLHDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with KLHDC9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHDC9 Gene

Pathways & Interactions for KLHDC9 Gene

PathCards logo

SuperPathways for KLHDC9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KLHDC9: view

No data available for Pathways by source and SIGNOR curated interactions for KLHDC9 Gene

Drugs & Compounds for KLHDC9 Gene

No Compound Related Data Available

Transcripts for KLHDC9 Gene

mRNA/cDNA for KLHDC9 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLHDC9

Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6
SP1: - -
SP2:
SP3: -
SP4: -
SP5: - - -

Relevant External Links for KLHDC9 Gene

GeneLoc Exon Structure for
KLHDC9

Expression for KLHDC9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLHDC9 Gene

mRNA differential expression in normal tissues according to GTEx for KLHDC9 Gene

This gene is overexpressed in Testis (x7.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLHDC9

SOURCE GeneReport for Unigene cluster for KLHDC9 Gene:

Hs.507290

Evidence on tissue expression from TISSUES for KLHDC9 Gene

  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with KLHDC9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHDC9 Gene

Orthologs for KLHDC9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHDC9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KLHDC9 30 31
  • 99.62 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KLHDC9 30 31
  • 85.98 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Klhdc9 30 17 31
  • 82.52 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Klhdc9 30
  • 82.14 (n)
Dog
(Canis familiaris)
Mammalia KLHDC9 30 31
  • 81.94 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia KLHDC9 31
  • 75 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KLHDC9 31
  • 56 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia klhdc9 30
  • 58.88 (n)
Species where no ortholog for KLHDC9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for KLHDC9 Gene

ENSEMBL:
Gene Tree for KLHDC9 (if available)
TreeFam:
Gene Tree for KLHDC9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLHDC9: view image

Paralogs for KLHDC9 Gene

Paralogs for KLHDC9 Gene

(1) SIMAP similar genes for KLHDC9 Gene using alignment to 1 proteins:

  • KLDC9_HUMAN
genes like me logo Genes that share paralogs with KLHDC9: view

Variants for KLHDC9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLHDC9 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1128750 -. - p.Asn288Serp.Ala282Thr
rs11576830 - p.Ser171Arg

Additional dbSNP identifiers (rs#s) for KLHDC9 Gene

Structural Variations from Database of Genomic Variants (DGV) for KLHDC9 Gene

Variant ID Type Subtype PubMed ID
nsv1161729 CNV duplication 26073780

Variation tolerance for KLHDC9 Gene

Residual Variation Intolerance Score: 70.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.41; 63.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLHDC9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHDC9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHDC9 Gene

Disorders for KLHDC9 Gene

No disorders were found for KLHDC9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHDC9 Gene

Publications for KLHDC9 Gene

  1. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. (PMID: 15159402) Diederichs S … Müller-Tidow C (The Journal of biological chemistry 2004) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for KLHDC9 Gene

Sources for KLHDC9 Gene