This gene encodes a kelch domain-containing protein which is upregulated in cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] See more...

Aliases for KLHDC8A Gene

Aliases for KLHDC8A Gene

  • Kelch Domain Containing 8A 2 3 5
  • Substitute For Delta-EGFR Expression 1 3 4
  • Kelch Domain-Containing Protein 8A 3 4
  • S-Delta-E1 3 4

External Ids for KLHDC8A Gene

Previous GeneCards Identifiers for KLHDC8A Gene

  • GC01M202038
  • GC01M203571
  • GC01M176471

Summaries for KLHDC8A Gene

Entrez Gene Summary for KLHDC8A Gene

  • This gene encodes a kelch domain-containing protein which is upregulated in cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

GeneCards Summary for KLHDC8A Gene

KLHDC8A (Kelch Domain Containing 8A) is a Protein Coding gene. An important paralog of this gene is KLHDC8B.

Additional gene information for KLHDC8A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLHDC8A Gene

Genomics for KLHDC8A Gene

GeneHancer (GH) Regulatory Elements for KLHDC8A Gene

Promoters and enhancers for KLHDC8A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J205354 Promoter/Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 768.3 +0.7 652 3.1 ZBTB33 IKZF1 CTCF ZNF24 RFX1 EGR1 ZBTB17 POLR2A ZFHX2 ZNF664 KLHDC8A lnc-NUAK2-2 lnc-TMCC2-2
GH01J205358 Enhancer 0.2 dbSUPER 762.6 -1.9 -1860 0.5 KLHDC8A MIR135B CDK18 LEMD1-AS1
GH01J205335 Enhancer 1.1 Ensembl ENCODE 24.5 +21.2 21190 1 SIN3A CTCF SREBF1 RBPJ ZNF362 CC2D1A RAD21 SP1 ZNF148 NKRF KLHDC8A ENSG00000225063 TMCC2 CDK18 HSALNG0009937 SNRPGP10
GH01J205343 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 17.4 +13.1 13089 0.8 SMARCE1 NR2F6 L3MBTL2 RERE SP1 SP7 ZSCAN21 PPARG TRIM24 KLF14 KLHDC8A NUAK2 LEMD1-AS1 CDK18 SNRPGP10 HSALNG0009937 lnc-NUAK2-2
GH01J205351 Enhancer 1 ENCODE CraniofacialAtlas dbSUPER 19.2 +4.5 4500 1.4 MNT SP7 ZIC2 REST PRDM10 ZSCAN4 POLR2A PATZ1 ZBTB48 SMARCA5 SNRPGP10 lnc-TMCC2-2 KLHDC8A lnc-NUAK2-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLHDC8A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLHDC8A gene promoter:
  • GCNF
  • GCNF-1
  • GCNF-2
  • HOXA9
  • HOXA9B
  • LyF-1
  • Meis-1
  • Meis-1b
  • Nkx2-2
  • Nkx6-1

Genomic Locations for KLHDC8A Gene

Genomic Locations for KLHDC8A Gene
21,026 bases
Minus strand
20,999 bases
Minus strand

Genomic View for KLHDC8A Gene

Genes around KLHDC8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHDC8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHDC8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHDC8A Gene

Proteins for KLHDC8A Gene

  • Protein details for KLHDC8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch domain-containing protein 8A
    Protein Accession:
    Secondary Accessions:
    • B3KU70
    • Q9NVG5

    Protein attributes for KLHDC8A Gene

    350 amino acids
    Molecular mass:
    38859 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHDC8A Gene

Post-translational modifications for KLHDC8A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KLHDC8A Gene

Domains & Families for KLHDC8A Gene

Gene Families for KLHDC8A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KLHDC8A Gene

Suggested Antigen Peptide Sequences for KLHDC8A Gene

GenScript: Design optimal peptide antigens:
  • Kelch domain-containing protein 8A (KLD8A_HUMAN)
genes like me logo Genes that share domains with KLHDC8A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KLHDC8A Gene

Function for KLHDC8A Gene

Phenotypes From GWAS Catalog for KLHDC8A Gene

genes like me logo Genes that share phenotypes with KLHDC8A: view

Animal Model Products

CRISPR Products

miRNA for KLHDC8A Gene

miRTarBase miRNAs that target KLHDC8A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHDC8A Gene

Localization for KLHDC8A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHDC8A gene
Compartment Confidence
mitochondrion 1
nucleus 1
cytosol 1
peroxisome 0
endoplasmic reticulum 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for KLHDC8A Gene

Pathways & Interactions for KLHDC8A Gene

PathCards logo

SuperPathways for KLHDC8A Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHDC8A Gene


No data available for Pathways by source and SIGNOR curated interactions for KLHDC8A Gene

Drugs & Compounds for KLHDC8A Gene

No Compound Related Data Available

Transcripts for KLHDC8A Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC8A Gene

No ASD Table

Relevant External Links for KLHDC8A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHDC8A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHDC8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLHDC8A Gene

This gene is overexpressed in Ovary (x29.5).

Protein differential expression in normal tissues from HIPED for KLHDC8A Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (68.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLHDC8A Gene

Protein tissue co-expression partners for KLHDC8A Gene

NURSA nuclear receptor signaling pathways regulating expression of KLHDC8A Gene:


SOURCE GeneReport for Unigene cluster for KLHDC8A Gene:


Evidence on tissue expression from TISSUES for KLHDC8A Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with KLHDC8A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHDC8A Gene

Orthologs for KLHDC8A Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHDC8A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLHDC8A 33 32
  • 99.52 (n)
(Ornithorhynchus anatinus)
Mammalia KLHDC8A 33
  • 92 (a)
(Canis familiaris)
Mammalia KLHDC8A 33 32
  • 91.9 (n)
(Bos Taurus)
Mammalia KLHDC8A 33 32
  • 90.76 (n)
(Rattus norvegicus)
Mammalia Klhdc8a 32
  • 89.71 (n)
(Mus musculus)
Mammalia Klhdc8a 17 33 32
  • 89.14 (n)
(Monodelphis domestica)
Mammalia KLHDC8A 33
  • 89 (a)
(Gallus gallus)
Aves KLHDC8A 33 32
  • 79.33 (n)
(Anolis carolinensis)
Reptilia KLHDC8A 33
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhdc8a 32
  • 68.1 (n)
Str.108 32
(Danio rerio)
Actinopterygii LOC794258 32
  • 60.73 (n)
  • 55 (a)
(Caenorhabditis elegans)
Secernentea C53A5.11 33
  • 16 (a)
C53A5.9 33
  • 13 (a)
C53A5.6 33
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 24 (a)
Species where no ortholog for KLHDC8A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLHDC8A Gene

Gene Tree for KLHDC8A (if available)
Gene Tree for KLHDC8A (if available)
Evolutionary constrained regions (ECRs) for KLHDC8A: view image

Paralogs for KLHDC8A Gene

(9) SIMAP similar genes for KLHDC8A Gene using alignment to 8 proteins:

  • F5H5F1_HUMAN
genes like me logo Genes that share paralogs with KLHDC8A: view

Variants for KLHDC8A Gene

Sequence variations from dbSNP and Humsavar for KLHDC8A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000218840 -- 205,354,620(-) G/A intron_variant
rs1000257355 -- 205,338,576(-) G/A/T coding_sequence_variant, stop_gained, synonymous_variant
rs1000350199 -- 205,338,256(-) C/T intron_variant
rs1000411588 -- 205,344,301(-) G/A 5_prime_UTR_variant, intron_variant
rs1000450132 -- 205,336,888(-) C/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for KLHDC8A Gene

Variant ID Type Subtype PubMed ID
nsv832381 CNV gain 17160897
nsv946606 CNV duplication 23825009

Variation tolerance for KLHDC8A Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLHDC8A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHDC8A Gene

Disorders for KLHDC8A Gene

Additional Disease Information for KLHDC8A

No disorders were found for KLHDC8A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHDC8A Gene

Publications for KLHDC8A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence. (PMID: 20133782) Mukasa A … Furnari F (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 56
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 56

Products for KLHDC8A Gene

Sources for KLHDC8A Gene