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This gene encodes a kelch domain-containing protein which is upregulated in cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
KLHDC8A (Kelch Domain Containing 8A) is a Protein Coding gene. An important paralog of this gene is KLHDC8B.
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | KLHDC8A 33 32 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | KLHDC8A 33 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | KLHDC8A 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | KLHDC8A 33 32 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Klhdc8a 32 |
|
||
mouse (Mus musculus) |
Mammalia | Klhdc8a 17 33 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | KLHDC8A 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | KLHDC8A 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | KLHDC8A 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | klhdc8a 32 |
|
||
Str.108 32 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | LOC794258 32 |
|
||
KLHDC8A 33 |
|
OneToOne | |||
worm (Caenorhabditis elegans) |
Secernentea | C53A5.11 33 |
|
ManyToMany | |
C53A5.9 33 |
|
ManyToMany | |||
C53A5.6 33 |
|
ManyToMany | |||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
ManyToMany |
SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000218840 | -- | 205,354,620(-) | G/A | intron_variant | |
rs1000257355 | -- | 205,338,576(-) | G/A/T | coding_sequence_variant, stop_gained, synonymous_variant | |
rs1000350199 | -- | 205,338,256(-) | C/T | intron_variant | |
rs1000411588 | -- | 205,344,301(-) | G/A | 5_prime_UTR_variant, intron_variant | |
rs1000450132 | -- | 205,336,888(-) | C/A | 3_prime_UTR_variant |
No disorders were found for KLHDC8A Gene.