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This gene encodes a kelch domain-containing protein which is upregulated in cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
KLHDC8A (Kelch Domain Containing 8A) is a Protein Coding gene. Diseases associated with KLHDC8A include Zellweger Syndrome. An important paralog of this gene is KLHDC8B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 25036637 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | KLHDC8A 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | KLHDC8A 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | KLHDC8A 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | KLHDC8A 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Klhdc8a 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Klhdc8a 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | KLHDC8A 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | KLHDC8A 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | KLHDC8A 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | klhdc8a 30 |
|
||
Str.108 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | LOC794258 30 |
|
||
KLHDC8A 31 |
|
OneToOne | |||
Worm (Caenorhabditis elegans) |
Secernentea | C53A5.11 31 |
|
ManyToMany | |
C53A5.9 31 |
|
ManyToMany | |||
C53A5.6 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
zellweger syndrome |
|
|