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Aliases for KLHDC2 Gene

Aliases for KLHDC2 Gene

  • Kelch Domain Containing 2 2 3 5
  • Hepatocellular Carcinoma-Associated Antigen 33 3 4
  • Host Cell Factor-Like Protein 1 3 4
  • Host Cell Factor Homolog LCP 3 4
  • HCLP-1 3 4
  • Kelch Domain-Containing Protein 2 3
  • HClp1 3
  • HCA33 4
  • LCP 3

External Ids for KLHDC2 Gene

Previous GeneCards Identifiers for KLHDC2 Gene

  • GC14P044030
  • GC14P048224
  • GC14P049304
  • GC14P050234
  • GC14P030362

Summaries for KLHDC2 Gene

GeneCards Summary for KLHDC2 Gene

KLHDC2 (Kelch Domain Containing 2) is a Protein Coding gene. Diseases associated with KLHDC2 include Osteochondrosis and Ischemic Bone Disease. An important paralog of this gene is KLHDC1.

UniProtKB/Swiss-Prot for KLHDC2 Gene

  • Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.

Additional gene information for KLHDC2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHDC2 Gene

Genomics for KLHDC2 Gene

GeneHancer (GH) Regulatory Elements for KLHDC2 Gene

Promoters and enhancers for KLHDC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I049766 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 552 +1.7 1722 5.7 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 KLHDC2 RPL36AL RNU6ATAC30P POLE2 KLHDC1 LRR1 GC14M049783
GH14I049860 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 19.7 +94.7 94705 4.6 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ENSG00000278002 GC14P049865 PIR56593 RN7SL2 GC14M049869 GC14M049865 KLHDC1 NEMF MAP4K5 KLHDC2
GH14I049583 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.6 -181.8 -181782 4 HDGF CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 ENSG00000283029 GC14M049586 GC14M049587 PIR42644 RN7SL1 GC14P049610 RPS29 RPL36AL LRR1 KLHDC1
GH14I050059 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.8 +295.5 295464 6.9 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B DMAP1 IRF4 YY1 POLR2B VCPKMT LINC01588 KLHDC2 RNU6-189P ATP5S ARF6 RPL36AL GC14P050069 RPS15AP2
GH14I050319 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 12.4 +553.2 553201 3.5 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 ZNF143 FOS SP3 JUNB REST ATP5S KLHDC2 NEMF SAV1 MAP4K5 CDKL1 PIR33272 L2HGDH
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KLHDC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLHDC2 gene promoter:

Genomic Locations for KLHDC2 Gene

Genomic Locations for KLHDC2 Gene
18,797 bases
Plus strand

Genomic View for KLHDC2 Gene

Genes around KLHDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHDC2 Gene

Proteins for KLHDC2 Gene

  • Protein details for KLHDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B3KPF9
    • Q6IAF0
    • Q86TY9

    Protein attributes for KLHDC2 Gene

    406 amino acids
    Molecular mass:
    46099 Da
    Quaternary structure:
    • Directly interacts with CREB3, but not with CREB1, ATF4, ATF6, JUN, FOS, CEBPA and herpes simplex virus transactivator VP16.

    Alternative splice isoforms for KLHDC2 Gene


neXtProt entry for KLHDC2 Gene

Post-translational modifications for KLHDC2 Gene

  • Ubiquitination at isoforms=251 and posLast=117117

Other Protein References for KLHDC2 Gene

No data available for DME Specific Peptides for KLHDC2 Gene

Domains & Families for KLHDC2 Gene

Gene Families for KLHDC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KLHDC2 Gene

Suggested Antigen Peptide Sequences for KLHDC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLHDC2: view

No data available for UniProtKB/Swiss-Prot for KLHDC2 Gene

Function for KLHDC2 Gene

Molecular function for KLHDC2 Gene

UniProtKB/Swiss-Prot Function:
Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.
genes like me logo Genes that share phenotypes with KLHDC2: view

Animal Models for KLHDC2 Gene

MGI Knock Outs for KLHDC2:

Animal Model Products

CRISPR Products

miRNA for KLHDC2 Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLHDC2 Gene

Localization for KLHDC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHDC2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHDC2 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nuclear membrane (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KLHDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0016604 nuclear body IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with KLHDC2: view

Pathways & Interactions for KLHDC2 Gene

SuperPathways for KLHDC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHDC2 Gene


No data available for Pathways by source and SIGNOR curated interactions for KLHDC2 Gene

Drugs & Compounds for KLHDC2 Gene

No Compound Related Data Available

Transcripts for KLHDC2 Gene

Unigene Clusters for KLHDC2 Gene

Kelch domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - - -
SP2: - - -
SP3: -
SP6: -

Relevant External Links for KLHDC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHDC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHDC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLHDC2 Gene

This gene is overexpressed in Adrenal (47.7) and Placenta (21.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KLHDC2 Gene

Protein tissue co-expression partners for KLHDC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLHDC2 Gene:


SOURCE GeneReport for Unigene cluster for KLHDC2 Gene:


mRNA Expression by UniProt/SwissProt for KLHDC2 Gene:

Tissue specificity: Widely expressed, with high levels in skeletal muscle, heart, pancreas and liver. Undetectable in peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for KLHDC2 Gene

  • Nervous system(4.8)
  • Kidney(4.3)
  • Intestine(2.7)
  • Lung(2.6)
  • Bone(2.4)
  • Liver(2.3)
  • Muscle(2.3)
  • Skin(2.3)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with KLHDC2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHDC2 Gene

Orthologs for KLHDC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLHDC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLHDC2 33 34
  • 99.75 (n)
(Canis familiaris)
Mammalia KLHDC2 33 34
  • 95.81 (n)
(Bos Taurus)
Mammalia KLHDC2 33 34
  • 94.09 (n)
(Rattus norvegicus)
Mammalia Klhdc2 33
  • 91.79 (n)
(Mus musculus)
Mammalia Klhdc2 33 16 34
  • 91.46 (n)
(Ornithorhynchus anatinus)
Mammalia KLHDC2 34
  • 89 (a)
(Monodelphis domestica)
Mammalia KLHDC2 34
  • 87 (a)
(Gallus gallus)
Aves KLHDC2 33 34
  • 79.06 (n)
(Anolis carolinensis)
Reptilia KLHDC2 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhdc2 33
  • 69.82 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19210 33
(Danio rerio)
Actinopterygii zgc:162310 33
  • 59.49 (n)
  • 50 (a)
Dr.15588 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KEL2 34
  • 10 (a)
KEL1 34
  • 8 (a)
Species where no ortholog for KLHDC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHDC2 Gene

Gene Tree for KLHDC2 (if available)
Gene Tree for KLHDC2 (if available)

Paralogs for KLHDC2 Gene

Paralogs for KLHDC2 Gene

(1) SIMAP similar genes for KLHDC2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KLHDC2: view

Variants for KLHDC2 Gene

Sequence variations from dbSNP and Humsavar for KLHDC2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000063197 -- 49,779,175(+) G/A intron_variant
rs1000163624 -- 49,773,346(+) A/G intron_variant
rs1000322368 -- 49,768,065(+) C/A/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000419891 -- 49,785,161(+) C/A/T genic_downstream_transcript_variant, intron_variant
rs1000531566 -- 49,772,790(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLHDC2 Gene

Variant ID Type Subtype PubMed ID
nsv509533 CNV insertion 20534489
nsv1269 CNV insertion 18451855
esv28926 CNV gain+loss 19812545

Variation tolerance for KLHDC2 Gene

Residual Variation Intolerance Score: 75.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLHDC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHDC2 Gene

Disorders for KLHDC2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KLHDC2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • juvenile osteochondrosis of tibial tubercle
ischemic bone disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for KLHDC2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KLHDC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLHDC2 Gene

Publications for KLHDC2 Gene

  1. Differential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2. (PMID: 16964437) Chin KT … Jin DY (Molecular and cellular biochemistry 2007) 3 4 22 58
  2. Inhibition of LZIP-mediated transcription through direct interaction with a novel host cell factor-like protein. (PMID: 11384994) Zhou HJ … Jin DY (The Journal of biological chemistry 2001) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies. (PMID: 12097419) Wang Y … Chen WF (Journal of immunology (Baltimore, Md. : 1950) 2002) 3 4 58

Products for KLHDC2 Gene

Sources for KLHDC2 Gene

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