Aliases for KLHDC10 Gene

Aliases for KLHDC10 Gene

  • Kelch Domain Containing 10 2 3 5
  • Kelch Domain-Containing Protein 10 3 4
  • Scruin Like At The Midline Homolog (Drosophila) 2
  • Scruin Like At The Midline Homolog 3
  • PNAS-119 3
  • KIAA0265 4
  • Slim 3

External Ids for KLHDC10 Gene

Previous GeneCards Identifiers for KLHDC10 Gene

  • GC07P129498
  • GC07P129710
  • GC07P124072

Summaries for KLHDC10 Gene

GeneCards Summary for KLHDC10 Gene

KLHDC10 (Kelch Domain Containing 10) is a Protein Coding gene. An important paralog of this gene is HCFC1.

UniProtKB/Swiss-Prot Summary for KLHDC10 Gene

  • Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5.

Additional gene information for KLHDC10 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLHDC10 Gene

Genomics for KLHDC10 Gene

GeneHancer (GH) Regulatory Elements for KLHDC10 Gene

Promoters and enhancers for KLHDC10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLHDC10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLHDC10 gene promoter:
  • AREB6
  • c-Myc
  • CBF(2)
  • CBF-A
  • CBF-B
  • GATA-1
  • Max
  • Max1
  • STAT3

Genomic Locations for KLHDC10 Gene

Genomic Locations for KLHDC10 Gene
chr7:130,070,509-130,135,720
(GRCh38/hg38)
Size:
65,212 bases
Orientation:
Plus strand
chr7:129,710,349-129,775,560
(GRCh37/hg19)
Size:
65,212 bases
Orientation:
Plus strand

Genomic View for KLHDC10 Gene

Genes around KLHDC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHDC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHDC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHDC10 Gene

Proteins for KLHDC10 Gene

  • Protein details for KLHDC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PID8-KLD10_HUMAN
    Recommended name:
    Kelch domain-containing protein 10
    Protein Accession:
    Q6PID8
    Secondary Accessions:
    • Q86Y99
    • Q92554

    Protein attributes for KLHDC10 Gene

    Size:
    442 amino acids
    Molecular mass:
    49098 Da
    Quaternary structure:
    • Interacts with CUL2, ELOB and ELOC; may be the substrate recognition component of an E3 ubiquitin ligase complex. Interacts (via the 6 Kelch repeats) with PPP5C.
    SequenceCaution:
    • Sequence=BAA13395.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHDC10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHDC10 Gene

Post-translational modifications for KLHDC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHDC10 Gene

No data available for DME Specific Peptides for KLHDC10 Gene

Domains & Families for KLHDC10 Gene

Gene Families for KLHDC10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KLHDC10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KLHDC10 Gene

GenScript: Design optimal peptide antigens:
  • Kelch domain-containing protein 10 (KLD10_HUMAN)
  • KLHDC10 protein (Q96G43_HUMAN)
genes like me logo Genes that share domains with KLHDC10: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KLHDC10 Gene

Function for KLHDC10 Gene

Molecular function for KLHDC10 Gene

UniProtKB/Swiss-Prot Function:
Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5.

Phenotypes From GWAS Catalog for KLHDC10 Gene

Gene Ontology (GO) - Molecular Function for KLHDC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20562859
genes like me logo Genes that share ontologies with KLHDC10: view
genes like me logo Genes that share phenotypes with KLHDC10: view

Animal Model Products

CRISPR Products

miRNA for KLHDC10 Gene

miRTarBase miRNAs that target KLHDC10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHDC10 Gene

Localization for KLHDC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHDC10 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHDC10 gene
Compartment Confidence
nucleus 5
peroxisome 1
cytosol 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KLHDC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with KLHDC10: view

Pathways & Interactions for KLHDC10 Gene

PathCards logo

SuperPathways for KLHDC10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHDC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032874 positive regulation of stress-activated MAPK cascade IBA 21873635
genes like me logo Genes that share ontologies with KLHDC10: view

No data available for Pathways by source and SIGNOR curated interactions for KLHDC10 Gene

Drugs & Compounds for KLHDC10 Gene

No Compound Related Data Available

Transcripts for KLHDC10 Gene

mRNA/cDNA for KLHDC10 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2:
SP3: - -

Relevant External Links for KLHDC10 Gene

GeneLoc Exon Structure for
KLHDC10
ECgene alternative splicing isoforms for
KLHDC10

Expression for KLHDC10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHDC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLHDC10 Gene

This gene is overexpressed in Pancreatic juice (23.4), Heart (21.2), and Platelet (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KLHDC10 Gene



Protein tissue co-expression partners for KLHDC10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KLHDC10 Gene:

KLHDC10

SOURCE GeneReport for Unigene cluster for KLHDC10 Gene:

Hs.520710

Evidence on tissue expression from TISSUES for KLHDC10 Gene

  • Bone marrow(4.1)
  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with KLHDC10: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHDC10 Gene

Orthologs for KLHDC10 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHDC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHDC10 33 32
  • 99.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KLHDC10 33 32
  • 96.32 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KLHDC10 33 32
  • 95.78 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLHDC10 33
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHDC10 33
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhdc10 17 33 32
  • 90.81 (n)
rat
(Rattus norvegicus)
Mammalia Klhdc10 32
  • 89.51 (n)
chicken
(Gallus gallus)
Aves KLHDC10 33 32
  • 80.46 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLHDC10 33
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhdc10 32
  • 75.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21326 32
zebrafish
(Danio rerio)
Actinopterygii klhdc10 33 32
  • 75.82 (n)
OneToOne
zgc55663 32
fruit fly
(Drosophila melanogaster)
Insecta slim 33 32
  • 48.59 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005004 32
  • 48.26 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y67H2A.2 32
  • 45.3 (n)
Y67H2A.2 33
  • 18 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8396 33
  • 44 (a)
OneToOne
Cin.2435 32
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2435 32
Species where no ortholog for KLHDC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLHDC10 Gene

ENSEMBL:
Gene Tree for KLHDC10 (if available)
TreeFam:
Gene Tree for KLHDC10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLHDC10: view image

Paralogs for KLHDC10 Gene

Paralogs for KLHDC10 Gene

genes like me logo Genes that share paralogs with KLHDC10: view

Variants for KLHDC10 Gene

Sequence variations from dbSNP and Humsavar for KLHDC10 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000062522 -- 130,085,081(+) C/T intron_variant
rs1000158491 -- 130,103,695(+) C/T intron_variant
rs1000180528 -- 130,112,246(+) G/T intron_variant
rs1000199041 -- 130,090,906(+) C/A/T intron_variant
rs1000241851 -- 130,091,511(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLHDC10 Gene

Variant ID Type Subtype PubMed ID
nsv366394 CNV deletion 16902084
nsv510968 OTHER complex 20534489

Variation tolerance for KLHDC10 Gene

Residual Variation Intolerance Score: 23.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLHDC10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHDC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHDC10 Gene

Disorders for KLHDC10 Gene

Additional Disease Information for KLHDC10

No disorders were found for KLHDC10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHDC10 Gene

Publications for KLHDC10 Gene

  1. The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5. (PMID: 23102700) Sekine Y … Ichijo H (Molecular cell 2012) 3 4 56
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 56
  3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 3 4 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. (PMID: 28581483) Scott DC … Guy RK (Nature chemical biology 2017) 3 56

Products for KLHDC10 Gene

Sources for KLHDC10 Gene