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Aliases for KLHDC10 Gene

Aliases for KLHDC10 Gene

  • Kelch Domain Containing 10 2 3 5
  • Scruin Like At The Midline Homolog (Drosophila) 2
  • Kelch Domain-Containing Protein 10 3
  • Scruin Like At The Midline Homolog 3
  • PNAS-119 3
  • KIAA0265 4
  • SLIM 3

External Ids for KLHDC10 Gene

Previous GeneCards Identifiers for KLHDC10 Gene

  • GC07P129498
  • GC07P129710
  • GC07P124072

Summaries for KLHDC10 Gene

GeneCards Summary for KLHDC10 Gene

KLHDC10 (Kelch Domain Containing 10) is a Protein Coding gene. An important paralog of this gene is LZTR1.

UniProtKB/Swiss-Prot for KLHDC10 Gene

  • Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5.

Additional gene information for KLHDC10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHDC10 Gene

Genomics for KLHDC10 Gene

GeneHancer (GH) Regulatory Elements for KLHDC10 Gene

Promoters and enhancers for KLHDC10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I130069 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.4 393 3.6 CLOCK IRF4 YY1 E2F8 ZNF143 ZNF548 SP3 NFYC MEF2D GLIS1 KLHDC10 NRF1 CDC26P1 TMEM209 KLF14 LOC100128325 PIR32855
GH07I130362 Enhancer 2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 15.4 +298.6 298571 12.7 PKNOX1 FOXA2 MLX ARID4B FEZF1 DMAP1 ZNF2 IRF4 SLC30A9 FOS LOC105375504 CPA5 CPA1 CPA2 MKLN1 MEST CDC26P1 KLHDC10 NRF1 CEP41
GH07I130008 Enhancer 1.5 FANTOM5 Ensembl ENCODE 10.3 -60.6 -60638 3.1 PKNOX1 ARNT ARID4B SIN3A IRF4 ZNF766 ZNF207 ZNF143 FOS JUNB ENSG00000199516 UBE2H TNPO3 KLHDC10 ZC3HC1 ENSG00000273319 NRF1 GC07P130029 GC07M129961 ENSG00000244036
GH07I130354 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.9 +287.1 287051 5.7 PKNOX1 ZNF133 SIN3A FEZF1 GLI4 ZNF2 FOS KLF13 YY2 TSHZ1 CPA5 MEST NRF1 CPA1 KLHDC10 CPA4 CPA2 COPG2 LOC105375504
GH07I129776 Enhancer 1.5 FANTOM5 Ensembl ENCODE 9.7 -291.0 -291023 6.4 HDGF CLOCK ARID4B SIN3A ZNF2 ZBTB7B POLR2B ZNF213 FOS SP3 TNPO3 KLHDC10 UBE2H ENSG00000273329 SMKR1 FLNC STRIP2 MIR183 GC07M129785
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KLHDC10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLHDC10 gene promoter:

Genomic Locations for KLHDC10 Gene

Genomic Locations for KLHDC10 Gene
65,212 bases
Plus strand

Genomic View for KLHDC10 Gene

Genes around KLHDC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHDC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHDC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHDC10 Gene

Proteins for KLHDC10 Gene

  • Protein details for KLHDC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch domain-containing protein 10
    Protein Accession:
    Secondary Accessions:
    • Q86Y99
    • Q92554

    Protein attributes for KLHDC10 Gene

    442 amino acids
    Molecular mass:
    49098 Da
    Quaternary structure:
    • Interacts with CUL2, ELOB and ELOC; may be the substrate recognition component of an E3 ubiquitin ligase complex. Interacts (via the 6 Kelch repeats) with PPP5C.
    • Sequence=BAA13395.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHDC10 Gene


neXtProt entry for KLHDC10 Gene

Post-translational modifications for KLHDC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHDC10 Gene

No data available for DME Specific Peptides for KLHDC10 Gene

Domains & Families for KLHDC10 Gene

Gene Families for KLHDC10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KLHDC10 Gene

Suggested Antigen Peptide Sequences for KLHDC10 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLHDC10: view

No data available for UniProtKB/Swiss-Prot for KLHDC10 Gene

Function for KLHDC10 Gene

Molecular function for KLHDC10 Gene

UniProtKB/Swiss-Prot Function:
Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5.

Phenotypes From GWAS Catalog for KLHDC10 Gene

Gene Ontology (GO) - Molecular Function for KLHDC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20562859
genes like me logo Genes that share ontologies with KLHDC10: view
genes like me logo Genes that share phenotypes with KLHDC10: view

Animal Model Products

miRNA for KLHDC10 Gene

miRTarBase miRNAs that target KLHDC10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHDC10 Gene

Localization for KLHDC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHDC10 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHDC10 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KLHDC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with KLHDC10: view

Pathways & Interactions for KLHDC10 Gene

SuperPathways for KLHDC10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHDC10 Gene


No data available for Pathways by source and SIGNOR curated interactions for KLHDC10 Gene

Drugs & Compounds for KLHDC10 Gene

No Compound Related Data Available

Transcripts for KLHDC10 Gene

Unigene Clusters for KLHDC10 Gene

Kelch domain containing 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP3: - -

Relevant External Links for KLHDC10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHDC10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHDC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLHDC10 Gene

This gene is overexpressed in Pancreatic juice (23.4), Heart (21.2), and Platelet (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KLHDC10 Gene

Protein tissue co-expression partners for KLHDC10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KLHDC10 Gene:


SOURCE GeneReport for Unigene cluster for KLHDC10 Gene:


Evidence on tissue expression from TISSUES for KLHDC10 Gene

  • Bone marrow(4.1)
  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with KLHDC10: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHDC10 Gene

Orthologs for KLHDC10 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHDC10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLHDC10 33 34
  • 99.85 (n)
(Canis familiaris)
Mammalia KLHDC10 33 34
  • 96.32 (n)
(Bos Taurus)
Mammalia KLHDC10 33 34
  • 95.78 (n)
(Monodelphis domestica)
Mammalia KLHDC10 34
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia KLHDC10 34
  • 91 (a)
(Mus musculus)
Mammalia Klhdc10 33 16 34
  • 90.81 (n)
(Rattus norvegicus)
Mammalia Klhdc10 33
  • 89.51 (n)
(Gallus gallus)
Aves KLHDC10 33 34
  • 80.46 (n)
(Anolis carolinensis)
Reptilia KLHDC10 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhdc10 33
  • 75.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21326 33
(Danio rerio)
Actinopterygii klhdc10 33 34
  • 75.82 (n)
zgc55663 33
fruit fly
(Drosophila melanogaster)
Insecta slim 33 34
  • 48.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005004 33
  • 48.26 (n)
(Caenorhabditis elegans)
Secernentea CELE_Y67H2A.2 33
  • 45.3 (n)
Y67H2A.2 34
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8396 34
  • 44 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2435 33
Species where no ortholog for KLHDC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLHDC10 Gene

Gene Tree for KLHDC10 (if available)
Gene Tree for KLHDC10 (if available)

Paralogs for KLHDC10 Gene

Paralogs for KLHDC10 Gene

genes like me logo Genes that share paralogs with KLHDC10: view

Variants for KLHDC10 Gene

Sequence variations from dbSNP and Humsavar for KLHDC10 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000062522 -- 130,085,081(+) C/T intron_variant
rs1000158491 -- 130,103,695(+) C/T intron_variant
rs1000180528 -- 130,112,246(+) G/T intron_variant
rs1000199041 -- 130,090,906(+) C/A intron_variant
rs1000241851 -- 130,091,511(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLHDC10 Gene

Variant ID Type Subtype PubMed ID
nsv366394 CNV deletion 16902084
nsv510968 OTHER complex 20534489

Variation tolerance for KLHDC10 Gene

Residual Variation Intolerance Score: 23.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLHDC10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHDC10 Gene

Disorders for KLHDC10 Gene

Additional Disease Information for KLHDC10

No disorders were found for KLHDC10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHDC10 Gene

Publications for KLHDC10 Gene

  1. The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5. (PMID: 23102700) Sekine Y … Ichijo H (Molecular cell 2012) 3 4 58
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress. (PMID: 26472337) Zhu X … Wellmann S (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016) 3 58

Products for KLHDC10 Gene

Sources for KLHDC10 Gene

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