KLF9 Gene (Protein Coding)

Kruppel Like Factor 9

GC09M070384
GIFtS:
37
The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription. [provided by RefSeq, Jul 2008] See more...

Aliases for KLF9 Gene

Aliases for KLF9 Gene

  • Kruppel Like Factor 9 2 3 5
  • Basic Transcription Element-Binding Protein 1 3 4
  • Transcription Factor BTEB1 3 4
  • GC-Box-Binding Protein 1 3 4
  • Krueppel-Like Factor 9 3 4
  • BTE-Binding Protein 1 3 4
  • BTEB1 3 4
  • BTEB 3 4
  • Basic Transcription Element Binding Protein 1 2

External Ids for KLF9 Gene

Previous HGNC Symbols for KLF9 Gene

  • BTEB1

Previous GeneCards Identifiers for KLF9 Gene

  • GC09M070230
  • GC09M072189
  • GC09M072999
  • GC09M042839

Summaries for KLF9 Gene

Entrez Gene Summary for KLF9 Gene

  • The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLF9 Gene

KLF9 (Kruppel Like Factor 9) is a Protein Coding gene. Diseases associated with KLF9 include Endometrial Cancer and Otosclerosis. Among its related pathways are Circadian rythm related genes and Diurnally Regulated Genes with Circadian Orthologs. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is KLF13.

UniProtKB/Swiss-Prot Summary for KLF9 Gene

  • Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation (PubMed:22711835).

Gene Wiki entry for KLF9 Gene

Additional gene information for KLF9 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLF9 Gene

Genomics for KLF9 Gene

GeneHancer (GH) Regulatory Elements for KLF9 Gene

Promoters and enhancers for KLF9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLF9 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLF9

Top Transcription factor binding sites by QIAGEN in the KLF9 gene promoter:
  • ARP-1
  • CBF(2)
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • LCR-F1
  • Sp1

Genomic Locations for KLF9 Gene

Genomic Locations for KLF9 Gene
chr9:70,384,597-70,414,657
(GRCh38/hg38)
Size:
30,061 bases
Orientation:
Minus strand
chr9:72,999,503-73,029,573
(GRCh37/hg19)
Size:
30,071 bases
Orientation:
Minus strand

Genomic View for KLF9 Gene

Genes around KLF9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF9 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for KLF9 Gene

Proteins for KLF9 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for KLF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13886-KLF9_HUMAN
    Recommended name:
    Krueppel-like factor 9
    Protein Accession:
    Q13886
    Secondary Accessions:
    • B2R943
    • Q16196

    Protein attributes for KLF9 Gene

    Size:
    244 amino acids
    Molecular mass:
    27235 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLF9 Gene

Post-translational modifications for KLF9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLF9 Gene

Domains & Families for KLF9 Gene

Gene Families for KLF9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for KLF9 Gene

Blocks:
  • C2H2-type zinc finger signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KLF9 Gene

GenScript: Design optimal peptide antigens:
  • Kruppel-like factor 9 (B5BUG8_HUMAN)
  • Transcription factor BTEB1 (KLF9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13886

UniProtKB/Swiss-Prot:

KLF9_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF9: view

Function for KLF9 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  6. Cell Line

Molecular function for KLF9 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation (PubMed:22711835).
UniProtKB/Swiss-Prot Induction:
Expression is highly sensitive to glucocorticoids and shows diurnal expression patterns. A strong induction of expression seen during keratinocyte differentiation in a cortisol dependent manner.

Phenotypes From GWAS Catalog for KLF9 Gene

Gene Ontology (GO) - Molecular Function for KLF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity TAS 1356762
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with KLF9: view
genes like me logo Genes that share phenotypes with KLF9: view

Animal Models for KLF9 Gene

MGI Knock Outs for KLF9:
  • Klf9 Klf9<tm1.1(KOMP)Vlcg>
  • Klf9 Klf9<tm1Yfk>

Animal Model Products

CRISPR Products

Targeted motifs for KLF9 Gene
HOMER Transcription Factor Regulatory Elements motif KLF9
  • Consensus sequence: GCCACRCCCACY Submotif: canonical Cell Type: GBM GEO ID: GSE62211

Clone Products

  • Addgene plasmids for KLF9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for KLF9 Gene

Localization for KLF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF9 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF9 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 2
cytoskeleton 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KLF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IDA,IBA 22711835
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with KLF9: view

Pathways & Interactions for KLF9 Gene

genes like me logo Genes that share pathways with KLF9: view

Pathways by source for KLF9 Gene

SIGNOR curated interactions for KLF9 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for KLF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA,TAS 21873635
GO:0007623 circadian rhythm IEP 22711835
GO:0010839 negative regulation of keratinocyte proliferation IMP 22711835
GO:0048511 rhythmic process IEA --
GO:0071387 cellular response to cortisol stimulus IDA 22711835
genes like me logo Genes that share ontologies with KLF9: view

Drugs & Compounds for KLF9 Gene

Products:

  1. Drug

(3) Drugs for KLF9 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KLF9: view

Transcripts for KLF9 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for KLF9 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for KLF9

Alternative Splicing Database (ASD) splice patterns (SP) for KLF9 Gene

No ASD Table

Relevant External Links for KLF9 Gene

GeneLoc Exon Structure for
KLF9

Expression for KLF9 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLF9 Gene

mRNA expression in normal human tissues for KLF9 Gene
mRNA expression by GTEx for KLF9 GenemRNA expression by BioGPS for KLF9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLF9

SOURCE GeneReport for Unigene cluster for KLF9 Gene:

Hs.150557

mRNA Expression by UniProt/SwissProt for KLF9 Gene:

Q13886-KLF9_HUMAN
Tissue specificity: Epidermis (at protein level).

Evidence on tissue expression from TISSUES for KLF9 Gene

  • Liver(4.5)
  • Lung(4.5)
  • Nervous system(3)
  • Thyroid gland(2.8)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with KLF9: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF9 Gene

Orthologs for KLF9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLF9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia KLF9 31 30
  • 99.45 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia KLF9 31
  • 98 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia KLF9 31 30
  • 96.86 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Klf9 30
  • 94.95 (n)
mouse
(Mus musculus)
 Mammalia Klf9 17 31 30
  • 94.13 (n)
oppossum
(Monodelphis domestica)
 Mammalia KLF9 31
  • 92 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia KLF9 31
  • 88 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves KLF9 31 30
  • 74.17 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia KLF9 31
  • 60 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia klf9 30
  • 71.94 (n)
African clawed frog
(Xenopus laevis)
 Amphibia bteb1-A 30
zebrafish
(Danio rerio)
 Actinopterygii klf9 31
  • 47 (a)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.1235 30
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes -- 33
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.7373 31
  • 14 (a)
 OneToMany
Species where no ortholog for KLF9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLF9 Gene

ENSEMBL:
Gene Tree for KLF9 (if available)
TreeFam:
Gene Tree for KLF9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLF9: view image

Paralogs for KLF9 Gene

Paralogs for KLF9 Gene

(32) SIMAP similar genes for KLF9 Gene using alignment to 2 proteins:

  • KLF9_HUMAN
  • B5BUG8_HUMAN
genes like me logo Genes that share paralogs with KLF9: view

Variants for KLF9 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for KLF9 Gene

Structural Variations from Database of Genomic Variants (DGV) for KLF9 Gene

Variant ID Type Subtype PubMed ID
esv1491500 CNV insertion 17803354
nsv1047862 CNV gain 25217958
nsv1049132 CNV gain 25217958
nsv428219 CNV loss 18775914
nsv831615 CNV gain 17160897

Variation tolerance for KLF9 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLF9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLF9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLF9 Gene

Disorders for KLF9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KLF9 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
endometrial cancer
  • endometrial cancer, familial
otosclerosis
- elite association - COSMIC cancer census association via MalaCards
Search KLF9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KLF9

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KLF9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLF9 Gene

Publications for KLF9 Gene

  1. Cell-specific translational control of transcription factor BTEB expression. The role of an upstream AUG in the 5'-untranslated region. (PMID: 8051167) Imataka H … Hayami M (The Journal of biological chemistry 1994) 3 4 23 54
  2. Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene. (PMID: 1356762) Imataka H … Fujii-Kuriyama Y (The EMBO journal 1992) 2 3 23 54
  3. Krüppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes. (PMID: 22711835) Spörl F … Kramer A (Proceedings of the National Academy of Sciences of the United States of America 2012) 3 4 54
  4. Kruppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor alpha signaling in Ishikawa endometrial adenocarcinoma cells. (PMID: 17717078) Velarde MC … Simmen RC (Molecular endocrinology (Baltimore, Md.) 2007) 3 23 54
  5. Progesterone receptor transactivation of the secretory leukocyte protease inhibitor gene in Ishikawa endometrial epithelial cells involves recruitment of Krüppel-like factor 9/basic transcription element binding protein-1. (PMID: 16384861) Velarde MC … Simmen RC (Endocrinology 2006) 3 23 54

ExternalLinks

View latest publications for KLF9 gene in Mastermind

Products for KLF9 Gene

  • Addgene plasmids for KLF9

Sources for KLF9 Gene