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The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription. [provided by RefSeq, Jul 2008]
KLF9 (Kruppel Like Factor 9) is a Protein Coding gene. Diseases associated with KLF9 include Endometrial Cancer and Otosclerosis. Among its related pathways are Diurnally Regulated Genes with Circadian Orthologs and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is KLF13.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IBA | 21873635 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | TAS | 1356762 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IBA,IDA | 22711835 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005829 | cytosol | IDA | -- |
GO:0005886 | plasma membrane | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Circadian rythm related genes | ||
2 | Diurnally Regulated Genes with Circadian Orthologs |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006357 | regulation of transcription by RNA polymerase II | TAS | 1356762 |
GO:0007623 | circadian rhythm | IEP | 22711835 |
GO:0010839 | negative regulation of keratinocyte proliferation | IMP | 22711835 |
GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0048511 | rhythmic process | IEA | -- |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | KLF9 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | KLF9 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | KLF9 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Klf9 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Klf9 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | KLF9 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | KLF9 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | KLF9 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | KLF9 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | klf9 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | bteb1-A 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | klf9 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1235 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 33 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7373 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1491500 | CNV | insertion | 17803354 |
nsv1047862 | CNV | gain | 25217958 |
nsv1049132 | CNV | gain | 25217958 |
nsv428219 | CNV | loss | 18775914 |
nsv831615 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
endometrial cancer |
|
|
otosclerosis |
|
|