The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secr... See more...

Aliases for KLF7 Gene

Aliases for KLF7 Gene

  • Kruppel Like Factor 7 2 3 5
  • Kruppel-Like Factor 7 (Ubiquitous) 2 3
  • Ubiquitous Kruppel-Like Factor 2 3
  • Krueppel-Like Factor 7 3 4
  • UKLF 3 4
  • Ubiquitous Kruppel-Like Transcription Factor 3
  • Ubiquitous Krueppel-Like Factor 4

External Ids for KLF7 Gene

Previous GeneCards Identifiers for KLF7 Gene

  • GC02M206161
  • GC02M206668
  • GC02M207909
  • GC02M208147
  • GC02M207770
  • GC02M207653
  • GC02M199795

Summaries for KLF7 Gene

Entrez Gene Summary for KLF7 Gene

  • The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for KLF7 Gene

KLF7 (Kruppel Like Factor 7) is a Protein Coding gene. Among its related pathways are Adipogenesis. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is KLF6.

UniProtKB/Swiss-Prot Summary for KLF7 Gene

  • Transcriptional factor (PubMed:9774444, PubMed:16339272). Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity). Represses the corneal epithelium differentiation (PubMed:28916725). Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells (PubMed:16339272). Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (PubMed:16339272).

Gene Wiki entry for KLF7 Gene

Additional gene information for KLF7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLF7 Gene

Genomics for KLF7 Gene

GeneHancer (GH) Regulatory Elements for KLF7 Gene

Promoters and enhancers for KLF7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J207161 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 509.7 +9.6 9594 7.7 EP300 FOXK2 ZNF217 SIN3A NRF1 TCF12 USF1 POLR2G SP1 NCOR1 KLF7 MYOSLID lnc-MDH1B-8 MIR1302-4 CREB1 ENSG00000240440 ENSG00000234902 METTL21A MIR7845 NONHSAG030356.2
GH02J207173 Enhancer 0.3 ENCODE 507.7 +0.0 46 1.3 ESR1 NCOA3 KLF7 ENSG00000224342 MIR2355 MYOSLID
GH02J207140 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 24.7 +30.9 30875 4.7 ZIC2 TRIM28 CTCF RAD21 OSR2 NR2F2 ZNF384 ZKSCAN1 POLR2A REST KLF7 MIR2355 MIR1302-4 CREB1 METTL21A KLF7-IT1 MYOSLID lnc-MDH1B-8
GH02J207225 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 -53.1 -53145 2.4 HDAC2 TCF12 YY1 POLR2A BATF FOS EBF1 ZSCAN16 SIN3A GATA2 ENSG00000225916 MIR1302-4 KLF7 DYTN ENSG00000240440 ENSG00000234902 MYOSLID-AS1 MYOSLID
GH02J207131 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 11.1 +39.5 39525 6.5 EP300 JUND TRIM28 ATF2 OSR2 KDM1A BCL11A KLF9 WT1 NFIC MIR2355 KLF7 KLF7-IT1 MYOSLID lnc-MDH1B-8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLF7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLF7

Top Transcription factor binding sites by QIAGEN in the KLF7 gene promoter:
  • AhR
  • Arnt
  • C/EBPalpha
  • FOXO4
  • N-Myc
  • Nkx6-1
  • POU2F1
  • POU2F1a
  • POU6F1 (c2)
  • RORalpha1

Genomic Locations for KLF7 Gene

Genomic Locations for KLF7 Gene
chr2:207,074,137-207,173,851
(GRCh38/hg38)
Size:
99,715 bases
Orientation:
Minus strand
chr2:207,938,861-208,031,991
(GRCh37/hg19)
Size:
93,131 bases
Orientation:
Minus strand

Genomic View for KLF7 Gene

Genes around KLF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF7 Gene

Proteins for KLF7 Gene

  • Protein details for KLF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75840-KLF7_HUMAN
    Recommended name:
    Krueppel-like factor 7
    Protein Accession:
    O75840
    Secondary Accessions:
    • B2RB03
    • B7Z4F7
    • C9JF04
    • E7EWH1
    • L0R4P2
    • Q7Z3H8
    • Q96E51

    Protein attributes for KLF7 Gene

    Size:
    302 amino acids
    Molecular mass:
    33362 Da
    Quaternary structure:
    • Interacts with FBXO38.

    Alternative splice isoforms for KLF7 Gene

neXtProt entry for KLF7 Gene

Post-translational modifications for KLF7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KLF7 Gene

Domains & Families for KLF7 Gene

Gene Families for KLF7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for KLF7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KLF7 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54523, highly similar to Krueppel-like factor 7 (B7Z4F7_HUMAN)
  • Ubiquitous krueppel-like factor (KLF7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75840

UniProtKB/Swiss-Prot:

KLF7_HUMAN :
  • The acidic N-terminal part may favor interaction with the basic domain of transcription factors.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The acidic N-terminal part may favor interaction with the basic domain of transcription factors.
  • The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In KLF7, the motif is inactive.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF7: view

Function for KLF7 Gene

Molecular function for KLF7 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional factor (PubMed:9774444, PubMed:16339272). Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity). Represses the corneal epithelium differentiation (PubMed:28916725). Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells (PubMed:16339272). Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (PubMed:16339272).
GENATLAS Biochemistry:
Kruppel-like factor 7 (ubiquitous),with homology to the core promoter element binding protein (COPEB)

Phenotypes From GWAS Catalog for KLF7 Gene

Gene Ontology (GO) - Molecular Function for KLF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 9774444
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IDA,ISA --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 9774444
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with KLF7: view
genes like me logo Genes that share phenotypes with KLF7: view

Animal Models for KLF7 Gene

MGI Knock Outs for KLF7:
  • Klf7 Klf7<tm1Rmz>
  • Klf7 Klf7<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for KLF7 Gene

miRTarBase miRNAs that target KLF7

Clone Products

  • Addgene plasmids for KLF7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLF7 Gene

Localization for KLF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF7 gene
Compartment Confidence
nucleus 5
extracellular 2
cytoskeleton 2
golgi apparatus 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KLF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA,IDA 9774444
genes like me logo Genes that share ontologies with KLF7: view

Pathways & Interactions for KLF7 Gene

PathCards logo

SuperPathways for KLF7 Gene

SuperPathway Contained pathways
1 Adipogenesis
genes like me logo Genes that share pathways with KLF7: view

Pathways by source for KLF7 Gene

1 BioSystems pathway for KLF7 Gene

SIGNOR curated interactions for KLF7 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for KLF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 16339272
GO:0006357 regulation of transcription by RNA polymerase II TAS,IBA 21873635
GO:0007409 axonogenesis ISS --
GO:0007411 axon guidance ISS --
GO:0042593 glucose homeostasis IMP 16339272
genes like me logo Genes that share ontologies with KLF7: view

Drugs & Compounds for KLF7 Gene

(1) Drugs for KLF7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KLF7: view

Transcripts for KLF7 Gene

mRNA/cDNA for KLF7 Gene

4 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for KLF7

Alternative Splicing Database (ASD) splice patterns (SP) for KLF7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5: - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - -
SP9: -

Relevant External Links for KLF7 Gene

GeneLoc Exon Structure for
KLF7

Expression for KLF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLF7 Gene

This gene is overexpressed in Pancreatic juice (58.7) and Urine (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLF7 Gene



Protein tissue co-expression partners for KLF7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLF7

SOURCE GeneReport for Unigene cluster for KLF7 Gene:

Hs.59908

mRNA Expression by UniProt/SwissProt for KLF7 Gene:

O75840-KLF7_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for KLF7 Gene

  • Nervous system(4.8)
  • Heart(4.2)
genes like me logo Genes that share expression patterns with KLF7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF7 Gene

Orthologs for KLF7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF7 31 30
  • 100 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLF7 31
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLF7 31 30
  • 94.81 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KLF7 31 30
  • 94.7 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Klf7 17 31 30
  • 92.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KLF7 31
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLF7 31 30
  • 81.87 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLF7 31
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf7 30
  • 73.87 (n)
African clawed frog
(Xenopus laevis)
Amphibia klf7-prov 30
zebrafish
(Danio rerio)
Actinopterygii klf7b 31
  • 69 (a)
OneToMany
klf7a 31 30
  • 64.65 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12029 32
  • 80 (a)
CG9895 32
  • 77 (a)
luna 31
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F56F11.3 32
  • 79 (a)
F53F8.1 32
  • 75 (a)
mua-1 32
  • 69 (a)
klf-3 31
  • 27 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG3 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3394 31
  • 40 (a)
OneToMany
Species where no ortholog for KLF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF7 Gene

ENSEMBL:
Gene Tree for KLF7 (if available)
TreeFam:
Gene Tree for KLF7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLF7: view image

Paralogs for KLF7 Gene

(42) SIMAP similar genes for KLF7 Gene using alignment to 8 proteins:

  • KLF7_HUMAN
  • C9JX20_HUMAN
  • E7EQY2_HUMAN
  • E7EUU0_HUMAN
  • E9PHC9_HUMAN
  • L8E9A5_HUMAN
  • Q4ZG79_HUMAN
  • Q53TP3_HUMAN

Pseudogenes.org Pseudogenes for KLF7 Gene

genes like me logo Genes that share paralogs with KLF7: view

Variants for KLF7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLF7 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
738810 Likely Benign: not provided 207,124,303(-) C/T SYNONYMOUS_VARIANT
778017 Benign: not provided 207,088,517(-) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
789158 Benign: not provided 207,124,261(-) G/A SYNONYMOUS_VARIANT
rs1057518995 Uncertain Significance: intellectual deficiency. - 207,088,525(-) C/Tp.Asp264Asn MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
rs1276619385 - p.Thr137Met

Additional dbSNP identifiers (rs#s) for KLF7 Gene

Structural Variations from Database of Genomic Variants (DGV) for KLF7 Gene

Variant ID Type Subtype PubMed ID
nsv1011347 CNV gain 25217958
nsv1138887 CNV deletion 24896259
nsv3129 CNV deletion 18451855
nsv954826 CNV duplication 24416366

Variation tolerance for KLF7 Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLF7 Gene

Human Gene Mutation Database (HGMD)
KLF7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLF7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF7 Gene

Disorders for KLF7 Gene

Additional Disease Information for KLF7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KLF7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLF7 Gene

Publications for KLF7 Gene

  1. Cloning the cDNA for a new human zinc finger protein defines a group of closely related Krüppel-like transcription factors. (PMID: 9774444) Matsumoto N … Terada M (The Journal of biological chemistry 1998) 2 3 4 23 54
  2. Overexpression of Kruppel-like factor 7 regulates adipocytokine gene expressions in human adipocytes and inhibits glucose-induced insulin secretion in pancreatic beta-cell line. (PMID: 16339272) Kawamura Y … Maeda S (Molecular endocrinology (Baltimore, Md.) 2006) 3 4 23 54
  3. Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes. (PMID: 15937668) Kanazawa A … Maeda S (Diabetologia 2005) 3 23 41 54
  4. De novo variants in KLF7 are a potential novel cause of developmental delay/intellectual disability, neuromuscular and psychiatric symptoms. (PMID: 29251763) Powis Z … Shinde DN (Clinical genetics 2018) 3 4 54
  5. Characterization of enhancers and the role of the transcription factor KLF7 in regulating corneal epithelial differentiation. (PMID: 28916725) Klein RH … Andersen B (The Journal of biological chemistry 2017) 3 4 54

Products for KLF7 Gene

Sources for KLF7 Gene