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Aliases for KLF7 Gene

Aliases for KLF7 Gene

  • Kruppel Like Factor 7 2 3 5
  • Kruppel-Like Factor 7 (Ubiquitous) 2 3
  • Ubiquitous Kruppel-Like Factor 2 3
  • UKLF 3 4
  • Ubiquitous Kruppel-Like Transcription Factor 3
  • Ubiquitous Krueppel-Like Factor 4
  • Krueppel-Like Factor 7 3

External Ids for KLF7 Gene

Previous GeneCards Identifiers for KLF7 Gene

  • GC02M206161
  • GC02M206668
  • GC02M207909
  • GC02M208147
  • GC02M207770
  • GC02M207653
  • GC02M199795

Summaries for KLF7 Gene

Entrez Gene Summary for KLF7 Gene

  • The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for KLF7 Gene

KLF7 (Kruppel Like Factor 7) is a Protein Coding gene. Diseases associated with KLF7 include Bruxism. Among its related pathways are Adipogenesis. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is KLF6.

UniProtKB/Swiss-Prot for KLF7 Gene

  • Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence.

Gene Wiki entry for KLF7 Gene

Additional gene information for KLF7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF7 Gene

Genomics for KLF7 Gene

GeneHancer (GH) Regulatory Elements for KLF7 Gene

Promoters and enhancers for KLF7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I207161 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 559.6 +9.2 9186 6.9 HDGF PKNOX1 FOXA2 SIN3A DMAP1 YY1 ZNF207 FOS SP3 NFYC KLF7 MIR7845 MIR1302-4 CREB1 ENSG00000240440 ENSG00000234902 METTL21A GC02P207167 GC02P207126
GH02I207131 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 561 +39.3 39250 7.2 ZSCAN4 RAD21 ZNF335 ZNF366 ATF7 RUNX3 ZNF362 ZNF398 ZEB2 ZNF843 KLF7 MIR2355 GC02P207126 MIR7845
GH02I207173 Enhancer 0.3 ENCODE 557.8 +0.0 46 1.3 NCOA3 KLF7 ENSG00000224342 MIR2355
GH02I207138 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 24.7 +31.8 31783 6.5 CTCF PKNOX1 SMAD1 RB1 MAX PAX8 ZNF384 ZIC2 RAD21 ZKSCAN1 KLF7 MIR2355 MIR1302-4 CREB1 METTL21A GC02P207126 MIR7845
GH02I207073 Enhancer 1.3 UCNEbase Ensembl ENCODE dbSUPER 11.6 +99.5 99487 2 CTCF ZNF335 POLR2A SCRT2 RUNX3 KLF7 MIR2355 PIR40017 PIR53902
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KLF7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLF7 gene promoter:

Genomic Locations for KLF7 Gene

Genomic Locations for KLF7 Gene
chr2:207,074,137-207,173,851
(GRCh38/hg38)
Size:
99,715 bases
Orientation:
Minus strand
chr2:207,938,861-208,031,991
(GRCh37/hg19)

Genomic View for KLF7 Gene

Genes around KLF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF7 Gene

Proteins for KLF7 Gene

  • Protein details for KLF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75840-KLF7_HUMAN
    Recommended name:
    Krueppel-like factor 7
    Protein Accession:
    O75840
    Secondary Accessions:
    • B2RB03
    • B7Z4F7
    • C9JF04
    • E7EWH1
    • L0R4P2
    • Q7Z3H8
    • Q96E51

    Protein attributes for KLF7 Gene

    Size:
    302 amino acids
    Molecular mass:
    33362 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLF7 Gene

neXtProt entry for KLF7 Gene

Post-translational modifications for KLF7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KLF7 Gene

Domains & Families for KLF7 Gene

Gene Families for KLF7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for KLF7 Gene

Suggested Antigen Peptide Sequences for KLF7 Gene

Graphical View of Domain Structure for InterPro Entry

O75840

UniProtKB/Swiss-Prot:

KLF7_HUMAN :
  • The acidic N-terminal part may favor interaction with the basic domain of transcription factors.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The acidic N-terminal part may favor interaction with the basic domain of transcription factors.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF7: view

Function for KLF7 Gene

Molecular function for KLF7 Gene

GENATLAS Biochemistry:
Kruppel-like factor 7 (ubiquitous),with homology to the core promoter element binding protein (COPEB)
UniProtKB/Swiss-Prot Function:
Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence.

Phenotypes From GWAS Catalog for KLF7 Gene

Gene Ontology (GO) - Molecular Function for KLF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 9774444
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA 9774444
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity TAS 9774444
genes like me logo Genes that share ontologies with KLF7: view
genes like me logo Genes that share phenotypes with KLF7: view

Animal Models for KLF7 Gene

MGI Knock Outs for KLF7:

Animal Model Products

miRNA for KLF7 Gene

miRTarBase miRNAs that target KLF7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLF7 Gene

Localization for KLF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF7 gene
Compartment Confidence
nucleus 5
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KLF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with KLF7: view

Pathways & Interactions for KLF7 Gene

SuperPathway Contained pathways
1 Adipogenesis
genes like me logo Genes that share pathways with KLF7: view

Pathways by source for KLF7 Gene

1 BioSystems pathway for KLF7 Gene

Gene Ontology (GO) - Biological Process for KLF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS 9774444
GO:0006366 transcription by RNA polymerase II IEA --
GO:0007409 axonogenesis IEA --
genes like me logo Genes that share ontologies with KLF7: view

No data available for SIGNOR curated interactions for KLF7 Gene

Drugs & Compounds for KLF7 Gene

(1) Drugs for KLF7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KLF7: view

Transcripts for KLF7 Gene

Unigene Clusters for KLF7 Gene

Kruppel-like factor 7 (ubiquitous):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLF7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5: - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - -
SP9: -

Relevant External Links for KLF7 Gene

GeneLoc Exon Structure for
KLF7
ECgene alternative splicing isoforms for
KLF7

Expression for KLF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLF7 Gene

This gene is overexpressed in Pancreatic juice (58.7) and Urine (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLF7 Gene



Protein tissue co-expression partners for KLF7 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLF7 Gene:

KLF7

SOURCE GeneReport for Unigene cluster for KLF7 Gene:

Hs.59908

mRNA Expression by UniProt/SwissProt for KLF7 Gene:

O75840-KLF7_HUMAN
Tissue specificity: Ubiquitous and highly expressed in brain and spinal cord in the adult, and in kidney and brain in the embryo.

Evidence on tissue expression from TISSUES for KLF7 Gene

  • Nervous system(4.8)
  • Heart(4.2)
genes like me logo Genes that share expression patterns with KLF7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF7 Gene

Orthologs for KLF7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF7 33 34
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia KLF7 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLF7 33 34
  • 94.81 (n)
dog
(Canis familiaris)
Mammalia KLF7 33 34
  • 94.7 (n)
mouse
(Mus musculus)
Mammalia Klf7 33 16 34
  • 92.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KLF7 34
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLF7 33 34
  • 81.87 (n)
lizard
(Anolis carolinensis)
Reptilia KLF7 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf7 33
  • 73.87 (n)
African clawed frog
(Xenopus laevis)
Amphibia klf7-prov 33
zebrafish
(Danio rerio)
Actinopterygii klf7b 34
  • 69 (a)
OneToMany
klf7a 33 34
  • 64.65 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12029 35
  • 80 (a)
CG9895 35
  • 77 (a)
luna 34
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F56F11.3 35
  • 79 (a)
F53F8.1 35
  • 75 (a)
mua-1 35
  • 69 (a)
klf-3 34
  • 27 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG3 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3394 34
  • 40 (a)
OneToMany
Species where no ortholog for KLF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF7 Gene

ENSEMBL:
Gene Tree for KLF7 (if available)
TreeFam:
Gene Tree for KLF7 (if available)

Paralogs for KLF7 Gene

Variants for KLF7 Gene

Sequence variations from dbSNP and Humsavar for KLF7 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1057518995 uncertain-significance, intellectual deficiency 207,088,525(-) C/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant, synonymous_variant
rs1000002541 -- 207,094,799(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000010961 -- 207,142,790(-) T/A genic_upstream_transcript_variant, intron_variant
rs1000049011 -- 207,098,125(-) C/G genic_downstream_transcript_variant, intron_variant
rs1000049233 -- 207,101,622(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLF7 Gene

Variant ID Type Subtype PubMed ID
nsv1011347 CNV gain 25217958
nsv1138887 CNV deletion 24896259
nsv3129 CNV deletion 18451855
nsv954826 CNV duplication 24416366

Variation tolerance for KLF7 Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLF7 Gene

Human Gene Mutation Database (HGMD)
KLF7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLF7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF7 Gene

Disorders for KLF7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLF7 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
bruxism
  • bruxism - teeth grinding
- elite association - COSMIC cancer census association via MalaCards
Search KLF7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KLF7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KLF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLF7 Gene

Publications for KLF7 Gene

  1. Cloning the cDNA for a new human zinc finger protein defines a group of closely related Krüppel-like transcription factors. (PMID: 9774444) Matsumoto N … Terada M (The Journal of biological chemistry 1998) 2 3 4 22 58
  2. Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes. (PMID: 15937668) Kanazawa A … Maeda S (Diabetologia 2005) 3 22 44 58
  3. Shaking the family tree: identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors. (PMID: 23134681) Camacho-Vanegas O … Martignetti JA (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013) 3 4 58
  4. Variation in the gene encoding Krüppel-like factor 7 influences body fat: studies of 14 818 Danes. (PMID: 19147600) Zobel DP … Hansen T (European journal of endocrinology 2009) 3 44 58
  5. Overexpression of Kruppel-like factor 7 regulates adipocytokine gene expressions in human adipocytes and inhibits glucose-induced insulin secretion in pancreatic beta-cell line. (PMID: 16339272) Kawamura Y … Maeda S (Molecular endocrinology (Baltimore, Md.) 2006) 3 22 58

Products for KLF7 Gene

Sources for KLF7 Gene

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