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This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009] See more...
Aliases for KLF6 Gene
Aliases for KLF6 Gene
- Kruppel Like Factor 6 2 3 5
- CPBP 2 3 4
- Suppressor Of Tumorigenicity 12 Protein 3 4
- Core Promoter Element Binding Protein 2 3
- GC-Rich Sites-Binding Factor GBF 3 4
- B-Cell-Derived Protein 1 3 4
- Transcription Factor Zf9 3 4
- GC-Rich Binding Factor 2 3
- Krueppel-Like Factor 6 3 4
- Proto-Oncogene BCD1 3 4
- COPEB 3 4
- BCD1 3 4
External Ids for KLF6 Gene
- HGNC: 2235
- NCBI Entrez Gene: 1316
- Ensembl: ENSG00000067082
- OMIM®: 602053
- UniProtKB/Swiss-Prot: Q99612
Previous HGNC Symbols for KLF6 Gene
- BCD1
- ST12
- COPEB
Previous GeneCards Identifiers for KLF6 Gene
- GC10M003812
Summaries for KLF6 Gene
-
This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009]
GeneCards Summary for KLF6 Gene
KLF6 (Kruppel Like Factor 6) is a Protein Coding gene. Diseases associated with KLF6 include Prostate Cancer and Gastric Cancer. Among its related pathways are Aryl Hydrocarbon Receptor and Adipogenesis. An important paralog of this gene is KLF7.
UniProtKB/Swiss-Prot Summary for KLF6 Gene
-
Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.
Additional gene information for KLF6 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLF6 Gene
Genomics for KLF6 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for KLF6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around KLF6 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLF6
- Top Transcription factor binding sites by QIAGEN in the KLF6 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- p53
- STAT3
Genomic Locations for KLF6 Gene
Latest Assembly
- chr10:3,775,996-3,785,281
- (GRCh38/hg38)
- Size:
- 9,286 bases
- Orientation:
- Minus strand
Previous Assembly
- chr10:3,818,188-3,827,401
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 9,214 bases
- Orientation:
- Minus strand
Genomic View for KLF6 Gene
Genes around KLF6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p15.2 by HGNC
- 10p15.2 by Entrez Gene
- 10p15.2 by Ensembl
KLF6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KLF6 Gene
Proteins for KLF6 Gene
-
Protein details for KLF6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99612-KLF6_HUMAN
- Recommended name:
- Krueppel-like factor 6
- Protein Accession:
- Q99612
- B2RE86
- B4DDN0
- D3DRR1
- F5H3M5
- Q5VUT7
- Q5VUT8
- Q9BT79
Protein attributes for KLF6 Gene
- Size:
- 283 amino acids
- Molecular mass:
- 31865 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAC23699.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAA33050.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for KLF6 Gene
Selected DME Specific Peptides for KLF6 Gene
- Q99612:
-
- HQRTHTGEKPY
- GDASPDG
Post-translational modifications for KLF6 Gene
Other Protein References for KLF6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences KLF6 Antibody
-
Custom Antibody ServicesOriGene Antibodies for KLF6
- Novus Biologicals Antibodies for KLF6
-
Abcam antibodies for KLF6
- Invitrogen Antibodies for KLF6 (AFLGC-Klf6)
-
Biorbyt antibodies for KLF6
-
Boster Bio Antibodies for KLF6
-
Santa Cruz Biotechnology (SCBT) Antibodies for KLF6
- Sino Biological Antibodies for KLF6
Protein products for research
- G Biosciences Human Krueppel-like factor 6/KLF6, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for KLF6
- Origene Custom Protein Services for KLF6
- ProSpec Recombinant Proteins for KLF6
-
ProSci Proteins for KLF6
-
Abcam proteins for KLF6
Assay products for research
- antibodies-online: Search results for available KLF6 related products ranked by validation data
Domains & Families for KLF6 Gene
Gene Families for KLF6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for KLF6 Gene
- InterPro:
Suggested Antigen Peptide Sequences for KLF6 Gene
- GenScript: Design optimal peptide antigens:
-
- Kruppel-like factor 6 variant SV2 (D3GC14_HUMAN)
- Transcription factor Zf9 (KLF6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q99612UniProtKB/Swiss-Prot:
KLF6_HUMAN :- The acidic N-terminal part may favor interaction with the basic domain of transcription factors.
- Belongs to the krueppel C2H2-type zinc-finger protein family.
- Domain:
-
- The acidic N-terminal part may favor interaction with the basic domain of transcription factors.
- The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In KLF6, the motif is inactive.
- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for KLF6 Gene
Molecular function for KLF6 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.
Enzyme Numbers (IUBMB) for KLF6 Gene
Phenotypes From GWAS Catalog for KLF6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 18755691 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 18755691 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 24634218 |
Phenotypes for KLF6 Gene
- MGI mutant phenotypes for KLF6:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for KLF6:
-
- no effect
- Decreased viability ratio
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased shRNA abundance (Z-score > 2)
- Decreased viability (cell death)
- Decreased shRNA abundance (Z-score < -2)
- Negative genetic interaction between BLM-/- and BLM+/+
- Increased endosome-nucleus distance (endosomes dispersed in the cell periphery)
- Downregulation of RLR pathway after Sendai virus (SeV) infection
Animal Models for KLF6 Gene
- MGI Knock Outs for KLF6:
-
- Klf6 Klf6<tm1Fdmn>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for KLF6 - Starting at $85 >
- * KLF6 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for KLF6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLF6
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLF6
miRNA for KLF6 Gene
- miRTarBase miRNAs that target KLF6
-
- mmu-miR-122-5p (MIRT005975)
- hsa-miR-181a-5p (MIRT006939)
- mmu-miR-24-3p (MIRT013903)
- hsa-miR-124-3p (MIRT022229)
- hsa-miR-148b-3p (MIRT043589)
- hsa-miR-9-5p (MIRT053362)
- hsa-miR-101-3p (MIRT054869)
- hsa-miR-410-3p (MIRT230420)
- hsa-miR-4796-3p (MIRT262478)
- hsa-miR-550a-5p (MIRT262499)
- hsa-miR-550a-3-5p (MIRT262500)
- hsa-miR-1271-3p (MIRT262501)
- hsa-miR-181c-5p (MIRT330481)
- hsa-miR-20b-5p (MIRT437997)
- hsa-miR-15a-5p (MIRT437998)
- hsa-miR-550b-2-5p (MIRT474582)
- hsa-miR-190b (MIRT474583)
- hsa-miR-190a-5p (MIRT474584)
- hsa-miR-4738-3p (MIRT474585)
- hsa-miR-4501 (MIRT474586)
- hsa-miR-4305 (MIRT474587)
- hsa-miR-4524b-3p (MIRT474588)
- hsa-miR-4774-3p (MIRT474589)
- hsa-miR-653-5p (MIRT474590)
- hsa-miR-4423-5p (MIRT474591)
- hsa-miR-495-5p (MIRT474592)
- hsa-miR-7-2-3p (MIRT474593)
- hsa-miR-7-1-3p (MIRT474594)
- hsa-miR-93-5p (MIRT474595)
- hsa-miR-526b-3p (MIRT474596)
- hsa-miR-519d-3p (MIRT474597)
- hsa-miR-20a-5p (MIRT474598)
- hsa-miR-106b-5p (MIRT474599)
- hsa-miR-17-5p (MIRT474600)
- hsa-miR-106a-5p (MIRT474601)
- hsa-miR-548ah-5p (MIRT474602)
- hsa-miR-3609 (MIRT474603)
- hsa-miR-1825 (MIRT485430)
- hsa-miR-575 (MIRT485431)
- hsa-miR-148a-3p (MIRT485432)
- hsa-miR-4676-5p (MIRT485433)
- hsa-miR-152-3p (MIRT485434)
- hsa-miR-3666 (MIRT485435)
- hsa-miR-301b-3p (MIRT485436)
- hsa-miR-4295 (MIRT485437)
- hsa-miR-454-3p (MIRT485438)
- hsa-miR-130b-3p (MIRT485439)
- hsa-miR-301a-3p (MIRT485440)
- hsa-miR-130a-3p (MIRT485441)
- hsa-miR-190a-3p (MIRT556773)
- hsa-miR-340-5p (MIRT556774)
- hsa-miR-223-5p (MIRT556775)
- hsa-miR-6867-5p (MIRT556776)
- hsa-miR-4717-3p (MIRT556777)
- hsa-miR-5011-5p (MIRT556778)
- hsa-miR-5590-3p (MIRT556779)
- hsa-miR-142-5p (MIRT556780)
- hsa-miR-1277-5p (MIRT556781)
- hsa-miR-4422 (MIRT556782)
- hsa-miR-6835-3p (MIRT556783)
- hsa-miR-129-5p (MIRT623425)
- hsa-miR-6885-3p (MIRT623426)
- hsa-miR-511-5p (MIRT623427)
- hsa-miR-6830-3p (MIRT623428)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLF6
- Browse OriGene Inhibitory RNA Products For KLF6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLF6
Clone products for research
- Applied Biological Materials (abm): Clones for KLF6 - Starting at $45 >
- * KLF6 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG204582
- MR204582
- MR204582L1
- MR204582L2
- MR204582L3
- MR204582L4
- RC201763
- RC201763L1
- RC201763L2
- RC201763L3
- RC201763L4
- RC228167
- RC228167L3
- RC228167L4
- RC228174
- RC228174L3
- RC228174L4
- RG201763
- RG228167
- RG228174
- RR200568
- RR200568L3
- RR200568L4
- MR204582L1V
- MR204582L2V
- MR204582L3V
- MR204582L4V
- RC201763L1V
- RC201763L2V
- RC201763L3V
- RC201763L4V
- RC228167L3V
- RC228167L4V
- RC228174L3V
- RC228174L4V
- RR200568L3V
- RR200568L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KLF6
- Addgene plasmids for KLF6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLF6
Cell Lines for research
-
Horizon Cell Lines for KLF6
No data available for Transcription Factor Targets and HOMER Transcription for KLF6 Gene
Localization for KLF6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KLF6 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (3)
- Cytosol (1)
- Nucleoli (1)
- Vesicles (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | ISA | -- |
| GO:0001650 | fibrillar center | IDA | -- |
| GO:0005634 | nucleus | TAS | 9689109 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005730 | nucleolus | IDA | -- |
Pathways & Interactions for KLF6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Adipogenesis | ||
| 2 | Aryl Hydrocarbon Receptor | ||
| 3 | TGF-beta Signaling Pathway (WikiPathways) | ||
Pathways by source for KLF6 Gene
3 BioSystems pathways for KLF6 Gene
Interacting Proteins for KLF6 Gene
Selected Interacting proteins:
Q99612-KLF6_HUMAN
ENSP00000419923
for KLF6 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for KLF6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0030183 | B cell differentiation | NAS | 9000136 |
| GO:0045893 | positive regulation of transcription, DNA-templated | TAS | 9083102 |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA | 18755691 |
Drugs & Compounds for KLF6 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug products for research
- G Biosciences Human Krueppel-like factor 6/KLF6, Lyophilized
Transcripts for KLF6 Gene
mRNA/cDNA for KLF6 Gene
- 4 REFSEQ mRNAs :
- 20 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000173785 925 nts (view in UCSC)
- ENST00000380946 744 nts (view in UCSC)
- ENST00000461124 764 nts (view in UCSC)
- ENST00000469435 2169 nts (view in UCSC)
- ENST00000492125 432 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for KLF6 - Starting at $85 >
- * KLF6 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for KLF6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLF6
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLF6
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLF6
- Browse OriGene Inhibitory RNA Products For KLF6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLF6
Clone products for research
- Applied Biological Materials (abm): Clones for KLF6 - Starting at $45 >
- * KLF6 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG204582
- MR204582
- MR204582L1
- MR204582L2
- MR204582L3
- MR204582L4
- RC201763
- RC201763L1
- RC201763L2
- RC201763L3
- RC201763L4
- RC228167
- RC228167L3
- RC228167L4
- RC228174
- RC228174L3
- RC228174L4
- RG201763
- RG228167
- RG228174
- RR200568
- RR200568L3
- RR200568L4
- MR204582L1V
- MR204582L2V
- MR204582L3V
- MR204582L4V
- RC201763L1V
- RC201763L2V
- RC201763L3V
- RC201763L4V
- RC228167L3V
- RC228167L4V
- RC228174L3V
- RC228174L4V
- RR200568L3V
- RR200568L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KLF6
- Addgene plasmids for KLF6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLF6
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | · | 3f | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||
| SP8: |
Relevant External Links for KLF6 Gene
- GeneLoc Exon Structure for
- KLF6
Expression for KLF6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Adult Corneal Superficial Epithelial Cells Corneal Epithelium
- Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
-
Epithelial Cells
- Adult Corneal Superficial Epithelial Cells Corneal Epithelium
- Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLF6 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLF6
SOURCE GeneReport for Unigene cluster for KLF6 Gene:
Hs.4055mRNA Expression by UniProt/SwissProt for KLF6 Gene:
Q99612-KLF6_HUMAN
Tissue specificity:
Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain, spleen and thymus.
Evidence on tissue expression from TISSUES for KLF6 Gene
- Nervous system(4.9)
- Lung(4.8)
- Blood(4.7)
- Liver(4.7)
- Intestine(3.9)
- Eye(3.5)
- Pancreas(3.5)
- Skin(3.4)
- Muscle(3)
- Bone marrow(2.9)
- Kidney(2.9)
- Heart(2.8)
- Thyroid gland(2.6)
- Lymph node(2.6)
- Spleen(2.6)
- Stomach(2.4)
- Adrenal gland(2.1)
- Gall bladder(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF6 Gene
Germ Layers:
- endoderm
- mesoderm
Systems:
- digestive
- reproductive
Regions:
Abdomen:
- stomach
Pelvis:
- prostate
Primer products for research
-
OriGene qPCR primer pairs for KLF6
-
OriGene qPCR primer pairs and template standards for KLF6
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for KLF6 Gene
Orthologs for KLF6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | KLF6 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | KLF6 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Klf6 29 16 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | KLF6 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Klf6 29 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | KLF6 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | KLF6 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | -- 30 |
|
OneToMany | |
| KLF6 29 30 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | KLF6 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | klf6 29 |
|
||
| Str.3143 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | copeb-prov 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | klf6a 29 30 |
|
OneToOne | |
| Dr.20339 29 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6586 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | luna 30 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3394 30 |
|
OneToMany |
- Species where no ortholog for KLF6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for KLF6 Gene
- ENSEMBL:
- Gene Tree for KLF6 (if available)
- TreeFam:
- Gene Tree for KLF6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KLF6: view image
- Alliance of Genome Resources:
- Additional Orthologs for KLF6
Paralogs for KLF6 Gene
Paralogs for KLF6 Gene
(33) SIMAP similar genes for KLF6 Gene using alignment to 2 proteins:
- KLF6_HUMAN
- D3GC14_HUMAN
Variants for KLF6 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLF6 Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs111743412 | Not Provided: Hypotension | 3,780,085(-) |
G/A NM_001300.6(KLF6):c.800+21C>T |
INTRON | |
| rs112418040 | Not Provided: Hypotension | 3,779,477(-) |
C/T NM_001300.6(KLF6):c.*62G>A |
NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR | |
| rs112847236 | Benign: Hypotension; not provided | 3,781,714(-) |
C/T NM_001300.6(KLF6):c.603G>A (p.Arg201=) |
SYNONYMOUS_VARIANT,INTRON | |
| rs121909139 | Pathogenic: Prostate cancer, somatic | 3,781,971(-) |
A/Gp.Ser116Pro NM_001300.6(KLF6):c.346T>C (p.Ser116Pro) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT | |
| rs121909140 | Pathogenic: Prostate cancer, somatic | 3,781,907(-) |
G/T NM_001300.6(KLF6):c.410C>A (p.Ser137Ter) |
NONSENSE,NON_CODING_TRANSCRIPT |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv661n100 | CNV | gain | 25217958 |
| nsv1126240 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
40.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.89;
35.22% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KLF6 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF6 Gene
Disorders for KLF6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| prostate cancer |
|
|
| gastric cancer |
|
|
| suppression of tumorigenicity 12 |
|
|
| transient global amnesia |
|
|
| hepatocellular carcinoma |
|
|
Search KLF6 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
KLF6_HUMAN- Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {ECO:0000269 PubMed:15824733}. Note=The disease is caused by variants affecting the gene represented in this entry.
- Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269 PubMed:11752579}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for KLF6
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for KLF6 Gene
Publications for KLF6 Gene
- KLF6, a candidate tumor suppressor gene mutated in prostate cancer. (PMID: 11752579) Narla G … Friedman SL (Science (New York, N.Y.) 2001) 3 4 22 72
- The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease. (PMID: 18515091) Miele L … Reeves HL (Gastroenterology 2008) 3 22 40
- KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations. (PMID: 19020536) Agell L … Lloreta J (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008) 3 22 40
- Genome-wide single nucleotide polymorphism analysis of lung cancer risk detects the KLF6 gene. (PMID: 17223258) Spinola M … Dragani TA (Cancer letters 2007) 3 22 40
- Mutation screening and association study of the candidate prostate cancer susceptibility genes MSR1, PTEN, and KLF6. (PMID: 16598737) Bar-Shira A … Orr-Urtreger A (The Prostate 2006) 3 22 40
ExternalLinks
Products for KLF6 Gene
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- RC228167L3V
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- RC228174L3V
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- RR200568L3V
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- antibodies-online: Show 10 available KLF6 Antibodies ranked by validation data
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- antibodies-online: Show 13 available KLF6 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for KLF6
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLF6
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- Boster Bio Antibodies for KLF6
- Browse Boster Bio ELISA Kits
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Sources for KLF6 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
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- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
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- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
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- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
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- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
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- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
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- (122) Horizon
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- (169) SRPDB
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- (171) TarBase
- (172) Open Targets Platform
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- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources