This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009] See more...

Aliases for KLF6 Gene

Aliases for KLF6 Gene

  • Kruppel Like Factor 6 2 3 5
  • Suppressor Of Tumorigenicity 12 Protein 3 4
  • Core Promoter Element-Binding Protein 3 4
  • GC-Rich Sites-Binding Factor GBF 3 4
  • Transcription Factor Zf9 3 4
  • B-Cell-Derived Protein 1 3 4
  • Krueppel-Like Factor 6 3 4
  • GC-Rich Binding Factor 2 3
  • Proto-Oncogene BCD1 3 4
  • COPEB 3 4
  • BCD1 3 4
  • ST12 3 4
  • CPBP 3 4
  • Suppression Of Tumorigenicity 12 (Prostate) 3
  • Core Promoter Element Binding Protein 2
  • Kruppel-Like Zinc Finger Protein Zf9 3
  • Protooncogene B-Cell Derived 1 3
  • EC 2.1.1.43 52
  • EC 6.1.1.15 52
  • CBA1 3
  • PAC1 3
  • GBF 3
  • ZF9 3

External Ids for KLF6 Gene

Previous HGNC Symbols for KLF6 Gene

  • BCD1
  • ST12
  • COPEB

Previous GeneCards Identifiers for KLF6 Gene

  • GC10M003812

Summaries for KLF6 Gene

Entrez Gene Summary for KLF6 Gene

  • This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009]

GeneCards Summary for KLF6 Gene

KLF6 (Kruppel Like Factor 6) is a Protein Coding gene. Diseases associated with KLF6 include Prostate Cancer and Gastric Cancer. Among its related pathways are Aryl Hydrocarbon Receptor and Adipogenesis. An important paralog of this gene is KLF7.

UniProtKB/Swiss-Prot Summary for KLF6 Gene

  • Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.

Gene Wiki entry for KLF6 Gene

Additional gene information for KLF6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLF6 Gene

Genomics for KLF6 Gene

GeneHancer (GH) Regulatory Elements for KLF6 Gene

Promoters and enhancers for KLF6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLF6 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLF6

Top Transcription factor binding sites by QIAGEN in the KLF6 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • p53
  • STAT3

Genomic Locations for KLF6 Gene

Genomic Locations for KLF6 Gene
chr10:3,775,996-3,785,281
(GRCh38/hg38)
Size:
9,286 bases
Orientation:
Minus strand
chr10:3,818,188-3,827,473
(GRCh37/hg19)
Size:
9,286 bases
Orientation:
Minus strand

Genomic View for KLF6 Gene

Genes around KLF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF6 Gene

Proteins for KLF6 Gene

  • Protein details for KLF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99612-KLF6_HUMAN
    Recommended name:
    Krueppel-like factor 6
    Protein Accession:
    Q99612
    Secondary Accessions:
    • B2RE86
    • B4DDN0
    • D3DRR1
    • F5H3M5
    • Q5VUT7
    • Q5VUT8
    • Q9BT79

    Protein attributes for KLF6 Gene

    Size:
    283 amino acids
    Molecular mass:
    31865 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC23699.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAA33050.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLF6 Gene

Selected DME Specific Peptides for KLF6 Gene

Q99612:
  • HQRTHTGEKPY
  • GDASPDG

Post-translational modifications for KLF6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF6 Gene

Domains & Families for KLF6 Gene

Gene Families for KLF6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for KLF6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KLF6 Gene

GenScript: Design optimal peptide antigens:
  • Kruppel-like factor 6 variant SV2 (D3GC14_HUMAN)
  • Transcription factor Zf9 (KLF6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99612

UniProtKB/Swiss-Prot:

KLF6_HUMAN :
  • The acidic N-terminal part may favor interaction with the basic domain of transcription factors.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The acidic N-terminal part may favor interaction with the basic domain of transcription factors.
  • The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In KLF6, the motif is inactive.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF6: view

Function for KLF6 Gene

Molecular function for KLF6 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.

Enzyme Numbers (IUBMB) for KLF6 Gene

Phenotypes From GWAS Catalog for KLF6 Gene

Gene Ontology (GO) - Molecular Function for KLF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 18755691
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 18755691
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with KLF6: view
genes like me logo Genes that share phenotypes with KLF6: view

Human Phenotype Ontology for KLF6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for KLF6 Gene

MGI Knock Outs for KLF6:
  • Klf6 Klf6<tm1Fdmn>

Animal Model Products

CRISPR Products

miRNA for KLF6 Gene

miRTarBase miRNAs that target KLF6

Clone Products

  • Addgene plasmids for KLF6

No data available for Transcription Factor Targets and HOMER Transcription for KLF6 Gene

Localization for KLF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF6 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KLF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus TAS,IBA 9689109
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with KLF6: view

Pathways & Interactions for KLF6 Gene

genes like me logo Genes that share pathways with KLF6: view

Pathways by source for KLF6 Gene

SIGNOR curated interactions for KLF6 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for KLF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0030183 B cell differentiation NAS 9000136
GO:0045893 positive regulation of transcription, DNA-templated TAS 9083102
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 18755691
genes like me logo Genes that share ontologies with KLF6: view

Drugs & Compounds for KLF6 Gene

(5) Drugs for KLF6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for KLF6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLF6: view

Transcripts for KLF6 Gene

mRNA/cDNA for KLF6 Gene

4 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for KLF6

Alternative Splicing Database (ASD) splice patterns (SP) for KLF6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - -
SP2:
SP3: - - - -
SP4: - - -
SP5: - - -
SP6: -
SP7: - -
SP8:

Relevant External Links for KLF6 Gene

GeneLoc Exon Structure for
KLF6

Expression for KLF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLF6 Gene



Protein tissue co-expression partners for KLF6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLF6

SOURCE GeneReport for Unigene cluster for KLF6 Gene:

Hs.4055

mRNA Expression by UniProt/SwissProt for KLF6 Gene:

Q99612-KLF6_HUMAN
Tissue specificity: Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain, spleen and thymus.

Evidence on tissue expression from TISSUES for KLF6 Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Blood(4.6)
  • Liver(4.6)
  • Intestine(3.7)
  • Eye(3.2)
  • Pancreas(3)
  • Skin(2.5)
  • Heart(2.4)
  • Kidney(2.4)
  • Muscle(2.4)
  • Bone marrow(2.2)
  • Gall bladder(2.1)
  • Lymph node(2.1)
  • Thyroid gland(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF6 Gene

Germ Layers:
  • endoderm
  • mesoderm
Systems:
  • digestive
  • reproductive
Regions:
Abdomen:
  • stomach
Pelvis:
  • prostate
genes like me logo Genes that share expression patterns with KLF6: view

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for KLF6 Gene

Orthologs for KLF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF6 31 30
  • 99.76 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KLF6 31 30
  • 88.69 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Klf6 17 31 30
  • 87.75 (n)
cow
(Bos Taurus)
Mammalia KLF6 31 30
  • 87.63 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klf6 30
  • 87.04 (n)
oppossum
(Monodelphis domestica)
Mammalia KLF6 31
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLF6 31
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 31
  • 82 (a)
OneToMany
KLF6 31 30
  • 80.65 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia KLF6 31
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf6 30
  • 76.34 (n)
Str.3143 30
African clawed frog
(Xenopus laevis)
Amphibia copeb-prov 30
zebrafish
(Danio rerio)
Actinopterygii klf6a 31 30
  • 71.46 (n)
OneToOne
Dr.20339 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6586 30
fruit fly
(Drosophila melanogaster)
Insecta luna 31
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3394 31
  • 40 (a)
OneToMany
Species where no ortholog for KLF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLF6 Gene

ENSEMBL:
Gene Tree for KLF6 (if available)
TreeFam:
Gene Tree for KLF6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLF6: view image

Paralogs for KLF6 Gene

(33) SIMAP similar genes for KLF6 Gene using alignment to 2 proteins:

  • KLF6_HUMAN
  • D3GC14_HUMAN
genes like me logo Genes that share paralogs with KLF6: view

Variants for KLF6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLF6 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs111743412 Not Provided: Hypotension 3,780,085(-) G/A INTRON_VARIANT
rs112418040 Not Provided: Hypotension 3,779,477(-) C/T NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT
rs112847236 Not Provided: Hypotension 3,781,714(-) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
rs121909139 Pathogenic: Prostate cancer, somatic. - 3,781,971(-) A/Gp.Ser116Pro MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs121909140 Pathogenic: Prostate cancer, somatic 3,781,907(-) G/T NONSENSE,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for KLF6 Gene

Structural Variations from Database of Genomic Variants (DGV) for KLF6 Gene

Variant ID Type Subtype PubMed ID
dgv661n100 CNV gain 25217958
nsv1126240 CNV deletion 24896259

Variation tolerance for KLF6 Gene

Residual Variation Intolerance Score: 40.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLF6 Gene

Human Gene Mutation Database (HGMD)
KLF6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLF6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF6 Gene

Disorders for KLF6 Gene

MalaCards: The human disease database

(8) MalaCards diseases for KLF6 Gene - From: OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, somatic
gastric cancer
  • gastric cancer, somatic
suppression of tumorigenicity 12
  • st12
transient global amnesia
  • amnesia, transient global
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search KLF6 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

KLF6_HUMAN
  • Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {ECO:0000269 PubMed:15824733}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269 PubMed:11752579}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for KLF6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KLF6: view

No data available for Genatlas for KLF6 Gene

Publications for KLF6 Gene

  1. The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease. (PMID: 18515091) Miele L … Reeves HL (Gastroenterology 2008) 3 23 41 54
  2. KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations. (PMID: 19020536) Agell L … Lloreta J (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008) 3 23 41 54
  3. Genome-wide single nucleotide polymorphism analysis of lung cancer risk detects the KLF6 gene. (PMID: 17223258) Spinola M … Dragani TA (Cancer letters 2007) 3 23 41 54
  4. Mutation screening and association study of the candidate prostate cancer susceptibility genes MSR1, PTEN, and KLF6. (PMID: 16598737) Bar-Shira A … Orr-Urtreger A (The Prostate 2006) 3 23 41 54
  5. A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk. (PMID: 15735005) Narla G … Martignetti JA (Cancer research 2005) 3 23 41 54

Products for KLF6 Gene