Aliases for KLF6 Gene
Aliases for KLF6 Gene
External Ids for KLF6 Gene
- HGNC: 2235
- Entrez Gene: 1316
- Ensembl: ENSG00000067082
- OMIM: 602053
- UniProtKB: Q99612
Previous HGNC Symbols for KLF6 Gene
- BCD1
- ST12
- COPEB
Summaries for KLF6 Gene
-
This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009]
GeneCards Summary for KLF6 Gene
KLF6 (Kruppel Like Factor 6) is a Protein Coding gene. Diseases associated with KLF6 include Gastric Cancer and Prostate Cancer. Among its related pathways are Aryl Hydrocarbon Receptor and Adipogenesis. An important paralog of this gene is KLF7.
UniProtKB/Swiss-Prot for KLF6 Gene
-
Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.
Additional gene information for KLF6 Gene
- Monarch Initiative
- Search for KLF6 at DataMed
- Search for KLF6 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF6 Gene
Genomics for KLF6 Gene
GeneHancer (GH) Regulatory Elements for KLF6 Gene
Promoters and enhancers for KLF6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around KLF6 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for KLF6 Gene
Genomic Locations for KLF6 Gene
- chr10:3,775,996-3,785,281
- (GRCh38/hg38)
- Size:
- 9,286 bases
- Orientation:
- Minus strand
- chr10:3,818,188-3,827,473
- (GRCh37/hg19)
Genomic View for KLF6 Gene
Genes around KLF6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p15.2 by Ensembl
- 10p15.2 by Entrez Gene
- 10p15.2 by HGNC
KLF6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KLF6 Gene
Proteins for KLF6 Gene
-
Protein details for KLF6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99612-KLF6_HUMAN
- Recommended name:
- Krueppel-like factor 6
- Protein Accession:
- Q99612
- B2RE86
- B4DDN0
- D3DRR1
- F5H3M5
- Q5VUT7
- Q5VUT8
- Q9BT79
Protein attributes for KLF6 Gene
- Size:
- 283 amino acids
- Molecular mass:
- 31865 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAC23699.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA33050.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for KLF6 Gene
Selected DME Specific Peptides for KLF6 Gene
- Q99612:
-
- HQRTHTGEKPY
- GDASPDG
Post-translational modifications for KLF6 Gene
No Post-translational modifications
Other Protein References for KLF6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for KLF6 (KLF6)
-
Custom Antibody ServicesOriGene Antibodies for KLF6
- Novus Biologicals Antibodies for KLF6
-
Abcam antibodies for KLF6
- Invitrogen Antibodies for KLF6
- Search GeneTex for Antibodies for KLF6
-
Santa Cruz Biotechnology (SCBT) Antibodies for KLF6
Protein Products
-
OriGene Purified Proteins for KLF6
- Search Origene for MassSpec and Protein Over-expression Lysates for KLF6
- Origene Custom Protein Services for KLF6
- ProSpec Recombinant Proteins for KLF6
- Search GeneTex for Proteins for KLF6
-
ProSci Proteins for KLF6
-
Abcam proteins for KLF6
Assay Products
- antibodies-online: Search results for available KLF6 related products ranked by validation data
Domains & Families for KLF6 Gene
Gene Families for KLF6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for KLF6 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for KLF6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99612UniProtKB/Swiss-Prot:
KLF6_HUMAN :- The acidic N-terminal part may favor interaction with the basic domain of transcription factors.
- Belongs to the krueppel C2H2-type zinc-finger protein family.
- Domain:
-
- The acidic N-terminal part may favor interaction with the basic domain of transcription factors.
- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for KLF6 Gene
Molecular function for KLF6 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.
Enzyme Numbers (IUBMB) for KLF6 Gene
Phenotypes From GWAS Catalog for KLF6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 18755691 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 18755691 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 24634218 |
Phenotypes for KLF6 Gene
- MGI mutant phenotypes for KLF6:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for KLF6:
-
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Increased shRNA abundance (Z-score > 2)
- Decreased viability ratio
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Negative genetic interaction between BLM-/- and BLM+/+
- Upregulation of RLR pathway after Sendai virus (SeV) infection
Animal Models for KLF6 Gene
- MGI Knock Outs for KLF6:
-
- Klf6 tm1Fdmn
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for KLF6
-
-
ViGene Biosciences lentiviral particle packaged cDNA for KLF6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KLF6 gene
- Search ViGene Biosciences for KLF6
CRISPR Products
-
OriGene CRISPR knockouts for KLF6
- genomics-online: gRNA clones - Search results for 128 available KLF6 gene related products
- Overview of 128 available KLF6 gene related products
- Applied Biological Materials CRISPR for KLF6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLF6
- GenScript: Design CRISPR guide RNA sequences for KLF6
miRNA for KLF6 Gene
- miRTarBase miRNAs that target KLF6
-
- hsa-mir-181a-5p (MIRT006939)
- hsa-mir-124-3p (MIRT022229)
- hsa-mir-148b-3p (MIRT043589)
- hsa-mir-9-5p (MIRT053362)
- hsa-mir-101-3p (MIRT054869)
- hsa-mir-410-3p (MIRT230420)
- hsa-mir-4796-3p (MIRT262478)
- hsa-mir-550a-5p (MIRT262499)
- hsa-mir-550a-3-5p (MIRT262500)
- hsa-mir-1271-3p (MIRT262501)
- hsa-mir-181c-5p (MIRT330481)
- hsa-mir-20b-5p (MIRT437997)
- hsa-mir-15a-5p (MIRT437998)
- hsa-mir-550b-2-5p (MIRT474582)
- hsa-mir-190b (MIRT474583)
- hsa-mir-190a-5p (MIRT474584)
- hsa-mir-4738-3p (MIRT474585)
- hsa-mir-4501 (MIRT474586)
- hsa-mir-4305 (MIRT474587)
- hsa-mir-4524b-3p (MIRT474588)
- hsa-mir-4774-3p (MIRT474589)
- hsa-mir-653-5p (MIRT474590)
- hsa-mir-4423-5p (MIRT474591)
- hsa-mir-495-5p (MIRT474592)
- hsa-mir-7-2-3p (MIRT474593)
- hsa-mir-7-1-3p (MIRT474594)
- hsa-mir-93-5p (MIRT474595)
- hsa-mir-526b-3p (MIRT474596)
- hsa-mir-519d-3p (MIRT474597)
- hsa-mir-20a-5p (MIRT474598)
- hsa-mir-106b-5p (MIRT474599)
- hsa-mir-17-5p (MIRT474600)
- hsa-mir-106a-5p (MIRT474601)
- hsa-mir-548ah-5p (MIRT474602)
- hsa-mir-3609 (MIRT474603)
- hsa-mir-1825 (MIRT485430)
- hsa-mir-575 (MIRT485431)
- hsa-mir-148a-3p (MIRT485432)
- hsa-mir-4676-5p (MIRT485433)
- hsa-mir-152-3p (MIRT485434)
- hsa-mir-3666 (MIRT485435)
- hsa-mir-301b-3p (MIRT485436)
- hsa-mir-4295 (MIRT485437)
- hsa-mir-454-3p (MIRT485438)
- hsa-mir-130b-3p (MIRT485439)
- hsa-mir-301a-3p (MIRT485440)
- hsa-mir-130a-3p (MIRT485441)
- hsa-mir-190a-3p (MIRT556773)
- hsa-mir-340-5p (MIRT556774)
- hsa-mir-223-5p (MIRT556775)
- hsa-mir-6867-5p (MIRT556776)
- hsa-mir-4717-3p (MIRT556777)
- hsa-mir-5011-5p (MIRT556778)
- hsa-mir-5590-3p (MIRT556779)
- hsa-mir-142-5p (MIRT556780)
- hsa-mir-1277-5p (MIRT556781)
- hsa-mir-4422 (MIRT556782)
- hsa-mir-6835-3p (MIRT556783)
- hsa-mir-129-5p (MIRT623425)
- hsa-mir-6885-3p (MIRT623426)
- hsa-mir-511-5p (MIRT623427)
- hsa-mir-6830-3p (MIRT623428)
miRNA Products
- Search ViGene Biosciences for KLF6
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for KLF6
- Browse OriGene Inhibitory RNA Products For KLF6
- genomics-online: shRNA clones - Search results for 128 available KLF6 gene related products
- Overview of 128 available KLF6 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for KLF6 gene
Clone Products
-
OriGene ORF clones in human for KLF6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KLF6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for KLF6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KLF6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for KLF6
- Applied Biological Materials Clones for KLF6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KLF6
-
ViGene Biosciences adenoviral particle packaged cDNA for KLF6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for KLF6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KLF6 gene
No data available for Transcription Factor Targets and HOMER Transcription for KLF6 Gene
Localization for KLF6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KLF6 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 1 |
- Cytosol (2)
- Nucleoli fibrillar center (2)
- Nucleus (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001650 | fibrillar center | IDA | -- |
| GO:0005634 | nucleus | TAS,IDA | 9689109 |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | -- |
Pathways & Interactions for KLF6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Adipogenesis | ||
| 2 | Aryl Hydrocarbon Receptor | ||
| 3 | TGF-beta Signaling Pathway (WikiPathways) | ||
Pathways by source for KLF6 Gene
3 BioSystems pathways for KLF6 Gene
Interacting Proteins for KLF6 Gene
Selected Interacting proteins:
ENSP00000419923
Q99612-KLF6_HUMAN
for KLF6 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | IEA | -- |
| GO:0030183 | B cell differentiation | NAS | 9000136 |
| GO:0045893 | positive regulation of transcription, DNA-templated | TAS | 9083102 |
Transcripts for KLF6 Gene
mRNA/cDNA for KLF6 Gene
- (4) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (765) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for KLF6
- genomics-online: gRNA clones - Search results for 128 available KLF6 gene related products
- Overview of 128 available KLF6 gene related products
- Applied Biological Materials CRISPR for KLF6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLF6
- GenScript: Design CRISPR guide RNA sequences for KLF6
miRNA Products
- Search ViGene Biosciences for KLF6
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for KLF6
- Browse OriGene Inhibitory RNA Products For KLF6
- genomics-online: shRNA clones - Search results for 128 available KLF6 gene related products
- Overview of 128 available KLF6 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for KLF6 gene
Clone Products
-
OriGene ORF clones in human for KLF6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KLF6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for KLF6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KLF6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for KLF6
- Applied Biological Materials Clones for KLF6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | · | 3f | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||
| SP8: |
Expression for KLF6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
- Adult Corneal Superficial Epithelial Cells Corneal Epithelium
-
Eye (Sensory Organs)
- Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
- Adult Corneal Superficial Epithelial Cells Corneal Epithelium
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLF6 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of KLF6 Gene:
KLF6SOURCE GeneReport for Unigene cluster for KLF6 Gene:
Hs.4055mRNA Expression by UniProt/SwissProt for KLF6 Gene:
Q99612-KLF6_HUMAN
Tissue specificity:
Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain, spleen and thymus.
Evidence on tissue expression from TISSUES for KLF6 Gene
- Nervous system(4.9)
- Lung(4.8)
- Blood(4.6)
- Liver(4.6)
- Intestine(3.7)
- Eye(3.2)
- Pancreas(3)
- Kidney(2.5)
- Skin(2.5)
- Heart(2.4)
- Muscle(2.4)
- Bone marrow(2.2)
- Gall bladder(2.1)
- Lymph node(2.1)
- Thyroid gland(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF6 Gene
Germ Layers:
- endoderm
- mesoderm
Systems:
- digestive
- reproductive
Regions:
Abdomen:
- stomach
Pelvis:
- prostate
Primer Products
-
OriGene qPCR primer pairs for KLF6
-
OriGene qPCR primer pairs and template standards for KLF6
- genomics-online: primer clones - Search results for 128 available KLF6 gene related products
- Overview of 128 available KLF6 gene related products
No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for KLF6 Gene
Orthologs for KLF6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KLF6 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | KLF6 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Klf6 33 16 34 |
|
||
| cow (Bos Taurus) |
Mammalia | KLF6 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Klf6 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | KLF6 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | KLF6 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| KLF6 33 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | KLF6 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | klf6 33 |
|
||
| Str.3143 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | copeb-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | klf6a 33 34 |
|
||
| Dr.20339 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6586 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | luna 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3394 34 |
|
OneToMany |
- Species where no ortholog for KLF6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for KLF6 Gene
(33) SIMAP similar genes for KLF6 Gene using alignment to 2 proteins:
Variants for KLF6 Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs111743412 | not-provided, Hypotension | 3,780,085(-) | G/A | intron_variant | |
| rs112418040 | not-provided, Hypotension | 3,779,477(-) | C/A/T | 3_prime_UTR_variant, non_coding_transcript_variant | |
| rs112847236 | not-provided, Hypotension | 3,781,714(-) | C/T | coding_sequence_variant, intron_variant, synonymous_variant | |
| rs121909139 | pathogenic, Prostate cancer, somatic | 3,781,971(-) | A/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs121909140 | pathogenic, Prostate cancer, somatic | 3,781,907(-) | G/A/C/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant, stop_gained |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1126240 | CNV | deletion | 24896259 |
| dgv661n100 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
40.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.89;
35.22% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KLF6 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF6 Gene
Disorders for KLF6 Gene
(6) MalaCards diseases for KLF6 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gastric cancer |
|
|
| prostate cancer |
|
|
| suppression of tumorigenicity 12 |
|
|
| transient global amnesia |
|
|
| hepatocellular carcinoma |
|
Search KLF6 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
KLF6_HUMAN- Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {ECO:0000269 PubMed:15824733}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269 PubMed:11752579}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for KLF6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for KLF6 Gene
Publications for KLF6 Gene
- The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease. (PMID: 18515091) Miele L … Reeves HL (Gastroenterology 2008) 3 22 44 58
- KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations. (PMID: 19020536) Agell L … Lloreta J (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008) 3 22 44 58
- Genome-wide single nucleotide polymorphism analysis of lung cancer risk detects the KLF6 gene. (PMID: 17223258) Spinola M … Dragani TA (Cancer letters 2007) 3 22 44 58
- Mutation screening and association study of the candidate prostate cancer susceptibility genes MSR1, PTEN, and KLF6. (PMID: 16598737) Bar-Shira A … Orr-Urtreger A (The Prostate 2006) 3 22 44 58
- Genetic alterations of the KLF6 gene in gastric cancer. (PMID: 15824733) Cho YG … Park WS (Oncogene 2005) 3 4 22 58
Products for KLF6 Gene
- R&D Systems Antibodies for KLF6 (KLF6)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for KLF6
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for KLF6
- Search Origene for MassSpec and Protein Over-expression Lysates for KLF6
- Origene Custom Protein Services for KLF6
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLF6
- Browse OriGene Inhibitory RNA Products For KLF6
- OriGene qPCR primer pairs and template standards for KLF6
- OriGene qPCR primer pairs for KLF6
- OriGene CRISPR knockouts for KLF6
- OriGene ORF clones in human for KLF6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For KLF6
- GenScript: Next-day shipping of latest version cDNA ORF clones for KLF6 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for KLF6
- GenScript Custom Assay Services for KLF6
- GenScript Custom overexpressing Cell Line Services for KLF6
- GenScript: Design CRISPR guide RNA sequences for KLF6
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for KLF6
- Sino Biological Human cDNA Clone for KLF6
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for KLF6
- Novus Biologicals lysates and proteins for KLF6
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for KLF6
- Abcam proteins for KLF6
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for KLF6
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for KLF6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for KLF6
- VectorBuilder custom plasmid, inducible vectors for KLF6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KLF6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for KLF6
- antibodies-online: Search results for 48 available KLF6 Antibodies ranked by validation data
- Compare Top KLF6 Antibodies
- antibodies-online: Search results for available KLF6 related products ranked by validation data
- antibodies-online: Search results for 18 available KLF6 Proteins ranked by validation data
- Compare Top KLF6 Proteins
- Search GeneTex for Antibodies for KLF6
- Search GeneTex for Proteins for KLF6
- ViGene Biosciences adenoviral particle packaged cDNA for KLF6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for KLF6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for KLF6 gene
- Search ViGene Biosciences for KLF6
- Santa Cruz Biotechnology (SCBT) Antibodies for KLF6
- Search Santa Cruz Biotechnology (SCBT) for KLF6 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for KLF6
- Search for KLF6 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for KLF6
- Horizon Cell Lines for KLF6
- genomics-online: cdna clones - Search results for 128 available KLF6 gene related products
- Overview of 128 available KLF6 gene related products
- orf clones - Search results for 128 available KLF6 gene related products
- Overview of 128 available KLF6 gene related products
- genomics-online: gRNA clones - Search results for 128 available KLF6 gene related products
- Overview of 128 available KLF6 gene related products
- genomics-online: primer clones - Search results for 128 available KLF6 gene related products
- Overview of 128 available KLF6 gene related products
- genomics-online: shRNA clones - Search results for 128 available KLF6 gene related products
- Overview of 128 available KLF6 gene related products
Sources for KLF6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew