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This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009]
KLF6 (Kruppel Like Factor 6) is a Protein Coding gene. Diseases associated with KLF6 include Prostate Cancer and Gastric Cancer. Among its related pathways are TGF-beta Signaling Pathway (WikiPathways) and Adipogenesis. An important paralog of this gene is KLF7.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IBA | 21873635 |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 18755691 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 18755691 |
GO:0003676 | nucleic acid binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0001650 | fibrillar center | IDA | -- |
GO:0005634 | nucleus | IBA,TAS | 9689109 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005730 | nucleolus | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Adipogenesis | ||
2 | Aryl Hydrocarbon Receptor | ||
3 | TGF-beta Signaling Pathway (WikiPathways) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | -- |
GO:0030183 | B cell differentiation | NAS | 9000136 |
GO:0045893 | positive regulation of transcription, DNA-templated | TAS | 9083102 |
GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA | 18755691 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
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Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | · | 3f | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||||||
SP8: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | KLF6 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | KLF6 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Klf6 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | KLF6 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Klf6 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | KLF6 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | KLF6 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
KLF6 30 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | KLF6 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | klf6 30 |
|
||
Str.3143 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | copeb-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | klf6a 30 31 |
|
OneToOne | |
Dr.20339 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6586 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | luna 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3394 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
717974 | Benign: not provided | 3,782,086(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
773788 | Benign: not provided | 3,781,723(-) | C/T | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
rs111743412 | Not Provided: Hypotension | 3,780,085(-) | G/A | INTRON_VARIANT | |
rs112418040 | Not Provided: Hypotension | 3,779,477(-) | C/T | NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT | |
rs112847236 | Benign: Hypotension; not provided | 3,781,714(-) | C/T | SYNONYMOUS_VARIANT,INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv661n100 | CNV | gain | 25217958 |
nsv1126240 | CNV | deletion | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
prostate cancer |
|
|
gastric cancer |
|
|
suppression of tumorigenicity 12 |
|
|
transient global amnesia |
|
|
colorectal cancer |
|