This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both prom... See more...

Aliases for KLF5 Gene

Aliases for KLF5 Gene

  • Kruppel Like Factor 5 2 3 5
  • Intestinal-Enriched Krueppel-Like Factor 3 4
  • Kruppel-Like Factor 5 (Intestinal) 2 3
  • (Intestinal Kruppel-Like Factor 2 3
  • Colon Krueppel-Like Factor 3 4
  • Transcription Factor BTEB2 3 4
  • Krueppel-Like Factor 5 3 4
  • BTE-Binding Protein 2 3 4
  • BTEB2 3 4
  • CKLF 3 4
  • IKLF 3 4
  • Basic Transcription Element Binding Protein 2 3
  • Basic Transcription Element-Binding Protein 2 4
  • Epididymis Secretory Sperm Binding Protein 3
  • Intestinal-Enriched Kruppel-Like Factor 3
  • Colon Kruppel-Like Factor 3
  • GC Box Binding Protein 2 3
  • GC-Box-Binding Protein 2 4
  • Klf5C Isoform 3

External Ids for KLF5 Gene

Previous HGNC Symbols for KLF5 Gene

  • BTEB2

Previous GeneCards Identifiers for KLF5 Gene

  • GC13P071600
  • GC13P067627
  • GC13P072569
  • GC13P071430
  • GC13P072530
  • GC13P073629
  • GC13P054330

Summaries for KLF5 Gene

Entrez Gene Summary for KLF5 Gene

  • This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

GeneCards Summary for KLF5 Gene

KLF5 (Kruppel Like Factor 5) is a Protein Coding gene. Diseases associated with KLF5 include Sigmoid Disease and Colorectal Cancer. Among its related pathways are Mesodermal Commitment Pathway and Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is KLF4.

UniProtKB/Swiss-Prot Summary for KLF5 Gene

  • Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Tocris Summary for KLF5 Gene

Gene Wiki entry for KLF5 Gene

Additional gene information for KLF5 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLF5 Gene

Genomics for KLF5 Gene

GeneHancer (GH) Regulatory Elements for KLF5 Gene

Promoters and enhancers for KLF5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J073054 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 507.7 +10.9 10949 23.6 ZNF217 EP300 NRF1 TCF12 POLR2G SP1 JUND FOS CTCF POLR2A KLF5 piR-50444-102 RNU4-10P
GH13J073597 Enhancer 0.8 Ensembl ENCODE 11.1 +543.7 543724 2.2 POLR2A CTBP1 ZNF184 FOS FOSL2 CEBPB JUN FOSL1 STAT3 JUND KLF5 LOC105370256 lnc-KLF12-2 LINC00393
GH13J073464 Enhancer 1.1 Ensembl ENCODE dbSUPER 7.4 +411.0 411025 3.6 EP300 POLR2A NCOR1 CTCF ZNF316 ARNT MAFF MYNN FOS MAFK KLF5 lnc-KLF5-11 piR-50437-154 LINC00393
GH13J073427 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 5.6 +374.3 374325 4.2 TCF12 JUND POLR2A EP300 FOS NR3C1 FOSL2 CEBPB CHD2 JUN KLF5 lnc-KLF12-3 lnc-KLF5-15 LINC00393
GH13J073617 Enhancer 0.7 Ensembl ENCODE 9.5 +563.9 563879 1.8 WT1 PRDM6 PRDM4 TRIM28 PKNOX1 NR3C1 ZNF561 KLF5 lnc-KLF12-2 LOC105370256 LINC00393
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLF5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLF5

Top Transcription factor binding sites by QIAGEN in the KLF5 gene promoter:
  • C/EBPalpha
  • C/EBPbeta
  • CREB
  • deltaCREB
  • E2F
  • E2F-2
  • NF-kappaB
  • NF-kappaB1
  • p53

Genomic Locations for KLF5 Gene

Genomic Locations for KLF5 Gene
chr13:73,054,976-73,077,542
(GRCh38/hg38)
Size:
22,567 bases
Orientation:
Plus strand
chr13:73,629,114-73,651,676
(GRCh37/hg19)
Size:
22,563 bases
Orientation:
Plus strand

Genomic View for KLF5 Gene

Genes around KLF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF5 Gene

Proteins for KLF5 Gene

  • Protein details for KLF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13887-KLF5_HUMAN
    Recommended name:
    Krueppel-like factor 5
    Protein Accession:
    Q13887
    Secondary Accessions:
    • A2TJX0
    • L0R3U5
    • L0R4T9
    • Q9UHP8

    Protein attributes for KLF5 Gene

    Size:
    457 amino acids
    Molecular mass:
    50792 Da
    Quaternary structure:
    • Interacts with WWP1.

    Three dimensional structures from OCA and Proteopedia for KLF5 Gene

    Alternative splice isoforms for KLF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLF5 Gene

Post-translational modifications for KLF5 Gene

  • Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLF5 Gene

Domains & Families for KLF5 Gene

Gene Families for KLF5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for KLF5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KLF5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58646, highly similar to Krueppel-like factor 5 (A2TJX0_HUMAN)
  • cDNA FLJ60663, highly similar to Krueppel-like factor 5 (B4DL96_HUMAN)
  • Transcription factor BTEB2 (KLF5_HUMAN)
  • Kruppel-like factor 5 (Intestinal), isoform CRA_a (Q5T6X2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13887

UniProtKB/Swiss-Prot:

KLF5_HUMAN :
  • The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF5: view

Function for KLF5 Gene

Molecular function for KLF5 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Phenotypes From GWAS Catalog for KLF5 Gene

Gene Ontology (GO) - Molecular Function for KLF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 16595680
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 16595680
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with KLF5: view
genes like me logo Genes that share phenotypes with KLF5: view

Animal Models for KLF5 Gene

MGI Knock Outs for KLF5:

Animal Model Products

CRISPR Products

Targeted motifs for KLF5 Gene
HOMER Transcription Factor Regulatory Elements motif KLF5
  • Consensus sequence: DGGGYGKGGC Submotif: canonical Cell Type: LoVo GEO ID: GSE49402

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLF5

Clone Products

  • Addgene plasmids for KLF5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for KLF5 Gene

Localization for KLF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF5 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
plasma membrane 3
cytosol 3
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Golgi apparatus (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KLF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with KLF5: view

Pathways & Interactions for KLF5 Gene

genes like me logo Genes that share pathways with KLF5: view

Pathways by source for KLF5 Gene

SIGNOR curated interactions for KLF5 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for KLF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001525 angiogenesis IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0006366 transcription by RNA polymerase II TAS 8479902
genes like me logo Genes that share ontologies with KLF5: view

Drugs & Compounds for KLF5 Gene

(8) Drugs for KLF5 Gene - From: Tocris and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Verteporfin Approved, Investigational Pharma YAP inhibitor; disrupts YAP-TEAD interactions 98
BI 6015 Pharma HNF4α antagonist, Hepatocyte nuclear factor 4alpha (HNF4alpha) antagonist 0

(3) Additional Compounds for KLF5 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CID 5951923
749872-43-3
RG 102240
162326-49-0
Stauprimide
154589-96-5

(5) Tocris Compounds for KLF5 Gene

Compound Action Cas Number
BI 6015 Hepatocyte nuclear factor 4alpha (HNF4alpha) antagonist 93987-29-2
CID 5951923 Kr�ppel-like factor 5 (KLF5) inhibitor 749872-43-3
RG 102240 Gene switch ligand for use in induceable gene expression systems 162326-49-0
Stauprimide Inhibits NME2 nuclear translocation; primes ESCs for differentiation 154589-96-5
Verteporfin YAP inhibitor; disrupts YAP-TEAD interactions 129497-78-5
genes like me logo Genes that share compounds with KLF5: view

Transcripts for KLF5 Gene

mRNA/cDNA for KLF5 Gene

2 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLF5

Clone Products

  • Addgene plasmids for KLF5

Alternative Splicing Database (ASD) splice patterns (SP) for KLF5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2:
SP3:

Relevant External Links for KLF5 Gene

GeneLoc Exon Structure for
KLF5

Expression for KLF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF5 Gene

This gene is overexpressed in Esophagus - Mucosa (x9.2), Skin - Sun Exposed (Lower leg) (x6.9), Skin - Not Sun Exposed (Suprapubic) (x6.6), and Colon - Transverse (x4.9).

Protein differential expression in normal tissues from HIPED for KLF5 Gene

This gene is overexpressed in Placenta (40.9) and Prostate (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KLF5 Gene



Protein tissue co-expression partners for KLF5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLF5

SOURCE GeneReport for Unigene cluster for KLF5 Gene:

Hs.508234

mRNA Expression by UniProt/SwissProt for KLF5 Gene:

Q13887-KLF5_HUMAN
Tissue specificity: Expressed only in testis and placenta.

Evidence on tissue expression from TISSUES for KLF5 Gene

  • Nervous system(4.2)
  • Intestine(3.8)
  • Skin(2.7)
  • Muscle(2.4)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with KLF5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF5 Gene

Orthologs for KLF5 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF5 31 30
  • 99.64 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLF5 31
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLF5 31 30
  • 94.53 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KLF5 31 30
  • 93.54 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klf5 30
  • 90.05 (n)
mouse
(Mus musculus)
Mammalia Klf5 17 31 30
  • 89.82 (n)
oppossum
(Monodelphis domestica)
Mammalia KLF5 31
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLF5 31 30
  • 82.21 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLF5 31
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf5 30
  • 72.65 (n)
Str.15084 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.14648 30
zebrafish
(Danio rerio)
Actinopterygii LOC100006043 30
  • 60.62 (n)
klf5b 31
  • 51 (a)
OneToMany
klf5a 31
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9895 32
  • 80 (a)
CG12029 32
  • 79 (a)
dar1 31
  • 16 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F56F11.3 32
  • 77 (a)
F53F8.1 32
  • 65 (a)
mua-1 32
  • 39 (a)
klf-2 31
  • 31 (a)
OneToMany
klf-1 31
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 23 (a)
OneToOne
Species where no ortholog for KLF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF5 Gene

ENSEMBL:
Gene Tree for KLF5 (if available)
TreeFam:
Gene Tree for KLF5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLF5: view image

Paralogs for KLF5 Gene

(27) SIMAP similar genes for KLF5 Gene using alignment to 3 proteins:

  • KLF5_HUMAN
  • A2TJX0_HUMAN
  • Q5T6X2_HUMAN
genes like me logo Genes that share paralogs with KLF5: view

Variants for KLF5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLF5 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
776799 Benign: not provided 73,062,344(+) A/G MISSENSE_VARIANT
VAR_035555 A colorectal cancer sample p.Pro301Ser

Additional dbSNP identifiers (rs#s) for KLF5 Gene

Structural Variations from Database of Genomic Variants (DGV) for KLF5 Gene

Variant ID Type Subtype PubMed ID
dgv998n106 CNV deletion 24896259
esv22464 CNV loss 19812545
esv3310189 CNV mobile element insertion 20981092
esv3336418 CNV insertion 20981092
nsv1070180 CNV deletion 25765185
nsv521789 CNV loss 19592680
nsv820122 CNV gain 19587683

Variation tolerance for KLF5 Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLF5 Gene

Human Gene Mutation Database (HGMD)
KLF5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLF5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF5 Gene

Disorders for KLF5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for KLF5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sigmoid disease
  • sigmoid diseases
colorectal cancer
  • crc
esophageal cancer
  • esophageal cancer, somatic
gastric adenocarcinoma
  • adenocarcinoma of stomach
- elite association - COSMIC cancer census association via MalaCards
Search KLF5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KLF5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KLF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLF5 Gene

Publications for KLF5 Gene

  1. cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2. (PMID: 8479902) Sogawa K … Fujii-Kuriyama Y (Nucleic acids research 1993) 2 3 4 23 54
  2. Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associated with human hypertension. (PMID: 20086047) Oishi Y … Nagai R (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010) 3 23 41 54
  3. Expression of Kruppel-like factor 5 gene in human brain and association of the gene with the susceptibility to schizophrenia. (PMID: 18226501) Yanagi M … Shirakawa O (Schizophrenia research 2008) 3 23 41 54
  4. Analysis of KLF transcription factor family gene variants in type 2 diabetes. (PMID: 17688680) Gutiérrez-Aguilar R … Neve B (BMC medical genetics 2007) 3 23 41 54
  5. Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells. (PMID: 15735697) Chen C … Dong JT (Oncogene 2005) 3 4 23 54

Products for KLF5 Gene

Sources for KLF5 Gene