Aliases for KLF3 Gene

Aliases for KLF3 Gene

  • Kruppel Like Factor 3 2 3 5
  • CACCC-Box-Binding Protein BKLF 3 4
  • Kruppel-Like Factor 3 (Basic) 2 3
  • Basic Krueppel-Like Factor 3 4
  • Basic Kruppel-Like Factor 2 3
  • Krueppel-Like Factor 3 3 4
  • TEF-2 3 4
  • BKLF 3 4
  • Basic Kruppel Like Factor 3
  • Transcript Ch138 3

External Ids for KLF3 Gene

Previous GeneCards Identifiers for KLF3 Gene

  • GC04P038830
  • GC04P038500
  • GC04P038563
  • GC04P038488
  • GC04P038342
  • GC04P037989

Summaries for KLF3 Gene

GeneCards Summary for KLF3 Gene

KLF3 (Kruppel Like Factor 3) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is KLF12.

UniProtKB/Swiss-Prot Summary for KLF3 Gene

  • Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity).

Gene Wiki entry for KLF3 Gene

Additional gene information for KLF3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLF3 Gene

Genomics for KLF3 Gene

GeneHancer (GH) Regulatory Elements for KLF3 Gene

Promoters and enhancers for KLF3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J038661 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 506.7 +4.7 4688 14.9 EP300 HNRNPK FOXK2 ZBTB40 CTCF TCF12 NRF1 POLR2G USF1 NCOR1 KLF3 KLF3-AS1 ENSG00000271958 WDR19 ENSG00000249863 KLHL5 TLR6 TLR1 lnc-TLR10-2 lnc-KLF3-1
GH04J038853 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.6 +192.3 192269 5.7 ZBTB40 CTCF TCF12 SIN3A SP1 GTF2E2 JUND FOS PHB2 EP300 TLR6 TLR1 TLR10 FAM114A1 KLF3 KLHL5 piR-40110-530
GH04J038619 Enhancer 1.1 Ensembl ENCODE 11.9 -43.0 -42969 4.4 ZNF217 ZSCAN5C TCF12 ZNF639 TCF7 AFF1 TRIM28 HES1 KLF4 KLF7 ENSG00000271958 KLF3-AS1 KLF3 piR-58297-337
GH04J038243 Enhancer 1.1 Ensembl ENCODE 10.4 -421.0 -420968 1.6 BCLAF1 PHB2 ZBTB11 AFF1 TSC22D4 ZNF740 TOE1 CTBP1 MYC TRIM25 LOC105374408 PGM2 ENSG00000249863 FAM114A1 WDR19 KLF3 ENSG00000251642 RF01061-123
GH04J038609 Enhancer 0.9 Ensembl ENCODE 11.9 -51.0 -50968 9.6 HNRNPK USF1 AFF1 MCM3 RBM25 WT1 ZNF316 NFIC ZNF426 SPI1 KLF3-AS1 ENSG00000271958 ENSG00000249863 PGM2 KLF3 FAM114A1 LOC102723415
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLF3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLF3

Top Transcription factor binding sites by QIAGEN in the KLF3 gene promoter:
  • GATA-1
  • Lmo2
  • Nkx2-5
  • p300
  • Pax-5
  • RFX1
  • Sox5
  • Sp1

Genomic Locations for KLF3 Gene

Genomic Locations for KLF3 Gene
37,349 bases
Plus strand
37,340 bases
Plus strand

Genomic View for KLF3 Gene

Genes around KLF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF3 Gene

Proteins for KLF3 Gene

  • Protein details for KLF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Krueppel-like factor 3
    Protein Accession:
    Secondary Accessions:
    • Q6PIR1
    • Q86TN0
    • Q9P2X6

    Protein attributes for KLF3 Gene

    345 amino acids
    Molecular mass:
    38829 Da
    Quaternary structure:
    • Monomer.
    • [Isoform 2]: May be due to intron retention.

    Alternative splice isoforms for KLF3 Gene


neXtProt entry for KLF3 Gene

Post-translational modifications for KLF3 Gene

  • Sumoylated with SUMO1. Sumoylation is enhanced by PIAS1, PIAS2alpha and PIAS2beta, and PIAS4, but not by Pc2. Enhances transcriptional repression, but has no effect on DNA binding. Sumoylation on Lys-198 is the major site (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLF3 Gene

Domains & Families for KLF3 Gene

Gene Families for KLF3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for KLF3 Gene


Suggested Antigen Peptide Sequences for KLF3 Gene

GenScript: Design optimal peptide antigens:
  • TEF-2 (KLF3_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In KLF3, the motif is inactive.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In KLF3, the motif is inactive.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF3: view

Function for KLF3 Gene

Molecular function for KLF3 Gene

UniProtKB/Swiss-Prot Function:
Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity).

Phenotypes From GWAS Catalog for KLF3 Gene

Gene Ontology (GO) - Molecular Function for KLF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity NAS 10582345
genes like me logo Genes that share ontologies with KLF3: view
genes like me logo Genes that share phenotypes with KLF3: view

Animal Models for KLF3 Gene

MGI Knock Outs for KLF3:
  • Klf3 Klf3<tm1Merc>

Animal Model Products

CRISPR Products

Targeted motifs for KLF3 Gene
HOMER Transcription Factor Regulatory Elements motif KLF3
  • Consensus sequence: NRGCCCCRCCCHBNN Submotif: canonical Cell Type: MEF GEO ID: GSE44748

Clone Products

  • Addgene plasmids for KLF3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for KLF3 Gene

Localization for KLF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF3 gene
Compartment Confidence
nucleus 5
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KLF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA,IBA --
genes like me logo Genes that share ontologies with KLF3: view

Pathways & Interactions for KLF3 Gene

PathCards logo

SuperPathways for KLF3 Gene

genes like me logo Genes that share pathways with KLF3: view

Pathways by source for KLF3 Gene

1 KEGG pathway for KLF3 Gene

SIGNOR curated interactions for KLF3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for KLF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0007275 multicellular organism development TAS 10582345
GO:1901653 cellular response to peptide IEA --
genes like me logo Genes that share ontologies with KLF3: view

Drugs & Compounds for KLF3 Gene

(1) Drugs for KLF3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KLF3: view

Transcripts for KLF3 Gene

mRNA/cDNA for KLF3 Gene

8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for KLF3

Alternative Splicing Database (ASD) splice patterns (SP) for KLF3 Gene

No ASD Table

Relevant External Links for KLF3 Gene

GeneLoc Exon Structure for

Expression for KLF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLF3 Gene

Protein differential expression in normal tissues from HIPED for KLF3 Gene

This gene is overexpressed in CD8 Tcells (44.6) and CD4 Tcells (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KLF3 Gene

Protein tissue co-expression partners for KLF3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLF3

SOURCE GeneReport for Unigene cluster for KLF3 Gene:


Evidence on tissue expression from TISSUES for KLF3 Gene

  • Nervous system(4.6)
  • Liver(4.4)
  • Bone marrow(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with KLF3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF3 Gene

Orthologs for KLF3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLF3 31 30
  • 99.9 (n)
(Bos Taurus)
Mammalia KLF3 31 30
  • 90.14 (n)
(Canis familiaris)
Mammalia KLF3 31 30
  • 87.73 (n)
(Rattus norvegicus)
Mammalia Klf3 30
  • 87.4 (n)
(Mus musculus)
Mammalia Klf3 17 31 30
  • 86.92 (n)
(Ornithorhynchus anatinus)
Mammalia KLF3 31
  • 84 (a)
(Monodelphis domestica)
Mammalia KLF3 31
  • 75 (a)
(Gallus gallus)
Aves KLF3 31 30
  • 75.58 (n)
(Anolis carolinensis)
Reptilia KLF3 31
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klf3 30
  • 68.53 (n)
(Danio rerio)
Actinopterygii klf3 31
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12029 32
  • 76 (a)
CG9895 32
  • 74 (a)
CG42741 31
  • 29 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010520 30
  • 68.94 (n)
(Caenorhabditis elegans)
Secernentea F56F11.3 32
  • 72 (a)
mua-1 32
  • 66 (a)
F53F8.1 32
  • 62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM101 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
Species where no ortholog for KLF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF3 Gene

Gene Tree for KLF3 (if available)
Gene Tree for KLF3 (if available)
Evolutionary constrained regions (ECRs) for KLF3: view image

Paralogs for KLF3 Gene

(6) SIMAP similar genes for KLF3 Gene using alignment to 1 proteins:

  • KLF3_HUMAN Pseudogenes for KLF3 Gene

genes like me logo Genes that share paralogs with KLF3: view

Variants for KLF3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLF3 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs17616226 - p.Arg207Ser

Additional dbSNP identifiers (rs#s) for KLF3 Gene

Structural Variations from Database of Genomic Variants (DGV) for KLF3 Gene

Variant ID Type Subtype PubMed ID
dgv9014n54 CNV gain 21841781
dgv9015n54 CNV loss 21841781
esv22862 CNV loss 19812545
nsv1074168 CNV deletion 25765185
nsv1122085 CNV deletion 24896259
nsv1145029 CNV deletion 24896259
nsv461336 CNV loss 19166990
nsv524237 CNV loss 19592680
nsv594009 CNV loss 21841781
nsv822539 CNV gain 20364138
nsv950574 CNV deletion 24416366

Variation tolerance for KLF3 Gene

Residual Variation Intolerance Score: 26.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF3 Gene

Disorders for KLF3 Gene

Additional Disease Information for KLF3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KLF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLF3 Gene

Publications for KLF3 Gene

  1. [cDNA cloning, subcellular localization and tissue expression of a new human Krüppel-like transcription factor: human basic Krüppel-like factor (hBKLF)]. (PMID: 12812068) Wang MJ … He FC (Yi chuan xue bao = Acta genetica Sinica 2003) 3 4 23 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  4. Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis. (PMID: 18391014) Sue N … Crossley M (Molecular and cellular biology 2008) 2 3 54
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54

Products for KLF3 Gene

Sources for KLF3 Gene