Aliases for KLF2 Gene
External Ids for KLF2 Gene
Previous GeneCards Identifiers for KLF2 Gene
This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disease including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability. [provided by RefSeq, Mar 2017]
GeneCards Summary for KLF2 Gene
KLF2 (Kruppel Like Factor 2) is a Protein Coding gene. Diseases associated with KLF2 include Splenic Marginal Zone Lymphoma and Cerebral Cavernous Malformations. Among its related pathways are Apelin signaling pathway and EV release from cardiac cells and their functional effects. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is KLF4.
UniProtKB/Swiss-Prot Summary for KLF2 Gene
Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed:21063504). Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed:28167758).