This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disea... See more...

Aliases for KLF2 Gene

Aliases for KLF2 Gene

  • Kruppel Like Factor 2 2 3 5
  • Kruppel-Like Factor 2 (Lung) 2 3
  • Lung Krueppel-Like Factor 3 4
  • Lung Kruppel-Like Factor 2 3
  • Krueppel-Like Factor 2 3 4
  • LKLF 3 4
  • Lung Kruppel-Like Zinc Finger Transcription Factor 3
  • Kruppel-Like Factor LKLF 3

External Ids for KLF2 Gene

Previous GeneCards Identifiers for KLF2 Gene

  • GC19P016929
  • GC19P016827
  • GC19P016280
  • GC19P016296
  • GC19P016435
  • GC19P016007
  • GC19P016576
  • GC19P016814
  • GC19P020443
  • GC19P020581
  • GC19P017591
  • GC19P018259
  • GC19P018660
  • GC19P018967
  • GC19P019293
  • GC19P019621
  • GC19P019984
  • GC19P020299

Summaries for KLF2 Gene

Entrez Gene Summary for KLF2 Gene

  • This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disease including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability. [provided by RefSeq, Mar 2017]

GeneCards Summary for KLF2 Gene

KLF2 (Kruppel Like Factor 2) is a Protein Coding gene. Diseases associated with KLF2 include Splenic Marginal Zone Lymphoma and Cerebral Cavernous Malformations. Among its related pathways are FoxO signaling pathway and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is KLF4.

UniProtKB/Swiss-Prot Summary for KLF2 Gene

  • Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed:21063504). Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed:28167758).

Gene Wiki entry for KLF2 Gene

Additional gene information for KLF2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLF2 Gene

Genomics for KLF2 Gene

GeneHancer (GH) Regulatory Elements for KLF2 Gene

Promoters and enhancers for KLF2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLF2 gene promoter:
  • AP-1
  • Arnt
  • ATF-2
  • c-Jun
  • C/EBPbeta
  • FOXC1

Genomic Locations for KLF2 Gene

Genomic Locations for KLF2 Gene
chr19:16,324,817-16,327,874
(GRCh38/hg38)
Size:
3,058 bases
Orientation:
Plus strand
chr19:16,435,628-16,438,685
(GRCh37/hg19)
Size:
3,058 bases
Orientation:
Plus strand

Genomic View for KLF2 Gene

Genes around KLF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF2 Gene

Proteins for KLF2 Gene

  • Protein details for KLF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5W3-KLF2_HUMAN
    Recommended name:
    Krueppel-like factor 2
    Protein Accession:
    Q9Y5W3
    Secondary Accessions:
    • Q6IPC4
    • Q9UJS5
    • Q9UKR6

    Protein attributes for KLF2 Gene

    Size:
    355 amino acids
    Molecular mass:
    37420 Da
    Quaternary structure:
    • Interacts with WWP1.

neXtProt entry for KLF2 Gene

Post-translational modifications for KLF2 Gene

  • Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for KLF2

No data available for DME Specific Peptides for KLF2 Gene

Domains & Families for KLF2 Gene

Gene Families for KLF2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for KLF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KLF2 Gene

GenScript: Design optimal peptide antigens:
  • Lung krueppel-like factor (KLF2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y5W3

UniProtKB/Swiss-Prot:

KLF2_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF2: view

Function for KLF2 Gene

Molecular function for KLF2 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed:21063504). Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed:28167758).
GENATLAS Biochemistry:
Kruppel-like factor 2 (lung),zinc finger transcription factor,homolog of a mouse gene,predominantly expressed in developing lung,spleen and vascular system,putatively involved in programming the quiescent state of single positive T cells and blood wall morphogenesis

Phenotypes From GWAS Catalog for KLF2 Gene

Gene Ontology (GO) - Molecular Function for KLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS,IMP 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IMP 22327366
GO:0003700 DNA-binding transcription factor activity IBA,IDA 21063504
GO:0005515 protein binding IPI 16617118
genes like me logo Genes that share ontologies with KLF2: view
genes like me logo Genes that share phenotypes with KLF2: view

Animal Models for KLF2 Gene

MGI Knock Outs for KLF2:

Animal Model Products

CRISPR Products

miRNA for KLF2 Gene

miRTarBase miRNAs that target KLF2

Clone Products

  • Addgene plasmids for KLF2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLF2 Gene

Localization for KLF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF2 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IMP 22327366
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with KLF2: view

Pathways & Interactions for KLF2 Gene

genes like me logo Genes that share pathways with KLF2: view

SIGNOR curated interactions for KLF2 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for KLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 26299712
GO:0000902 cell morphogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0032715 negative regulation of interleukin-6 production IEA --
genes like me logo Genes that share ontologies with KLF2: view

Drugs & Compounds for KLF2 Gene

(2) Drugs for KLF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KLF2: view

Transcripts for KLF2 Gene

mRNA/cDNA for KLF2 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(428) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for KLF2

Alternative Splicing Database (ASD) splice patterns (SP) for KLF2 Gene

No ASD Table

Relevant External Links for KLF2 Gene

GeneLoc Exon Structure for
KLF2
ECgene alternative splicing isoforms for
KLF2

Expression for KLF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF2 Gene

This gene is overexpressed in Whole Blood (x6.8).

Protein differential expression in normal tissues from HIPED for KLF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.0), Blymphocyte (22.4), and CD8 Tcells (21.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLF2 Gene



Protein tissue co-expression partners for KLF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KLF2 Gene:

KLF2

SOURCE GeneReport for Unigene cluster for KLF2 Gene:

Hs.744182

Evidence on tissue expression from TISSUES for KLF2 Gene

  • Lung(4.8)
  • Spleen(4.5)
  • Skin(4.2)
  • Heart(3.7)
  • Blood(3.4)
  • Muscle(3.1)
  • Nervous system(2.5)
  • Intestine(2.3)
  • Kidney(2.3)
  • Lymph node(2.3)
  • Liver(2.2)
  • Pancreas(2.2)
  • Bone marrow(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with KLF2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF2 Gene

Orthologs for KLF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF2 33 32
  • 99.25 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLF2 33
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klf2 17 33 32
  • 81.87 (n)
rat
(Rattus norvegicus)
Mammalia Klf2 32
  • 81.62 (n)
oppossum
(Monodelphis domestica)
Mammalia KLF2 33
  • 73 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 33
  • 14 (a)
ManyToMany
chicken
(Gallus gallus)
Aves KLF2 33
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 56 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii klf2b 33
  • 48 (a)
OneToMany
klf2a 33
  • 46 (a)
OneToMany
-- 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5981 32
fruit fly
(Drosophila melanogaster)
Insecta CG9895 34
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea F56F11.3 34
  • 79 (a)
mua-1 34
  • 62 (a)
F53F8.1 34
  • 59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 25 (a)
OneToMany
Species where no ortholog for KLF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KLF2 Gene

ENSEMBL:
Gene Tree for KLF2 (if available)
TreeFam:
Gene Tree for KLF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLF2: view image

Paralogs for KLF2 Gene

(9) SIMAP similar genes for KLF2 Gene using alignment to 2 proteins:

  • KLF2_HUMAN
  • K7EJ60_HUMAN

Pseudogenes.org Pseudogenes for KLF2 Gene

genes like me logo Genes that share paralogs with KLF2: view

Variants for KLF2 Gene

Sequence variations from dbSNP and Humsavar for KLF2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000315963 -- 16,328,316(+) C/T 3_prime_UTR_variant
rs1000346869 -- 16,328,670(+) G/T downstream_transcript_variant
rs1000964898 -- 16,323,370(+) G/C upstream_transcript_variant
rs1001312342 -- 16,323,580(+) C/T upstream_transcript_variant
rs1001602351 -- 16,326,751(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLF2 Gene

Variant ID Type Subtype PubMed ID
nsv1072333 CNV deletion 25765185
nsv1118817 CNV deletion 24896259
nsv833767 CNV loss 17160897

Variation tolerance for KLF2 Gene

Gene Damage Index Score: 0.59; 12.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLF2 Gene

Human Gene Mutation Database (HGMD)
KLF2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLF2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF2 Gene

Disorders for KLF2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KLF2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
splenic marginal zone lymphoma
  • smzl
cerebral cavernous malformations
  • cam
heritable pulmonary arterial hypertension
  • familial pulmonary arterial hypertension
- elite association - COSMIC cancer census association via MalaCards
Search KLF2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KLF2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KLF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLF2 Gene

Publications for KLF2 Gene

  1. Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus. (PMID: 10217429) Kozyrev SV … Kisselev LL (FEBS letters 1999) 2 3 4 23 56
  2. cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung Kruppel-like factor. (PMID: 10458913) Wani MA … Lingrel JB (Genomics 1999) 2 3 4 23 56
  3. A study of the relationships between KLF2 polymorphisms and body weight control in a French population. (PMID: 16542423) Meirhaeghe A … Amouyel P (BMC medical genetics 2006) 3 23 43 56
  4. MicroRNA-10a is crucial for endothelial response to different flow patterns via interaction of retinoid acid receptors and histone deacetylases. (PMID: 28167758) Lee DY … Chiu JJ (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 4 56
  5. A novel role of CCN3 in regulating endothelial inflammation. (PMID: 21063504) Lin Z … Jain MK (Journal of cell communication and signaling 2010) 3 4 56

Products for KLF2 Gene

Sources for KLF2 Gene