Aliases for KLF17 Gene
External Ids for KLF17 Gene
Previous HGNC Symbols for KLF17 Gene
Previous GeneCards Identifiers for KLF17 Gene
GeneCards Summary for KLF17 Gene
KLF17 (Kruppel Like Factor 17) is a Protein Coding gene. Diseases associated with KLF17 include Chondrosarcoma, Extraskeletal Myxoid and Breast Cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is KLF18.
UniProtKB/Swiss-Prot Summary for KLF17 Gene
Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).