Aliases for KLF17 Gene

Aliases for KLF17 Gene

  • Kruppel Like Factor 17 2 3 5
  • Zinc Finger Protein 393 2 3 4
  • Krueppel-Like Factor 17 3 4
  • ZNF393 3 4
  • Novel Zinc-Finger Protein 3
  • ZLF393 3
  • Zfp393 3

External Ids for KLF17 Gene

Previous HGNC Symbols for KLF17 Gene

  • ZNF393

Previous GeneCards Identifiers for KLF17 Gene

  • GC01P044357
  • GC01P044584
  • GC01P042699

Summaries for KLF17 Gene

GeneCards Summary for KLF17 Gene

KLF17 (Kruppel Like Factor 17) is a Protein Coding gene. Diseases associated with KLF17 include Chondrosarcoma, Extraskeletal Myxoid and Breast Cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is KLF18.

UniProtKB/Swiss-Prot Summary for KLF17 Gene

  • Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).

Gene Wiki entry for KLF17 Gene

Additional gene information for KLF17 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLF17 Gene

Genomics for KLF17 Gene

GeneHancer (GH) Regulatory Elements for KLF17 Gene

Promoters and enhancers for KLF17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J044047 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 500.4 +5.0 5049 3.5 CTCF TCF12 BCLAF1 JUND FOS POLR2A ZBTB11 AFF1 REST DNMT1 KLF17 ENSG00000237950 IPO13 ARTN ENSG00000230615 B4GALT2 piR-38814-001
GH01J044044 Enhancer 1.1 Ensembl ENCODE 500.7 +0.1 77 1.6 ZBTB11 RFX1 TOE1 MYC CTBP1 TAF9B HDAC3 SIN3A NCOR1 MBD2 KLF17 DMAP1 SZT2 IPO13 ENSG00000237950 ENSG00000230615 ARTN piR-38814-001
GH01J044045 Enhancer 0.5 Ensembl 500.7 +1.3 1274 0.4 ZNF263 ATF2 ZNF395 REST ZBTB21 ATF3 E2F1 ZNF512 ATF7 KLF17 IPO13 ENSG00000237950 DMAP1 B4GALT2 ENSG00000230615 piR-38814-001
GH01J044118 Promoter 0.3 EPDnew 500.2 +75.0 75003 0.1 RN7SL479P RF00017-187 lnc-KLF18-8 KLF17 ENSG00000233514 lnc-KLF18-9
GH01J044034 Enhancer 1.7 VISTA ENCODE CraniofacialAtlas dbSUPER 5.3 -7.7 -7739 3 CTCF NRF1 PHB2 ZBTB5 ZIC2 ZBTB11 AFF1 TARDBP REST HES1 ENSG00000237950 PTCH2 ENSG00000230615 KLF17 lnc-SLC6A9-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLF17 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLF17

Top Transcription factor binding sites by QIAGEN in the KLF17 gene promoter:
  • AREB6
  • Bach1
  • COMP1
  • FAC1
  • FOXD3
  • FOXO3
  • FOXO3a
  • FOXO3b
  • FOXO4
  • ISGF-3

Genomic Locations for KLF17 Gene

Genomic Locations for KLF17 Gene
chr1:44,043,927-44,135,140
(GRCh38/hg38)
Size:
91,214 bases
Orientation:
Plus strand
chr1:44,584,522-44,600,812
(GRCh37/hg19)
Size:
16,291 bases
Orientation:
Plus strand

Genomic View for KLF17 Gene

Genes around KLF17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF17 Gene

Proteins for KLF17 Gene

  • Protein details for KLF17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JT82-KLF17_HUMAN
    Recommended name:
    Krueppel-like factor 17
    Protein Accession:
    Q5JT82
    Secondary Accessions:
    • Q86VQ7
    • Q8N805

    Protein attributes for KLF17 Gene

    Size:
    389 amino acids
    Molecular mass:
    42577 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLF17 Gene

Post-translational modifications for KLF17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF17 Gene

Antibody Products

  • Abcam antibodies for KLF17
  • Santa Cruz Biotechnology (SCBT) Antibodies for KLF17

No data available for DME Specific Peptides for KLF17 Gene

Domains & Families for KLF17 Gene

Gene Families for KLF17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for KLF17 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KLF17 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 393 (KLF17_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5JT82

UniProtKB/Swiss-Prot:

KLF17_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF17: view

Function for KLF17 Gene

Molecular function for KLF17 Gene

UniProtKB/Swiss-Prot Function:
Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).

Phenotypes From GWAS Catalog for KLF17 Gene

Gene Ontology (GO) - Molecular Function for KLF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity ISS --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KLF17: view
genes like me logo Genes that share phenotypes with KLF17: view

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for KLF17

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLF17 Gene

Localization for KLF17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF17 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF17 gene
Compartment Confidence
nucleus 5
extracellular 2
cytoskeleton 2
cytosol 2
golgi apparatus 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for KLF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with KLF17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLF17 Gene

Pathways & Interactions for KLF17 Gene

PathCards logo

SuperPathways for KLF17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II ISS --
genes like me logo Genes that share ontologies with KLF17: view

No data available for Pathways by source and SIGNOR curated interactions for KLF17 Gene

Drugs & Compounds for KLF17 Gene

No Compound Related Data Available

Transcripts for KLF17 Gene

mRNA/cDNA for KLF17 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for KLF17

Alternative Splicing Database (ASD) splice patterns (SP) for KLF17 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP2: - -
SP3:

Relevant External Links for KLF17 Gene

GeneLoc Exon Structure for
KLF17

Expression for KLF17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLF17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF17 Gene

This gene is overexpressed in Testis (x29.8).

Protein differential expression in normal tissues from HIPED for KLF17 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLF17 Gene



Protein tissue co-expression partners for KLF17 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLF17

SOURCE GeneReport for Unigene cluster for KLF17 Gene:

Hs.567674

Evidence on tissue expression from TISSUES for KLF17 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with KLF17: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF17 Gene

Orthologs for KLF17 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLF17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF17 31 30
  • 99.06 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KLF17 31 30
  • 78.57 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KLF17 30
  • 75.7 (n)
-- 31
  • 61 (a)
OneToMany
-- 31
  • 55 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Klf17 17 31 30
  • 65.86 (n)
rat
(Rattus norvegicus)
Mammalia Klf17 30
  • 65.84 (n)
oppossum
(Monodelphis domestica)
Mammalia KLF17 31
  • 20 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii AL929286.1 31
  • 19 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta btd 31
  • 13 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM101 33
Species where no ortholog for KLF17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLF17 Gene

ENSEMBL:
Gene Tree for KLF17 (if available)
TreeFam:
Gene Tree for KLF17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLF17: view image

Paralogs for KLF17 Gene

Pseudogenes.org Pseudogenes for KLF17 Gene

genes like me logo Genes that share paralogs with KLF17: view

Variants for KLF17 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLF17 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs11210969 - p.Ile35Asn
rs2429051 - p.Ser57Thr
rs2485652 - p.Asn156Ser
rs6656945 - p.Gln80His

Additional dbSNP identifiers (rs#s) for KLF17 Gene

Structural Variations from Database of Genomic Variants (DGV) for KLF17 Gene

Variant ID Type Subtype PubMed ID
nsv829704 CNV loss 17160897

Variation tolerance for KLF17 Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.86; 89.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLF17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLF17

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF17 Gene

Disorders for KLF17 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KLF17 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chondrosarcoma, extraskeletal myxoid
  • emc
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search KLF17 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KLF17

genes like me logo Genes that share disorders with KLF17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLF17 Gene

Publications for KLF17 Gene

  1. Human KLF17 is a new member of the Sp/KLF family of transcription factors. (PMID: 16460907) van Vliet J … Crossley M (Genomics 2006) 2 3 4 23 54
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Krüppel-like factor 17 inhibits urokinase plasminogen activator gene expression to suppress cell invasion through the Src/p38/ MAPK signaling pathway in human lung adenocarcionma. (PMID: 28454121) Cai XD … Zhou YB (Oncotarget 2017) 3 54

Products for KLF17 Gene

Sources for KLF17 Gene