Aliases for KLF15 Gene
External Ids for KLF15 Gene
Previous GeneCards Identifiers for KLF15 Gene
GeneCards Summary for KLF15 Gene
KLF15 (Kruppel Like Factor 15) is a Protein Coding gene. Diseases associated with KLF15 include Aortic Aneurysm and Muscle Hypertrophy. Among its related pathways are BMAL1-CLOCK,NPAS2 activates circadian gene expression and Adipogenesis. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is KLF4.
UniProtKB/Swiss-Prot Summary for KLF15 Gene
Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.