Aliases for KLF15 Gene

Aliases for KLF15 Gene

  • Kruppel Like Factor 15 2 3 5
  • Kidney-Enriched Krueppel-Like Factor 3 4
  • Kidney-Enriched Kruppel-Like Factor 2 3
  • Krueppel-Like Factor 15 3 4
  • KKLF 3 4

External Ids for KLF15 Gene

Previous GeneCards Identifiers for KLF15 Gene

  • GC03M122845
  • GC03M126092
  • GC03M127343
  • GC03M127382
  • GC03M127544
  • GC03M123442
  • GC03M126061

Summaries for KLF15 Gene

GeneCards Summary for KLF15 Gene

KLF15 (Kruppel Like Factor 15) is a Protein Coding gene. Diseases associated with KLF15 include Aortic Aneurysm and Muscle Hypertrophy. Among its related pathways are BMAL1-CLOCK,NPAS2 activates circadian gene expression and Adipogenesis. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is KLF4.

UniProtKB/Swiss-Prot Summary for KLF15 Gene

  • Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.

Gene Wiki entry for KLF15 Gene

Additional gene information for KLF15 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLF15 Gene

Genomics for KLF15 Gene

GeneHancer (GH) Regulatory Elements for KLF15 Gene

Promoters and enhancers for KLF15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J126353 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 516.6 +1.6 1635 5.5 EP300 FOXK2 ZNF217 POLR2G USF1 NCOR1 ZIC2 ZBTB26 TARDBP SAP30 KLF15 lnc-ZXDC-2 ALDH1L1 OR7E29P CFAP100 UROC1
GH03J126266 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 +89.7 89693 3.8 MYC POLR2G USF1 FOS TEAD4 CTCF SKI TEAD1 ATF2 ZKSCAN8 ENSG00000250934 ALDH1L1 KLF15 CCDC37-DT CFAP100 ALDH1L1-AS2 ENPP7P4 lnc-KLF15-3
GH03J126178 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 9.4 +177.2 177176 3.6 POLR2G USF1 NCOR1 ZBTB26 TGIF2 ZBTB7A MXI1 POLR2A EZH2 KMT2B ALDH1L1-AS2 RF00017-4100 ALDH1L1 KLF15
GH03J126388 Promoter/Enhancer 1.5 ENCODE CraniofacialAtlas 11.3 -31.9 -31923 1.3 ZNF217 CTCF GABPA ZBTB26 REST KLF4 RFX1 ZBTB25 RAD21 CTBP1 lnc-CFAP100-7 KLF15 CCDC37-DT piR-61514-115
GH03J126207 Enhancer 1 Ensembl ENCODE 10.1 +148.9 148928 2.2 FOS ZIC2 ZBTB11 RFX1 EP300 ZNF341 NFIC SP2 ZBTB17 GABPA KLF15 ALDH1L1-AS2 ALDH1L1 ENSG00000287232 piR-50444-320
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLF15 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLF15

Top Transcription factor binding sites by QIAGEN in the KLF15 gene promoter:
  • C/EBPalpha
  • E2F-3a
  • PPAR-gamma1
  • PPAR-gamma2
  • Sp1

Genomic Locations for KLF15 Gene

Genomic Locations for KLF15 Gene
chr3:126,342,635-126,357,408
(GRCh38/hg38)
Size:
14,774 bases
Orientation:
Minus strand
chr3:126,061,478-126,076,285
(GRCh37/hg19)
Size:
14,808 bases
Orientation:
Minus strand

Genomic View for KLF15 Gene

Genes around KLF15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF15 Gene

Proteins for KLF15 Gene

  • Protein details for KLF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIH9-KLF15_HUMAN
    Recommended name:
    Krueppel-like factor 15
    Protein Accession:
    Q9UIH9

    Protein attributes for KLF15 Gene

    Size:
    416 amino acids
    Molecular mass:
    43992 Da
    Quaternary structure:
    • Interacts with MYOCD and EP300.

    Three dimensional structures from OCA and Proteopedia for KLF15 Gene

neXtProt entry for KLF15 Gene

Post-translational modifications for KLF15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLF15 Gene

Domains & Families for KLF15 Gene

Gene Families for KLF15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for KLF15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KLF15 Gene

GenScript: Design optimal peptide antigens:
  • Kidney-enriched krueppel-like factor (KLF15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UIH9

UniProtKB/Swiss-Prot:

KLF15_HUMAN :
  • The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Domain:
  • The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF15: view

Function for KLF15 Gene

Molecular function for KLF15 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.
UniProtKB/Swiss-Prot Induction:
In podocytes, up-regulated by retinoic acid.

Phenotypes From GWAS Catalog for KLF15 Gene

Gene Ontology (GO) - Molecular Function for KLF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 19767294
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 19767294
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IMP 19767294
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with KLF15: view
genes like me logo Genes that share phenotypes with KLF15: view

Animal Models for KLF15 Gene

MGI Knock Outs for KLF15:

Animal Model Products

CRISPR Products

miRNA for KLF15 Gene

miRTarBase miRNAs that target KLF15

Clone Products

  • Addgene plasmids for KLF15

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLF15 Gene

Localization for KLF15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF15 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for KLF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005623 cell IEA --
GO:0005634 nucleus IBA,IDA 17438289
genes like me logo Genes that share ontologies with KLF15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLF15 Gene

Pathways & Interactions for KLF15 Gene

genes like me logo Genes that share pathways with KLF15: view

Pathways by source for KLF15 Gene

1 BioSystems pathway for KLF15 Gene

SIGNOR curated interactions for KLF15 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for KLF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001678 cellular glucose homeostasis IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0010001 glial cell differentiation IEA --
GO:0010468 regulation of gene expression IEA --
GO:0014898 cardiac muscle hypertrophy in response to stress IEA --
genes like me logo Genes that share ontologies with KLF15: view

Drugs & Compounds for KLF15 Gene

(1) Drugs for KLF15 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KLF15: view

Transcripts for KLF15 Gene

mRNA/cDNA for KLF15 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for KLF15

Alternative Splicing Database (ASD) splice patterns (SP) for KLF15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4
SP1: - -
SP2: -
SP3:

Relevant External Links for KLF15 Gene

GeneLoc Exon Structure for
KLF15

Expression for KLF15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLF15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLF15 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLF15 Gene



Protein tissue co-expression partners for KLF15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLF15

SOURCE GeneReport for Unigene cluster for KLF15 Gene:

Hs.272215

mRNA Expression by UniProt/SwissProt for KLF15 Gene:

Q9UIH9-KLF15_HUMAN
Tissue specificity: Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues.

Evidence on tissue expression from TISSUES for KLF15 Gene

  • Kidney(4.4)
  • Skin(4)
  • Muscle(2.4)
  • Heart(2.2)
  • Liver(2)
genes like me logo Genes that share expression patterns with KLF15: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF15 Gene

Orthologs for KLF15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLF15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF15 31 30
  • 94.67 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KLF15 31 30
  • 86.39 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klf15 30
  • 83.45 (n)
mouse
(Mus musculus)
Mammalia Klf15 17 31 30
  • 82.81 (n)
cow
(Bos Taurus)
Mammalia KLF15 31 30
  • 82.75 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLF15 31
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLF15 31
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLF15 31 30
  • 68 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLF15 31
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf15 30
  • 62.93 (n)
zebrafish
(Danio rerio)
Actinopterygii klf15 31 30
  • 59.02 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EP2237 32
  • 66 (a)
CG9895 32
  • 65 (a)
Bteb2 31
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F53F8.1 32
  • 61 (a)
mua-1 32
  • 59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FZF1 33
Species where no ortholog for KLF15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF15 Gene

ENSEMBL:
Gene Tree for KLF15 (if available)
TreeFam:
Gene Tree for KLF15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLF15: view image

Paralogs for KLF15 Gene

(1) SIMAP similar genes for KLF15 Gene using alignment to 1 proteins:

  • KLF15_HUMAN
genes like me logo Genes that share paralogs with KLF15: view

Variants for KLF15 Gene

Additional dbSNP identifiers (rs#s) for KLF15 Gene

Structural Variations from Database of Genomic Variants (DGV) for KLF15 Gene

Variant ID Type Subtype PubMed ID
dgv8548n54 CNV gain 21841781
esv29660 CNV loss 19812545
nsv1073676 CNV deletion 25765185
nsv1112833 CNV deletion 24896259
nsv1126654 CNV deletion 24896259
nsv591500 CNV loss 21841781
nsv591502 CNV loss 21841781
nsv591503 CNV loss 21841781
nsv591504 CNV gain 21841781

Variation tolerance for KLF15 Gene

Residual Variation Intolerance Score: 51.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLF15 Gene

Human Gene Mutation Database (HGMD)
KLF15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLF15

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLF15 Gene

Disorders for KLF15 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KLF15 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
aortic aneurysm
  • abdominal aortic aneurysm, ruptured
muscle hypertrophy
  • mslhp
glomerular disease
- elite association - COSMIC cancer census association via MalaCards
Search KLF15 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

KLF15_HUMAN
  • Note=KLF15 deficiency results in loss of rhythmic QT variation and abnormal heart repolarization (PubMed:22367544). It may play a role in susceptibility to ventricular arrhythmias (PubMed:22367544), and development of pathological cardiac hypertrophy leading to heart failure (PubMed:20375365). {ECO:0000269 PubMed:20375365, ECO:0000269 PubMed:22367544}.

Additional Disease Information for KLF15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KLF15: view

No data available for Genatlas for KLF15 Gene

Publications for KLF15 Gene

  1. Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Krüppel-like factor, a novel zinc finger repressor. (PMID: 10982849) Uchida S … Marumo F (Molecular and cellular biology 2000) 2 3 4 23 54
  2. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. (PMID: 17438289) Fisch S … Jain MK (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 4 23 54
  3. Kruppel-like factor 15 is critical for vascular inflammation. (PMID: 23999430) Lu Y … Jain MK (The Journal of clinical investigation 2013) 3 4 54
  4. Kruppel-like factor 15 (KLF15) is a key regulator of podocyte differentiation. (PMID: 22493483) Mallipattu SK … He JC (The Journal of biological chemistry 2012) 3 4 54
  5. Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation. (PMID: 20375365) Haldar SM … Jain MK (Science translational medicine 2010) 3 4 54

Products for KLF15 Gene

Sources for KLF15 Gene